PE20040563A1 - Compuesto de imidazol y metodo para su produccion - Google Patents
Compuesto de imidazol y metodo para su produccionInfo
- Publication number
- PE20040563A1 PE20040563A1 PE2003000593A PE2003000593A PE20040563A1 PE 20040563 A1 PE20040563 A1 PE 20040563A1 PE 2003000593 A PE2003000593 A PE 2003000593A PE 2003000593 A PE2003000593 A PE 2003000593A PE 20040563 A1 PE20040563 A1 PE 20040563A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- ethyl
- trifluoroetoxy
- lil
- sulfinyl
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 2
- -1 IMIDAZOLE COMPOUND Chemical class 0.000 title 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical group C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 3
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 229930195733 hydrocarbon Natural products 0.000 abstract 3
- 150000002430 hydrocarbons Chemical class 0.000 abstract 3
- XTQHKBHJIVJGKJ-UHFFFAOYSA-N sulfur monoxide Chemical compound S=O XTQHKBHJIVJGKJ-UHFFFAOYSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000007882 Gastritis Diseases 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000000689 peptic esophagitis Diseases 0.000 abstract 1
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE, EL ANILLO A ES PIRIDINA; EL ANILLO B ES BENCENO, HETEROCICLO AROMATICO MONICICLICO; X1 Y X2 SON CADA UNO O, S; W ES HIDROCARBURO DE CADENA DIVALENTE; R ES HIDROCARBURO, GRUPO HETEROCICLO; R Y W PUEDEN ENLAZARSE; D1 Y D2 SON CADA UNO O, S, ENTRE OTROS; Y ES HIDROCARBURO, HETEROCICLO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-[METIL[[(R)-2-[[[3-METIL-4-(2,2,2-TRIFLUOROETOXI)-2-PIRIDIL]METIL]SULFINIL]-1H-BENCIMIDAZO-1-LIL]CARBONIL]AMINO]ETIL ACETATO; ETIL-2-[METIL[[(R)-2-[[[3-METIL-4-(2,2,2-TRIFLUOROETOXI)-2-PIRIDIL]METIL]SULFINIL]-1H-BENCIMIDAZO-1-LIL]CARBONIL]AMINO]ETIL-CARBONATO Y 2-[METIL[[(R)-2-[[[3-METIL-4-(2,2,2-TRIFLUOROETOXI)-2-PIRIDIL]METIL]SULFINIL]-1H-BENCIMIDAZO-1-LIL]CARBONIL]AMINO]ETIL TETRAHIDROPIRA-4-NIL-CARBONATO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA UTIL EN LA PROFILAXIS O TRATAMIENTO DE ULCERA PEPTICA, GASTRITIS, ESOFAGITIS PEPTICA, ENTRE OTROS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002175086 | 2002-06-14 | ||
| JP2003041085 | 2003-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040563A1 true PE20040563A1 (es) | 2004-10-21 |
Family
ID=29738411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000593A PE20040563A1 (es) | 2002-06-14 | 2003-06-13 | Compuesto de imidazol y metodo para su produccion |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7410981B2 (es) |
| EP (2) | EP1513527B1 (es) |
| JP (1) | JPWO2003106429A1 (es) |
| KR (1) | KR20050009751A (es) |
| CN (1) | CN1678315A (es) |
| AR (1) | AR040221A1 (es) |
| AT (1) | ATE437642T1 (es) |
| AU (2) | AU2003242390A1 (es) |
| BR (1) | BR0311801A (es) |
| CA (2) | CA2489361A1 (es) |
| DE (1) | DE60328603D1 (es) |
| IL (1) | IL165562A0 (es) |
| MX (1) | MXPA04012396A (es) |
| NO (1) | NO20050141L (es) |
| OA (1) | OA12867A (es) |
| PE (1) | PE20040563A1 (es) |
| PL (1) | PL373085A1 (es) |
| TW (1) | TW200307544A (es) |
| WO (2) | WO2003105845A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1740571E (pt) | 2004-04-28 | 2009-09-02 | Hetero Drugs Ltd | Processo para preparar compostos de piridinilmetil-1hbenzimidazol na forma enantiomericamente enriquecida ou como enantiómeros únicos |
| CA2784881C (en) | 2005-02-25 | 2016-02-09 | Takeda Pharmaceutical Company Limited | Method for producing granules |
| KR101148399B1 (ko) * | 2005-06-22 | 2012-05-23 | 일양약품주식회사 | 항궤양제 및 점막보호제를 함유하는 경구용 위장질환치료용 약제 조성물 |
| US20100317689A1 (en) * | 2006-09-19 | 2010-12-16 | Garst Michael E | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
| MX2009004475A (es) | 2006-10-27 | 2009-08-12 | Univ Missouri | Composiciones que comprenden agentes acido labiles que inhiben la bomba de protones, por lo menos otro agente farmaceuticamente activo y metodos de uso de las misma. |
| CA2716367C (en) | 2008-02-20 | 2015-05-26 | The Curators Of The University Of Missouri | Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same |
| ES2601226T3 (es) | 2009-10-28 | 2017-02-14 | Newlink Genetics Corporation | Derivados de imidazol como inhibidores de IDO |
| US8916563B2 (en) | 2010-07-16 | 2014-12-23 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| WO2016172436A1 (en) * | 2015-04-23 | 2016-10-27 | Temple University-Of The Commonwealth System Of Higher Education | Polycationic amphiphiles and polymers thereof as antimicrobial agents and methods using same |
| DK3352754T3 (da) | 2016-06-21 | 2020-12-07 | Univ Columbia | Aldosereduktaseinhibitorer og fremgangsmåder til anvendelse deraf |
| US11111216B2 (en) | 2016-10-26 | 2021-09-07 | Temple University-Of The Commonwealth System Of Higher Education | Polycationic amphiphiles as antimicrobial agents and methods using same |
| CN119633117A (zh) | 2017-07-28 | 2025-03-18 | 应用治疗公司 | 用于治疗半乳糖血症的组合物和方法 |
| JP7623292B2 (ja) | 2019-04-01 | 2025-01-28 | アプライド セラピューティクス， インコーポレイテッド | アルドースレダクターゼの阻害剤 |
| CA3136100A1 (en) | 2019-05-07 | 2020-11-12 | Stephan L. ZUCHNER | Treatment and detection of inherited neuropathies and associated disorders |
| HUE070031T2 (hu) * | 2020-06-17 | 2025-05-28 | Ildong Pharmaceutical Co Ltd | Új savszekréciós inhibitor és alkalmazása |
| IT202200001022A1 (it) * | 2022-01-21 | 2023-07-21 | Exo Lab Italia | Composti farmaceutici ibridi ottenuti mediante coniugazione di un inibitore delle pompe protoniche e un inibitore delle anidrasi carboniche |
| CN120590773B (zh) * | 2025-08-06 | 2025-12-26 | 广州仕天材料科技有限公司 | 一种增强型聚碳酸酯和制备方法及在汽车照明系统中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE416649B (sv) | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
| SE8300736D0 (sv) | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
| KR890000387B1 (ko) | 1984-09-24 | 1989-03-16 | 디 엎존 캄파니 | 2-(피리딜알켄술 피닐)벤즈 이미드아졸류의 n-치환 유도체의 제조방법 |
| IL76839A (en) | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| SE8505112D0 (sv) | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
| US4965269A (en) | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
| US5614549A (en) * | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US6093734A (en) | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
| BR0009653A (pt) * | 1999-04-09 | 2002-01-08 | Basf Ag | Composto, medicamento, e, uso de compostos |
| US6765019B1 (en) * | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
| EP1334104A2 (en) * | 2000-07-07 | 2003-08-13 | Neotherapeutics, Inc. | Methods for treatment of drug-induced peripheral neuropathy and related conditions |
| AU2001294228A1 (en) | 2000-10-12 | 2002-04-22 | Takeda Chemical Industries Ltd. | Benzimidazole compounds, process for producing the same and use thereof |
| MXPA03011094A (es) * | 2001-05-31 | 2004-12-06 | Medarex Inc | Citotoxinas, profarmacos, ligadores, y estabilizadores utiles para ello. |
| US20040248941A1 (en) | 2001-09-25 | 2004-12-09 | Keiji Kamiyama | Benzimidazone compound, process for producing the same, and use thereof |
-
2003
- 2003-06-13 PE PE2003000593A patent/PE20040563A1/es not_active Application Discontinuation
- 2003-06-13 MX MXPA04012396A patent/MXPA04012396A/es not_active Application Discontinuation
- 2003-06-13 TW TW092116056A patent/TW200307544A/zh unknown
- 2003-06-13 AU AU2003242390A patent/AU2003242390A1/en not_active Abandoned
- 2003-06-13 BR BR0311801-0A patent/BR0311801A/pt not_active IP Right Cessation
- 2003-06-13 AR ARP030102114A patent/AR040221A1/es not_active Application Discontinuation
- 2003-06-13 KR KR10-2004-7020371A patent/KR20050009751A/ko not_active Withdrawn
- 2003-06-13 US US10/517,633 patent/US7410981B2/en not_active Expired - Fee Related
- 2003-06-13 WO PCT/JP2003/007546 patent/WO2003105845A1/en not_active Ceased
- 2003-06-13 JP JP2004513262A patent/JPWO2003106429A1/ja active Pending
- 2003-06-13 AU AU2003242388A patent/AU2003242388A1/en not_active Abandoned
- 2003-06-13 WO PCT/JP2003/007545 patent/WO2003106429A1/ja not_active Ceased
- 2003-06-13 EP EP03733426A patent/EP1513527B1/en not_active Expired - Lifetime
- 2003-06-13 CA CA002489361A patent/CA2489361A1/en not_active Abandoned
- 2003-06-13 DE DE60328603T patent/DE60328603D1/de not_active Expired - Lifetime
- 2003-06-13 US US10/517,847 patent/US20060293371A1/en not_active Abandoned
- 2003-06-13 PL PL03373085A patent/PL373085A1/xx not_active Application Discontinuation
- 2003-06-13 CA CA002489470A patent/CA2489470A1/en not_active Abandoned
- 2003-06-13 EP EP03733425A patent/EP1514870A4/en not_active Withdrawn
- 2003-06-13 OA OA1200400327A patent/OA12867A/en unknown
- 2003-06-13 AT AT03733426T patent/ATE437642T1/de not_active IP Right Cessation
- 2003-06-13 CN CNA038188953A patent/CN1678315A/zh active Pending
-
2004
- 2004-12-05 IL IL16556204A patent/IL165562A0/xx unknown
-
2005
- 2005-01-11 NO NO20050141A patent/NO20050141L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1513527A1 (en) | 2005-03-16 |
| EP1514870A4 (en) | 2006-08-23 |
| EP1514870A1 (en) | 2005-03-16 |
| DE60328603D1 (de) | 2009-09-10 |
| PL373085A1 (en) | 2005-08-08 |
| CA2489361A1 (en) | 2003-12-24 |
| NO20050141D0 (no) | 2005-01-11 |
| CA2489470A1 (en) | 2003-12-24 |
| AU2003242388A1 (en) | 2003-12-31 |
| WO2003105845A1 (en) | 2003-12-24 |
| KR20050009751A (ko) | 2005-01-25 |
| ATE437642T1 (de) | 2009-08-15 |
| BR0311801A (pt) | 2005-04-12 |
| AU2003242390A1 (en) | 2003-12-31 |
| US7410981B2 (en) | 2008-08-12 |
| EP1513527B1 (en) | 2009-07-29 |
| IL165562A0 (en) | 2006-01-15 |
| AR040221A1 (es) | 2005-03-16 |
| US20050222210A1 (en) | 2005-10-06 |
| WO2003106429A1 (ja) | 2003-12-24 |
| US20060293371A1 (en) | 2006-12-28 |
| NO20050141L (no) | 2005-01-27 |
| OA12867A (en) | 2006-09-15 |
| JPWO2003106429A1 (ja) | 2005-10-13 |
| MXPA04012396A (es) | 2005-06-17 |
| CN1678315A (zh) | 2005-10-05 |
| TW200307544A (en) | 2003-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FC | Refusal |