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PE20110300A1 - Compuestos de pirrol como inhibidores de la bomba de protones - Google Patents

Compuestos de pirrol como inhibidores de la bomba de protones

Info

Publication number
PE20110300A1
PE20110300A1 PE2011000194A PE2011000194A PE20110300A1 PE 20110300 A1 PE20110300 A1 PE 20110300A1 PE 2011000194 A PE2011000194 A PE 2011000194A PE 2011000194 A PE2011000194 A PE 2011000194A PE 20110300 A1 PE20110300 A1 PE 20110300A1
Authority
PE
Peru
Prior art keywords
halogen
fluoropyridin
sulfonil
methylmethanamine
pyrrol
Prior art date
Application number
PE2011000194A
Other languages
English (en)
Inventor
Haruyuki Nishida
Yasuyoshi Arikawa
Ikuo Fujimori
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41508823&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110300(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20110300A1 publication Critical patent/PE20110300A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE PIRROL DE FORMULA (I), DONDE A ES UN GRUPO PIRIDILO DE FORMULA (A-1) O (A-2); R1, R2 Y R3 SON H, HALOGENO, ALQUILO C1-C6, ENTRE OTROS; R4 Y R6 SON H, HALOGENO O ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON HALOGENO; R5 ES H, HALOGENO, ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON HALOGENO O ALCOXI C1-C6 OPCIONALMENTE SUSTITUIDO CON HALOGENO; R7 ES H O ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON HALOGENO. SON COMPUESTOS PREFERIDOS: 1-{4-FLUORO-5-(2-FLUOROPIRIDIN-3-IL)-1-[(4-METILPIRIDIN-2-IL)SULFONIL]-1H-PIRROL-3-IL}-N-METILMETANAMINA, 1-{4-FLUORO-5-(2-FLUOROPIRIDIN-3-IL)-1-[(5-FLUOROPIRIDIN-2-IL)SULFONIL]-1H-PIRROL-3-IL}-N-METILMETANAMINA, 1-{4-FLUORO-5-(2-FLUOROPIRIDIN-3-IL)-1-[(4-METOXIPIRIDIN-2-IL)SULFONIL]-1H-PIRROL-3-IL}-N-METILMETANAMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD INHIBIDORA DE LA BOMBA DE PROTONES, INHIBIENDO LA SECRECION ACIDA GASTRICA Y SON UTILES EN EL TRATAMIENTO DE ULCERA PEPTICA, GASTRITIS, ESOFAGITIS DE REFLUJO, ENTRE OTRAS
PE2011000194A 2008-08-27 2009-08-26 Compuestos de pirrol como inhibidores de la bomba de protones PE20110300A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008218851 2008-08-27
JP2008269099 2008-10-17

Publications (1)

Publication Number Publication Date
PE20110300A1 true PE20110300A1 (es) 2011-06-16

Family

ID=41508823

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2013002359A PE20141174A1 (es) 2008-08-27 2009-08-26 Compuestos de pirrol como inhibidores de la bomba de protones
PE2011000194A PE20110300A1 (es) 2008-08-27 2009-08-26 Compuestos de pirrol como inhibidores de la bomba de protones

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2013002359A PE20141174A1 (es) 2008-08-27 2009-08-26 Compuestos de pirrol como inhibidores de la bomba de protones

Country Status (38)

Country Link
US (3) US8592597B2 (es)
EP (1) EP2318390B1 (es)
JP (1) JP5638515B2 (es)
KR (1) KR101629181B1 (es)
CN (1) CN102197033B (es)
AR (1) AR073136A1 (es)
AU (1) AU2009284867B2 (es)
BR (1) BRPI0917705A2 (es)
CA (1) CA2735162C (es)
CL (1) CL2011000402A1 (es)
CO (1) CO6321166A2 (es)
CR (1) CR20110169A (es)
CY (1) CY1114452T1 (es)
DK (1) DK2318390T3 (es)
DO (1) DOP2011000061A (es)
EA (1) EA019741B1 (es)
EC (1) ECSP11010912A (es)
ES (1) ES2423289T3 (es)
GE (1) GEP20135786B (es)
HR (1) HRP20130653T1 (es)
IL (1) IL211335A (es)
JO (1) JO2871B1 (es)
MA (1) MA32647B1 (es)
ME (1) ME01598B (es)
MX (1) MX2011001955A (es)
MY (1) MY152008A (es)
NZ (1) NZ591793A (es)
PE (2) PE20141174A1 (es)
PL (1) PL2318390T3 (es)
PT (1) PT2318390E (es)
RS (1) RS52872B (es)
SI (1) SI2318390T1 (es)
SM (1) SMT201300085B (es)
TW (1) TWI473798B (es)
UA (1) UA105185C2 (es)
UY (1) UY32074A (es)
WO (1) WO2010024451A1 (es)
ZA (1) ZA201101774B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2423289T3 (es) * 2008-08-27 2013-09-19 Takeda Pharmaceutical Company Limited Compuestos de pirrol
US20110229879A1 (en) * 2010-03-19 2011-09-22 University Of Rochester Methods and compositions for nuclear staining
CN102452979B (zh) * 2010-11-03 2015-04-01 天津药明康德新药开发有限公司 5-氟-3-吡啶磺酰氯的合成方法
CN102863371B (zh) * 2011-07-06 2016-04-13 中国科学院上海有机化学研究所 氟代二氢吡咯或氟代吡咯
US10039813B2 (en) 2012-02-07 2018-08-07 Massachusetts Institute Of Technology Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
CN110917130A (zh) 2012-06-27 2020-03-27 武田药品工业株式会社 用盐稳定的胺和有机酸的液体制剂
CN105143187B (zh) * 2013-02-28 2018-04-03 武田药品工业株式会社 制备磺酰氯化合物的方法
WO2014144231A1 (en) 2013-03-15 2014-09-18 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
KR102084185B1 (ko) * 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
CN105367550A (zh) * 2014-08-11 2016-03-02 江苏柯菲平医药股份有限公司 四氢环戊二烯并[c]吡咯类衍生物、其制备方法及其在医药上的应用
UY36547A (es) 2015-02-05 2016-06-01 Bayer Cropscience Ag Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas
US10317418B2 (en) 2015-02-24 2019-06-11 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
PH12018500236B1 (en) 2015-07-30 2023-12-06 Takeda Pharmaceuticals Co Tablet
PE20180783A1 (es) 2015-08-07 2018-05-07 Bayer Cropscience Ag Derivados heterociclicos condensados sustituidos por 2-(het) arilo como pesticidas
CN106430006B (zh) * 2016-08-18 2018-06-12 国网湖南省电力公司带电作业中心 配电线路移动式绝缘登高作业装置及方法
CN108203430A (zh) * 2016-12-16 2018-06-26 天地人和生物科技有限公司 一种新型可逆性质子泵抑制剂及其制备方法和用途
SG11202000136YA (en) 2017-07-10 2020-02-27 Takeda Pharmaceuticals Co Preparation comprising vonoprazan
KR102126576B1 (ko) 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법
CN113527536B (zh) * 2020-04-21 2024-03-22 杭州德柯医疗科技有限公司 一种含氟多糖高分子化合物及其制备方法
HUE070031T2 (hu) * 2020-06-17 2025-05-28 Ildong Pharmaceutical Co Ltd Új savszekréciós inhibitor és alkalmazása
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors
CN113620930B (zh) * 2021-07-12 2022-08-16 南京烁慧医药科技有限公司 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用
CN118401510A (zh) * 2021-12-15 2024-07-26 日东制药株式会社 1-磺酰基吡咯衍生物的新颖盐类、其制备方法及包含其的药物组合物
KR20240119083A (ko) * 2021-12-15 2024-08-06 일동제약(주) 1-설포닐 피롤 유도체의 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물
KR20230102353A (ko) * 2021-12-30 2023-07-07 주식회사 대웅제약 삼중음성유방암의 예방 또는 치료용 약학적 조성물

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2031514T3 (es) 1986-08-29 1992-12-16 Pfizer Inc. 2-guanidino-4-ariltiazoles para el tratamiento de ulceras pepticas.
US5128366A (en) 1990-07-05 1992-07-07 Shinogi & Co., Ltd. Pyrrole derivatives
US5331006A (en) * 1990-08-31 1994-07-19 Warner-Lambert Company Amino acid analogs as CCK antagonists
AU8653891A (en) 1990-08-31 1992-03-30 Warner-Lambert Company Amino acid analogs as cck antagonists
WO1993007751A1 (en) 1991-10-18 1993-04-29 Monsanto Company Fungicides for the control of take-all disease of plants
ZA927272B (en) 1991-10-29 1994-03-23 Du Pont Herbicidal triazolecarboxamides
JPH06135961A (ja) 1992-10-23 1994-05-17 Nippon Iyakuhin Kogyo Kk 新規ジフェニルピロリルフラン誘導体
US5286742A (en) 1992-11-03 1994-02-15 American Cyanamid Company Pyrrole thiocarboxamide insecticidal and acaricidal agents
US5480902A (en) * 1993-08-31 1996-01-02 American Cyanamid Company Thienylpyrrole fungicidal agents
JPH08119936A (ja) 1994-10-18 1996-05-14 Fujisawa Pharmaceut Co Ltd 複素環式誘導体
JPH0930967A (ja) 1995-07-17 1997-02-04 Chugai Pharmaceut Co Ltd 抗潰瘍剤
NZ334256A (en) 1996-08-28 2000-11-24 Procter & Gamble 1-substituted sulphonyl-pyrrolidine derivatives useful as metalloprotease inhibitors
HUP0000735A3 (en) 1996-12-23 2002-03-28 Bristol Myers Squibb Pharma Co Nitrogen containing heteroaromatics as factor xa inhibitors
JPH11209344A (ja) 1998-01-26 1999-08-03 Kyowa Hakko Kogyo Co Ltd 含窒素複素環化合物
GB9817548D0 (en) * 1998-08-12 1998-10-07 Novartis Ag Organic compounds
AU2825000A (en) 1999-03-10 2000-09-28 Shionogi & Co., Ltd. Medicinal compositions with (2.2.1) and (3.1.1) bicycloskeleton antagonistic to both of pgd2/txa2 receptors
TW575561B (en) 1999-03-25 2004-02-11 Hoffmann La Roche 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives
AU3783100A (en) 1999-06-14 2000-12-21 Dow Agrosciences Llc Substituted triazoles, imidazoles and pyrazoles as herbicides
AU7812900A (en) * 1999-08-26 2001-03-19 Aventis Pharmaceuticals Inc. Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benozopyrans
CA2410338A1 (en) 2000-05-22 2001-11-29 Takeda Chemical Industries, Ltd. Tyrosine phosphatase inhibitors
US6589978B2 (en) 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
GB0016453D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Pyrrole derivatives
EP1432693A2 (en) 2001-10-01 2004-06-30 Taisho Pharmaceutical Co. Ltd. Mch receptor antagonists
CA2466375A1 (en) 2001-11-08 2003-05-15 Pharmacia & Upjohn Company Azabicyclic-substituted-heteroaryl compounds for the treatment of disease
JP2005520792A (ja) 2001-11-22 2005-07-14 チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド ピロール合成
WO2003057669A1 (fr) 2001-12-28 2003-07-17 Takeda Chemical Industries, Ltd. Antagonistes du recepteur androgene
WO2003068738A1 (en) 2002-02-11 2003-08-21 Neurocrine Biosciences, Inc. Pyrrole derivatives as ligands of melanocortin receptors
WO2003068740A1 (en) 2002-02-14 2003-08-21 Wyeth Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands
TW200306191A (en) 2002-02-22 2003-11-16 Teijin Ltd Pyrrolopyrimidine derivatives
CN100335477C (zh) 2002-06-13 2007-09-05 纳幕尔杜邦公司 吡唑甲酰胺杀虫剂
JP2006501217A (ja) * 2002-08-12 2006-01-12 スージェン・インコーポレーテッド 新規キナーゼ阻害剤としての３−ピロリル−ピリドピラゾールおよび３−ピロリル−インダゾール
JP2004315511A (ja) 2003-03-31 2004-11-11 Taisho Pharmaceut Co Ltd Ｍｃｈ受容体アンタゴニスト
JP4716996B2 (ja) 2003-05-26 2011-07-06 武田薬品工業株式会社 スルホピロール
EP1803709B1 (en) 2004-09-30 2013-01-02 Takeda Pharmaceutical Company Limited Proton pump inhibitors
EP1655284A1 (en) 2004-10-26 2006-05-10 Aponetics AG 2-Phenylsulfopyrroles
ATE504567T1 (de) * 2005-08-30 2011-04-15 Takeda Pharmaceutical 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl-substitutierte 1-h-pyrrolderivate als säuresekretionshemmer
US8512761B2 (en) 2006-01-27 2013-08-20 Yale University Fast acting inhibitor of gastric acid secretion
US7994205B2 (en) 2006-03-31 2011-08-09 Takeda Pharmaceutical Company Limited Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors
US8933105B2 (en) 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
WO2009041705A2 (en) 2007-09-28 2009-04-02 Takeda Pharmaceutical Company Limited 5-membered heterocyclic compounds as proton pump inhibitors
US20090318429A1 (en) * 2008-04-28 2009-12-24 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives
PE20141375A1 (es) 2008-05-16 2014-10-23 Takeda San Diego Inc Activadores de glucoquinasa
ES2423289T3 (es) * 2008-08-27 2013-09-19 Takeda Pharmaceutical Company Limited Compuestos de pirrol

Also Published As

Publication number Publication date
BRPI0917705A2 (pt) 2016-02-16
ES2423289T3 (es) 2013-09-19
SI2318390T1 (sl) 2013-08-30
US8592597B2 (en) 2013-11-26
IL211335A (en) 2013-12-31
US8993598B2 (en) 2015-03-31
UA105185C2 (uk) 2014-04-25
CR20110169A (es) 2011-05-16
DOP2011000061A (es) 2011-04-15
NZ591793A (en) 2012-11-30
ZA201101774B (en) 2012-06-27
RS52872B (sr) 2013-12-31
ECSP11010912A (es) 2011-04-29
US8969387B2 (en) 2015-03-03
PE20141174A1 (es) 2014-09-19
US20100056577A1 (en) 2010-03-04
CY1114452T1 (el) 2016-10-05
EA019741B1 (ru) 2014-05-30
HRP20130653T1 (en) 2013-08-31
CO6321166A2 (es) 2011-09-20
AU2009284867B2 (en) 2014-08-28
PT2318390E (pt) 2013-07-10
US20110172275A1 (en) 2011-07-14
JP5638515B2 (ja) 2014-12-10
UY32074A (es) 2010-03-26
GEP20135786B (en) 2013-03-11
MA32647B1 (fr) 2011-09-01
AU2009284867A2 (en) 2011-04-21
IL211335A0 (en) 2011-04-28
WO2010024451A1 (en) 2010-03-04
MY152008A (en) 2014-08-15
AU2009284867A1 (en) 2010-03-04
US20140031393A1 (en) 2014-01-30
CA2735162A1 (en) 2010-03-04
EP2318390A1 (en) 2011-05-11
KR20110071067A (ko) 2011-06-28
AR073136A1 (es) 2010-10-13
EA201170384A1 (ru) 2011-10-31
JP2012501296A (ja) 2012-01-19
HK1157756A1 (en) 2012-07-06
TW201010993A (en) 2010-03-16
CL2011000402A1 (es) 2011-07-29
TWI473798B (zh) 2015-02-21
MX2011001955A (es) 2011-03-29
CA2735162C (en) 2015-06-23
PL2318390T3 (pl) 2013-09-30
EP2318390B1 (en) 2013-05-01
DK2318390T3 (da) 2013-07-08
ME01598B (me) 2014-09-20
JO2871B1 (en) 2015-03-15
KR101629181B1 (ko) 2016-06-13
CN102197033B (zh) 2014-07-16
SMT201300085B (it) 2013-09-06
CN102197033A (zh) 2011-09-21

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