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PE20070082A1 - Formas polimorficas del ester etilico del acido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}1-metil-h-bencimidazol-5-carbonil)-piridin-2-il-amino]-propionico - Google Patents

Formas polimorficas del ester etilico del acido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}1-metil-h-bencimidazol-5-carbonil)-piridin-2-il-amino]-propionico

Info

Publication number
PE20070082A1
PE20070082A1 PE2006000604A PE2006000604A PE20070082A1 PE 20070082 A1 PE20070082 A1 PE 20070082A1 PE 2006000604 A PE2006000604 A PE 2006000604A PE 2006000604 A PE2006000604 A PE 2006000604A PE 20070082 A1 PE20070082 A1 PE 20070082A1
Authority
PE
Peru
Prior art keywords
methyl
benzymidazole
hexyloxycarbonylamino
phenylamine
imino
Prior art date
Application number
PE2006000604A
Other languages
English (en)
Inventor
Norbert Hauel
Rolf Schmid
Rainer Sobotta
Peter Sieger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36812978&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070082(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20070082A1 publication Critical patent/PE20070082A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

REFERIDA A UN POLIMORFO DEL ESTER ETILICO DEL ACIDO 3-[(2-{[4-(HEXILOXICARBONILAMINO-IMINO-METIL)-FENILAMINO]-METIL}-1-METIL-1H-BENCIMIDAZOL-5-CARBONIL)-PIRIDIN-2-IL-AMINO]-PROPIONICO (ETEXILATO DE DABIGATRAN). TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION. DICHO PRINCIPIO ACTIVO ES UTIL EN LA PROFILAXIS POSTOPERATIVA DE TROMBOSIS Y DE APOPLEJIAS
PE2006000604A 2005-06-04 2006-06-02 Formas polimorficas del ester etilico del acido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}1-metil-h-bencimidazol-5-carbonil)-piridin-2-il-amino]-propionico PE20070082A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005025728A DE102005025728A1 (de) 2005-06-04 2005-06-04 Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-Propionsäure-ethylester

Publications (1)

Publication Number Publication Date
PE20070082A1 true PE20070082A1 (es) 2007-01-16

Family

ID=36812978

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000604A PE20070082A1 (es) 2005-06-04 2006-06-02 Formas polimorficas del ester etilico del acido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}1-metil-h-bencimidazol-5-carbonil)-piridin-2-il-amino]-propionico

Country Status (22)

Country Link
US (1) US20060276513A1 (es)
EP (3) EP1891046A1 (es)
JP (1) JP2008545734A (es)
KR (1) KR20080021763A (es)
CN (1) CN101189224B (es)
AR (1) AR054278A1 (es)
AU (1) AU2006256778A1 (es)
BR (1) BRPI0611099A2 (es)
CA (1) CA2609583A1 (es)
DE (1) DE102005025728A1 (es)
EA (1) EA014082B1 (es)
EC (1) ECSP077981A (es)
IL (1) IL187845A0 (es)
MX (1) MX2007014892A (es)
NO (1) NO20075862L (es)
NZ (1) NZ564621A (es)
PE (1) PE20070082A1 (es)
TW (1) TW200716107A (es)
UA (1) UA92349C2 (es)
UY (1) UY29575A1 (es)
WO (1) WO2006131491A1 (es)
ZA (1) ZA200709715B (es)

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US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
DE10339862A1 (de) * 2003-08-29 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel
DE102006054005A1 (de) * 2006-11-16 2008-05-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester
MX2010010647A (es) * 2008-03-28 2010-10-20 Boehringer Ingelheim Int Proceso para preparar formulaciones de dabigatran para administracion oral.
AU2009272796A1 (en) * 2008-07-14 2010-01-21 Boehringer Ingelheim International Gmbh Method for manufacturing medicinal compounds containing dabigatran
PE20110431A1 (es) 2008-11-11 2011-07-13 Boehringer Ingelheim Int Etexilato de dabigatran o una sal del mismo
HUP1000069A2 (en) 2010-02-02 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag New salts for the preparation of pharmaceutical composition
JP2013521318A (ja) 2010-03-08 2013-06-10 ラティオファルム ゲー・エム・ベー・ハー ダビガトランエテキシラートを含有する医薬組成物
WO2012027543A1 (en) 2010-08-25 2012-03-01 Teva Pharmaceuticals Usa, Inc. Solid state forms of dabigatran etexilate, dabigatran etexilate mesylate and processes for preparation thereof
US9174609B2 (en) 2011-04-21 2015-11-03 Pylon Manufacturing Corp. Wiper blade with cover
HUP1100244A2 (hu) 2011-05-11 2012-11-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Gyógyszeripari intermedierek és eljárás elõállításukra
WO2012162492A1 (en) 2011-05-24 2012-11-29 Teva Pharmaceutical Industries Ltd. Compressed core comprising organic acids for a pharmaceutical composition
EP2610251A1 (en) * 2011-12-29 2013-07-03 Zaklady Farmaceutyczne Polpharma SA Novel polymorphic forms of dabigatran etexilate and process for the preparation thereof
WO2013111163A2 (en) 2012-01-20 2013-08-01 Cadila Healthcare Limited Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof
WO2013124749A1 (en) * 2012-02-20 2013-08-29 Alembic Pharmaceuticals Limited Novel polymorph of dabigatran etexilate
US20130219649A1 (en) 2012-02-24 2013-08-29 Pylon Manufacturing Corp. Wiper blade
US9365544B2 (en) * 2012-07-16 2016-06-14 Interquim, S.A. Process for the preparation of intermediates for the synthesis of Dabigatran Etexilate, and crystalline forms of said intermediates
WO2014020546A2 (en) 2012-07-31 2014-02-06 Ranbaxy Laboratories Limited Crystalline forms of dabigatran etexilate and process for their preparation
IN2015DN01414A (es) 2012-08-31 2015-07-03 Ranbaxy Lab Ltd
CN103664881A (zh) * 2012-09-20 2014-03-26 天津药物研究院 结晶变体形态b的达比加群酯及其制备方法和用途
IN2015DN02616A (es) 2012-09-28 2015-09-18 Ranbaxy Lab Ltd
IN2015DN02601A (es) 2012-09-28 2015-09-18 Ranbaxy Lab Ltd
EP2722033A1 (en) * 2012-10-19 2014-04-23 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical Compositions of Dabigatran Free Base
CN103788063B (zh) * 2012-10-29 2016-01-20 天津药物研究院 四水合达比加群酯晶体及其制备方法和药物用途
CN103864756B (zh) * 2012-12-11 2018-06-15 四川海思科制药有限公司 丁二磺酸达比加群酯及其制备方法和用途
WO2014178017A1 (en) 2013-04-30 2014-11-06 Ranbaxy Laboratories Limited Dabigatran etexilate impurity, process of its preparation, and its use as a reference standard
WO2015124764A1 (en) 2014-02-24 2015-08-27 Erregierre S.P.A. Synthesis process of dabigatran etexilate mesylate, intermediates of the process and novel polymorph of dabigatran etexilate
IN2014MU00675A (es) 2014-02-26 2015-10-23 Megafine Pharma P Ltd
CN104892574A (zh) * 2014-03-04 2015-09-09 浙江海正药业股份有限公司 达比加群酯甲磺酸盐的晶型及其制备方法和用途
CN104974137A (zh) * 2014-04-04 2015-10-14 江苏天士力帝益药业有限公司 达比加群酯甲磺酸盐新晶型及其制备方法
WO2017037743A2 (en) * 2015-09-03 2017-03-09 Sun Pharmaceutical Industries Limited Dabigatran etexilate 1,4-butanedisulfonate salt and its crystal form
CN105859686B (zh) 2016-05-24 2021-10-08 浙江华海药业股份有限公司 一种达比加群酯游离碱的精制方法
CN106349221A (zh) * 2016-08-29 2017-01-25 常州市阳光药业有限公司 高纯度达比加群酯的制备方法
CN107778291A (zh) * 2016-08-31 2018-03-09 亚宝药业集团股份有限公司 一种甲磺酸达比加群酯晶型ⅱ的制备方法
JP2020193184A (ja) * 2019-05-30 2020-12-03 ダイト株式会社 ダビガトランエテキシラートメタンスルホン酸塩の形態ｉの製造方法

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US5416099A (en) * 1991-10-29 1995-05-16 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
PE121699A1 (es) * 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
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US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
NZ535663A (en) 2002-03-07 2006-06-30 Boehringer Ingelheim Pharma Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino] propionic acid ethyl ester and the salts thereof
DE10235639A1 (de) * 2002-08-02 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Prodrugs von 1-Methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carbonsäure-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amid, ihre Herstellung und ihre Verwendung als Arzneimittel
DE10339862A1 (de) * 2003-08-29 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel

Also Published As

Publication number Publication date
DE102005025728A1 (de) 2006-12-07
MX2007014892A (es) 2008-04-17
NO20075862L (no) 2008-02-26
KR20080021763A (ko) 2008-03-07
CA2609583A1 (en) 2006-12-14
IL187845A0 (en) 2008-03-20
EA014082B1 (ru) 2010-08-30
AU2006256778A8 (en) 2008-03-13
EP1891046A1 (de) 2008-02-27
WO2006131491A1 (de) 2006-12-14
UA92349C2 (ru) 2010-10-25
NZ564621A (en) 2011-03-31
US20060276513A1 (en) 2006-12-07
JP2008545734A (ja) 2008-12-18
CN101189224B (zh) 2012-03-28
BRPI0611099A2 (pt) 2010-08-10
EP2088146A2 (de) 2009-08-12
TW200716107A (en) 2007-05-01
EA200702541A1 (ru) 2008-06-30
ECSP077981A (es) 2008-01-23
AR054278A1 (es) 2007-06-13
EP2305665A1 (de) 2011-04-06
UY29575A1 (es) 2006-12-29
EP2088146A3 (de) 2009-10-28
AU2006256778A1 (en) 2006-12-14
ZA200709715B (en) 2008-10-29
WO2006131491A8 (de) 2007-12-27
CN101189224A (zh) 2008-05-28

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