PE20060311A1 - Formulacion en aerosol para la inhalacion de beta-agonistas - Google Patents
Formulacion en aerosol para la inhalacion de beta-agonistasInfo
- Publication number
- PE20060311A1 PE20060311A1 PE2005000529A PE2005000529A PE20060311A1 PE 20060311 A1 PE20060311 A1 PE 20060311A1 PE 2005000529 A PE2005000529 A PE 2005000529A PE 2005000529 A PE2005000529 A PE 2005000529A PE 20060311 A1 PE20060311 A1 PE 20060311A1
- Authority
- PE
- Peru
- Prior art keywords
- hydroxy
- dimethyl
- acid
- formulation
- beta
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000443 aerosol Substances 0.000 title abstract 2
- 229940125388 beta agonist Drugs 0.000 title abstract 2
- -1 METANSULPHONATE Chemical compound 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- JITFIYFVPMQJOK-UHFFFAOYSA-N 1-(4-fluorophenyl)-2-methylpropan-2-amine Chemical compound CC(C)(N)CC1=CC=C(F)C=C1 JITFIYFVPMQJOK-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 208000011623 Obstructive Lung disease Diseases 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 238000002663 nebulization Methods 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 229960000257 tiotropium bromide Drugs 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/04—Amoebicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIERE A UNA FORMULACION FARMACEUTICA EN AEROSOL SIN GAS PROPELENTE QUE COMPRENDE a) COMO PRINCIPIO ACTIVO UN COMPUESTO BETA-AGONISTA DE FORMULA (I), EN DONDE R1 Y R2 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C4), ALCOXI(C1-C4) O HALOGENO; R3 ES R1 O R2, OH, -O-ALQUILEN(C1-C4)-COOH U -O-ALQUILEN(C1-C4)-ALQUILO(C1-C4); X- ES CLORURO, BROMURO, SULFATO, METANSULFONATO, MALEATO, ACETATO, ENTRE OTROS. SON PREFERIDOS: 6-HIDROXI-8-{1-HIDROXI-2,6-DIMETIL-FENIL)-1,1-DIMETIL-ETILAMINO]-ETIL}-4H-BENZO[1,4]OXAZIN-3-ON-METANOSULFONATO, SAL POR ADICION DE ACIDO DE 8-{2-[2-(4-FLUORO-FENIL)-1,1-DIMETIL-ETILAMINO}-1-HIDROXI-ETIL}-6*-HIDROXI-4H-BENZO[1,4}OXAZIN-3-ONA, ENTRE OTROS; b) AL MENOS UN ACIDO INORGANICO TAL COMO ACIDO CLORHIDRICO, BROMHIDRICO, NITRICO, ENTRE OTROS O UN ACIDO ORGANICO TAL COMO ACIDO ASCORBICO, CITRICO, MALICO, TARTARICO, ENTRE OTROS; c) EVENTULAMENTE COADYUVANTES COMO CLORURO DE BENZALCONIO Y/O FORMADORES DE COMPLEJOS Y d) COMO DISOLVENTES AGUA O ETANOL O UNA MEZCLA DE ESTOS. ESTA FORMULACION TIENE UN VALOR pH DE 2,5 A 6,5 Y ES UTIL PARA EL TRATAMIENTO DE ENFERMEDADES DE LAS VIAS RESPIRATORIAS COMO ASMA, ENFERMEDADES PULMONARES OBSTRUCTIVAS. TAMBIEN SE REFIERE A UN KIT DE INHALACION QUE COMPRENDE LA FORMULACION Y UN INHALADOR PARA LA NEBULIZACION (RESPIMAT)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004024452A DE102004024452A1 (de) | 2004-05-14 | 2004-05-14 | Aerosolformulierung für die Inhalation von Betaagonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060311A1 true PE20060311A1 (es) | 2006-05-08 |
Family
ID=34979667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000529A PE20060311A1 (es) | 2004-05-14 | 2005-05-12 | Formulacion en aerosol para la inhalacion de beta-agonistas |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1809293B1 (es) |
| JP (1) | JP4620730B2 (es) |
| KR (1) | KR101288791B1 (es) |
| CN (1) | CN101056640A (es) |
| AR (1) | AR049096A1 (es) |
| AU (1) | AU2005244414B2 (es) |
| BR (1) | BRPI0511135B8 (es) |
| CA (1) | CA2564379C (es) |
| DE (1) | DE102004024452A1 (es) |
| DK (1) | DK1809293T3 (es) |
| EA (1) | EA012583B1 (es) |
| EC (1) | ECSP067004A (es) |
| ES (1) | ES2575925T3 (es) |
| HU (1) | HUE027780T2 (es) |
| IL (1) | IL179218A (es) |
| MX (1) | MXPA06013216A (es) |
| MY (1) | MY148403A (es) |
| NO (1) | NO20065030L (es) |
| PE (1) | PE20060311A1 (es) |
| PL (1) | PL1809293T3 (es) |
| SG (1) | SG152265A1 (es) |
| TW (1) | TWI356703B (es) |
| UA (1) | UA87312C2 (es) |
| UY (1) | UY28891A1 (es) |
| WO (1) | WO2005110421A2 (es) |
| ZA (1) | ZA200607462B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7056916B2 (en) | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
| US7220742B2 (en) | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
| MX2008001976A (es) | 2005-08-15 | 2008-03-25 | Boehringer Ingelheim Int | Procedimiento para la preparacion de betamimeticos. |
| EA200801139A1 (ru) * | 2005-11-09 | 2008-10-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Композиция для аэрозольной ингаляции |
| UY30543A1 (es) * | 2006-08-18 | 2008-03-31 | Boehringer Ingelheim Int | Formulacion de aerosol para la inhalacion de beta- agonistas |
| WO2010057927A1 (en) * | 2008-11-21 | 2010-05-27 | Boehringer Ingelheim International Gmbh | Aerosol formulation for the inhalation of beta agonists |
| EP2358350A1 (en) * | 2008-11-21 | 2011-08-24 | Boehringer Ingelheim International GmbH | Aerosol formulation for the inhalation of beta agonists |
| JP2015533131A (ja) | 2012-10-09 | 2015-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 咳を治療するためのベータ２−アドレナリン受容体作動薬 |
| WO2018108669A1 (en) | 2016-12-12 | 2018-06-21 | Boehringer Ingelheim International Gmbh | Nintedanib for use in methods for the treatment of interstitial lung diseases by coadministration with olodaterol |
| BR112022010802A2 (pt) * | 2019-12-05 | 2022-08-23 | Syngenta Crop Protection Ag | Processo de um passo para a preparação de derivados de feniletilamina |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3134590A1 (de) * | 1981-09-01 | 1983-03-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue benzo-heterocyclen |
| US4460581A (en) * | 1982-10-12 | 1984-07-17 | Boehringer Ingelheim Kg | (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones |
| JPH0637388B2 (ja) * | 1986-02-17 | 1994-05-18 | 千寿製薬株式会社 | 水性液剤 |
| GB9405019D0 (en) * | 1994-03-15 | 1994-04-27 | Smithkline Beecham Plc | Novel compounds |
| DE10253282A1 (de) * | 2002-11-15 | 2004-05-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung |
| EP1781298B1 (de) * | 2004-04-22 | 2012-01-04 | Boehringer Ingelheim International GmbH | Arzneinmittelkombinationen enthaltend benzoxazine zur behandlung von atemwegserkrankungen |
| DE102004019539A1 (de) * | 2004-04-22 | 2005-11-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittel zur Behandlung von Atemwegserkrankungen |
| DE102004024454A1 (de) * | 2004-05-14 | 2005-12-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004024451A1 (de) * | 2004-05-14 | 2005-12-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverformulierungen für die Inhalation, die Enantiomerenreine Betaagonisten enthalten |
-
2004
- 2004-05-14 DE DE102004024452A patent/DE102004024452A1/de not_active Withdrawn
-
2005
- 2005-05-10 JP JP2007512068A patent/JP4620730B2/ja not_active Expired - Lifetime
- 2005-05-10 CN CNA2005800154865A patent/CN101056640A/zh active Pending
- 2005-05-10 KR KR1020067026225A patent/KR101288791B1/ko not_active Expired - Lifetime
- 2005-05-10 DK DK05747843.0T patent/DK1809293T3/en active
- 2005-05-10 MX MXPA06013216A patent/MXPA06013216A/es active IP Right Grant
- 2005-05-10 BR BRPI0511135A patent/BRPI0511135B8/pt active IP Right Grant
- 2005-05-10 EP EP05747843.0A patent/EP1809293B1/de not_active Expired - Lifetime
- 2005-05-10 CA CA2564379A patent/CA2564379C/en not_active Expired - Lifetime
- 2005-05-10 ES ES05747843.0T patent/ES2575925T3/es not_active Expired - Lifetime
- 2005-05-10 UA UAA200612949A patent/UA87312C2/ru unknown
- 2005-05-10 WO PCT/EP2005/005028 patent/WO2005110421A2/de not_active Ceased
- 2005-05-10 HU HUE05747843A patent/HUE027780T2/en unknown
- 2005-05-10 PL PL05747843.0T patent/PL1809293T3/pl unknown
- 2005-05-10 SG SG200902777-2A patent/SG152265A1/en unknown
- 2005-05-10 EA EA200602017A patent/EA012583B1/ru not_active IP Right Cessation
- 2005-05-10 AU AU2005244414A patent/AU2005244414B2/en not_active Expired
- 2005-05-11 UY UY28891A patent/UY28891A1/es not_active Application Discontinuation
- 2005-05-12 PE PE2005000529A patent/PE20060311A1/es not_active Application Discontinuation
- 2005-05-12 MY MYPI20052158A patent/MY148403A/en unknown
- 2005-05-13 TW TW094115491A patent/TWI356703B/zh not_active IP Right Cessation
- 2005-05-13 AR ARP050101959A patent/AR049096A1/es unknown
-
2006
- 2006-09-06 ZA ZA200607462A patent/ZA200607462B/en unknown
- 2006-11-02 NO NO20065030A patent/NO20065030L/no not_active Application Discontinuation
- 2006-11-13 IL IL179218A patent/IL179218A/en active IP Right Grant
- 2006-11-13 EC EC2006007004A patent/ECSP067004A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |