PE20040548A1 - Lamina revestida de adhesivo para administracion dermica de un inhibidor selectivo de ciclooxigenasa-2 - Google Patents
Lamina revestida de adhesivo para administracion dermica de un inhibidor selectivo de ciclooxigenasa-2Info
- Publication number
- PE20040548A1 PE20040548A1 PE2003001177A PE2003001177A PE20040548A1 PE 20040548 A1 PE20040548 A1 PE 20040548A1 PE 2003001177 A PE2003001177 A PE 2003001177A PE 2003001177 A PE2003001177 A PE 2003001177A PE 20040548 A1 PE20040548 A1 PE 20040548A1
- Authority
- PE
- Peru
- Prior art keywords
- adhesive
- skin
- active agent
- layer
- parecoxib
- Prior art date
Links
- 102000010907 Cyclooxygenase 2 Human genes 0.000 title 1
- 108010037462 Cyclooxygenase 2 Proteins 0.000 title 1
- 229940124639 Selective inhibitor Drugs 0.000 title 1
- 230000002500 effect on skin Effects 0.000 title 1
- 239000000853 adhesive Substances 0.000 abstract 4
- 230000001070 adhesive effect Effects 0.000 abstract 4
- 239000013543 active substance Substances 0.000 abstract 3
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229960004662 parecoxib Drugs 0.000 abstract 2
- TZRHLKRLEZJVIJ-UHFFFAOYSA-N parecoxib Chemical compound C1=CC(S(=O)(=O)NC(=O)CC)=CC=C1C1=C(C)ON=C1C1=CC=CC=C1 TZRHLKRLEZJVIJ-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000003505 terpenes Chemical class 0.000 abstract 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 229960005233 cineole Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 150000002191 fatty alcohols Chemical class 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229960002004 valdecoxib Drugs 0.000 abstract 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Materials For Medical Uses (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA, QUE COMPRENDE: 1)UNA LAMINA DE SOPORTE QUE SE ADAPTA FLEXIBLEMENTE A LA PIEL, LA CUAL TIENE SUPERFICIES OPUESTAS DISTALES Y PROXIMALES A LA PIEL CUANDO SE APLICA; 2)UN REVESTIMIENTO SOBRE LA SUPERFICIE PROXIMAL DE (1), QUE COMPRENDE a)DE 70% A 97% DE UN ADHESIVO, b)DE 1% A 10% DE UN AGENTE ACTIVO, SELECCIONADO DE VALDECOXIB, PARECOXIB Y PARECOXIB SODICO, O UNO DE SUS PROFARMACOS O UNA DE SUS SALES, QUE VA DISPERSO EN UNA MATRIZ, QUE COMPRENDE UNA CANTIDAD EFECTIVA QUE SOLUBILIZA AL AGENTE ACTIVO EN TOTAL DE UNO O MAS DISOLVENTES DIFERENTES DEL ADHESIVO, SIENDO R1 Y R2 INDEPENDIENTEMENTE HIDROGENO O UN GRUPO QUE ES METABOLICAMENTE REEMPLAZABLE POR HIDROGENO O UNA SAL FARMACEUTICAMENTE ESTABLE DE TAL COMPUESTO; c)UNA MEMBRANA ENTRE LA CAPA DE RESERVA Y LA CAPA DEL ADHESIVO, PERMITIENDO EL PASO DEL AGENTE ACTIVO; Y, d)DE 2% A 20% DE UNO O MAS POTENCIADORES DE PENETRACION A TRAVES DE LA PIEL, SELECCIONADO DE TERPENOS, TERPENOIDES, ALCOHOLES GRASOS, EUCALIPTOL, ESTERES DE SORBITAN, ENTRE OTROS; Y, 3)UN RECUBRIMIENTO DE LIBERACION QUE SE PUEDE DESPEGAR, QUE ANTES DE SU USO ES ADYACENTE A LA CAPA QUE CONTIENE EL ADHESIVO. TIENE APLICACION EN EL TRATAMIENTO LOCAL DE DOLOR Y/O INFLAMACION PROPORCIONANDO UN EFECTO TERAPEUTICO, LOCAL O SISTEMICO, PRESENTANDOSE EN LA FORMA DE PARCHES, EMPLASTOS, CATAPLASMAS Y SIMILARES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42820802P | 2002-11-21 | 2002-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040548A1 true PE20040548A1 (es) | 2004-08-28 |
Family
ID=32393363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003001177A PE20040548A1 (es) | 2002-11-21 | 2003-11-20 | Lamina revestida de adhesivo para administracion dermica de un inhibidor selectivo de ciclooxigenasa-2 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20040127531A1 (es) |
| EP (1) | EP1565169A1 (es) |
| JP (1) | JP2006509761A (es) |
| AR (1) | AR042104A1 (es) |
| AU (1) | AU2003287732A1 (es) |
| BR (1) | BR0316275A (es) |
| CA (1) | CA2501287A1 (es) |
| GT (1) | GT200300247A (es) |
| MX (1) | MXPA05005510A (es) |
| NL (1) | NL1024816C2 (es) |
| PA (1) | PA8589101A1 (es) |
| PE (1) | PE20040548A1 (es) |
| TW (1) | TW200427471A (es) |
| UY (1) | UY28087A1 (es) |
| WO (1) | WO2004047815A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4283507B2 (ja) * | 2002-08-02 | 2009-06-24 | 久光製薬株式会社 | 経皮投与用貼付剤 |
| WO2005065684A1 (en) * | 2003-12-24 | 2005-07-21 | Pharmacia Corporation | Metal salts of parecoxib as prodrugs of the cox-2 inhibitor valdecoxib for the treatment of inflammation, pain and/or fever |
| US7666914B2 (en) * | 2004-06-03 | 2010-02-23 | Richlin David M | Topical preparation and method for transdermal delivery and localization of therapeutic agents |
| US20070259029A1 (en) * | 2006-05-08 | 2007-11-08 | Mcentire Edward Enns | Water-dispersible patch containing an active agent for dermal delivery |
| US20070258935A1 (en) * | 2006-05-08 | 2007-11-08 | Mcentire Edward Enns | Water dispersible films for delivery of active agents to the epidermis |
| US20080057090A1 (en) * | 2006-09-01 | 2008-03-06 | Mcentire Edward Enns | Wrinkle masking film composition for skin |
| US7879942B2 (en) * | 2006-10-05 | 2011-02-01 | Eastman Chemical Company | Switchable adhesive article for attachment to skin and method of using the same |
| US8445037B2 (en) * | 2008-10-28 | 2013-05-21 | A. M. Todd Company | Volatile distillate by-product of mint oil that promotes absorption and/or bioavailability of compounds of bio-medical and nutritional interest |
| US8563031B2 (en) * | 2010-05-27 | 2013-10-22 | Absize, Inc. | Piroxicam-containing matrix patches and methods for the topical treatment of acute and chronic pain and inflammation therewith |
| JP2012020991A (ja) * | 2010-06-16 | 2012-02-02 | Takasago Internatl Corp | 経皮吸収促進剤、及びこれを含有する皮膚外用製剤 |
| JP5285822B1 (ja) * | 2012-12-19 | 2013-09-11 | ニチバン株式会社 | 顔面用貼付材 |
| US20160256407A1 (en) * | 2013-10-11 | 2016-09-08 | Xep, Inc. | Energy patch |
| KR20230137362A (ko) | 2016-05-05 | 2023-10-04 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 강화된 전달 에프네프린 조성물 |
| EP3687509A1 (en) * | 2017-09-27 | 2020-08-05 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
| KR102042456B1 (ko) * | 2018-03-22 | 2019-11-08 | 크리스탈지노믹스(주) | 경피흡수제제 |
| US20200405609A1 (en) * | 2019-06-26 | 2020-12-31 | Johnson & Johnson Consumer Inc. | Topical compositions containing n-acyl dipeptide derivatives and glycolic acid |
| US12465564B2 (en) | 2021-10-25 | 2025-11-11 | Aquestive Therapeutics, Inc. | Oral and nasal compositions and methods of treatment |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR199802049T2 (xx) * | 1996-04-12 | 1999-01-18 | G.D.Searle & Co. | COX-2 Inhibit�rlerinin �nilac� olarak s�bstit�e edilmi� benzens�lfonamid t�revleri. |
| EP0942697A1 (en) * | 1996-10-30 | 1999-09-22 | THERATECH, INC. (a Delaware Corporation) | Fatty acid esters of lactic acid salts as permeation enhancers |
| EP1158967B1 (en) * | 1999-03-01 | 2003-04-16 | Amarin Technologies S.A. | Transdermal device comprising non-steroidal anti-inflammatory drugs incorporated in acrylic adhesive polymer matrix |
| US6309663B1 (en) * | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
| IN191512B (es) * | 2000-01-21 | 2003-12-06 | Panacea Biotech | |
| DE10032132A1 (de) * | 2000-07-01 | 2002-01-17 | Lohmann Therapie Syst Lts | Dermales Therapeutisches System enthaltend nichtsteroidale Antiphlogistika mit selektiver COX-2-Hemmung |
| OA12613A (en) * | 2001-05-31 | 2006-06-09 | Pharmacia Corp | Skin-permeable composition comprising a selective cyclooxygenase-2 inhibitor a monohydric alcohol. |
| JP4283507B2 (ja) * | 2002-08-02 | 2009-06-24 | 久光製薬株式会社 | 経皮投与用貼付剤 |
-
2003
- 2003-10-28 US US10/695,025 patent/US20040127531A1/en not_active Abandoned
- 2003-11-12 BR BR0316275-3A patent/BR0316275A/pt not_active IP Right Cessation
- 2003-11-12 CA CA002501287A patent/CA2501287A1/en not_active Abandoned
- 2003-11-12 WO PCT/US2003/036362 patent/WO2004047815A1/en not_active Ceased
- 2003-11-12 JP JP2004555449A patent/JP2006509761A/ja not_active Withdrawn
- 2003-11-12 EP EP03781939A patent/EP1565169A1/en not_active Withdrawn
- 2003-11-12 MX MXPA05005510A patent/MXPA05005510A/es unknown
- 2003-11-12 AU AU2003287732A patent/AU2003287732A1/en not_active Abandoned
- 2003-11-19 NL NL1024816A patent/NL1024816C2/nl not_active IP Right Cessation
- 2003-11-19 PA PA20038589101A patent/PA8589101A1/es unknown
- 2003-11-20 GT GT200300247A patent/GT200300247A/es unknown
- 2003-11-20 TW TW092132571A patent/TW200427471A/zh unknown
- 2003-11-20 PE PE2003001177A patent/PE20040548A1/es not_active Application Discontinuation
- 2003-11-20 AR ARP030104296A patent/AR042104A1/es unknown
- 2003-11-21 UY UY28087A patent/UY28087A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006509761A (ja) | 2006-03-23 |
| BR0316275A (pt) | 2005-10-04 |
| UY28087A1 (es) | 2004-06-30 |
| CA2501287A1 (en) | 2004-06-10 |
| NL1024816A1 (nl) | 2004-05-26 |
| US20040127531A1 (en) | 2004-07-01 |
| GT200300247A (es) | 2004-07-12 |
| AR042104A1 (es) | 2005-06-08 |
| TW200427471A (en) | 2004-12-16 |
| MXPA05005510A (es) | 2005-07-25 |
| AU2003287732A1 (en) | 2004-06-18 |
| PA8589101A1 (es) | 2005-02-04 |
| WO2004047815A1 (en) | 2004-06-10 |
| NL1024816C2 (nl) | 2006-03-06 |
| EP1565169A1 (en) | 2005-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |