BR0311801A - Composição de imidazol, método para produção do mesmo, composição farmacêutica, embalagem comercial, método para a profilaxia ou tratamento de doenças, método para erradicar helicobacter pylori de um animal infectado com helicobacter pylori, e, uso de um composto - Google Patents
Composição de imidazol, método para produção do mesmo, composição farmacêutica, embalagem comercial, método para a profilaxia ou tratamento de doenças, método para erradicar helicobacter pylori de um animal infectado com helicobacter pylori, e, uso de um compostoInfo
- Publication number
- BR0311801A BR0311801A BR0311801-0A BR0311801A BR0311801A BR 0311801 A BR0311801 A BR 0311801A BR 0311801 A BR0311801 A BR 0311801A BR 0311801 A BR0311801 A BR 0311801A
- Authority
- BR
- Brazil
- Prior art keywords
- helicobacter pylori
- compound
- treatment
- composition
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSTO DE IMIDAZOL, MéTODO PARA PRODUçãO DO MESMO, COMPOSIçãO FARMACêUTICA, EMBALAGEM COMERCIAL, MéTODO PARA A PROFILAXIA OU TRATAMENTO DE DOENçAS, MéTODO PARA ERRADICAR HELICOBACTER PYLORI DE UM ANIMAL INFECTADO COM HELICOBACTER PYLORI, E, USO DE UM COMPOSTO". Um composto de imidazol representado pela fórmula (I) um sal do mesmo e um composto da fórmula (V) que é um dos intermediários do mesmo, sendo que cada símbolo é como definido na presente descrição. O composto da presente invenção apresenta uma atividade superior anti-úlcera, uma ação inibidora de secreção de ácido gástrico, uma ação protetora de mucosa, uma ação anti-Helicobacter pylori action e análogos. Como apresenta baixa toxicidade, o composto é útil como um produto farmacêutico.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002175086 | 2002-06-14 | ||
| JP2003041085 | 2003-02-19 | ||
| PCT/JP2003/007546 WO2003105845A1 (en) | 2002-06-14 | 2003-06-13 | Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. peptic ulcers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0311801A true BR0311801A (pt) | 2005-04-12 |
Family
ID=29738411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0311801-0A BR0311801A (pt) | 2002-06-14 | 2003-06-13 | Composição de imidazol, método para produção do mesmo, composição farmacêutica, embalagem comercial, método para a profilaxia ou tratamento de doenças, método para erradicar helicobacter pylori de um animal infectado com helicobacter pylori, e, uso de um composto |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7410981B2 (pt) |
| EP (2) | EP1513527B1 (pt) |
| JP (1) | JPWO2003106429A1 (pt) |
| KR (1) | KR20050009751A (pt) |
| CN (1) | CN1678315A (pt) |
| AR (1) | AR040221A1 (pt) |
| AT (1) | ATE437642T1 (pt) |
| AU (2) | AU2003242390A1 (pt) |
| BR (1) | BR0311801A (pt) |
| CA (2) | CA2489470A1 (pt) |
| DE (1) | DE60328603D1 (pt) |
| IL (1) | IL165562A0 (pt) |
| MX (1) | MXPA04012396A (pt) |
| NO (1) | NO20050141L (pt) |
| OA (1) | OA12867A (pt) |
| PE (1) | PE20040563A1 (pt) |
| PL (1) | PL373085A1 (pt) |
| TW (1) | TW200307544A (pt) |
| WO (2) | WO2003106429A1 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004022337D1 (de) | 2004-04-28 | 2009-09-10 | Hetero Drugs Ltd | Verfahren zur herstellung von pyridinylmethyl-1h-benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere |
| WO2006090845A1 (ja) | 2005-02-25 | 2006-08-31 | Takeda Pharmaceutical Company Limited | 顆粒の製造方法 |
| KR101148399B1 (ko) * | 2005-06-22 | 2012-05-23 | 일양약품주식회사 | 항궤양제 및 점막보호제를 함유하는 경구용 위장질환치료용 약제 조성물 |
| US20100317689A1 (en) * | 2006-09-19 | 2010-12-16 | Garst Michael E | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
| MX2009004475A (es) | 2006-10-27 | 2009-08-12 | Univ Missouri | Composiciones que comprenden agentes acido labiles que inhiben la bomba de protones, por lo menos otro agente farmaceuticamente activo y metodos de uso de las misma. |
| US8247440B2 (en) | 2008-02-20 | 2012-08-21 | Curators Of The University Of Missouri | Composition comprising omeprazole, lansoprazole and at least one buffering agent |
| WO2011056652A1 (en) | 2009-10-28 | 2011-05-12 | Newlink Genetics | Imidazole derivatives as ido inhibitors |
| US8916563B2 (en) | 2010-07-16 | 2014-12-23 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| WO2016172436A1 (en) * | 2015-04-23 | 2016-10-27 | Temple University-Of The Commonwealth System Of Higher Education | Polycationic amphiphiles and polymers thereof as antimicrobial agents and methods using same |
| EP3757107B1 (en) * | 2016-06-21 | 2023-10-25 | The Trustees of Columbia University in the City of New York | 4-oxo-3,4-dihydrothieno[3,4-d]pyridazine compounds as aldose reductase inhibitors and methods of use thereof |
| WO2018081347A1 (en) | 2016-10-26 | 2018-05-03 | Temple University-Of The Commonwealth System Of Higher Education | Polycationic amphiphiles as antimicrobial agents and methods using same |
| ES2983586T3 (es) | 2017-07-28 | 2024-10-23 | Applied Therapeutics Inc | Composiciones y procedimientos para el tratamiento de la galactosemia |
| CN113840825A (zh) | 2019-04-01 | 2021-12-24 | 应用治疗公司 | 醛糖还原酶抑制剂 |
| JP2022531466A (ja) | 2019-05-07 | 2022-07-06 | ユニバーシティ オブ マイアミ | 遺伝性ニューロパチーおよび関連障害の処置および検出 |
| PT4148050T (pt) * | 2020-06-17 | 2025-01-29 | Ildong Pharmaceutical Co Ltd | Novo inibidor da secreção ácida e sua utilização |
| IT202200001022A1 (it) * | 2022-01-21 | 2023-07-21 | Exo Lab Italia | Composti farmaceutici ibridi ottenuti mediante coniugazione di un inibitore delle pompe protoniche e un inibitore delle anidrasi carboniche |
| CN120590773B (zh) * | 2025-08-06 | 2025-12-26 | 广州仕天材料科技有限公司 | 一种增强型聚碳酸酯和制备方法及在汽车照明系统中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
| SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
| KR890000387B1 (ko) * | 1984-09-24 | 1989-03-16 | 디 엎존 캄파니 | 2-(피리딜알켄술 피닐)벤즈 이미드아졸류의 n-치환 유도체의 제조방법 |
| IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
| US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
| US5614549A (en) * | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US6093734A (en) * | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
| KR20020004995A (ko) * | 1999-04-09 | 2002-01-16 | 스타르크, 카르크 | 트롬빈 억제제의 프로드럭 |
| US6765019B1 (en) * | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
| DE60144123D1 (de) * | 2000-07-07 | 2011-04-07 | Spectrum Pharmaceuticals Inc | Verfahren zur Behandlung von Arzneimittelinduzierter peripherer Neuropathie und verwandten Krankheitsformen |
| AU2001294228A1 (en) | 2000-10-12 | 2002-04-22 | Takeda Chemical Industries Ltd. | Benzimidazole compounds, process for producing the same and use thereof |
| KR20030033007A (ko) * | 2001-05-31 | 2003-04-26 | 코울터 파머수티컬, 인코포레이티드 | 세포독소, 약물전구체, 링커 및 이에 유용한 안정화제 |
| EP1437352A4 (en) | 2001-09-25 | 2004-12-08 | Takeda Chemical Industries Ltd | BENZIMIDAZOLE COMPOUND, METHOD FOR THE PRODUCTION AND USE THEREOF |
-
2003
- 2003-06-13 US US10/517,633 patent/US7410981B2/en not_active Expired - Fee Related
- 2003-06-13 AT AT03733426T patent/ATE437642T1/de not_active IP Right Cessation
- 2003-06-13 TW TW092116056A patent/TW200307544A/zh unknown
- 2003-06-13 BR BR0311801-0A patent/BR0311801A/pt not_active IP Right Cessation
- 2003-06-13 AU AU2003242390A patent/AU2003242390A1/en not_active Abandoned
- 2003-06-13 EP EP03733426A patent/EP1513527B1/en not_active Expired - Lifetime
- 2003-06-13 KR KR10-2004-7020371A patent/KR20050009751A/ko not_active Withdrawn
- 2003-06-13 AU AU2003242388A patent/AU2003242388A1/en not_active Abandoned
- 2003-06-13 AR ARP030102114A patent/AR040221A1/es not_active Application Discontinuation
- 2003-06-13 MX MXPA04012396A patent/MXPA04012396A/es not_active Application Discontinuation
- 2003-06-13 EP EP03733425A patent/EP1514870A4/en not_active Withdrawn
- 2003-06-13 DE DE60328603T patent/DE60328603D1/de not_active Expired - Lifetime
- 2003-06-13 US US10/517,847 patent/US20060293371A1/en not_active Abandoned
- 2003-06-13 CA CA002489470A patent/CA2489470A1/en not_active Abandoned
- 2003-06-13 CN CNA038188953A patent/CN1678315A/zh active Pending
- 2003-06-13 PE PE2003000593A patent/PE20040563A1/es not_active Application Discontinuation
- 2003-06-13 CA CA002489361A patent/CA2489361A1/en not_active Abandoned
- 2003-06-13 WO PCT/JP2003/007545 patent/WO2003106429A1/ja not_active Ceased
- 2003-06-13 WO PCT/JP2003/007546 patent/WO2003105845A1/en not_active Ceased
- 2003-06-13 JP JP2004513262A patent/JPWO2003106429A1/ja active Pending
- 2003-06-13 OA OA1200400327A patent/OA12867A/en unknown
- 2003-06-13 PL PL03373085A patent/PL373085A1/xx not_active Application Discontinuation
-
2004
- 2004-12-05 IL IL16556204A patent/IL165562A0/xx unknown
-
2005
- 2005-01-11 NO NO20050141A patent/NO20050141L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003105845A1 (en) | 2003-12-24 |
| EP1513527A1 (en) | 2005-03-16 |
| TW200307544A (en) | 2003-12-16 |
| IL165562A0 (en) | 2006-01-15 |
| OA12867A (en) | 2006-09-15 |
| AU2003242388A1 (en) | 2003-12-31 |
| EP1514870A1 (en) | 2005-03-16 |
| US7410981B2 (en) | 2008-08-12 |
| AR040221A1 (es) | 2005-03-16 |
| AU2003242390A1 (en) | 2003-12-31 |
| DE60328603D1 (de) | 2009-09-10 |
| CA2489470A1 (en) | 2003-12-24 |
| NO20050141L (no) | 2005-01-27 |
| NO20050141D0 (no) | 2005-01-11 |
| PL373085A1 (en) | 2005-08-08 |
| WO2003106429A1 (ja) | 2003-12-24 |
| EP1514870A4 (en) | 2006-08-23 |
| CN1678315A (zh) | 2005-10-05 |
| JPWO2003106429A1 (ja) | 2005-10-13 |
| US20050222210A1 (en) | 2005-10-06 |
| CA2489361A1 (en) | 2003-12-24 |
| EP1513527B1 (en) | 2009-07-29 |
| MXPA04012396A (es) | 2005-06-17 |
| US20060293371A1 (en) | 2006-12-28 |
| ATE437642T1 (de) | 2009-08-15 |
| KR20050009751A (ko) | 2005-01-25 |
| PE20040563A1 (es) | 2004-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2064 DE 27/07/2010. |