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ATE555104T1 - 5-substituierte chinazolinon-derivate als antitumorverbindungen - Google Patents

5-substituierte chinazolinon-derivate als antitumorverbindungen

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Publication number
ATE555104T1
ATE555104T1 AT07838876T AT07838876T ATE555104T1 AT E555104 T1 ATE555104 T1 AT E555104T1 AT 07838876 T AT07838876 T AT 07838876T AT 07838876 T AT07838876 T AT 07838876T AT E555104 T1 ATE555104 T1 AT E555104T1
Authority
AT
Austria
Prior art keywords
antitumor compounds
quinazolinone derivatives
substituted quinazolinone
substituted
derivatives
Prior art date
Application number
AT07838876T
Other languages
English (en)
Inventor
George W Muller
Hon-Wah Man
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Application granted granted Critical
Publication of ATE555104T1 publication Critical patent/ATE555104T1/de

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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877780B2 (en) * 2006-08-30 2014-11-04 Celgene Corporation 5-substituted isoindoline compounds
DK2428513T3 (en) * 2006-09-26 2017-08-21 Celgene Corp 5-substituted quinazolinone derivatives as anti-cancer agents
EP2200999B1 (de) * 2007-09-26 2014-08-13 Celgene Corporation 6-, 7- oder 8-substituierte chinazolinonderivate und zusammensetzungen, die diese enthalten, sowie verfahren zu deren anwendung
US8354417B2 (en) * 2007-09-26 2013-01-15 Celgene Corporation Solid forms comprising 3-(2,5-dimethyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the same, and methods of using the same
US7786171B2 (en) * 2008-04-04 2010-08-31 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
US8835506B2 (en) 2008-06-05 2014-09-16 Stc.Unm Methods and related compositions for the treatment of cancer
US20100160368A1 (en) 2008-08-18 2010-06-24 Gregory Jefferson J Methods of Treating Dermatological Disorders and Inducing Interferon Biosynthesis With Shorter Durations of Imiquimod Therapy
EP2378876B1 (de) 2008-12-19 2018-11-14 Medicis Pharmaceutical Corporation Imiquimod-formulierungen mit geringerer dosisstärke und kurze dosierpläne zur behandlung von aktinischer keratose
CN102460165B (zh) * 2009-05-19 2016-08-17 维维雅生物技术公司 用于为血液肿瘤提供离体个体化药物测试的方法
CN102448472A (zh) 2009-05-25 2012-05-09 国立大学法人东京工业大学 包含与中枢神经细胞的增殖和分化相关的核因子的药物组合物
EP2453747B1 (de) 2009-07-13 2017-08-30 Medicis Pharmaceutical Corporation Imiquimod-formulierungen mit geringerer dosisstärke und kurze dosierpläne zur behandlung von warzen im genital- und perianalbereich
CN101913846B (zh) * 2010-08-11 2012-05-23 昆明理工大学 一种用煤泥磷石膏冶金废渣合成陶粒的方法
CN106083812A (zh) 2011-03-11 2016-11-09 细胞基因公司 3‑(5‑氨基‑2‑甲基‑4‑氧‑4h‑喹唑啉‑3‑基)‑哌啶‑2,6‑二酮的固体形式及其药物组合物和用途
HUE027481T2 (en) * 2011-03-11 2016-09-28 Celgene Corp Methods of treating cancer using 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
WO2012135299A1 (en) 2011-03-28 2012-10-04 Deuteria Pharmaceuticals Inc 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
CA2834535A1 (en) 2011-04-29 2012-11-01 Celgene Corporation Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
EP2867671B1 (de) 2012-06-29 2018-10-24 Celgene Corporation Verfahren zur bestimmung der wirksamkeit von arzneimitteln anhand von cereblonassoziierten proteinen
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
EP2892887B1 (de) * 2012-09-04 2020-07-15 Celgene Corporation Isotopologe des 3-(5-amino-2-methyl-4-oxochinazolin-3(4h)-yl) piperidin-2,6-dions und methoden zu dessen herstellung
JP6306592B2 (ja) * 2012-09-10 2018-04-04 セルジーン コーポレイション 局所進行乳癌を治療するための方法
AU2014205043B2 (en) 2013-01-14 2018-10-04 Deuterx, Llc 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
CA2941560A1 (en) 2013-03-14 2014-09-25 Deuterx, Llc 3-(substituted-4-oxo-quinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
CN105339009B (zh) 2013-04-17 2018-08-28 西格诺药品有限公司 用于治疗癌症的包括tor激酶抑制剂和5-取代喹唑啉酮化合物的组合疗法
DK2991976T3 (da) * 2013-05-01 2017-11-06 Celgene Corp Syntese af 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidin-2,6-dion
WO2014179661A1 (en) 2013-05-03 2014-11-06 Celgene Corporation Methods for treating cancer using combination therapy
UA117141C2 (uk) 2013-10-08 2018-06-25 Селджин Корпорейшн Склади (s)-3-(4-((4-(морфолінометил)бензил)оксі)-1-оксоізоіндолін-2-іл)піперидин-2,6-діону
CN103645259B (zh) * 2013-12-12 2015-03-11 深圳海王药业有限公司 一种同时测定泊马度胺及其有关物质的方法
US20150196562A1 (en) 2014-01-15 2015-07-16 Celgene Corporation Formulations of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
EP3152216B1 (de) 2014-06-05 2019-07-24 Bayer CropScience Aktiengesellschaft Bicyclische verbindungen als schädlingsbekämpfungsmittel
ES2843973T3 (es) 2014-06-27 2021-07-21 Celgene Corp Composiciones y métodos para inducir cambios conformacionales en cereblon y otras ubiquitina ligasas E3
ES3043078T3 (en) 2014-08-22 2025-11-24 Celgene Corp Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
TW201642857A (zh) 2015-04-06 2016-12-16 西建公司 以組合療法治療肝細胞癌
AU2016288246A1 (en) 2015-07-02 2018-02-01 Celgene Corporation Combination therapy for treatment of hematological cancers and solid tumors
US9809603B1 (en) 2015-08-18 2017-11-07 Deuterx, Llc Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same
CA2996641A1 (en) 2015-08-27 2017-03-02 Celgene Corporation Pharmaceutical compositions comprising 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
CN106551934B (zh) * 2015-09-29 2020-09-11 康朴生物医药技术（上海）有限公司 一种药物组合物及其应用
KR20180088401A (ko) 2015-12-02 2018-08-03 셀진 코포레이션 3-(5-아미노-2-메틸-4-옥소-4h-퀴나졸린-3-일)-피페리딘-2,6-다이온을 사용한 주기 요법
WO2017117118A1 (en) 2015-12-28 2017-07-06 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases
RU2730500C2 (ru) * 2016-01-14 2020-08-24 Канпу Биофармасьютикалз, Лтд Производное хиназолинона, способ его получения, фармацевтическая композиция и применения
EP4483875A3 (de) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Spirocyclische degronimere für zielproteinabbau
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
EP3455219A4 (de) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. Amingebundene c3-glutarimiddegronimere für zielproteinabbau
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
CN110049765B (zh) 2016-12-16 2022-02-01 康朴生物医药技术（上海）有限公司 一种组合、其应用及治疗方法
PL3581182T3 (pl) 2017-02-13 2022-01-17 Kangpu Biopharmaceuticals, Ltd. Kombinacja lecząca nowotwór złośliwy gruczołu krokowego, kompozycja farmaceutyczna i sposób leczenia
WO2018165142A1 (en) 2017-03-07 2018-09-13 Celgene Corporation Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses
KR102014478B1 (ko) 2017-05-12 2019-08-26 한국화학연구원 신규한 피페리딘-2,6-디온 유도체 및 이의 용도
EP3641762A4 (de) 2017-06-20 2021-03-10 C4 Therapeutics, Inc. N/o-gebundene degrone und degronimere zum proteinabbau
CA3072735A1 (en) 2017-08-21 2019-02-28 Celgene Corporation Processes for the preparation of (s)-tert-butyl 4,5-diamino-5-oxopentanoate
EP3679026A1 (de) 2017-09-04 2020-07-15 C4 Therapeutics, Inc. Glutarimid
EP3679027A1 (de) 2017-09-04 2020-07-15 C4 Therapeutics, Inc. Dihydrobenzimidazolone
EP3679028A1 (de) 2017-09-04 2020-07-15 C4 Therapeutics, Inc. Dihydrochinolinone
WO2019099868A2 (en) 2017-11-16 2019-05-23 C4 Therapeutics, Inc. Degraders and degrons for targeted protein degradation
BR112020014421A2 (pt) 2018-01-17 2020-12-01 Aurigene Discovery Technologies Limited compostos de alquinileno substituídos como agentes anticâncer
JP2021514193A (ja) 2018-02-21 2021-06-10 セルジーン コーポレイション Ｂｃｍａ結合抗体及びその使用
KR20210018199A (ko) 2018-03-26 2021-02-17 씨4 테라퓨틱스, 인코포레이티드 이카로스의 분해를 위한 세레블론 결합제
EP3781156A4 (de) 2018-04-16 2022-05-18 C4 Therapeutics, Inc. Spirocyclische verbindungen
EP3578561A1 (de) 2018-06-04 2019-12-11 F. Hoffmann-La Roche AG Spiroverbindungen
WO2020097403A1 (en) 2018-11-08 2020-05-14 Juno Therapeutics, Inc. Methods and combinations for treatment and t cell modulation
WO2020132561A1 (en) 2018-12-20 2020-06-25 C4 Therapeutics, Inc. Targeted protein degradation
BR112021019669A2 (pt) 2019-04-12 2021-12-07 C4 Therapeutics Inc Composto, composição farmacêutica, método para tratar um transtorno, composto para uso na produção de um medicamento, e, uso de um composto no tratamento de um transtorno
CN115023419A (zh) 2019-11-27 2022-09-06 凯普托尔治疗学股份有限公司 与cereblon结合的哌啶-2,6-二酮及其使用方法
EP4065576A1 (de) 2019-11-27 2022-10-05 Captor Therapeutics S.A. Piperidin-2,6-dion-derivate, die an cereblon binden, und verfahren zur verwendung davon
US11807620B2 (en) 2020-02-21 2023-11-07 Plexium, Inc. Quinazolinone compounds and related compounds
BR112022026090A2 (pt) 2020-06-25 2023-01-17 Celgene Corp Métodos para tratar câncer com terapias de combinação
JP2023535453A (ja) * 2020-07-24 2023-08-17 イニファーム，インク． キナゾリノンｈｓｄ１７ｂ１３阻害剤とその使用
EP4188373A1 (de) 2020-08-03 2023-06-07 Captor Therapeutics S.A. Niedermolekulare proteinabbauer und deren anwendungen
CA3189456A1 (en) * 2020-08-14 2022-02-17 Xiaobao Yang Immunoregulatory compounds and anti-tumor application thereof
MX2023005550A (es) 2020-11-13 2023-07-18 Inipharm Inc Inhibidores de diclorofenol hsd17b13 y usos de los mismos.
WO2022146151A1 (en) 2020-12-30 2022-07-07 Captor Therapeutics S.A. Novel compounds which bind to cereblon, and methods of use thereof
WO2022255889A1 (en) 2021-06-01 2022-12-08 Captor Therapeutics S.A. Compounds which bind to cereblon, and use thereof
WO2022255890A1 (en) 2021-06-01 2022-12-08 Captor Therapeutics S.A. Compounds which bind to cereblon, and use thereof
EP4480948A4 (de) * 2022-02-14 2025-06-11 Gluetacs Therapeutics (Shanghai) Co., Ltd. Verbindung auf basis eines chinazolinsubstituierten glutarimidgerüsts und verwendung davon
IL316803A (en) 2022-06-06 2025-01-01 C4 Therapeutics Inc Bicyclic glutarimide-modified cervalon-binding agents
WO2024167423A1 (en) 2023-02-07 2024-08-15 Captor Therapeutics S.A. Gspt1 degrader compounds
CN116789530A (zh) * 2023-05-16 2023-09-22 杭州师范大学 一种紫苏醇酚类衍生物及其制备方法和应用

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1997563A (en) * 1929-05-31 1935-04-09 Karmazin Engineering Company Method of making heat radiators
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US5001116A (en) 1982-12-20 1991-03-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US4994443A (en) 1982-12-20 1991-02-19 The Children's Medical Center Corporation Inhibition of angiogenesis
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
WO1995003807A1 (en) 1993-07-27 1995-02-09 The University Of Sydney Treatment of age-related macular degeneration
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
IT1274549B (it) 1995-05-23 1997-07-17 Indena Spa Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno
US5800819A (en) 1996-01-25 1998-09-01 National Institute For Pharmaceutical Research And Development Federal Ministry Of Science And Technology Piper guineense, pterocarpus osun, eugenia caryophyllata, and sorghum bicolor extracts for treating sickle cell disease
SK9199A3 (en) 1996-07-24 1999-07-12 Celgene Corp 2,6-dioxopiperidines, pharmaceutical composition them containing and their use
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US6015803A (en) 1998-05-04 2000-01-18 Wirostko; Emil Antibiotic treatment of age-related macular degeneration
US6225348B1 (en) 1998-08-20 2001-05-01 Alfred W. Paulsen Method of treating macular degeneration with a prostaglandin derivative
US6001368A (en) 1998-09-03 1999-12-14 Protein Technologies International, Inc. Method for inhibiting or reducing the risk of macular degeneration
US7182953B2 (en) 1999-12-15 2007-02-27 Celgene Corporation Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders
EA007538B1 (ru) * 2000-12-11 2006-10-27 Туларик Инк. Антагонисты cxcr3
AU2002317377A1 (en) 2001-07-20 2003-03-03 Cancer Research Technology Limited Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer
WO2003041326A2 (en) 2001-11-09 2003-05-15 Matsushita Electric Industrial Co., Ltd. Moving picture coding method and apparatus
FR2837201A1 (fr) * 2002-03-18 2003-09-19 Servier Lab Nouveaux composes derives de la quinazoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7393862B2 (en) 2002-05-17 2008-07-01 Celgene Corporation Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
US7189740B2 (en) 2002-10-15 2007-03-13 Celgene Corporation Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
US20050203142A1 (en) 2002-10-24 2005-09-15 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
US20040091455A1 (en) 2002-10-31 2004-05-13 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US20050024328A1 (en) 2003-07-23 2005-02-03 Graham Oldfield Control area selection in a computing device with a graphical user interface
AP2006003637A0 (en) 2003-11-06 2006-06-30 Celgene Corp Methods and compositions using thalidomide for thetreatment and management of cancers and other diseases
US20050100529A1 (en) 2003-11-06 2005-05-12 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
CA2545725A1 (en) 2003-11-14 2005-06-02 Merck Sharp & Dohme Limited Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1)
AU2004296765B2 (en) 2003-12-02 2011-03-24 Celgene Corporation Methods and compositions for the treatment and management of hemoglobinopathy and anemia
US20050143344A1 (en) 2003-12-30 2005-06-30 Zeldis Jerome B. Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
KR101224262B1 (ko) 2004-03-22 2013-01-21 셀진 코포레이션 면역조절 화합물을 포함하는 피부 질환 또는 장애의 치료및 관리용 조성물 및 이의 사용 방법
US20050222209A1 (en) 2004-04-01 2005-10-06 Zeldis Jerome B Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
US20050239842A1 (en) 2004-04-23 2005-10-27 Zeldis Jerome B Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of pulmonary hypertension
CN101098694A (zh) 2004-11-12 2008-01-02 细胞基因公司 使用免疫调节化合物治疗和控制寄生性疾病的方法和组合物
EP1827431A1 (de) 2004-11-23 2007-09-05 Celgene Corporation Verfahren und zusammensetzungen unter verwendung immunmodulatorischer verbindungen zur behandlung und verwaltung von verletzungen des zentralen nervensystems
GB0506147D0 (en) 2005-03-24 2005-05-04 Merck Sharp & Dohme Therapeutic agents
CA2607929A1 (en) 2005-05-11 2006-11-16 Merck Sharp & Dohme Limited 2,3-substituted fused bicyclic pyrimidin-4(3h)-ones modulating the function of the vanilloid-1 receptor (vr1)
GB0509573D0 (en) 2005-05-11 2005-06-15 Merck Sharp & Dohme Therapeutic compounds
WO2007113558A2 (en) 2006-04-05 2007-10-11 Astrazeneca Ab Quinazolinone derivatives having b-raf inhibitory activity
JP2009532449A (ja) 2006-04-05 2009-09-10 アストラゼネカ アクチボラグ 抗癌活性のある置換キナゾリン
WO2007119055A1 (en) 2006-04-18 2007-10-25 Astrazeneca Ab Quinazolin-4-one derivatives, process for their preparation and pharmaceutical compositions containing them
DK2428513T3 (en) * 2006-09-26 2017-08-21 Celgene Corp 5-substituted quinazolinone derivatives as anti-cancer agents
EP2200999B1 (de) 2007-09-26 2014-08-13 Celgene Corporation 6-, 7- oder 8-substituierte chinazolinonderivate und zusammensetzungen, die diese enthalten, sowie verfahren zu deren anwendung
US9095596B2 (en) 2009-10-15 2015-08-04 Southern Research Institute Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
WO2012027065A2 (en) 2010-08-27 2012-03-01 Celgene Corporation Combination therapy for treatment of disease
WO2012066330A1 (en) 2010-11-17 2012-05-24 Heptares Therapeutics Limited Compounds useful as a2a receptor inhibitors
AU2011329619A1 (en) 2010-11-18 2013-05-02 Deuteria Pharmaceuticals, Inc. 3-deutero-pomalidomide
CN106083812A (zh) 2011-03-11 2016-11-09 细胞基因公司 3‑(5‑氨基‑2‑甲基‑4‑氧‑4h‑喹唑啉‑3‑基)‑哌啶‑2,6‑二酮的固体形式及其药物组合物和用途
HUE027481T2 (en) 2011-03-11 2016-09-28 Celgene Corp Methods of treating cancer using 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
CA2834535A1 (en) 2011-04-29 2012-11-01 Celgene Corporation Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
CA2871535A1 (en) 2012-01-13 2013-07-18 Celgene Corporation Biomarkers for the treatment of hepatocellular carcinoma
EP2867671B1 (de) 2012-06-29 2018-10-24 Celgene Corporation Verfahren zur bestimmung der wirksamkeit von arzneimitteln anhand von cereblonassoziierten proteinen
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
EP2892887B1 (de) 2012-09-04 2020-07-15 Celgene Corporation Isotopologe des 3-(5-amino-2-methyl-4-oxochinazolin-3(4h)-yl) piperidin-2,6-dions und methoden zu dessen herstellung
JP6306592B2 (ja) 2012-09-10 2018-04-04 セルジーン コーポレイション 局所進行乳癌を治療するための方法
AU2014205043B2 (en) 2013-01-14 2018-10-04 Deuterx, Llc 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
KR20150126618A (ko) 2013-03-14 2015-11-12 셀진 코포레이션 아프레밀라스트를 사용하는 건선성 관절염의 치료
AU2014254056B2 (en) 2013-04-17 2019-06-06 Signal Pharmaceuticals, Llc Combination therapy comprising a TOR kinase inhibitor and an IMiD compound for treating cancer
CN105339009B (zh) 2013-04-17 2018-08-28 西格诺药品有限公司 用于治疗癌症的包括tor激酶抑制剂和5-取代喹唑啉酮化合物的组合疗法
MX2015014455A (es) 2013-04-17 2016-07-21 Signal Pharm Llc Terapia de combinacion que comprende un inhibidor de tor cinasa y n-(3-(5-fluoro-2-(4-(2-metoxietoxi)fenilamino)pirimidin-4-ilamino )fenil)acrilamida para tratar cancer.
DK2991976T3 (da) 2013-05-01 2017-11-06 Celgene Corp Syntese af 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidin-2,6-dion
WO2014179661A1 (en) 2013-05-03 2014-11-06 Celgene Corporation Methods for treating cancer using combination therapy
EA201691144A1 (ru) 2013-12-06 2016-11-30 Селджин Корпорейшн Способы определения эффективности лекарственного средства для лечения диффузной крупноклеточной b-клеточной лимфомы, множественной миеломы и злокачественных новообразований миелоидного ростка
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
US20150196562A1 (en) 2014-01-15 2015-07-16 Celgene Corporation Formulations of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
WO2015107196A1 (en) 2014-01-20 2015-07-23 Institut Curie Use of thalidomide or analogs thereof for preventing neurologic disorders induced by brain irradiation
US20150258082A1 (en) 2014-03-14 2015-09-17 Francesco Parlati Combination therapy with glutaminase inhibitors
KR102320082B1 (ko) 2014-04-14 2021-10-29 아비나스 오퍼레이션스, 인코포레이티드 단백질분해의 이미드-기초된 조절인자 및 연관된 이용 방법
ES2843973T3 (es) 2014-06-27 2021-07-21 Celgene Corp Composiciones y métodos para inducir cambios conformacionales en cereblon y otras ubiquitina ligasas E3
HK1231381A1 (zh) 2014-07-11 2017-12-22 Celgene Corporation 癌症组合疗法
WO2016014890A1 (en) 2014-07-24 2016-01-28 Calithera Biosciences, Inc. Treatment of multiple myeloma with heterocyclic inhibitors of glutaminase
EA037738B1 (ru) 2014-08-07 2021-05-17 Калитера Байосайенсиз, Инк. Кристаллические формы ингибиторов глутаминазы
EP3188745A1 (de) 2014-08-15 2017-07-12 Celgene Corporation Dosierungstitrierung von apremilast zur behandlung von durch pde4-hemmung gelinderte krankheiten
WO2016060702A1 (en) 2014-10-13 2016-04-21 Celgene Corporaton Methods for treating solid tumors and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies
CN107257800B (zh) 2014-12-23 2020-06-30 达纳-法伯癌症研究所股份有限公司 通过双功能分子诱导靶蛋白降解的方法
US9717745B2 (en) 2015-03-19 2017-08-01 Zhejiang DTRM Biopharma Co. Ltd. Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
WO2016153948A1 (en) 2015-03-20 2016-09-29 Deuterx, Llc Combination therapy using enantiopure, oxy-substituted, deuterium-enriched 5-(benzyl)-5-deutero-thiazolidine-2, 4-diones for treatment of medical disorders
EP3277676B1 (de) 2015-03-25 2023-03-22 Pierre Fabre Médicament Substituierte chinazolin-derivate als dna-methyltransferaseinhibitoren
TW201642857A (zh) 2015-04-06 2016-12-16 西建公司 以組合療法治療肝細胞癌

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