BR9815378A - Sistema de fornecimento de droga transdérmico para agente analgésico antiinflamatório compreendendo sal de dietilamÈnio diclofenac e o método de fabricação do mesmo. - Google Patents
Sistema de fornecimento de droga transdérmico para agente analgésico antiinflamatório compreendendo sal de dietilamÈnio diclofenac e o método de fabricação do mesmo.Info
- Publication number
- BR9815378A BR9815378A BR9815378-1A BR9815378A BR9815378A BR 9815378 A BR9815378 A BR 9815378A BR 9815378 A BR9815378 A BR 9815378A BR 9815378 A BR9815378 A BR 9815378A
- Authority
- BR
- Brazil
- Prior art keywords
- diclofenac
- transdermal drug
- analgesic agent
- manufacturing
- inflammatory analgesic
- Prior art date
Links
- 239000000730 antalgic agent Substances 0.000 title abstract 5
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 title abstract 4
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 3
- 229960001259 diclofenac Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical class CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 title abstract 2
- 238000013271 transdermal drug delivery Methods 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- ZQVZPANTCLRASL-UHFFFAOYSA-N 2-[2-(2,6-dichloroanilino)phenyl]acetate;diethylazanium Chemical compound CCNCC.OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl ZQVZPANTCLRASL-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 229920000058 polyacrylate Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003505 terpenes Chemical class 0.000 abstract 1
- 235000007586 terpenes Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
<B>SISTEMA DE FORNECIMENTO DE DROGA TRANSDéRMICO PARA AGENTE ANALGéSICO ANTIINFLAMATóRIO COMPREENDENDO SAL DE DIETILAMÈNIO DICLOFENAC, E O MéTODO DE FABRICAçãO DO MESMO<D> A invenção refere-se a um sistema de fornecimento de droga transdérmico para agente analgésico antiinflamatório compreendendo sal de dietilamónio diclofenac, onde uma película de forro (1), uma camada de matriz (2) contendo ingredientes ativos, um revestimento de liberação (3), que é retirado antes da aplicação sobre a pele, são laminados no mesmo. Mais particularmente, a presente invenção refere-se a um sistema de fornecimento de droga transdérmico para agente analgésico antiinflamatório compreendendo sal de dietilamónio diclofenac, onde a penetração e adesão transdérmica da placa ao corpo são aumentadas por meio de uma camada de matriz que compreende um sal de dietilamónio diclofenac como ingrediente ativo além de polímero acrílico como constituinte adesivo, agente tensoativo não iónico como intensificador de absorção, terpeno e meio auxiliar de dissolução, e os constituintes volátil e não volátil da composição são aplicados separadamente no mesmo para reduzir, de modo significativo, o tempo de fabricação do mesmo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019970049084A KR19990026792A (ko) | 1997-09-26 | 1997-09-26 | 디클로페낙 디에틸암모늄염을 함유한 매트릭스형 패취제제 |
| PCT/KR1998/000295 WO1999016434A1 (en) | 1997-09-26 | 1998-09-25 | A transdermal drug delivery system for anti-inflammatory analgesic agent comprising diclofenac diethylammonium salt, and the manufacturing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9815378A true BR9815378A (pt) | 2000-11-21 |
| BR9815378B1 BR9815378B1 (pt) | 2010-05-18 |
Family
ID=19521757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9815378-1A BR9815378B1 (pt) | 1997-09-26 | 1998-09-25 | sistema de fornecimento de droga transdérmico para agente analgésico antiinflamatório e método de fabricação do mesmo. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6723337B1 (pt) |
| EP (1) | EP1030660B1 (pt) |
| JP (1) | JP2001517696A (pt) |
| KR (2) | KR19990026792A (pt) |
| CN (1) | CN1180773C (pt) |
| AU (1) | AU726448B2 (pt) |
| BR (1) | BR9815378B1 (pt) |
| CA (1) | CA2304784C (pt) |
| DE (1) | DE69822327T2 (pt) |
| ES (1) | ES2213916T3 (pt) |
| NZ (1) | NZ503112A (pt) |
| WO (1) | WO1999016434A1 (pt) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4627945B2 (ja) * | 1999-07-15 | 2011-02-09 | 久光製薬株式会社 | 経皮吸収製剤 |
| KR20010026619A (ko) * | 1999-09-08 | 2001-04-06 | 김동회 | 벌레물린 부위 처치용 패취제제 |
| JP4653893B2 (ja) * | 2000-01-27 | 2011-03-16 | 純一 須藤 | 二層型経皮吸収製剤 |
| KR20010077445A (ko) * | 2000-02-02 | 2001-08-20 | 김윤 | 세라믹이 함유된 매트릭스형 패취제 |
| ATE517614T1 (de) | 2000-04-18 | 2011-08-15 | Hisamitsu Pharmaceutical Co | Pflaster enthaltend einen anti-inflammatorischen wirkstoff |
| US6455067B1 (en) * | 2000-05-24 | 2002-09-24 | Sang-A Pharmaceutical Co., Ltd. | Transdermal patch for nonsteroidal antiinflammatory drug(s) |
| KR100363476B1 (ko) * | 2000-06-27 | 2002-12-05 | 대신제약주식회사 | 디크로 페낙 또는 그의 염들을 함유한 경피투과용 경고제 |
| DE10032537A1 (de) * | 2000-07-05 | 2002-01-31 | Labtec Gmbh | Dermales System, enthaltend 2-(3-Benzophenyl)Propionsäure |
| TWI290464B (en) * | 2000-09-01 | 2007-12-01 | Novartis Consumer Health Sa | Treatment of burns |
| DE10049225A1 (de) * | 2000-09-28 | 2002-04-11 | Labtec Gmbh | Dermales System, enthaltend Diclofenac |
| MXPA03003957A (es) * | 2000-11-06 | 2003-08-19 | Samyang Corp | Sistema de liberacion transdermica de farmacos, con propiedades mejoradas de adhesion y absorbencia de agua. |
| KR20020035398A (ko) * | 2000-11-06 | 2002-05-11 | 김윤 | 수지(手指)용 진통 소염 경피투여제 |
| DE60236084D1 (de) * | 2001-05-31 | 2010-06-02 | Hisamitsu Pharmaceutical Co | Perkutan resorbierbare pflaster |
| US20040258739A1 (en) * | 2001-09-04 | 2004-12-23 | Rudy Susilo | Plaster for the treatment of dysfunctions and disorders of nails |
| DE10256774A1 (de) * | 2002-12-05 | 2004-06-24 | Lts Lohmann Therapie-Systeme Ag | Transmucosale und transdermale Arzneimittel mit verbesserter Wirkstoffresorption |
| WO2004103338A1 (en) * | 2003-05-19 | 2004-12-02 | Bioprogress Plc | Adhesives and film modifying compositions |
| JP4344175B2 (ja) * | 2003-06-13 | 2009-10-14 | リンテック株式会社 | マトリックス型経皮吸収製剤の製造方法 |
| JP2005325165A (ja) * | 2004-05-12 | 2005-11-24 | Three M Innovative Properties Co | １００℃以下の温度で溶融塗布可能なヨウ素含有ホットメルト粘着剤および該粘着剤を用いた医療用粘着シート製品 |
| ATE471146T1 (de) | 2004-10-21 | 2010-07-15 | Durect Corp | Transdermale verabreichungssysteme |
| US8252319B2 (en) | 2004-10-21 | 2012-08-28 | Durect Corporation | Transdermal delivery system for sufentanil |
| CN1895242B (zh) * | 2006-04-13 | 2011-08-31 | 沈阳药科大学 | 双氯芬酸盐的透皮贴剂及制备方法 |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| JP5542436B2 (ja) | 2006-07-25 | 2014-07-09 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚透過率を有するジクロフェナクの正荷電水溶性プロドラッグ |
| KR20100020008A (ko) * | 2007-05-18 | 2010-02-19 | 티티아이 엘뷰 가부시키가이샤 | 생물학적 인터페이스를 통한 활성 성분의 방출을 개선한 경피 전달 장치 |
| KR20210103586A (ko) * | 2007-06-04 | 2021-08-23 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도 |
| BRPI0812368A2 (pt) * | 2007-06-08 | 2015-02-03 | Samyang Corp | Sistemas de liberação de droga transdérmica do tipo matriz e respectivo método de preparação. |
| EP2055298A1 (en) * | 2007-10-30 | 2009-05-06 | Novartis AG | Topical composition |
| US8445037B2 (en) * | 2008-10-28 | 2013-05-21 | A. M. Todd Company | Volatile distillate by-product of mint oil that promotes absorption and/or bioavailability of compounds of bio-medical and nutritional interest |
| CA3213470A1 (en) | 2008-12-04 | 2010-06-10 | Chongxi Yu | High penetration compositions and their applications |
| US9078863B2 (en) * | 2009-11-13 | 2015-07-14 | The Invention Science Fund I, Llc | Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject |
| US8439896B2 (en) * | 2009-11-13 | 2013-05-14 | The Invention Science Fund I, Llc | Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject |
| US8894630B2 (en) * | 2009-11-13 | 2014-11-25 | The Invention Science Fund I, Llc | Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject |
| EP2455066B1 (en) * | 2010-11-08 | 2018-10-17 | EPITECH GROUP S.p.A. | Pharmacological preparation for topical use containing N-palmitoyl-vanillamide |
| BR112013016998A2 (pt) * | 2010-12-29 | 2016-10-25 | Pharmafilm S R L | emplastro medicamentoso para a permeação transdérmica melhorada de diclofenaco dietilamônio |
| EP2865377B1 (en) * | 2012-06-20 | 2020-10-14 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneous absorption promoter and skin patch comprising same |
| WO2014068600A1 (en) | 2012-11-02 | 2014-05-08 | Zydus Technologies Limited | Stable transdermal pharmaceutical drug delivery system comprising diclofenac |
| JP6295949B2 (ja) | 2013-02-28 | 2018-03-20 | 東レ株式会社 | 複合半透膜およびその製造方法 |
| EP3096746B1 (en) | 2014-01-22 | 2019-03-13 | 4P Therapeutics | Abuse and misuse deterrent transdermal systems |
| CN105708823A (zh) * | 2016-04-08 | 2016-06-29 | 中国药科大学 | 一种长效双氯芬酸类透皮贴剂及其制备工艺 |
| JP6918543B2 (ja) * | 2017-03-27 | 2021-08-11 | 株式会社アルビオン | 皮膚外用剤または化粧料用組成物 |
| US20180311928A1 (en) * | 2017-04-27 | 2018-11-01 | Tesa Se | Adhesive tape for splicing of metal sheets used in high-tension, high temperature processes |
| WO2021201059A1 (ja) * | 2020-03-30 | 2021-10-07 | 三生医薬株式会社 | メントールを含有する組成物 |
| WO2022224184A1 (en) * | 2021-04-22 | 2022-10-27 | Pike Therapeutics, Inc. | Transdermal pharmaceutical formulations for the treatment of chronic pain |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT380166B (de) * | 1981-02-16 | 1986-04-25 | Ciba Geigy Ag | Verfahren zur herstellung topisch applizierbarer pharmazeutischer praeparate, enthaltend salze von alkancarbonsaeuren |
| US4537776A (en) | 1983-06-21 | 1985-08-27 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone |
| JPS61280426A (ja) | 1985-06-04 | 1986-12-11 | Ikeda Mohandou:Kk | 消炎鎮痛用貼付剤 |
| CH666621A5 (de) * | 1986-06-27 | 1988-08-15 | Ciba Geigy Ag | Topisch applizierbare pharmazeutische zusammensetzungen mit systemischer wirkung. |
| IT1223343B (it) * | 1987-11-03 | 1990-09-19 | Also Lab Sas | Formulazioni farmaceutiche per somministrazione transdermica |
| US5641504A (en) * | 1988-06-09 | 1997-06-24 | Alza Corporation | Skin permeation enhancer compositions using glycerol monolinoleate |
| DK0428352T3 (da) | 1989-11-14 | 1995-12-27 | Beta Pharm Co | Antiinflammatoriske præparater til udvendig anvendelse |
| JP3046346B2 (ja) * | 1990-03-12 | 2000-05-29 | 昭和電工株式会社 | 外用剤基剤又は補助剤とそれを含有する人又は動物の外用剤 |
| JP2849937B2 (ja) * | 1990-04-18 | 1999-01-27 | 日東電工株式会社 | 医療用貼付剤 |
| CA2058975C (en) | 1990-10-30 | 2000-06-06 | Shuichi Kasai | Antiinflammatory gel preparation |
| JPH04193826A (ja) | 1990-11-27 | 1992-07-13 | Shirogane Seiyaku Kk | ジクロフェナクナトリウム含有の経皮吸収型消炎・鎮痛貼布剤 |
| MX9202350A (es) | 1991-05-20 | 1992-11-01 | Alza Corp | Composiciones de incrementador de penetracion a la piel que usan monolinoleato de glicerol. |
| JP3086290B2 (ja) * | 1991-07-26 | 2000-09-11 | エスエス製薬株式会社 | ジクロフェナクナトリウム貼付剤 |
| EP0581587A3 (en) * | 1992-07-31 | 1995-05-17 | Tanabe Seiyaku Co | Base material for transdermal administration. |
| GB2273044B (en) * | 1992-12-02 | 1997-04-09 | Pacific Chem Co Ltd | Medicinal patches for percutaneous administration |
| US5429590A (en) * | 1992-12-01 | 1995-07-04 | Nitto Denko Corporation | Medical water-absorptive polymer and dressing for wound and medical bandage using the same |
| JP2523428B2 (ja) | 1992-12-04 | 1996-08-07 | エスエス製薬株式会社 | 消炎鎮痛ゲル製剤 |
| EP0682942A4 (en) * | 1993-01-21 | 1996-12-04 | Yamanouchi Pharma Co Ltd | NEW ABSORBABLE PERCUTANEOUS PREPARATION. |
| JP3526887B2 (ja) | 1993-04-23 | 2004-05-17 | 帝國製薬株式会社 | 消炎鎮痛外用貼付剤 |
| JPH07206710A (ja) * | 1994-01-21 | 1995-08-08 | Nitto Denko Corp | 経皮投薬用テープ製剤 |
-
1997
- 1997-09-26 KR KR1019970049084A patent/KR19990026792A/ko active Pending
-
1998
- 1998-09-04 KR KR1019980036559A patent/KR100305216B1/ko not_active Expired - Lifetime
- 1998-09-25 CN CNB988094738A patent/CN1180773C/zh not_active Expired - Lifetime
- 1998-09-25 EP EP98947969A patent/EP1030660B1/en not_active Expired - Lifetime
- 1998-09-25 CA CA002304784A patent/CA2304784C/en not_active Expired - Lifetime
- 1998-09-25 WO PCT/KR1998/000295 patent/WO1999016434A1/en not_active Ceased
- 1998-09-25 ES ES98947969T patent/ES2213916T3/es not_active Expired - Lifetime
- 1998-09-25 JP JP2000513570A patent/JP2001517696A/ja active Pending
- 1998-09-25 US US09/509,303 patent/US6723337B1/en not_active Expired - Lifetime
- 1998-09-25 DE DE69822327T patent/DE69822327T2/de not_active Expired - Lifetime
- 1998-09-25 NZ NZ503112A patent/NZ503112A/en not_active IP Right Cessation
- 1998-09-25 AU AU94647/98A patent/AU726448B2/en not_active Expired
- 1998-09-25 BR BRPI9815378-1A patent/BR9815378B1/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU9464798A (en) | 1999-04-23 |
| BR9815378B1 (pt) | 2010-05-18 |
| NZ503112A (en) | 2002-02-01 |
| US6723337B1 (en) | 2004-04-20 |
| DE69822327D1 (de) | 2004-04-15 |
| DE69822327T2 (de) | 2005-03-17 |
| WO1999016434A1 (en) | 1999-04-08 |
| CN1180773C (zh) | 2004-12-22 |
| HK1030161A1 (en) | 2001-04-27 |
| KR100305216B1 (ko) | 2001-11-30 |
| CA2304784A1 (en) | 1999-04-08 |
| JP2001517696A (ja) | 2001-10-09 |
| EP1030660A1 (en) | 2000-08-30 |
| KR19990029556A (ko) | 1999-04-26 |
| CN1271280A (zh) | 2000-10-25 |
| ES2213916T3 (es) | 2004-09-01 |
| CA2304784C (en) | 2003-04-22 |
| KR19990026792A (ko) | 1999-04-15 |
| EP1030660B1 (en) | 2004-03-10 |
| AU726448B2 (en) | 2000-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9815378A (pt) | Sistema de fornecimento de droga transdérmico para agente analgésico antiinflamatório compreendendo sal de dietilamÈnio diclofenac e o método de fabricação do mesmo. | |
| JP2655983B2 (ja) | チロシナーゼ抑制活性を有する薬物の安定性を改善する方法、及び、皮膚美白用貼付剤 | |
| KR100212961B1 (ko) | 경피투여시스템 | |
| RU2176499C2 (ru) | Композиция для чрескожного введения стероидных лекарственных средств и содержащий ее препарат | |
| NO962933L (no) | Östradiol-penetrasjonsforsterker for transdermal administrering | |
| EP0314528B1 (en) | Article for the controlled release and delivery of substances to animal tissues | |
| ES2152979T3 (es) | Sistema terapeutico transdermal que contiene estradiol. | |
| BRPI0416063A (pt) | composição de administração de medicamento por via transdérmica, método de produzir a composição de administração de medicamento por via transdérmica e método de controle de fluxo de um medicmanto de uma composição de administração de medicamento dérmica | |
| WO2004047820A1 (ja) | 温感パップ剤 | |
| CA2499093A1 (en) | Pharmaceutical composition for topical delivery of meloxicam comprising an amine or amine as penetration enhancer. | |
| PT957900E (pt) | Composicoes e metodos para aplicacao topica de agentes terapeuticos | |
| CN1172430A (zh) | 含雌二醇的药膏 | |
| AR021459A1 (es) | PARCHE QUE CONTIENE ESTRADIOL PARA LA APLICACIoN PERCUTÁNEA DE HORMONAS. | |
| PE20040548A1 (es) | Lamina revestida de adhesivo para administracion dermica de un inhibidor selectivo de ciclooxigenasa-2 | |
| JP2002284701A (ja) | ざ瘡の局所治療用パッチ | |
| ES2197077T3 (es) | Dispositivo transdermico que comprende farmacos anti-inflamatorios no esteroides incorporados en una matriz de un polimero acrilico adhesivo. | |
| CO5640120A2 (es) | Formulacion y metodods para el tratamiento de trombocitemia | |
| NO20031211L (no) | Plaster omfattende diclofenac | |
| BR0109893A (pt) | Preparação farmacêutica de lerisetron na forma de um sistema terapêutico transdêrmico, uso da preparação, uso da substância ativa lerisetron e método para administrar a substância ativa lerisetron a um paciente | |
| BRPI0415725A (pt) | formulação aspergìvel transdérmica, método para administrar um agente farmaceuticamente ativo e método para formar uma pelìcula farmaceuticamente ativa | |
| KR20210065931A (ko) | 함수계 첩부제 | |
| BR9506279A (pt) | Composição para uso em um sistema de liberação de droga transdérmica sistema de liberação transdérmica processo de administração de estrogênio através da pele e uso de um sistema de liberação transdérmica | |
| ES2626597T3 (es) | Preparación endérmica que contiene piroxicam | |
| WO2007112287A3 (en) | Hme transdermal compositions containing testosterone | |
| BRPI0621577A2 (pt) | sistema terapêutico transdermal para substáncias voláteis e/ou termolábeis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11N | Dismissal: publication cancelled [chapter 11.14 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 18/05/2010, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B25D | Requested change of name of applicant approved |
Owner name: SAMYANG CORPORATION (KR) |
|
| B25D | Requested change of name of applicant approved |
Owner name: SAMYANG HOLDINGS CORPORATION (KR) |
|
| B25A | Requested transfer of rights approved |
Owner name: SAMYANG BIOPHARMACEUTICALS CORPORATION (KR) |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 18.05.2020 |