[go: up one dir, main page]

PE20030186A1 - Compuestos ciclicos fusionados como moduladores del receptor hormonal nuclear - Google Patents

Compuestos ciclicos fusionados como moduladores del receptor hormonal nuclear

Info

Publication number
PE20030186A1
PE20030186A1 PE2001000651A PE2001000651A PE20030186A1 PE 20030186 A1 PE20030186 A1 PE 20030186A1 PE 2001000651 A PE2001000651 A PE 2001000651A PE 2001000651 A PE2001000651 A PE 2001000651A PE 20030186 A1 PE20030186 A1 PE 20030186A1
Authority
PE
Peru
Prior art keywords
cr7r7
alkyl
link
modulators
heterocycle
Prior art date
Application number
PE2001000651A
Other languages
English (en)
Inventor
James Aaron Balog
Weifang Shan
Mark E Salvati
Soren Giese
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20030186A1 publication Critical patent/PE20030186A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS CICLICOS FUSIONADOS DE FORMULA I DONDE G ES ARILO, HETEROCICLO, HETEROARILO OPCIONALMENTE SUSTITUIDO CON H, CN, R1R2NC=O, HOCR3R3', R1R1'P=O, ENTRE OTROS; E ES C=Z2, CR7R7', SO2, P=OR2; Z1 Y Z2 SON O, S, NH, NR6; A1 Y A2 SON CR7, N; Y ES J-J'-J"; J Y J" SON (CR7R7')n; n ES 0-3; J' ES UN ENLACE, O, S, SO, SO2, NH, NR6, NR1C0, CR7R7', C=CR8R8', R2P=O, OPOOR2, ENTRE OTROS; W ES CR7R7'-CR7R7', R8C=CR8', N=CR8, N=N, ENTRE OTROS; Q ES H, ALQUILO, ALQUENILO, ENTRE OTROS; M ES UN ENLACE, O, CR7R7', NR10, M' ES UN ENLACE, NR10, AL MENOS UNO DE M Y M' ES UN ENLACE; L ES UN ENLACE, (CR7R7')n, NH, NR5, N(CR7R7')n, n ES 0-3; R1 Y R1' SON H, ALQUILO, HETEROCICLO, ENTRE OTROS; R2 ES ALQUILO, CICLOALQUILO, HETEROCICLO, ENTRE OTROS; R6 ES ALQUILO, CICLOALQUILO, HETEROCICLO, ENTRE OTROS; R7 Y R7' SON H, ALQUILO, CICLOALQUILO, HETEROCILO, ENTRE OTROS; R8 Y R8' SON H, ALQUILO, HETEROCICLO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS (5O,8O,8aO)-8,8a-DIHIDRO-2-[3-(TRIFLUOROMETIL)FENIL]-5,8-METANOIMIDAZO[1,5-a]PIRIDIN-1,3(2H,5H)-DIONA, (5O,8O,8aO)-8,8a-DIHIDRO-2-[1-NAFTALENIL]-5,8-METANOIMIDAZO[1,5-a]PIRIDIN-1,3(2H,5H)-DIONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS OTRO AGENTE ANTICANCEROSO. LOS COMPUESTOS SON MIMETICOS ESTEROIDES Y MODULADORES DE LA FUNCION DEL RECEPTOR DE HORMONAS NUCLEARES DE ENLACE A ESTEROIDES Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS, CANCER, HIPERTROFIA BENIGNA DE PROSTATA, ENFERMEDAD CARDIACA,
PE2001000651A 2000-06-28 2001-08-23 Compuestos ciclicos fusionados como moduladores del receptor hormonal nuclear PE20030186A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21439200P 2000-06-28 2000-06-28
US28443801P 2001-04-18 2001-04-18
US28461701P 2001-04-18 2001-04-18

Publications (1)

Publication Number Publication Date
PE20030186A1 true PE20030186A1 (es) 2003-03-23

Family

ID=27395986

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000651A PE20030186A1 (es) 2000-06-28 2001-08-23 Compuestos ciclicos fusionados como moduladores del receptor hormonal nuclear

Country Status (9)

Country Link
KR (1) KR20030014407A (es)
CN (1) CN1443187A (es)
AR (1) AR031709A1 (es)
CZ (1) CZ20024250A3 (es)
IL (1) IL152890A0 (es)
PE (1) PE20030186A1 (es)
PL (1) PL366565A1 (es)
TR (1) TR200202702T2 (es)
UY (1) UY26809A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
EP2455362A1 (en) * 2005-11-28 2012-05-23 GTX, Inc. Nuclear receptor binding agents
US8546451B2 (en) 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
CN102875556B (zh) * 2011-07-12 2016-03-30 天津药明康德新药开发有限公司 (4s)-1-取代-2,5-二氮杂双环[2,2,1]庚烷衍生物及制备方法
CN110184346A (zh) * 2019-07-11 2019-08-30 德阳市人民医院 男性骨质疏松症的诊断标志物

Also Published As

Publication number Publication date
UY26809A1 (es) 2002-01-31
TR200202702T2 (tr) 2004-12-21
IL152890A0 (en) 2003-06-24
CN1443187A (zh) 2003-09-17
KR20030014407A (ko) 2003-02-17
CZ20024250A3 (cs) 2003-10-15
PL366565A1 (en) 2005-02-07
AR031709A1 (es) 2003-10-01

Similar Documents

Publication Publication Date Title
PE20060555A1 (es) Derivados de pirrol-oxindol como moduladores del receptor de progesterona
PE20051054A1 (es) Compuestos heterociclicos utiles como secretagogos de la hormona de crecimiento
AR039489A1 (es) Derivados de tetrahidropiranil ciclopentil tetrahidropiridopiridina, moduladores de actividad de receptores de citoquinas
PE20011371A1 (es) Derivados de 3-(3-isopropil-5-metil-4h-1,2,4-triazol-4-il)-exo-8-azabiciclo[3.2.1]octano como antagonistas de los receptores de quimiocina ccr5
PE20030431A1 (es) DERIVADOS QUINUCLIDINAS COMO AGONISTAS DEL RECEPTOR NICOTINICO DE LA ACETILCOLINA TIPO a7
BR0009320A (pt) Dibenzopiranos como antagonistas do receptor glicocorticóide para o tratamento da diabete
BR0016665A (pt) Composição alvejante, e, métodos de alvejamento e de preparação de uma composição alvejante
PE20060459A1 (es) DERIVADOS DE AMINO-5,5-DIFENILIMIDAZOLONA COMO INHIBIDORES DE LA ß-SECRETASA
AR028824A1 (es) Compuestos antagonistas npy-5 y su uso en la manufactura de medicamentos.
PE20060486A1 (es) Derivados de pirrol-oxindol como moduladores del receptor de progesterona
AR071609A1 (es) Inhibidores ciclicos de 11(beta) -hidroxiesteroide deshidrogenasa 1
PT1173197E (pt) Intervencao metabolica com glp-1, para melhorar a funcao do tecido isquemico e reperfundido
PE20020729A1 (es) Compuestos de succinimida heterociclicos fusionados y analogos de los mismos
AU2003301020A8 (en) Isoquinolinone derivatives and their use as therapeutic agents
BR0309063A (pt) Composição amaciante de tecido e métodos para fabricação e uso
AR034091A1 (es) Composiciones farmaceuticas que contienen un modulador selectivo del receptor de estrogeno; metodos de tratamiento y prevencion de la resistencia a la insulina y un compuesto modulador selectivo del receptor de estrogeno
PE20070093A1 (es) Derivados dihidrobenzofuranos como moduladores del receptor 5-ht2c
CO5680438A2 (es) Uso de derivados de ciclotiocarbamato en tratamiento de condiciones relacionadas con hormonas
PE20050576A1 (es) Compuestos de pirazolilo e imidazolilo biciclicos como ligandos de receptores cannabinoides
ES2062374T3 (es) Heteroarilpiperazinas, agentes antipsicoticos.
PE20030944A1 (es) Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos y procedimientos para su uso
EA200601895A1 (ru) 3-(4-гетероарилциклогексиламино)циклопентанкарбоксамиды в качестве модуляторов хемокиновых рецепторов
AR046756A1 (es) Derivados de hidronopol como agonistas de receptores orl-1 humanos.
PE29798A1 (es) Acetidinas
BRPI0017528B8 (pt) uso de uma composição contendo sal de cetotifeno

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed