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PE20061197A1 - Aminoalcoholes triciclicos, como inhibidores de la secresion de citoquina il-8 - Google Patents

Aminoalcoholes triciclicos, como inhibidores de la secresion de citoquina il-8

Info

Publication number
PE20061197A1
PE20061197A1 PE2006000009A PE2006000009A PE20061197A1 PE 20061197 A1 PE20061197 A1 PE 20061197A1 PE 2006000009 A PE2006000009 A PE 2006000009A PE 2006000009 A PE2006000009 A PE 2006000009A PE 20061197 A1 PE20061197 A1 PE 20061197A1
Authority
PE
Peru
Prior art keywords
alkyl
inhibitors
hexahidrobenzo
trifluoromethyl
cycloalkyl
Prior art date
Application number
PE2006000009A
Other languages
English (en)
Inventor
Markus Berger
Norbert Schmees
Stefan Baurle
Anne Mengel
Danja Grossbach
David Voigtlander
Konrand Krolikiewicz
Hartmut Rehwinkel
Heike Schacke
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20061197A1 publication Critical patent/PE20061197A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 Y R2 SON CADA UNO H, HIDROXI, HALOGENO, ALQUILO C1-C10, ENTRE OTROS; R3 ES H, HIDROXI, HALOGENO, ALQUILTIO C1-C10, ENTRE OTROS; R4 ES ALQUILO C1-C10 SUSTITUIDO O NO, CICLOALQUILO C3-C7, HETEROCICLILO SUSTUITUIDO O NO, ENTRE OTROS; R5 ES ALQUILO C1-C5, CICLOALQUILO C3-C7, (CICLOALQUILO C3-C7)-(ALQUENILO C2-C8), HETEROCICLILO, ENTRE OTROS; R6 Y R7 SON CADA UNO H, HALOGENO, ALQUILO C1-C5 SUSTITUIDO O NO, ENTRE OTROS; p ES 1-3; X ES O, S, CH2, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-[(7-FLUORO-2-METILQUINAZOLIN-5-IL)AMINO]-5-(TRIFLUOROMETIL)-2,3,3a,4,5,6-HEXAHIDROBENZO[DE]CROMEN-5-OL; 9-FLUORO-6-[(2-METILQUINOLIN-5-IL)AMINO]-5-(TRIFLUOROMETIL)-2,3,3a,4,5,6-HEXAHIDROBENZO[DE]CROMEN-5-OL; 5-{[5-HIDROXI-5-(TRIFLUOROMETIL)-2,3,3a,4,5,6-HEXAHIDROBENZO[DE]CROMEN-6-IL]AMINO}-2-METILFTALAZIN-1-ONA; ENTRE OTROS. REFERIDA TAMBIEN A UN COMPOSCION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA SECRESION DE LA CITOQUINA IL-8 PROVOCADA POR LIPOPOLISACARIDOS (LPS) UTILES EN EL TRATAMIENTO DE LA INFLAMACION
PE2006000009A 2004-12-22 2006-01-03 Aminoalcoholes triciclicos, como inhibidores de la secresion de citoquina il-8 PE20061197A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004063227A DE102004063227A1 (de) 2004-12-22 2004-12-22 Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer

Publications (1)

Publication Number Publication Date
PE20061197A1 true PE20061197A1 (es) 2006-12-07

Family

ID=36250953

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000009A PE20061197A1 (es) 2004-12-22 2006-01-03 Aminoalcoholes triciclicos, como inhibidores de la secresion de citoquina il-8

Country Status (14)

Country Link
JP (1) JP2008524300A (es)
KR (1) KR20070089948A (es)
CN (1) CN101087780A (es)
AR (1) AR055016A1 (es)
AU (1) AU2005318354A1 (es)
BR (1) BRPI0519710A2 (es)
CA (1) CA2586973A1 (es)
DE (1) DE102004063227A1 (es)
GT (1) GT200500385A (es)
IL (1) IL183060A0 (es)
MX (1) MX2007007420A (es)
PA (1) PA8657801A1 (es)
PE (1) PE20061197A1 (es)
WO (1) WO2006066950A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638515B2 (en) 2003-10-08 2009-12-29 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7662821B2 (en) 2003-10-08 2010-02-16 Bayer Schering Pharma Ag Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
PT1670458E (pt) 2003-10-08 2007-03-30 Schering Ag Derivados de tetra-hidronaftaleno, processo para a sua preparação e utilização como inibidor de inflamação
US20080153859A1 (en) 2004-04-05 2008-06-26 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7402596B2 (en) 2005-03-24 2008-07-22 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
EP1834948A1 (de) 2006-03-15 2007-09-19 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
TWI464148B (zh) 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
EP1917963A1 (en) * 2006-10-31 2008-05-07 Bayer Schering Pharma Aktiengesellschaft Cyclic phenyl-substituted indazols, a process for their production and their use as anti-inflammatory agents
EP2072509A1 (en) 2007-12-18 2009-06-24 Bayer Schering Pharma Aktiengesellschaft 1-Aryl-1H-quinoline-2-ones: process for their production and their use as anti-inflammatory agents
CA3132120C (en) 2012-02-08 2023-10-24 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
JP2019523279A (ja) 2016-07-29 2019-08-22 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 化合物および組成物ならびにそれらの使用
SG11201900689RA (en) 2016-07-29 2019-02-27 Sunovion Pharmaceuticals Inc Compounds and compositions and uses thereof
AU2018312559B2 (en) 2017-08-02 2022-06-02 Pgi Drug Discovery Llc Isochroman compounds and uses thereof
JP7703449B2 (ja) 2019-03-14 2025-07-07 スミトモ・ファーマ・アメリカ・インコーポレイテッド イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物
KR102462991B1 (ko) * 2020-11-02 2022-11-04 한국해양과학기술원 남극-유래 진균 균주 아크레모늄(Acremonium sp.) SF-7394에서 분리한 화합물 및 이를 포함하는 항염증, 항암 또는 항당뇨용 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10038639A1 (de) * 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer
KR101022977B1 (ko) * 2002-03-26 2011-03-18 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 글루코코르티코이드 모사체, 이의 제조방법, 약제학적조성물 및 이의 용도
DE10215316C1 (de) * 2002-04-02 2003-12-18 Schering Ag Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer
PT1670458E (pt) * 2003-10-08 2007-03-30 Schering Ag Derivados de tetra-hidronaftaleno, processo para a sua preparação e utilização como inibidor de inflamação
GB0418045D0 (en) * 2004-08-12 2004-09-15 Glaxo Group Ltd Compounds
DE102004044680B3 (de) * 2004-09-09 2006-06-08 Schering Ag Alkyliden-Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
CN101087780A (zh) 2007-12-12
KR20070089948A (ko) 2007-09-04
WO2006066950A3 (de) 2006-08-17
AU2005318354A1 (en) 2006-06-29
IL183060A0 (en) 2007-09-20
GT200500385A (es) 2006-08-03
BRPI0519710A2 (pt) 2009-03-10
PA8657801A1 (es) 2006-12-07
AR055016A1 (es) 2007-08-01
DE102004063227A1 (de) 2006-07-06
WO2006066950A2 (de) 2006-06-29
JP2008524300A (ja) 2008-07-10
MX2007007420A (es) 2007-07-17
CA2586973A1 (en) 2006-06-29

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