PE20030364A1 - Sistemas de indan-1-ol varias veces sustituidos y procedimiento para su preparacion - Google Patents
Sistemas de indan-1-ol varias veces sustituidos y procedimiento para su preparacionInfo
- Publication number
- PE20030364A1 PE20030364A1 PE2002000818A PE2002000818A PE20030364A1 PE 20030364 A1 PE20030364 A1 PE 20030364A1 PE 2002000818 A PE2002000818 A PE 2002000818A PE 2002000818 A PE2002000818 A PE 2002000818A PE 20030364 A1 PE20030364 A1 PE 20030364A1
- Authority
- PE
- Peru
- Prior art keywords
- indan
- preparation
- procedure
- systems
- several times
- Prior art date
Links
- YIAPLDFPUUJILH-UHFFFAOYSA-N indan-1-ol Chemical compound C1=CC=C2C(O)CCC2=C1 YIAPLDFPUUJILH-UHFFFAOYSA-N 0.000 title abstract 3
- 230000001539 anorectic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/17—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/20—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE REFIERE INDAN-1-OL VARIAS VECES DE FORMULA I DONDE R1-R4 SON H, F, Cl, Br, I, CN, N3, NO2, OH, OALQUILO (C1-C8), OCICLOALQUILO(C3-C8), O-CH2-FENILO, ENTRE OTROS; R2 Y R3 JUNTOS FORMAN EL RADICAL -O-CH2-O-; X ES S, SO, SO2; Y ES (CH2)p DONDE p PUEDE SER 0-3; R5 ALQUILO C1-C18, CICLOALQUILO C3-C4, CICLOALQUILO C6-C8, DONDE LOS GRUPOS ALQUILO PUEDEN ESTAR REEMPLAZADOS CON F, (CH2)1-6-COOH, ENTRE OTROS; R6 ES (CH2)0-6-R9, (CH2)0-6-COOH, (CH2)0-6-CONH2, ENTRE OTROS; R7 ES (CH2)0-4-R12, H,LQUILO C1-C12, CICLOALQUILO C3-C4, CICLOALQUILO C3-C8, COOALQUILO C1-C6, ENTRE OTROS; R8 ES (CH2)0-4-R14, ALQUILO C1-C12, CICLOALQUILO C3-C4, CICLOALQUILO C6-C8, ENTRE OTROS; R9, R12 Y R14 SON FENILO, 1-, 2-NAFTILO, BIFENILO, UN RADICAL HETEROCICLICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. SON COMPUESTOS PREFERIDOS 5-CLORO-2-FLUORO-2-METANSULFANIL-INDAN-1-OL, 5-CLORO-2-FLUORO-2-METANOSULFONIL-1-TRIFLUOROMETIL-INDAN-1-OL. LOS COMPUESTOS MENCIONADOS SON UTILES COMO ANOREXICOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10142661A DE10142661B4 (de) | 2001-08-31 | 2001-08-31 | Mehrfach substituierte Indan-1-ol-Systeme und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030364A1 true PE20030364A1 (es) | 2003-06-04 |
Family
ID=7697232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000818A PE20030364A1 (es) | 2001-08-31 | 2002-08-26 | Sistemas de indan-1-ol varias veces sustituidos y procedimiento para su preparacion |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6670401B2 (es) |
| EP (1) | EP1423358B1 (es) |
| JP (1) | JP4250077B2 (es) |
| AT (1) | ATE476413T1 (es) |
| AU (1) | AU2002329252B2 (es) |
| CA (1) | CA2458520C (es) |
| DE (2) | DE10142661B4 (es) |
| IL (1) | IL160602A0 (es) |
| MX (1) | MXPA04001854A (es) |
| PE (1) | PE20030364A1 (es) |
| WO (1) | WO2003020693A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10142659A1 (de) * | 2001-08-31 | 2003-03-20 | Aventis Pharma Gmbh | Verwendung von mehrfach substituierten Indan-1-ol. Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
| DE10142663B4 (de) | 2001-08-31 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | C2-Disubstituierte Indan-1-ol-Systeme |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2201882B1 (es) * | 1972-07-20 | 1975-10-31 | Logeais Labor Jacques | |
| GB1465794A (en) * | 1974-05-17 | 1977-03-02 | Wyeth John & Brother Ltd | Thiourea derivatives |
| DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| DE2965279D1 (en) * | 1978-07-27 | 1983-06-01 | Schering Ag | Indanyl derivatives, process for their preparation and pharmaceutical compositions containing these compounds |
| DE3103372A1 (de) * | 1981-01-27 | 1982-09-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue indanyl-derivate, ihre herstellung und verwendung |
| GB2322859A (en) * | 1995-12-06 | 1998-09-09 | Venantius Limited | Indane compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity |
| WO1997026265A1 (en) | 1996-01-17 | 1997-07-24 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
| IL128332A0 (en) | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| ATE246190T1 (de) | 1996-12-31 | 2003-08-15 | Reddys Lab Ltd Dr | Heterozyklische verbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen die diese enthalten und ihre anwendung in der behandlung von diabetis und verwandten krankheiten |
| KR20010021936A (ko) | 1997-07-16 | 2001-03-15 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 융합된 1,2,4-티아디아진 유도체, 그의 제조와 사용 |
| FR2769312B1 (fr) * | 1997-10-03 | 1999-12-03 | Adir | Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2782515B1 (fr) * | 1998-08-21 | 2000-09-22 | Adir | NOUVEAUX DERIVES DE L'INDANE-1-Ol, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT |
| EP1078632A1 (en) | 1999-08-16 | 2001-02-28 | Sanofi-Synthelabo | Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity |
| DE10142659A1 (de) * | 2001-08-31 | 2003-03-20 | Aventis Pharma Gmbh | Verwendung von mehrfach substituierten Indan-1-ol. Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
| DE10142662B4 (de) * | 2001-08-31 | 2004-07-08 | Aventis Pharma Deutschland Gmbh | Derivate von C2-substituierten Indan-1-ol-Systemen und ihre Verwendung als Arzneimittel |
-
2001
- 2001-08-31 DE DE10142661A patent/DE10142661B4/de not_active Expired - Fee Related
-
2002
- 2002-08-17 CA CA2458520A patent/CA2458520C/en not_active Expired - Fee Related
- 2002-08-17 AU AU2002329252A patent/AU2002329252B2/en not_active Ceased
- 2002-08-17 EP EP02764854A patent/EP1423358B1/de not_active Expired - Lifetime
- 2002-08-17 JP JP2003524964A patent/JP4250077B2/ja not_active Expired - Fee Related
- 2002-08-17 AT AT02764854T patent/ATE476413T1/de active
- 2002-08-17 MX MXPA04001854A patent/MXPA04001854A/es active IP Right Grant
- 2002-08-17 IL IL16060202A patent/IL160602A0/xx unknown
- 2002-08-17 DE DE50214570T patent/DE50214570D1/de not_active Expired - Lifetime
- 2002-08-17 WO PCT/EP2002/009201 patent/WO2003020693A1/de not_active Ceased
- 2002-08-26 PE PE2002000818A patent/PE20030364A1/es not_active Application Discontinuation
- 2002-08-30 US US10/231,362 patent/US6670401B2/en not_active Expired - Lifetime
-
2003
- 2003-10-27 US US10/693,102 patent/US20040092489A1/en not_active Abandoned
- 2003-10-27 US US10/692,735 patent/US20040092749A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL160602A0 (en) | 2004-07-25 |
| EP1423358B1 (de) | 2010-08-04 |
| DE10142661B4 (de) | 2004-06-09 |
| MXPA04001854A (es) | 2004-06-15 |
| CA2458520C (en) | 2010-12-14 |
| DE10142661A1 (de) | 2003-03-27 |
| EP1423358A1 (de) | 2004-06-02 |
| AU2002329252B2 (en) | 2007-08-23 |
| US20040092489A1 (en) | 2004-05-13 |
| JP2005501901A (ja) | 2005-01-20 |
| US6670401B2 (en) | 2003-12-30 |
| DE50214570D1 (de) | 2010-09-16 |
| WO2003020693A1 (de) | 2003-03-13 |
| US20040092749A1 (en) | 2004-05-13 |
| ATE476413T1 (de) | 2010-08-15 |
| JP4250077B2 (ja) | 2009-04-08 |
| CA2458520A1 (en) | 2003-03-13 |
| US20030105145A1 (en) | 2003-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |