PE20080744A1 - IMIDAZOL AMINAS COMO INHIBIDORES DE LA ß-SECRETASA - Google Patents
IMIDAZOL AMINAS COMO INHIBIDORES DE LA ß-SECRETASAInfo
- Publication number
- PE20080744A1 PE20080744A1 PE2007001049A PE2007001049A PE20080744A1 PE 20080744 A1 PE20080744 A1 PE 20080744A1 PE 2007001049 A PE2007001049 A PE 2007001049A PE 2007001049 A PE2007001049 A PE 2007001049A PE 20080744 A1 PE20080744 A1 PE 20080744A1
- Authority
- PE
- Peru
- Prior art keywords
- som
- pyrimidin
- halogen
- amine
- phenyl
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title abstract 3
- -1 IMIDAZOLE AMINES Chemical class 0.000 title 1
- 239000002439 beta secretase inhibitor Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
- 201000010374 Down Syndrome Diseases 0.000 abstract 1
- 208000008574 Intracranial Hemorrhages Diseases 0.000 abstract 1
- 206010044688 Trisomy 21 Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 206010002022 amyloidosis Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- OYRRZWATULMEPF-UHFFFAOYSA-N pyrimidin-4-amine Chemical compound NC1=CC=NC=N1 OYRRZWATULMEPF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
REFERIDA A UN DERIVADO DE IMIDAZOL DE FORMULA (I), DONDE Q ES O, S O CH2; W ES O, S O CH2; X ES N, NO, SOm, O O CH; Y ES N, NO, SOm, O, CR10; Z ES N, NO, O, SOm O CR11; m ES 0, 1 O 2; n ES 0 O 1; R1 Y R2 SON H, ALQUILO C1-C4, ENTRE OTROS; R3 Y R4 SON H, ALQUILO C1-C4, ENTRE OTROS; R5 Y R6 SON H, HALOGENO, NO2, ENTRE OTROS; R7 Y R8 SON H, HALOGENO, NO2, CN, ENTRE OTROS; R9 ES H, HALOGENO, NO2, CN, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 8-[3-(2-FLUOROPIRIDIN-3-IL)-FENIL]-8-PIRIDIN-4-IL-2,3,4,8-TETRAHIDROIMIDAZO[1,5-a]PIRIMIDIN-6-AMINA, 8-(2,6-DIETILPIRIDIN-4-IL)-8-[3-(2-FLUROPIRIDIN-3-IL)-FENIL]-2,3,4,8-TETRAHIDRO-IMIDAZO[1,5-a]PIRIMIDIN-6-AMINA, 8-(1-ETIL-1H-PIRAZOL-4-IL)-8-[3-(2-FLUOROPIRIDIN-3-IL)FENIL]-2,3,4,8-TETRAHIDRO-IMIDAZOL[1,5-a]PIRIMIDIN-6-AMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y UN PROCESO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA ß-SECRETASA Y SON UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, SINDROME DE DOWN, HEMORRAGIA CEREBRAL HEREDITARIA CON AMILOIDOSIS DEL TIPO DUTCH, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83835706P | 2006-08-17 | 2006-08-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080744A1 true PE20080744A1 (es) | 2008-05-24 |
Family
ID=38988046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001049A PE20080744A1 (es) | 2006-08-17 | 2007-08-07 | IMIDAZOL AMINAS COMO INHIBIDORES DE LA ß-SECRETASA |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2054414A2 (es) |
| JP (1) | JP2010500999A (es) |
| AR (1) | AR062409A1 (es) |
| CA (1) | CA2660441A1 (es) |
| CL (1) | CL2007002288A1 (es) |
| MX (1) | MX2009001699A (es) |
| PE (1) | PE20080744A1 (es) |
| TW (1) | TW200817406A (es) |
| WO (1) | WO2008022024A2 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| JP2008543849A (ja) | 2005-06-14 | 2008-12-04 | シェーリング コーポレイション | アスパルチルプロテアーゼ阻害剤 |
| BRPI0612545A2 (pt) | 2005-06-14 | 2010-11-23 | Schering Corp | compostos inibidores de protease, composições farmacêuticas e uso dos mesmos |
| AU2006307314C1 (en) | 2005-10-25 | 2011-08-25 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivative |
| CA2653650A1 (en) | 2006-06-12 | 2007-12-21 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| WO2008133273A1 (ja) | 2007-04-24 | 2008-11-06 | Shionogi & Co., Ltd. | アルツハイマー症治療用医薬組成物 |
| EP2147914B1 (en) | 2007-04-24 | 2014-06-04 | Shionogi&Co., Ltd. | Aminodihydrothiazine derivatives substituted with cyclic groups |
| MX2010011563A (es) | 2008-04-22 | 2010-11-12 | Schering Corp | Compuestos 2-imino-3-metil pirrolo pirimidinona fenil-sustituidos como inhibidores de enzima de escision de proteina precursora amiloide sitio beta-1, composiciones y su uso. |
| EA020740B1 (ru) | 2008-06-13 | 2015-01-30 | Шионоги & Ко., Лтд. | Серосодержащее гетероциклическое производное, обладающее активностью ингибитора бета-секретазы |
| CN102186841A (zh) | 2008-10-22 | 2011-09-14 | 盐野义制药株式会社 | 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物 |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| TWI488852B (zh) | 2009-12-11 | 2015-06-21 | Shionogi & Co | 衍生物 |
| EP2634188A4 (en) * | 2010-10-29 | 2014-05-07 | Shionogi & Co | FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE |
| AU2011321427A1 (en) | 2010-10-29 | 2013-05-02 | Shionogi & Co., Ltd. | Naphthyridine derivative |
| US9221839B2 (en) | 2011-04-07 | 2015-12-29 | Merck Sharp & Dohme Corp. | C5-C6 oxacyclic-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use |
| US9145426B2 (en) | 2011-04-07 | 2015-09-29 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use |
| CN103608345A (zh) | 2011-04-26 | 2014-02-26 | 盐野义制药株式会社 | 噁嗪衍生物和含有该噁嗪衍生物的bace1抑制剂 |
| BR112014004181A2 (pt) | 2011-08-22 | 2017-06-13 | Merck Sharp & Dohme | composto, composição farmacêutica, e, método de tratamento, prevenção, e / ou retardo do início de uma doença ou patologia |
| WO2014065434A1 (en) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070026811A (ko) * | 2004-06-16 | 2007-03-08 | 와이어쓰 | 베타-세크리타제 억제제로서의 디페닐이미다조피리미딘 및디페닐이미다졸 아민 |
| JP2008503459A (ja) * | 2004-06-16 | 2008-02-07 | ワイス | β−セクレターゼを阻害するためのアミノ−５，５−ジフェニルイミダゾロン誘導体 |
| EP2264036A1 (en) * | 2005-01-14 | 2010-12-22 | Wyeth LLC (Formerly Known As Wyeth) | Amino-imidazolones for the inhibition of beta-secretase |
| TW200738683A (en) * | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
| CA2613435A1 (en) * | 2005-06-30 | 2007-01-11 | Wyeth | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for .beta.-secretase modulation |
-
2007
- 2007-07-24 TW TW096126963A patent/TW200817406A/zh unknown
- 2007-08-07 CL CL200702288A patent/CL2007002288A1/es unknown
- 2007-08-07 PE PE2007001049A patent/PE20080744A1/es not_active Application Discontinuation
- 2007-08-10 CA CA002660441A patent/CA2660441A1/en not_active Abandoned
- 2007-08-10 EP EP07840855A patent/EP2054414A2/en not_active Withdrawn
- 2007-08-10 JP JP2009524746A patent/JP2010500999A/ja not_active Withdrawn
- 2007-08-10 MX MX2009001699A patent/MX2009001699A/es not_active Application Discontinuation
- 2007-08-10 WO PCT/US2007/075690 patent/WO2008022024A2/en not_active Ceased
- 2007-08-16 AR ARP070103654A patent/AR062409A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010500999A (ja) | 2010-01-14 |
| AR062409A1 (es) | 2008-11-05 |
| CL2007002288A1 (es) | 2008-02-08 |
| EP2054414A2 (en) | 2009-05-06 |
| TW200817406A (en) | 2008-04-16 |
| MX2009001699A (es) | 2009-02-25 |
| WO2008022024A2 (en) | 2008-02-21 |
| WO2008022024A3 (en) | 2008-05-22 |
| CA2660441A1 (en) | 2008-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |