PE20040327A1 - Medicamento que contiene betamimeticos y un nuevo anticolinergico - Google Patents
Medicamento que contiene betamimeticos y un nuevo anticolinergicoInfo
- Publication number
- PE20040327A1 PE20040327A1 PE2003000367A PE2003000367A PE20040327A1 PE 20040327 A1 PE20040327 A1 PE 20040327A1 PE 2003000367 A PE2003000367 A PE 2003000367A PE 2003000367 A PE2003000367 A PE 2003000367A PE 20040327 A1 PE20040327 A1 PE 20040327A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- dissolvent
- salts
- phylloric
- alkylen
- Prior art date
Links
- 239000000808 adrenergic beta-agonist Substances 0.000 title abstract 2
- 230000001078 anti-cholinergic effect Effects 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- -1 METHANOSULPHONATE Chemical compound 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 150000001450 anions Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960002848 formoterol Drugs 0.000 abstract 1
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 150000008282 halocarbons Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000001282 iso-butane Substances 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 abstract 1
- 230000000414 obstructive effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000001294 propane Substances 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 229960004017 salmeterol Drugs 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
- NNPPMTNAJDCUHE-UHFFFAOYSA-N trimethylmethane Natural products CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN: a) BETAMIMETICOS DE LARGA DURACION COMO SALMETEROL, FORMOTEROL CONTENIDOS EN FORMA DE SALES DE ACIDO CLORHIDRICO, BROMHIDRICO, SULFURICO, FOSFORICO, FUMARICO, 4-FENILCINAMICO, 5-(2,4-DIFLUOROFENIL)SALICILICO, ENTRE OTROS O SALES POR ADICION DE LOS ACIDOS DE LOS COMPUESTOS DE FORMULA 2a' DONDE R1 Y R2 SON H, O ALQUILO C1-C4 Y R3 Y R4 SON H, ALQUILO C1-C4, O-ALQUILO C1-C4, -ALQUILEN C1-C4-O-ALQUILO C1-C4 O JUNTOS SON -ALQUILEN C1-C4- U -O-ALQUILEN C1-C4-O-. Y b) SALES DE UN ANTICOLINERGICO DE FORMULA I DONDE X ES UN ANION DE CLORURO, BROMURO, IODURO, SULFATO, FOSFATO, METANOSULFONATO, NITRATO, MALEATO, ACETATO, ENTRE OTROS. ESTOS COMPUESTOS PUEDEN ESTAR PRESENTES CONJUNTAMENTE EN UNA UNICA FORMULACION O EN DOS FORMAS SEPARADAS Y LAS RELACION DE PESO DE LOS COMPONENTES SE ENCUENTRAN EN UN INTERVALO APROXIMADO DE 1:30 A 400:1. LAS FORMAS DE ADMINISTRACION SON POLVOS DE INHALACION QUE CONTIENEN LOS PRINCIPIOS ACTIVOS EN MEZCLA CON COADYUVANTES FISIOLOGICAMENTE INOCUOS; AEROSOLES DE DOSIFICACION CON CONTENIDO DE GAS PROPULSOR COMO HIDROCARBUROS N-PROPANO, N-BUTANO O ISOBUTANO O HIDROCARBUROS HALOGENADOS, ENTRE OTROS Y SOLUCIONES DE PROPULSION EXENTAS DE GAS PROPULSOR QUE COMO DISOLVENTE CONTIENE AGUA, ETANOL Y PUEDEN CONTENER OTROS CO-DISOLVENTES Y/O COADYUVANTES. SE UTILIZAN PARA EL TRATAMIENTO DE ENFERMEDADES DE LAS VIAS RESPIRATORIAS, INFLAMATORIAS U OBSTRUCTIVAS, EN PARTICULAR DE ASMA O COPD
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10216428 | 2002-04-12 | ||
| DE10256317A DE10256317A1 (de) | 2002-04-12 | 2002-12-03 | Arzneimittel enthaltend Betamimetika und ein neues Anticholinergikum |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040327A1 true PE20040327A1 (es) | 2004-07-12 |
Family
ID=28458801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000367A PE20040327A1 (es) | 2002-04-12 | 2003-04-10 | Medicamento que contiene betamimeticos y un nuevo anticolinergico |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1586574A1 (es) |
| KR (1) | KR20040108719A (es) |
| AR (1) | AR039634A1 (es) |
| DE (2) | DE10256317A1 (es) |
| EA (1) | EA007048B1 (es) |
| EC (1) | ECSP045357A (es) |
| MY (1) | MY141724A (es) |
| PE (1) | PE20040327A1 (es) |
| TW (1) | TWI296928B (es) |
| ZA (1) | ZA200406881B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004024453A1 (de) * | 2004-05-14 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Bronchodilatoren zur Behandlung von Atemwegserkrankungen |
| US7745621B2 (en) | 2004-05-14 | 2010-06-29 | Boehringer Ingelheim International Gmbh | Long acting bronchodilators for the treatment of respiratory diseases |
| GB0511066D0 (en) * | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
| GB0511065D0 (en) * | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4108393A1 (de) * | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln |
| DE10050994A1 (de) * | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung |
| DE10050995A1 (de) * | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
-
2002
- 2002-12-03 DE DE10256317A patent/DE10256317A1/de not_active Withdrawn
-
2003
- 2003-04-09 DE DE50301052T patent/DE50301052D1/de not_active Expired - Lifetime
- 2003-04-09 KR KR10-2004-7016153A patent/KR20040108719A/ko not_active Ceased
- 2003-04-09 EP EP05010708A patent/EP1586574A1/de not_active Withdrawn
- 2003-04-09 EA EA200401302A patent/EA007048B1/ru not_active IP Right Cessation
- 2003-04-10 PE PE2003000367A patent/PE20040327A1/es not_active Application Discontinuation
- 2003-04-10 TW TW092108234A patent/TWI296928B/zh active
- 2003-04-10 MY MYPI20031338A patent/MY141724A/en unknown
- 2003-04-11 AR ARP030101266A patent/AR039634A1/es not_active Application Discontinuation
-
2004
- 2004-08-30 ZA ZA200406881A patent/ZA200406881B/xx unknown
- 2004-10-11 EC EC2004005357A patent/ECSP045357A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA200401302A1 (ru) | 2005-04-28 |
| EA007048B1 (ru) | 2006-06-30 |
| DE50301052D1 (de) | 2005-09-29 |
| TWI296928B (en) | 2008-05-21 |
| MY141724A (en) | 2010-06-15 |
| AR039634A1 (es) | 2005-03-02 |
| DE10256317A1 (de) | 2003-10-23 |
| KR20040108719A (ko) | 2004-12-24 |
| ECSP045357A (es) | 2005-01-28 |
| ZA200406881B (en) | 2006-06-28 |
| TW200307550A (en) | 2003-12-16 |
| EP1586574A1 (de) | 2005-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |