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PE20110431A1 - Etexilato de dabigatran o una sal del mismo - Google Patents

Etexilato de dabigatran o una sal del mismo

Info

Publication number
PE20110431A1
PE20110431A1 PE2011001005A PE2011001005A PE20110431A1 PE 20110431 A1 PE20110431 A1 PE 20110431A1 PE 2011001005 A PE2011001005 A PE 2011001005A PE 2011001005 A PE2011001005 A PE 2011001005A PE 20110431 A1 PE20110431 A1 PE 20110431A1
Authority
PE
Peru
Prior art keywords
salt
same
dabigatran etexylate
etexylate
dabigatran
Prior art date
Application number
PE2011001005A
Other languages
English (en)
Inventor
Paul A Reilly
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20110431A1 publication Critical patent/PE20110431A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA AL ETEXILATO DE DABIGATRAN O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO. TAMBIEN ESTA REFERIDA A LA COMBINACION DE ETEXILATO DE DABIGATRAN CON UN AGENTE ANTIPLAQUETARIO TAL COMO ASPIRINA, DIPIRIDAMOL, CLOPIDOGREL, ENTRE OTROS, O CON UN AGENTE ANTIARRITMICO TAL COMO QUINIDINA, LIDOCAINA, PROCAINAMIDA, TIMOLOL, ENTRE OTROS. DICHO FARMACO ES UTIL EN EL TRATAMIENTO Y/O PREVENCION DEL ICTUS EN UN PACIENTE QUE PADECE FIBRILACION AURICULAR EN EL QUE EL PACIENTE TIENE AL MENOS UN FACTOR DE RIESGO PARA ACONTECIMIENTOS HEMORRAGICOS
PE2011001005A 2008-11-11 2009-11-10 Etexilato de dabigatran o una sal del mismo PE20110431A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11340408P 2008-11-11 2008-11-11
US23755209P 2009-08-27 2009-08-27

Publications (1)

Publication Number Publication Date
PE20110431A1 true PE20110431A1 (es) 2011-07-13

Family

ID=41463076

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001005A PE20110431A1 (es) 2008-11-11 2009-11-10 Etexilato de dabigatran o una sal del mismo

Country Status (21)

Country Link
US (3) US8962574B2 (es)
EP (1) EP2358368A1 (es)
JP (1) JP2013510072A (es)
KR (1) KR20110086700A (es)
CN (2) CN103356614A (es)
AR (1) AR074313A1 (es)
AU (1) AU2009315729A1 (es)
BR (1) BRPI0921479A2 (es)
CA (1) CA2738883A1 (es)
CL (1) CL2011000798A1 (es)
CO (1) CO6361938A2 (es)
EA (1) EA201100756A1 (es)
EC (1) ECSP11011030A (es)
IL (1) IL211852A0 (es)
MA (1) MA32786B1 (es)
MX (1) MX2011004614A (es)
NZ (1) NZ592616A (es)
PE (1) PE20110431A1 (es)
TN (1) TN2011000228A1 (es)
TW (1) TW201022237A (es)
WO (1) WO2010055021A1 (es)

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PE20110431A1 (es) 2008-11-11 2011-07-13 Boehringer Ingelheim Int Etexilato de dabigatran o una sal del mismo
WO2012122024A2 (en) * 2011-03-04 2012-09-13 Russell Medford Screening method for identifying patients at risk of drug induced liver injury
BR112014014795A2 (pt) * 2011-12-22 2017-06-13 Boehringer Ingelheim Int sistema de pélete de multiunidade de liberação imediata
WO2014001220A1 (en) 2012-06-25 2014-01-03 Boehringer Ingelheim International Gmbh Method for prevention of stroke
EP2722033A1 (en) * 2012-10-19 2014-04-23 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical Compositions of Dabigatran Free Base
EP2722034B1 (en) * 2012-10-19 2020-09-16 Sanovel Ilac Sanayi ve Ticaret A.S. Oral pharmaceutical formulations comprising dabigatran
CN103788063B (zh) * 2012-10-29 2016-01-20 天津药物研究院 四水合达比加群酯晶体及其制备方法和药物用途
IN2013CH05441A (es) * 2013-11-26 2015-05-29 Aurobindo Pharma Ltd
CN104291789B (zh) * 2014-09-28 2016-03-02 定远县绿苑新型建材有限公司 一种吸水性强的多孔砖及其制备方法
CN105560236B (zh) * 2014-10-30 2019-03-15 成都百裕制药股份有限公司 一种含有银杏内酯b和非肽类凝血酶抑制剂的药物组合物及其制备方法和用途
CN108133754B (zh) * 2017-12-19 2019-03-12 中国医学科学院阜外医院 一种溶栓后出血风险的预测系统
CN110339193B (zh) 2018-04-04 2022-04-29 上海汉都医药科技有限公司 含达比加群酯的药物组合物及其制备方法
US11344518B2 (en) 2018-08-14 2022-05-31 AltaThera Pharmaceuticals LLC Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame
US11610660B1 (en) 2021-08-20 2023-03-21 AltaThera Pharmaceuticals LLC Antiarrhythmic drug dosing methods, medical devices, and systems
US11696902B2 (en) 2018-08-14 2023-07-11 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US12396970B2 (en) 2021-08-20 2025-08-26 AltaThera Pharmaceuticals LLC Anti-arrhythmic compositions and methods
US10512620B1 (en) 2018-08-14 2019-12-24 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
CN111983085B (zh) * 2020-08-21 2022-05-31 江苏省食品药品监督检验研究院 一组血清代谢标志物在预测华法林个体药效和指导华法林个体化用药中的应用

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Also Published As

Publication number Publication date
CA2738883A1 (en) 2010-05-20
NZ592616A (en) 2013-04-26
AU2009315729A1 (en) 2010-05-20
CN103356614A (zh) 2013-10-23
IL211852A0 (en) 2011-06-30
BRPI0921479A2 (pt) 2016-01-12
KR20110086700A (ko) 2011-07-29
CN102209544A (zh) 2011-10-05
US20100322869A1 (en) 2010-12-23
JP2013510072A (ja) 2013-03-21
MA32786B1 (fr) 2011-11-01
CL2011000798A1 (es) 2012-01-27
TW201022237A (en) 2010-06-16
TN2011000228A1 (en) 2012-12-17
EP2358368A1 (en) 2011-08-24
CO6361938A2 (es) 2012-01-20
EA201100756A1 (ru) 2011-12-30
WO2010055021A1 (en) 2010-05-20
US8962574B2 (en) 2015-02-24
MX2011004614A (es) 2011-05-31
ECSP11011030A (es) 2011-07-29
US20120282187A1 (en) 2012-11-08
US20110269703A1 (en) 2011-11-03
AR074313A1 (es) 2011-01-05

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