PE20061197A1 - TRICYCLIC AMINOALCOHOLS, AS INHIBITORS OF IL-8 CYTOKINE SECRETION - Google Patents
TRICYCLIC AMINOALCOHOLS, AS INHIBITORS OF IL-8 CYTOKINE SECRETIONInfo
- Publication number
- PE20061197A1 PE20061197A1 PE2006000009A PE2006000009A PE20061197A1 PE 20061197 A1 PE20061197 A1 PE 20061197A1 PE 2006000009 A PE2006000009 A PE 2006000009A PE 2006000009 A PE2006000009 A PE 2006000009A PE 20061197 A1 PE20061197 A1 PE 20061197A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- inhibitors
- hexahidrobenzo
- trifluoromethyl
- cycloalkyl
- Prior art date
Links
- 108090001007 Interleukin-8 Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001414 amino alcohols Chemical class 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical group F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 239000002158 endotoxin Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 2
- UNVNVCMGCFNMQD-UHFFFAOYSA-N 2h-chromen-5-ol Chemical compound O1CC=CC2=C1C=CC=C2O UNVNVCMGCFNMQD-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 Y R2 SON CADA UNO H, HIDROXI, HALOGENO, ALQUILO C1-C10, ENTRE OTROS; R3 ES H, HIDROXI, HALOGENO, ALQUILTIO C1-C10, ENTRE OTROS; R4 ES ALQUILO C1-C10 SUSTITUIDO O NO, CICLOALQUILO C3-C7, HETEROCICLILO SUSTUITUIDO O NO, ENTRE OTROS; R5 ES ALQUILO C1-C5, CICLOALQUILO C3-C7, (CICLOALQUILO C3-C7)-(ALQUENILO C2-C8), HETEROCICLILO, ENTRE OTROS; R6 Y R7 SON CADA UNO H, HALOGENO, ALQUILO C1-C5 SUSTITUIDO O NO, ENTRE OTROS; p ES 1-3; X ES O, S, CH2, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-[(7-FLUORO-2-METILQUINAZOLIN-5-IL)AMINO]-5-(TRIFLUOROMETIL)-2,3,3a,4,5,6-HEXAHIDROBENZO[DE]CROMEN-5-OL; 9-FLUORO-6-[(2-METILQUINOLIN-5-IL)AMINO]-5-(TRIFLUOROMETIL)-2,3,3a,4,5,6-HEXAHIDROBENZO[DE]CROMEN-5-OL; 5-{[5-HIDROXI-5-(TRIFLUOROMETIL)-2,3,3a,4,5,6-HEXAHIDROBENZO[DE]CROMEN-6-IL]AMINO}-2-METILFTALAZIN-1-ONA; ENTRE OTROS. REFERIDA TAMBIEN A UN COMPOSCION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA SECRESION DE LA CITOQUINA IL-8 PROVOCADA POR LIPOPOLISACARIDOS (LPS) UTILES EN EL TRATAMIENTO DE LA INFLAMACIONREFERS TO A COMPOUND OF FORMULA I WHERE R1 AND R2 ARE EACH H, HYDROXY, HALOGEN, C1-C10 ALKYL, AMONG OTHERS; R3 IS H, HYDROXY, HALOGEN, C1-C10 ALKYLTIO, AMONG OTHERS; R4 IS C1-C10 ALKYL, SUBSTITUTED OR NOT, C3-C7 CYCLOALKYL, HETEROCYCLYL SUBSTITUTE OR NOT, AMONG OTHERS; R5 IS C1-C5 ALKYL, C3-C7 CYCLOALKYL, (C3-C7 CYCLOALKYL) - (C2-C8 ALKENYL), HETEROCYCLYL, AMONG OTHERS; R6 AND R7 ARE EACH H, HALOGEN, C1-C5 ALKYL SUBSTITUTED OR NOT, AMONG OTHERS; p IS 1-3; X IS O, S, CH2, AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: 6 - [(7-FLUORO-2-METHYLQUINAZOLIN-5-IL) AMINO] -5- (TRIFLUORomethyl) -2,3,3a, 4,5,6-HEXAHIDROBENZO [DE] CROMEN-5-OL ; 9-FLUORO-6 - [(2-METHYLQUINOLIN-5-IL) AMINO] -5- (TRIFLUORomethyl) -2,3,3a, 4,5,6-HEXAHIDROBENZO [DE] CHROMEN-5-OL; 5 - {[5-HYDROXY-5- (TRIFLUOROMETHYL) -2,3,3a, 4,5,6-HEXAHIDROBENZO [DE] CHROMEN-6-IL] AMINO} -2-METHYLPHTHALAZIN-1-ONA; AMONG OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSTION AND A PREPARATION PROCEDURE. SAID COMPOUNDS ARE INHIBITORS OF THE SECTION OF IL-8 CYTOKINE CAUSED BY LIPOPOLYSACCHARIDES (LPS) USEFUL IN THE TREATMENT OF INFLAMMATION
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004063227A DE102004063227A1 (en) | 2004-12-22 | 2004-12-22 | Tricylic amino alcohols, process for their preparation and their use as anti-inflammatory agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061197A1 true PE20061197A1 (en) | 2006-12-07 |
Family
ID=36250953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000009A PE20061197A1 (en) | 2004-12-22 | 2006-01-03 | TRICYCLIC AMINOALCOHOLS, AS INHIBITORS OF IL-8 CYTOKINE SECRETION |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JP2008524300A (en) |
| KR (1) | KR20070089948A (en) |
| CN (1) | CN101087780A (en) |
| AR (1) | AR055016A1 (en) |
| AU (1) | AU2005318354A1 (en) |
| BR (1) | BRPI0519710A2 (en) |
| CA (1) | CA2586973A1 (en) |
| DE (1) | DE102004063227A1 (en) |
| GT (1) | GT200500385A (en) |
| IL (1) | IL183060A0 (en) |
| MX (1) | MX2007007420A (en) |
| PA (1) | PA8657801A1 (en) |
| PE (1) | PE20061197A1 (en) |
| WO (1) | WO2006066950A2 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7638515B2 (en) | 2003-10-08 | 2009-12-29 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| US7662821B2 (en) | 2003-10-08 | 2010-02-16 | Bayer Schering Pharma Ag | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| PT1670458E (en) | 2003-10-08 | 2007-03-30 | Schering Ag | 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics |
| US20080153859A1 (en) | 2004-04-05 | 2008-06-26 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| US7402596B2 (en) | 2005-03-24 | 2008-07-22 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| EP1834948A1 (en) | 2006-03-15 | 2007-09-19 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiinflammatory drugs |
| TWI464148B (en) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
| EP1917963A1 (en) * | 2006-10-31 | 2008-05-07 | Bayer Schering Pharma Aktiengesellschaft | Cyclic phenyl-substituted indazols, a process for their production and their use as anti-inflammatory agents |
| EP2072509A1 (en) | 2007-12-18 | 2009-06-24 | Bayer Schering Pharma Aktiengesellschaft | 1-Aryl-1H-quinoline-2-ones: process for their production and their use as anti-inflammatory agents |
| CA3132120C (en) | 2012-02-08 | 2023-10-24 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| JP2019523279A (en) | 2016-07-29 | 2019-08-22 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | Compounds and compositions and their use |
| SG11201900689RA (en) | 2016-07-29 | 2019-02-27 | Sunovion Pharmaceuticals Inc | Compounds and compositions and uses thereof |
| AU2018312559B2 (en) | 2017-08-02 | 2022-06-02 | Pgi Drug Discovery Llc | Isochroman compounds and uses thereof |
| JP7703449B2 (en) | 2019-03-14 | 2025-07-07 | スミトモ・ファーマ・アメリカ・インコーポレイテッド | Salts of isochromanyl compounds and their crystals, as well as their preparation methods, therapeutic uses and pharmaceutical compositions |
| KR102462991B1 (en) * | 2020-11-02 | 2022-11-04 | 한국해양과학기술원 | Compound from a Antarctic-Derived Fungal Strains Acremonium sp. SF-7394 and Composition for Anti-Inflammation, Anticancer or Anti-Diabetes Comprising the Same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10038639A1 (en) * | 2000-07-28 | 2002-02-21 | Schering Ag | New and known N-aryl 2-hydroxy-omega-arylalkanamide derivatives, useful e.g. for treating inflammatory diseases such as rheumatism |
| KR101022977B1 (en) * | 2002-03-26 | 2011-03-18 | 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 | Glucocorticoid mimetics, preparation methods thereof, pharmaceutical compositions and uses thereof |
| DE10215316C1 (en) * | 2002-04-02 | 2003-12-18 | Schering Ag | Quinoline and isoquinoline derivatives, a pharmaceutical agent and their use as anti-inflammatory agents |
| PT1670458E (en) * | 2003-10-08 | 2007-03-30 | Schering Ag | 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics |
| GB0418045D0 (en) * | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
| DE102004044680B3 (en) * | 2004-09-09 | 2006-06-08 | Schering Ag | Alkylidene tetrahydronaphthalene derivatives, process for their preparation and their use as anti-inflammatory agents and pharmaceutical compositions containing them |
-
2004
- 2004-12-22 DE DE102004063227A patent/DE102004063227A1/en not_active Withdrawn
-
2005
- 2005-12-20 BR BRPI0519710-4A patent/BRPI0519710A2/en not_active Application Discontinuation
- 2005-12-20 MX MX2007007420A patent/MX2007007420A/en not_active Application Discontinuation
- 2005-12-20 CN CNA2005800442843A patent/CN101087780A/en active Pending
- 2005-12-20 KR KR1020077014116A patent/KR20070089948A/en not_active Withdrawn
- 2005-12-20 JP JP2007547379A patent/JP2008524300A/en active Pending
- 2005-12-20 AU AU2005318354A patent/AU2005318354A1/en not_active Abandoned
- 2005-12-20 CA CA002586973A patent/CA2586973A1/en not_active Abandoned
- 2005-12-20 WO PCT/EP2005/013943 patent/WO2006066950A2/en not_active Ceased
- 2005-12-22 AR ARP050105486A patent/AR055016A1/en not_active Application Discontinuation
- 2005-12-22 GT GT200500385A patent/GT200500385A/en unknown
- 2005-12-22 PA PA20058657801A patent/PA8657801A1/en unknown
-
2006
- 2006-01-03 PE PE2006000009A patent/PE20061197A1/en not_active Application Discontinuation
-
2007
- 2007-05-08 IL IL183060A patent/IL183060A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101087780A (en) | 2007-12-12 |
| KR20070089948A (en) | 2007-09-04 |
| WO2006066950A3 (en) | 2006-08-17 |
| AU2005318354A1 (en) | 2006-06-29 |
| IL183060A0 (en) | 2007-09-20 |
| GT200500385A (en) | 2006-08-03 |
| BRPI0519710A2 (en) | 2009-03-10 |
| PA8657801A1 (en) | 2006-12-07 |
| AR055016A1 (en) | 2007-08-01 |
| DE102004063227A1 (en) | 2006-07-06 |
| WO2006066950A2 (en) | 2006-06-29 |
| JP2008524300A (en) | 2008-07-10 |
| MX2007007420A (en) | 2007-07-17 |
| CA2586973A1 (en) | 2006-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |