AR055016A1 - Aminoalcoholes triciclicos, procedimientos para su preparacion y su uso para la preparacion de medicamentos - Google Patents
Aminoalcoholes triciclicos, procedimientos para su preparacion y su uso para la preparacion de medicamentosInfo
- Publication number
- AR055016A1 AR055016A1 ARP050105486A ARP050105486A AR055016A1 AR 055016 A1 AR055016 A1 AR 055016A1 AR P050105486 A ARP050105486 A AR P050105486A AR P050105486 A ARP050105486 A AR P050105486A AR 055016 A1 AR055016 A1 AR 055016A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- groups
- alkyl
- atoms
- optionally substituted
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000005843 halogen group Chemical group 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 2
- 125000000468 ketone group Chemical group 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Abstract
Procedimientos para la preparacion de los impulsos y su uso para la preparacion de medicamentos. Estos compuestos pueden ser utilizados como antiinflamatorios. Reivindicacion 1: Estereoisomeros de la formula general (1), en donde: R1 y R2 son, independientemente entre sí, un átomo de hidrogeno, un grupo hidroxi, un átomo de halogeno, un grupo alquilo C1-10 eventualmente sustituido, un grupo alcoxi C1-10, un grupo alquiltio C1-10, un grupo perfluoroalquilo C1-5, un grupo ciano, un grupo nitro; o R1 y R2 son juntos un grupo seleccionado de los grupos -O-(CH2)n-O-, -O-(CH2) n-CH2-, -O-CH=CH-, -(CH2)n+2-, -NH-(CH2)n+1, N(alquilC1-3)-(CH2)n+1, -NH-N=CH-, en donde n = 1 o 2 y los átomos terminales están unidos con átomos de carbono del anillo directamente adyacentes, o NR8R9, en donde R8 y R9 pueden ser, independientemente entre sí, hidrogeno, alquilo C1-5 o (CO)-alquiloC1-5; R3 es un átomo de hidrogeno, un grupo hidroxi, un átomo de halogeno, un grupo alquilo C1-10 eventualmente sustituido, un grupo alcoxi C1-10, un grupo alquiltio C1-10, un grupo perfluoroalquilo C1-5, un grupo ciano; R4 es un grupo alquilo C1-10, un grupo alquilo C1-10 sustituido con uno o varios grupos seleccionados de 1-3 grupos hidroxi, átomos de halogeno, 1-3 grupos alcoxi C1-5; un grupo cicloalquilo C3-7 eventualmente sustituido; un grupo heterociclilo eventualmente sustituido; un grupo arilo eventualmente sustituido; un grupo heteroarilo mono- o bicíclico eventualmente sustituido con uno o varios grupos seleccionados de grupos alquilo C1-5 (que puede estar eventualmente sustituido con 1-3 grupos hidroxi o 1-3 grupos COOR10, en donde R10 significa alquilo C1-6 o bencilo), grupos alcoxi C1-5, grupos hidroxi, átomos de halogeno, grupos exoalquilideno C1-3, que eventualmente contiene 1-4 átomos de nitrogeno y/o 1-2 átomos de oxígeno y/o 1-2 átomos de azufre y/o 1-2 grupos ceto, en donde este grupo puede estar unido a través de cualquier posicion con la amina del sistema tricíclico y eventualmente hidrogenado en uno o varios sitios; R5 es un grupo alquilo C1-5 o un grupo alquilo C1-5 eventualmente fluorado de modo parcial o total, un grupo cicloalquilo C3-7, un grupo cicloalquilC3-7-alquiloC1-8, un grupo cicloalquilC3-7- alqueniloC2-8, un grupo heterociclilo, un grupo heterociclilalquilo C1-8, un grupo heterociclilalquenilo C2-8, un grupo arilo, un grupo arilalquilo C1-8, un grupo arilalquenilo C2-8, un grupo arilalquinilo C2-8, un grupo heteroarilo mono- o bicíclico eventualmente sustituido con uno o varios grupos ceto, grupos alquilo C1-5, grupos alcoxi C1-5, átomos de halogeno, grupos exoalquilideno C1-3, que contiene uno o varios átomos de nitrogeno y/o átomos de oxígeno y/o átomos de azufre, un grupo heteroarilalquilo C1-8 o un grupo heteroarilalquenilo C2-8, en donde estos grupos pueden estar unidos a través de cualquier posicion con la amina del sistema tricíclico y eventualmente hidrogenados en uno o varios sitios; R6 y R7 son, independientemente entre sí, un átomo de hidrogeno, un átomo de halogeno, un grupo alquilo C1-5, que puede estar sustituido con OR8, SR8, NR8R9; o es 1, 2 o 3; y X es un átomo de oxígeno, un átomo de azufre, un grupo CH2 o un grupo NR9.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004063227A DE102004063227A1 (de) | 2004-12-22 | 2004-12-22 | Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055016A1 true AR055016A1 (es) | 2007-08-01 |
Family
ID=36250953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105486A AR055016A1 (es) | 2004-12-22 | 2005-12-22 | Aminoalcoholes triciclicos, procedimientos para su preparacion y su uso para la preparacion de medicamentos |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JP2008524300A (es) |
| KR (1) | KR20070089948A (es) |
| CN (1) | CN101087780A (es) |
| AR (1) | AR055016A1 (es) |
| AU (1) | AU2005318354A1 (es) |
| BR (1) | BRPI0519710A2 (es) |
| CA (1) | CA2586973A1 (es) |
| DE (1) | DE102004063227A1 (es) |
| GT (1) | GT200500385A (es) |
| IL (1) | IL183060A0 (es) |
| MX (1) | MX2007007420A (es) |
| PA (1) | PA8657801A1 (es) |
| PE (1) | PE20061197A1 (es) |
| WO (1) | WO2006066950A2 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7638515B2 (en) | 2003-10-08 | 2009-12-29 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| US7662821B2 (en) | 2003-10-08 | 2010-02-16 | Bayer Schering Pharma Ag | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| PT1670458E (pt) | 2003-10-08 | 2007-03-30 | Schering Ag | Derivados de tetra-hidronaftaleno, processo para a sua preparação e utilização como inibidor de inflamação |
| US20080153859A1 (en) | 2004-04-05 | 2008-06-26 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| US7402596B2 (en) | 2005-03-24 | 2008-07-22 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| EP1834948A1 (de) | 2006-03-15 | 2007-09-19 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
| TWI464148B (zh) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途 |
| EP1917963A1 (en) * | 2006-10-31 | 2008-05-07 | Bayer Schering Pharma Aktiengesellschaft | Cyclic phenyl-substituted indazols, a process for their production and their use as anti-inflammatory agents |
| EP2072509A1 (en) | 2007-12-18 | 2009-06-24 | Bayer Schering Pharma Aktiengesellschaft | 1-Aryl-1H-quinoline-2-ones: process for their production and their use as anti-inflammatory agents |
| CA3132120C (en) | 2012-02-08 | 2023-10-24 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| JP2019523279A (ja) | 2016-07-29 | 2019-08-22 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 化合物および組成物ならびにそれらの使用 |
| SG11201900689RA (en) | 2016-07-29 | 2019-02-27 | Sunovion Pharmaceuticals Inc | Compounds and compositions and uses thereof |
| AU2018312559B2 (en) | 2017-08-02 | 2022-06-02 | Pgi Drug Discovery Llc | Isochroman compounds and uses thereof |
| JP7703449B2 (ja) | 2019-03-14 | 2025-07-07 | スミトモ・ファーマ・アメリカ・インコーポレイテッド | イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物 |
| KR102462991B1 (ko) * | 2020-11-02 | 2022-11-04 | 한국해양과학기술원 | 남극-유래 진균 균주 아크레모늄(Acremonium sp.) SF-7394에서 분리한 화합물 및 이를 포함하는 항염증, 항암 또는 항당뇨용 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10038639A1 (de) * | 2000-07-28 | 2002-02-21 | Schering Ag | Nichtsteroidale Entzündungshemmer |
| KR101022977B1 (ko) * | 2002-03-26 | 2011-03-18 | 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 | 글루코코르티코이드 모사체, 이의 제조방법, 약제학적조성물 및 이의 용도 |
| DE10215316C1 (de) * | 2002-04-02 | 2003-12-18 | Schering Ag | Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer |
| PT1670458E (pt) * | 2003-10-08 | 2007-03-30 | Schering Ag | Derivados de tetra-hidronaftaleno, processo para a sua preparação e utilização como inibidor de inflamação |
| GB0418045D0 (en) * | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
| DE102004044680B3 (de) * | 2004-09-09 | 2006-06-08 | Schering Ag | Alkyliden-Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate |
-
2004
- 2004-12-22 DE DE102004063227A patent/DE102004063227A1/de not_active Withdrawn
-
2005
- 2005-12-20 BR BRPI0519710-4A patent/BRPI0519710A2/pt not_active Application Discontinuation
- 2005-12-20 MX MX2007007420A patent/MX2007007420A/es not_active Application Discontinuation
- 2005-12-20 CN CNA2005800442843A patent/CN101087780A/zh active Pending
- 2005-12-20 KR KR1020077014116A patent/KR20070089948A/ko not_active Withdrawn
- 2005-12-20 JP JP2007547379A patent/JP2008524300A/ja active Pending
- 2005-12-20 AU AU2005318354A patent/AU2005318354A1/en not_active Abandoned
- 2005-12-20 CA CA002586973A patent/CA2586973A1/en not_active Abandoned
- 2005-12-20 WO PCT/EP2005/013943 patent/WO2006066950A2/de not_active Ceased
- 2005-12-22 AR ARP050105486A patent/AR055016A1/es not_active Application Discontinuation
- 2005-12-22 GT GT200500385A patent/GT200500385A/es unknown
- 2005-12-22 PA PA20058657801A patent/PA8657801A1/es unknown
-
2006
- 2006-01-03 PE PE2006000009A patent/PE20061197A1/es not_active Application Discontinuation
-
2007
- 2007-05-08 IL IL183060A patent/IL183060A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101087780A (zh) | 2007-12-12 |
| KR20070089948A (ko) | 2007-09-04 |
| WO2006066950A3 (de) | 2006-08-17 |
| AU2005318354A1 (en) | 2006-06-29 |
| IL183060A0 (en) | 2007-09-20 |
| GT200500385A (es) | 2006-08-03 |
| BRPI0519710A2 (pt) | 2009-03-10 |
| PA8657801A1 (es) | 2006-12-07 |
| DE102004063227A1 (de) | 2006-07-06 |
| WO2006066950A2 (de) | 2006-06-29 |
| JP2008524300A (ja) | 2008-07-10 |
| MX2007007420A (es) | 2007-07-17 |
| CA2586973A1 (en) | 2006-06-29 |
| PE20061197A1 (es) | 2006-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR055016A1 (es) | Aminoalcoholes triciclicos, procedimientos para su preparacion y su uso para la preparacion de medicamentos | |
| AR046062A1 (es) | Derivados de tetrahidronaftaleno procedimiento para su preparacion y su uso antiinflamatorio | |
| PE20221283A1 (es) | Compuestos triciclicos sustituidos | |
| CO5700780A2 (es) | Derivados de quinolina como inhibidores, selectivos, de de fosfodiesterasa pde 4b | |
| PA8564201A1 (es) | Compuestos de espiropiperidina n-sustituidos como ligandos para el receptor orl-1 | |
| AR061923A1 (es) | Compuestos derivados de benzofuran-piperidina | |
| AR066561A1 (es) | Derivados de imidazol, composiciones farmaceuticas y usos | |
| AR061058A1 (es) | Derivados de piridopirimidininona. procesos de obtencion y composiciones farmaceuticas | |
| AR061372A1 (es) | Amino-imidazoles y sus usos como medicamentos para el tratamiento de mal de alzheimer, demencia y neurodegeneracion | |
| AR066290A1 (es) | Derivados heterociclicos, procesos para su produccion, medicamentos que comprende estos compuestos y su uso | |
| PE20061335A1 (es) | Compuestos derivados de benzodioxano y benzodioxolano como moduladores del receptor 5-ht2c | |
| AR060593A1 (es) | 5-amido-2-carboxiamida-indoles | |
| CO6321130A2 (es) | Piridinas carboxamidas como inhibidores de la 11 beta-hsd1 | |
| AR040567A1 (es) | Derivados de 1- heterociclilalquil 3- sulfonilindol o -indazol como ligandos de 5- hidroxitriptamina -6 | |
| AR065795A1 (es) | Derivados de aza-piridopirimidinona,metodo de preparacion,medicamentos que los contienen y usos como agentes antitromboticos, antihiperlipidemicos y antidiabeticos,entre otros. | |
| AR072016A1 (es) | Derivados de isoxazol que funcionan como potenciadores de los receptores de glutamato | |
| AR060590A1 (es) | Compuestos imidazo | |
| AR059896A1 (es) | Derivados estereoisomericos de tetrahidronaftaleno, metodo de preparacion, medicamentos que los contienen, y uso como agentes antiinflamatorios. | |
| PE20011084A1 (es) | Derivados de quinolina como antagonistas alfa-2 | |
| AR074466A1 (es) | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. | |
| AR066603A1 (es) | Derivados de arilamida pirimidona | |
| CY1116391T1 (el) | Αιθινυλο παραγωγα ως θετικοι αλλοστερικοι ρυθμιστες του mglur5 | |
| PE20060483A1 (es) | Compuestos heterociclicos como antagonistas de nk1 | |
| AR077301A1 (es) | Derivados de 2-carboxamida-7-piperazinil-benzofurano como antagonistas de 5-ht1a y 5-ht1b | |
| AR067075A1 (es) | Derivados de isoxasol - imidazol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |