PE20060942A1 - Derivados nonadepsipeptidos acilados ii como agentes bactericidas - Google Patents
Derivados nonadepsipeptidos acilados ii como agentes bactericidasInfo
- Publication number
- PE20060942A1 PE20060942A1 PE2005001295A PE2005001295A PE20060942A1 PE 20060942 A1 PE20060942 A1 PE 20060942A1 PE 2005001295 A PE2005001295 A PE 2005001295A PE 2005001295 A PE2005001295 A PE 2005001295A PE 20060942 A1 PE20060942 A1 PE 20060942A1
- Authority
- PE
- Peru
- Prior art keywords
- butyl
- nonadepsipeptide
- derivatives
- alanil
- leucil
- Prior art date
Links
- 239000003899 bactericide agent Substances 0.000 title 1
- -1 2,2-DIMETHYL-1-BUTYL Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010027202 Meningitis bacterial Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 201000009904 bacterial meningitis Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000002421 cell wall Anatomy 0.000 abstract 1
- 206010014665 endocarditis Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R1 ES H O TRIFLUOROMETILO; R2 ES 2,2-DIMETIL-1-BUTILO, 2-ETIL-2-METIL-1-BUTILO, 2,2-DIETIL-1-BUTILO, ENTRE OTROS. ES UN COMPUESTO PREFERIDO: 3-(TRIMETILSILIL)-D-ALANIL-3-(PIRIDIN-3-IL)-L-ALANIL-DES-(1-D-LEUCIL-2-L-LEUCIL)LISOBACTINA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA SINTESIS DE LA PARED CELULAR SIENDO UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS TALES COMO INFECCIONES URINARIAS, MENINGITIS BACTERIANA, ENDOCARDITIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004053407A DE102004053407A1 (de) | 2004-11-05 | 2004-11-05 | Acylierte Nonadepsipeptide II |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060942A1 true PE20060942A1 (es) | 2006-10-20 |
Family
ID=35462537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001295A PE20060942A1 (es) | 2004-11-05 | 2005-11-04 | Derivados nonadepsipeptidos acilados ii como agentes bactericidas |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7531507B2 (es) |
| EP (1) | EP1807443A1 (es) |
| JP (1) | JP4843614B2 (es) |
| KR (1) | KR20070083984A (es) |
| CN (1) | CN101056887A (es) |
| AR (1) | AR053775A1 (es) |
| AU (1) | AU2005300815B2 (es) |
| BR (1) | BRPI0516677A (es) |
| CA (1) | CA2586704A1 (es) |
| CR (1) | CR9079A (es) |
| DE (1) | DE102004053407A1 (es) |
| GT (1) | GT200500308A (es) |
| HN (1) | HN2005030779A (es) |
| IL (1) | IL182739A (es) |
| MA (1) | MA29218B1 (es) |
| MX (1) | MX2007005382A (es) |
| MY (1) | MY145448A (es) |
| NO (1) | NO20072854L (es) |
| NZ (1) | NZ554813A (es) |
| PE (1) | PE20060942A1 (es) |
| RU (1) | RU2414477C2 (es) |
| SV (1) | SV2006002290A (es) |
| TW (1) | TW200621799A (es) |
| UA (1) | UA89800C2 (es) |
| UY (1) | UY29189A1 (es) |
| WO (1) | WO2006048139A1 (es) |
| ZA (1) | ZA200703674B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004051025A1 (de) * | 2004-10-20 | 2006-04-27 | Bayer Healthcare Ag | Substituierte Nonadepsipeptide |
| DE102004051024A1 (de) * | 2004-10-20 | 2006-04-27 | Bayer Healthcare Ag | Heterocyclyl-substituierte Nonadepsipeptide |
| DE102004051023A1 (de) * | 2004-10-20 | 2006-05-04 | Bayer Healthcare Ag | Desoxo-Nonadepsipeptide |
| DE102004053410A1 (de) * | 2004-11-05 | 2006-05-11 | Bayer Healthcare Ag | Cyclische Nonadepsipeptidamide |
| DE102006003443A1 (de) * | 2006-01-25 | 2007-07-26 | Aicuris Gmbh & Co. Kg | Asparagin-10-substituierte Nonadepsipeptide |
| DE102006018080A1 (de) * | 2006-04-13 | 2007-10-18 | Aicuris Gmbh & Co. Kg | Lysobactinamide |
| DE102006018250A1 (de) * | 2006-04-13 | 2007-10-18 | Aicuris Gmbh & Co. Kg | Verfahren zum Herstellen von cyclischen Depsipeptiden |
| TW201717991A (zh) * | 2015-08-17 | 2017-06-01 | 拜耳動物保健有限公司 | 用於治療牛乳房炎之溶桿菌素 |
| US10100066B2 (en) * | 2015-10-23 | 2018-10-16 | Navitor Pharmaceuticals, Inc. | Modulators of sestrin-GATOR2 interaction and uses thereof |
| EP3363452A1 (en) * | 2017-02-17 | 2018-08-22 | Bayer Animal Health GmbH | Combinations of lysobactin and aminogylcosides against diseases caused by gram-positive and gram-negative bacteria in non-human animals |
| AU2018258355B2 (en) | 2017-04-26 | 2024-05-30 | Navitor Pharmaceuticals, Inc. | Modulators of sestrin-gator2 interaction and uses thereof |
| WO2021087432A1 (en) | 2019-11-01 | 2021-05-06 | Navitor Pharmaceuticals, Inc. | Methods of treatment using an mtorc1 modulator |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1266247C (en) | 1985-03-25 | 1990-02-27 | ANTIBIOTIC PREPARED BY LYSOBACTER SP. SC14.067 | |
| JPH01132600A (ja) | 1987-11-17 | 1989-05-25 | Shionogi & Co Ltd | カタノシンａおよびｂならびにその製造法 |
| DE10320781A1 (de) * | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | Acylierte Nonadepsipeptide |
-
2004
- 2004-11-05 DE DE102004053407A patent/DE102004053407A1/de not_active Withdrawn
-
2005
- 2005-10-22 KR KR1020077010212A patent/KR20070083984A/ko not_active Ceased
- 2005-10-22 ZA ZA200703674A patent/ZA200703674B/xx unknown
- 2005-10-22 EP EP05798234A patent/EP1807443A1/de not_active Withdrawn
- 2005-10-22 WO PCT/EP2005/011363 patent/WO2006048139A1/de not_active Ceased
- 2005-10-22 MX MX2007005382A patent/MX2007005382A/es active IP Right Grant
- 2005-10-22 RU RU2007120686/04A patent/RU2414477C2/ru not_active IP Right Cessation
- 2005-10-22 AU AU2005300815A patent/AU2005300815B2/en not_active Ceased
- 2005-10-22 UA UAA200705852A patent/UA89800C2/ru unknown
- 2005-10-22 CN CNA2005800371138A patent/CN101056887A/zh active Pending
- 2005-10-22 CA CA002586704A patent/CA2586704A1/en not_active Abandoned
- 2005-10-22 BR BRPI0516677-2A patent/BRPI0516677A/pt not_active Application Discontinuation
- 2005-10-22 JP JP2007539492A patent/JP4843614B2/ja not_active Expired - Fee Related
- 2005-10-22 NZ NZ554813A patent/NZ554813A/en not_active IP Right Cessation
- 2005-10-27 GT GT200500308A patent/GT200500308A/es unknown
- 2005-11-02 AR ARP050104586A patent/AR053775A1/es unknown
- 2005-11-02 MY MYPI20055197A patent/MY145448A/en unknown
- 2005-11-03 HN HN2005030779A patent/HN2005030779A/es unknown
- 2005-11-03 UY UY29189A patent/UY29189A1/es unknown
- 2005-11-04 US US11/267,063 patent/US7531507B2/en not_active Expired - Fee Related
- 2005-11-04 SV SV2005002290A patent/SV2006002290A/es not_active Application Discontinuation
- 2005-11-04 PE PE2005001295A patent/PE20060942A1/es not_active Application Discontinuation
- 2005-11-04 TW TW094138656A patent/TW200621799A/zh unknown
-
2007
- 2007-04-20 CR CR9079A patent/CR9079A/es not_active Application Discontinuation
- 2007-04-23 IL IL182739A patent/IL182739A/en not_active IP Right Cessation
- 2007-05-30 MA MA29955A patent/MA29218B1/fr unknown
- 2007-06-05 NO NO20072854A patent/NO20072854L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US7531507B2 (en) | 2009-05-12 |
| AU2005300815B2 (en) | 2011-05-19 |
| ZA200703674B (en) | 2008-09-25 |
| GT200500308A (es) | 2006-06-02 |
| JP4843614B2 (ja) | 2011-12-21 |
| UA89800C2 (en) | 2010-03-10 |
| HN2005030779A (es) | 2010-08-19 |
| MA29218B1 (fr) | 2008-02-01 |
| NO20072854L (no) | 2007-08-01 |
| MY145448A (en) | 2012-02-15 |
| MX2007005382A (es) | 2007-08-14 |
| DE102004053407A1 (de) | 2006-05-11 |
| WO2006048139A1 (de) | 2006-05-11 |
| CA2586704A1 (en) | 2006-05-11 |
| CN101056887A (zh) | 2007-10-17 |
| CR9079A (es) | 2007-08-28 |
| RU2007120686A (ru) | 2008-12-10 |
| IL182739A0 (en) | 2007-07-24 |
| EP1807443A1 (de) | 2007-07-18 |
| JP2008518982A (ja) | 2008-06-05 |
| BRPI0516677A (pt) | 2008-09-16 |
| TW200621799A (en) | 2006-07-01 |
| US20060264358A1 (en) | 2006-11-23 |
| AU2005300815A1 (en) | 2006-05-11 |
| IL182739A (en) | 2013-03-24 |
| SV2006002290A (es) | 2006-10-13 |
| UY29189A1 (es) | 2006-06-30 |
| AR053775A1 (es) | 2007-05-23 |
| KR20070083984A (ko) | 2007-08-24 |
| RU2414477C2 (ru) | 2011-03-20 |
| NZ554813A (en) | 2009-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |