PE20071235A1 - Metodo para producir l-amino acidos - Google Patents
Metodo para producir l-amino acidosInfo
- Publication number
- PE20071235A1 PE20071235A1 PE2007000097A PE2007000097A PE20071235A1 PE 20071235 A1 PE20071235 A1 PE 20071235A1 PE 2007000097 A PE2007000097 A PE 2007000097A PE 2007000097 A PE2007000097 A PE 2007000097A PE 20071235 A1 PE20071235 A1 PE 20071235A1
- Authority
- PE
- Peru
- Prior art keywords
- phosphotransacetilase
- seq
- amino acid
- activity
- medium
- Prior art date
Links
- 150000008575 L-amino acids Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940024606 amino acid Drugs 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- XUJNEKJLAYXESH-XQSDEXCQSA-N (2r)-2-azanyl-3-sulfanyl-propanoic acid Chemical compound [35SH]C[C@H](N)C(O)=O XUJNEKJLAYXESH-XQSDEXCQSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 241000588914 Enterobacter Species 0.000 abstract 1
- 241000588722 Escherichia Species 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- 241000520272 Pantoea Species 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 229960002989 glutamic acid Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/10—Citrulline; Arginine; Ornithine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/14—Glutamic acid; Glutamine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/24—Proline; Hydroxyproline; Histidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
REFERIDA A UN METODO PARA PRODUCIR UN L-AMINOACIDO TAL COMO ACIDO DE L-GLUTAMICO, L-GLUTAMINA, L-PROLINA, L-ARGININA, L-LEUCINA O L-CISTEINA, QUE COMPRENDE EL CULTIVO DE UNA BACTERIA QUE TIENE LA CAPACIDAD DE PRODUCIR L-AMINOACIDO Y QUE ESTA MODIFICADA DE MANERA TAL QUE LA ACTIVIDAD FOSFOTRANSACETILASA SE AMPLIA EN UN MEDIO PARA CAUSAR LA ACUMULACION DE UN L-AMINOACIDO EN EL MEDIO O CELULAS BACTERIANAS Y LUEGO RECOGER EL L-AMINOACIDO DEL MEDIO O CELULAS BACTERIANAS. LA ACTIVIDAD FOSFOTRANSACETILASA SE AMPLIA AUMENTANDO UN NUMERO COPIA DE UN GEN QUE CODIFICA FOSFOTRANZACETILASA O MODIFICANDO UNA SECUENCIA REGULATORIA DE EXPRESION DEL GEN QUE CODIFICA FOSFOTRANSACETILASA. EL GEN QUE CODIFICA FOSFOTRANSACETILASA ES a) UN ADN QUE COMPRENDE NUMEROS DE NUCLEOTIDOS 1214 A 2641 DE SEQ ID NO:34 O LA SECUENCIA DE NUCLEOTIDO DE SEQ ID:40 O b) UN ADEN QUE HIBRIDA CON UNA CEPA COMPLEMENTARIA DE LA SECUENCIA DE NUCLEOTIDOS 1214 A 2641 DE SEQ ID:34 O SECUENCIA DE NUCLEOTIDOS DE SEQ ID NO:40 BAJO CONDICIONES EXIGENTES Y CODIFICA UNA PROTEINA QUE TIENE ACTIVIDAD FOSFOTRANSACETILASA. LA BACTERIA EMPLEADA ES UNA BACTERIA CORINEFORME, PANTOEA, ENTEROBACTER O ESCHERICHIA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006019562 | 2006-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071235A1 true PE20071235A1 (es) | 2007-12-02 |
Family
ID=37908222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000097A PE20071235A1 (es) | 2006-01-27 | 2007-01-29 | Metodo para producir l-amino acidos |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8012722B2 (es) |
| EP (1) | EP1976995B1 (es) |
| CN (1) | CN101374953B (es) |
| BR (1) | BRPI0707229B8 (es) |
| PE (1) | PE20071235A1 (es) |
| WO (1) | WO2007086608A1 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| US7794989B2 (en) * | 2004-12-28 | 2010-09-14 | Ajinomoto Co., Inc. | L-glutamic acid-producing microorganism and a method for producing L-glutamic acid |
| JP2012223091A (ja) * | 2009-08-25 | 2012-11-15 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| US8871488B2 (en) * | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| WO2012137689A1 (ja) * | 2011-04-01 | 2012-10-11 | 味の素株式会社 | Ｌ－システインの製造法 |
| AU2012335091B2 (en) | 2011-11-09 | 2016-06-16 | Amyris, Inc. | Production of acetyl-coenzyme a derived isoprenoids |
| EP2778228B1 (en) | 2011-11-11 | 2017-05-17 | Ajinomoto Co., Inc. | Method for producing 2-ketoglutaric acid and derivatives thereof by using a bacterium from the genus pantoea or the genus corynebacterium |
| JP6519476B2 (ja) | 2013-10-23 | 2019-05-29 | 味の素株式会社 | 目的物質の製造法 |
| KR101601404B1 (ko) | 2014-04-09 | 2016-03-09 | 씨제이제일제당 (주) | Ｌ-라이신 생산능을 갖는 미생물 및 이를 이용한 ｌ-라이신 생산 방법 |
| KR101735935B1 (ko) * | 2015-07-20 | 2017-05-16 | 씨제이제일제당 (주) | 퓨트레신 또는 오르니틴 생산 미생물 및 이를 이용한 퓨트레신 또는 오르니틴 생산방법 |
| CN106148261B (zh) * | 2016-07-01 | 2019-09-03 | 江南大学 | 一种提高乙酰氨基葡萄糖产量的重组枯草芽孢杆菌及其构建方法 |
| CN105566136A (zh) * | 2016-01-19 | 2016-05-11 | 天津科技大学 | 一种从发酵液中分离提取4-羟基异亮氨酸的方法 |
| US10428359B2 (en) * | 2016-10-03 | 2019-10-01 | Ajinomoto Co, Inc. | Method for producing L-amino acid |
| JP7066977B2 (ja) * | 2017-04-03 | 2022-05-16 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
| CN110218710B (zh) * | 2019-04-30 | 2020-06-23 | 中国科学院天津工业生物技术研究所 | 活性提高的磷酸转酮酶及在生产代谢物中的应用 |
| CN112410389B (zh) * | 2019-08-23 | 2023-07-18 | 中国科学院微生物研究所 | 支链α-酮酸脱氢酶复合体在制备丙二酸单酰辅酶A中的应用 |
| CN113025542B (zh) * | 2019-12-25 | 2022-09-16 | 中国科学院微生物研究所 | 产l-谷氨酰胺的重组大肠杆菌及其构建方法与应用 |
| CN112143751B (zh) * | 2020-09-22 | 2022-05-06 | 廊坊梅花生物技术开发有限公司 | 高产核苷的枯草芽孢杆菌工程菌及其构建方法与应用 |
| CN114107141B (zh) * | 2021-08-19 | 2022-07-12 | 中国科学院天津工业生物技术研究所 | 高产l-脯氨酸的谷氨酸棒杆菌以及高产l-脯氨酸的方法 |
| CN114134185B (zh) * | 2021-10-30 | 2024-06-21 | 新泰市佳禾生物科技有限公司 | 一种发酵生产l-丝氨酸的方法 |
| CN114277070B (zh) * | 2021-11-29 | 2024-07-09 | 新泰市佳禾生物科技有限公司 | 一种发酵生产l-鸟氨酸的方法 |
| CN116536227A (zh) * | 2022-01-26 | 2023-08-04 | 廊坊梅花生物技术开发有限公司 | 一种生产苏氨酸的修饰的棒状杆菌属微生物及其构建方法与应用 |
| CN116555131A (zh) * | 2022-01-27 | 2023-08-08 | 廊坊梅花生物技术开发有限公司 | 一种重组微生物及其构建方法和应用 |
| CN114478724B (zh) * | 2022-04-18 | 2022-06-24 | 中国科学院天津工业生物技术研究所 | 一种ramB突变体及其构建赖氨酸生产菌株的方法 |
| CN114874959B (zh) * | 2022-04-27 | 2024-04-16 | 天津科技大学 | 一种利用葡萄糖从头发酵生产l-茶氨酸的基因工程菌、方法及应用 |
| CN117165504A (zh) * | 2023-08-03 | 2023-12-05 | 天津世纪伟康生物科技有限公司 | 一种发酵法高效生产γ-氨基丁酸的工程菌及其应用 |
| KR20250078646A (ko) * | 2023-11-23 | 2025-06-04 | 대상 주식회사 | L-글루탐산 생산능이 향상된 변이 미생물 및 이를 이용한 l-글루탐산의 생산 방법 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56144093A (en) | 1980-04-14 | 1981-11-10 | Ajinomoto Co Inc | Preparation of l-proline by fermentation |
| US4372753A (en) | 1980-04-23 | 1983-02-08 | Source Technology, Inc. | Liquid fuel for use in internal combustion engines |
| JPS56151495A (en) | 1980-04-25 | 1981-11-24 | Ajinomoto Co Inc | Production of l-glutamine through fermentation |
| DE3127361A1 (de) | 1981-07-08 | 1983-02-03 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Herstellung und anwendung von plasmiden mit genen fuer die biosynthese von l-prolin |
| JPH0783714B2 (ja) * | 1983-08-29 | 1995-09-13 | 味の素株式会社 | 発酵法によるｌ―アミノ酸の製造法 |
| JPS61202694A (ja) | 1985-03-07 | 1986-09-08 | Ajinomoto Co Inc | 発酵法によるｌ−グルタミンの製造法 |
| JPH03232497A (ja) | 1990-02-08 | 1991-10-16 | Asahi Chem Ind Co Ltd | 発酵法によるｌ―グルタミンの製造方法 |
| US5569595A (en) * | 1991-09-27 | 1996-10-29 | Center For Innovative Technology | Production of poly-β-hydroxybutyrate in prokaryotic host cells |
| JPH099982A (ja) * | 1995-07-04 | 1997-01-14 | Chikyu Kankyo Sangyo Gijutsu Kenkyu Kiko | Ｌ−含硫アミノ酸の製造法 |
| US7223572B1 (en) | 1999-04-09 | 2007-05-29 | Ajinomoto Co., Inc. | Methylophilus methylotrophus having enhanced dihydrodipicolinate synthase and/or aspartokinase activity for L-amino acid production |
| JP2001046067A (ja) | 1999-08-04 | 2001-02-20 | Ajinomoto Co Inc | 好熱性バチルス属細菌由来のｌ−リジン生合成系遺伝子 |
| JP2001120292A (ja) | 1999-08-17 | 2001-05-08 | Ajinomoto Co Inc | 発酵法によるｌ−アミノ酸の製造法 |
| RU2207376C2 (ru) * | 1999-10-14 | 2003-06-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислоты методом ферментации, штамм бактерии escherichia coli - продуцент l-аминокислоты (варианты) |
| RU2207371C2 (ru) | 2000-09-26 | 2003-06-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислот семейства l-глутаминовой кислоты, штамм бактерии escherichia coli - продуцент l-аминокислоты (варианты) |
| US7476531B2 (en) | 2001-02-13 | 2009-01-13 | Ajinomoto Co., Inc. | Method for producing L-amino acid using bacteria belonging to the genus Escherichia |
| EP1266966B1 (en) | 2001-06-12 | 2009-04-29 | Ajinomoto Co., Inc. | Method for producing L-lysine or L-arginine by using methanol assimilating bacterium |
| US20050176121A1 (en) | 2001-09-06 | 2005-08-11 | Ryo Takeshita | Method for producing alcohol by using microorganism |
| RU2230114C2 (ru) | 2001-11-30 | 2004-06-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Мутантная глутаминсинтетаза, фрагмент днк, штамм escherichia coli - продуцент l-глутамина и способ получения l-аминокислот |
| SE0200857D0 (sv) | 2002-03-19 | 2002-03-19 | Forskarpatent I Syd Ab | Metabolic engineering for improved xylose utilisation of saccharomyces cerevisiae |
| US6911332B2 (en) | 2002-06-12 | 2005-06-28 | Ajinomoto Co., Inc. | Isolated polynucleotides encoding d-arabino-3-hexulose-6-phosphate synthases from Methylophilus methylotrophus |
| JP2004166595A (ja) | 2002-11-20 | 2004-06-17 | Ajinomoto Co Inc | メチロトローフを用いたｌ−アミノ酸の製造法 |
| JP2004166592A (ja) | 2002-11-20 | 2004-06-17 | Ajinomoto Co Inc | メチロトローフを用いたｌ−アミノ酸の製造法 |
| JP4120364B2 (ja) | 2002-11-20 | 2008-07-16 | 味の素株式会社 | メタノール資化性菌を用いたｌ−リジンまたはｌ−アルギニンの製造法 |
| DE60335774D1 (de) | 2002-11-26 | 2011-03-03 | Ajinomoto Kk | Methode für die Produktion von L-Glutamin und L-Glutamin-produzierendes Bakterium |
| DE102004001674B4 (de) | 2003-01-29 | 2019-01-24 | Ajinomoto Co., Inc. | Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien |
| US20060019356A1 (en) | 2003-02-28 | 2006-01-26 | Yoshihiro Usuda | Polynucleotides encoding polypeptides involved in intermediates metabolism of the central metabolic pathway in Methylophilus methylotrophus |
| US7060475B2 (en) | 2003-02-28 | 2006-06-13 | Ajinomoto Co., Inc. | Polynucleotides encoding polypeptides involved in intermediates metabolism of central metabolic pathway in methylophilus methylotrophus |
| US7026149B2 (en) | 2003-02-28 | 2006-04-11 | Ajinomoto Co., Inc. | Polynucleotides encoding polypeptides involved in the stress response to environmental changes in Methylophilus methylotrophus |
| US7029893B2 (en) | 2003-02-28 | 2006-04-18 | Ajinomoto Co., Inc. | Polynucleotides encoding polypeptides involved in amino acid biosynthesis in methylophilus methylotrophus |
| JP2004261150A (ja) | 2003-03-04 | 2004-09-24 | Ajinomoto Co Inc | 目的物質の製造法 |
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| ES2341264T3 (es) * | 2004-08-10 | 2010-06-17 | Ajinomoto Co., Inc. | El uso de fosfocetolasa para producir metabolitos utiles. |
| US7205132B2 (en) | 2004-09-10 | 2007-04-17 | Ajinomoto Co., Inc. | L-glutamic acid-producing microorganism and a method for producing L-glutamic acid |
| JP4595506B2 (ja) | 2004-11-25 | 2010-12-08 | 味の素株式会社 | Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造方法 |
| US7794989B2 (en) | 2004-12-28 | 2010-09-14 | Ajinomoto Co., Inc. | L-glutamic acid-producing microorganism and a method for producing L-glutamic acid |
-
2007
- 2007-01-29 WO PCT/JP2007/051837 patent/WO2007086608A1/en not_active Ceased
- 2007-01-29 EP EP07737282A patent/EP1976995B1/en active Active
- 2007-01-29 PE PE2007000097A patent/PE20071235A1/es active IP Right Grant
- 2007-01-29 BR BRPI0707229A patent/BRPI0707229B8/pt active IP Right Grant
- 2007-01-29 CN CN2007800037625A patent/CN101374953B/zh active Active
-
2008
- 2008-07-25 US US12/179,845 patent/US8012722B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101374953B (zh) | 2011-09-28 |
| EP1976995B1 (en) | 2010-08-04 |
| CN101374953A (zh) | 2009-02-25 |
| BRPI0707229B1 (pt) | 2016-12-20 |
| WO2007086608A1 (en) | 2007-08-02 |
| BRPI0707229A2 (pt) | 2011-04-26 |
| US20100099152A1 (en) | 2010-04-22 |
| US8012722B2 (en) | 2011-09-06 |
| EP1976995A1 (en) | 2008-10-08 |
| BRPI0707229B8 (pt) | 2017-06-27 |
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