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HUP1100244A2 - Gyógyszeripari intermedierek és eljárás elõállításukra - Google Patents

Gyógyszeripari intermedierek és eljárás elõállításukra

Info

Publication number
HUP1100244A2
HUP1100244A2 HU1100244A HUP1100244A HUP1100244A2 HU P1100244 A2 HUP1100244 A2 HU P1100244A2 HU 1100244 A HU1100244 A HU 1100244A HU P1100244 A HUP1100244 A HU P1100244A HU P1100244 A2 HUP1100244 A2 HU P1100244A2
Authority
HU
Hungary
Prior art keywords
production
pharmaceutical intermediates
intermediates
pharmaceutical
Prior art date
Application number
HU1100244A
Other languages
English (en)
Inventor
Imre Dr Kiraly
Tibor Szabo
Gyula Dr Simig
Balazs Dr Volk
Laszlo Szlavik
Jozsef Dr Barkoczy
Gyoergy Ruzsics
Gyula Dr Lukacs
Laszlo Dr Pongo
Andras Boza
Lauritz Maria Tothne
Maria Kovacs
Original Assignee
Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag filed Critical Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag
Priority to HU1100244A priority Critical patent/HUP1100244A2/hu
Priority to US14/116,464 priority patent/US9260421B2/en
Priority to BR112013028751A priority patent/BR112013028751A2/pt
Priority to HUE12737338A priority patent/HUE030696T2/hu
Priority to EP12737338.9A priority patent/EP2707364B1/en
Priority to CN201280029071.3A priority patent/CN103619832A/zh
Priority to PCT/HU2012/000036 priority patent/WO2012153158A1/en
Publication of HUP1100244A2 publication Critical patent/HUP1100244A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU1100244A 2011-05-11 2011-05-11 Gyógyszeripari intermedierek és eljárás elõállításukra HUP1100244A2 (hu)

Priority Applications (7)

Application Number Priority Date Filing Date Title
HU1100244A HUP1100244A2 (hu) 2011-05-11 2011-05-11 Gyógyszeripari intermedierek és eljárás elõállításukra
US14/116,464 US9260421B2 (en) 2011-05-11 2012-05-10 Pharmaceutical intermediates and process for the preparation thereof
BR112013028751A BR112013028751A2 (pt) 2011-05-11 2012-05-10 processo para a fabricação de etexilato de dabigatrana e intermediários do mesmo
HUE12737338A HUE030696T2 (hu) 2011-05-11 2012-05-10 Eljárás dabigatran etexilát és intermedierjei elõállítására
EP12737338.9A EP2707364B1 (en) 2011-05-11 2012-05-10 Process for the manufacture of dabigatran etexilate and intermediates thereof
CN201280029071.3A CN103619832A (zh) 2011-05-11 2012-05-10 达比加群酯的制备方法及其中间体
PCT/HU2012/000036 WO2012153158A1 (en) 2011-05-11 2012-05-10 Process for the manufacture of dabigatran etexilate and intermediates thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1100244A HUP1100244A2 (hu) 2011-05-11 2011-05-11 Gyógyszeripari intermedierek és eljárás elõállításukra

Publications (1)

Publication Number Publication Date
HUP1100244A2 true HUP1100244A2 (hu) 2012-11-28

Family

ID=89990279

Family Applications (2)

Application Number Title Priority Date Filing Date
HU1100244A HUP1100244A2 (hu) 2011-05-11 2011-05-11 Gyógyszeripari intermedierek és eljárás elõállításukra
HUE12737338A HUE030696T2 (hu) 2011-05-11 2012-05-10 Eljárás dabigatran etexilát és intermedierjei elõállítására

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE12737338A HUE030696T2 (hu) 2011-05-11 2012-05-10 Eljárás dabigatran etexilát és intermedierjei elõállítására

Country Status (6)

Country Link
US (1) US9260421B2 (hu)
EP (1) EP2707364B1 (hu)
CN (1) CN103619832A (hu)
BR (1) BR112013028751A2 (hu)
HU (2) HUP1100244A2 (hu)
WO (1) WO2012153158A1 (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111060452A (zh) * 2019-12-23 2020-04-24 山西斯珂炜瑞光电科技有限公司 一种补偿古依相移增加非线性相互作用的晶体炉装置

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2013CH03939A (hu) * 2013-09-03 2015-09-11 Laurus Labs Pvt Ltd
IN2014MU00675A (hu) 2014-02-26 2015-10-23 Megafine Pharma P Ltd
CN103896919A (zh) * 2014-04-21 2014-07-02 南京靖龙药物研发有限公司 一种氘代达比加群的制备方法
CN104628714B (zh) * 2015-02-04 2018-02-16 沈阳工业大学 达比加群的酯衍生物及其制备方法和用途
CN105646531B (zh) * 2016-03-28 2017-11-21 沈阳工业大学 达比加群环状衍生物及其制备方法和用途
CN111334537A (zh) * 2020-04-01 2020-06-26 中山万汉制药有限公司 酶催化的达比加群酯中间体的合成方法
CN114113346B (zh) * 2020-08-25 2024-01-12 石药集团恩必普药业有限公司 一种达比加群酯原料药或制剂中对甲苯磺酸乙酯、对甲苯磺酸异丙酯的检测方法

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PE121699A1 (es) 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
ZA988735B (en) * 1997-10-06 2000-03-23 Du Pont Pharm Co An efficient method for the conversion of nitriles to amidines.
US6248770B1 (en) 1998-07-09 2001-06-19 Boehringer Ingelheim Pharma Kg Benzimidazoles having antithrombotic activity
EP1612220A3 (en) 1999-03-23 2006-02-15 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6451832B2 (en) 1999-12-23 2002-09-17 Boehringer Ingelheim Pharma Kg Benzimidazoles with antithrombotic activity
CN1697665A (zh) 2003-05-08 2005-11-16 钟渊化学工业株式会社 能处理全血以吸附低密度脂蛋白和纤维蛋白原的吸附剂和吸附器
DE10339862A1 (de) 2003-08-29 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel
EP1609784A1 (de) 2004-06-25 2005-12-28 Boehringer Ingelheim Pharma GmbH & Co.KG Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen
DE102005025728A1 (de) 2005-06-04 2006-12-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-Propionsäure-ethylester
US7782189B2 (en) 2005-06-20 2010-08-24 Carestream Health, Inc. System to monitor the ingestion of medicines
ITTO20050486A1 (it) 2005-07-14 2005-10-13 Dumitru Bucuresteanu Compressore ad aria funzionante a elica continua in un tubo girevole
UY29896A1 (es) 2005-11-04 2007-06-29 Astrazeneca Ab Nuevos derivados de cromano, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones
FR2894963A1 (fr) 2005-12-16 2007-06-22 Inst Nat Sante Rech Med Nouveaux composes interagissant avec pea-15
DE102005061623A1 (de) 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen
DE102006054005A1 (de) 2006-11-16 2008-05-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester
CZ305085B6 (cs) 2008-03-14 2015-04-29 Zentiva, K.S. Způsob přípravy dabigatranu
CA2728057C (en) 2008-06-16 2016-09-27 Boehringer Ingelheim International Gmbh Process for the manufacture of an intermediate in the synthesis of dabigatran
DK2297132T3 (da) 2008-06-16 2015-05-26 Boehringer Ingelheim Int Fremgangsmåde til fremstilling af et mellemprodukt af dabigatran-etexilat
CZ2008669A3 (cs) 2008-10-24 2010-05-05 Zentiva, A. S. Zpusob prípravy dabigatranu a jeho meziprodukty
EP2649060B1 (en) 2010-12-06 2017-04-05 MSN Laboratories Limited Process for the preparation of benzimidazole derivatives and its salts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111060452A (zh) * 2019-12-23 2020-04-24 山西斯珂炜瑞光电科技有限公司 一种补偿古依相移增加非线性相互作用的晶体炉装置

Also Published As

Publication number Publication date
BR112013028751A2 (pt) 2016-08-09
US9260421B2 (en) 2016-02-16
EP2707364A1 (en) 2014-03-19
EP2707364B1 (en) 2016-08-24
WO2012153158A1 (en) 2012-11-15
CN103619832A (zh) 2014-03-05
US20140155614A1 (en) 2014-06-05
HUE030696T2 (hu) 2017-05-29

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished