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AR039489A1 - Derivados de tetrahidropiranil ciclopentil tetrahidropiridopiridina, moduladores de actividad de receptores de citoquinas - Google Patents

Derivados de tetrahidropiranil ciclopentil tetrahidropiridopiridina, moduladores de actividad de receptores de citoquinas

Info

Publication number
AR039489A1
AR039489A1 ARP030101487A ARP030101487A AR039489A1 AR 039489 A1 AR039489 A1 AR 039489A1 AR P030101487 A ARP030101487 A AR P030101487A AR P030101487 A ARP030101487 A AR P030101487A AR 039489 A1 AR039489 A1 AR 039489A1
Authority
AR
Argentina
Prior art keywords
modulators
activity
tetrahydropiridopiridine
tetrahydropiranil
cyclopentil
Prior art date
Application number
ARP030101487A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Merck Sharp & Dohme filed Critical Merck & Co Inc
Publication of AR039489A1 publication Critical patent/AR039489A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Son útiles como moduladores de la actividad de receptores de citoquinas. En particular, estos compuestos son útiles como moduladores del receptor de citoquinas CCR-2. Reivindicación 1: Un compuesto de la fórmula (1) donde: R3 es oxigeno o está ausente; R8 se selecciona a partir de: (a) hidrógeno, (b) C1-3alquilo, que no es sustituido o es sustituido con flúor 1-6, (c) -O-C1-3alquilo, (d) flúor, y (e) hidroxi; y sales farmacéuticamente aceptables del mismo y diastómeros individuales del mismo.
ARP030101487A 2002-04-29 2003-04-29 Derivados de tetrahidropiranil ciclopentil tetrahidropiridopiridina, moduladores de actividad de receptores de citoquinas AR039489A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37629102P 2002-04-29 2002-04-29

Publications (1)

Publication Number Publication Date
AR039489A1 true AR039489A1 (es) 2005-02-23

Family

ID=29401326

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101487A AR039489A1 (es) 2002-04-29 2003-04-29 Derivados de tetrahidropiranil ciclopentil tetrahidropiridopiridina, moduladores de actividad de receptores de citoquinas

Country Status (22)

Country Link
US (1) US7786305B2 (es)
KR (1) KR100754760B1 (es)
CN (1) CN1310917C (es)
AR (1) AR039489A1 (es)
AU (1) AU2003234251A1 (es)
BR (1) BR0309650A (es)
DO (1) DOP2003000638A (es)
EC (1) ECSP045392A (es)
HR (1) HRP20041023A2 (es)
IL (1) IL164909A (es)
IS (1) IS7512A (es)
JO (1) JO2479B1 (es)
MA (1) MA27119A1 (es)
MX (1) MXPA04010702A (es)
MY (1) MY129850A (es)
NO (1) NO20045235L (es)
PE (1) PE20040598A1 (es)
PL (1) PL373401A1 (es)
RU (1) RU2285004C2 (es)
TW (1) TWI262077B (es)
UA (1) UA75828C2 (es)
WO (1) WO2003093266A1 (es)

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US20060030582A1 (en) * 2002-04-29 2006-02-09 Demartino Julie Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
US7834021B2 (en) 2002-11-27 2010-11-16 Incyte Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
US7393844B2 (en) * 2003-03-18 2008-07-01 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity
WO2004110376A2 (en) * 2003-06-06 2004-12-23 Merck & Co., Inc. Ccr-2 antagonists for treatment of neuropathic pain
AU2004287416C1 (en) 2003-10-27 2010-09-09 Merck Sharp & Dohme Corp. CCR-2 antagonist salt
CA2550596C (en) 2003-12-18 2011-03-15 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
CA2551869A1 (en) * 2004-01-02 2005-07-28 Merck & Co., Inc. Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
CA2564489A1 (en) * 2004-04-26 2005-11-24 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl 1-substituted and 1,1-disubstituted tetrahydroisoquinoline modulators of chemokine receptor activity
CA2564561A1 (en) * 2004-04-28 2005-11-10 Merck & Co., Inc. 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity
EP1746997A4 (en) 2004-05-11 2010-12-29 Incyte Corp 3- (4-HETEROARYLCYCLOHEXYLAMINE) CYCLOPENTANCARBOXAMIDE AS MODULATORS OF CHEMOKIN RECEPTORS
AP2006003848A0 (en) 2004-06-28 2006-12-31 Incyte Corp 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors
JP4116670B2 (ja) * 2004-06-28 2008-07-09 インサイト コーポレイション ケモカイン受容体の調節剤としての３−アミノシクロペンタンカルボキサミド
WO2007053499A2 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
WO2007053498A1 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
US7977358B2 (en) 2007-07-26 2011-07-12 Hoffmann-La Roche Inc. Pyrazol derivatives
ES2415430T3 (es) * 2008-11-26 2013-07-25 Pfizer Inc. 3-Aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
TWI471321B (zh) * 2009-06-08 2015-02-01 亞培公司 Ｂｃｌ－２族群抑制劑之口服醫藥劑型
SG10201500152UA (en) * 2009-12-22 2015-03-30 Abbvie Inc Abt-263 capsule
IL225340A (en) 2010-10-29 2017-05-29 Abbvie Inc Solid dispersions containing cell mortality
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
US20120129853A1 (en) 2010-11-23 2012-05-24 Abbott Laboratories Methods of treatment using selective bcl-2 inhibitors
SI2643322T1 (en) 2010-11-23 2018-01-31 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
EP2685978A2 (en) * 2011-03-17 2014-01-22 Merck Sharp & Dohme Corp. Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
TW201249846A (en) 2011-03-17 2012-12-16 Bristol Myers Squibb Co Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
CN105358551A (zh) 2012-07-19 2016-02-24 詹森药业有限公司 Ccr2的八氢环戊并吡咯基拮抗剂
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
PT3297438T (pt) 2015-05-21 2022-01-25 Chemocentryx Inc Moduladores de ccr2
CN111712242B (zh) 2017-09-25 2023-11-24 凯莫森特里克斯股份有限公司 使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
AU2019205784B2 (en) 2018-01-08 2024-07-25 Chemocentryx, Inc. Methods of treating solid tumors with CCR2 antagonists

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ES2271063T3 (es) 2000-08-17 2007-04-16 MERCK & CO., INC. Moduladores ciclopentilos de la actividad del receptor de la quimioquina.
WO2002070523A1 (en) * 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
EP1501507B1 (en) 2002-04-29 2008-05-28 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
DE60322877D1 (de) 2002-04-29 2008-09-25 Merck Sharp & Dohme Tetrahydropyranylcyclopentyltetrahydroisochino-linmodulatoren der chemokinrezeptoraktivität
US7390803B2 (en) 2002-10-30 2008-06-24 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
AU2004287416C1 (en) 2003-10-27 2010-09-09 Merck Sharp & Dohme Corp. CCR-2 antagonist salt
CA2564561A1 (en) 2004-04-28 2005-11-10 Merck & Co., Inc. 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity

Also Published As

Publication number Publication date
WO2003093266A1 (en) 2003-11-13
AU2003234251A8 (en) 2003-11-17
HK1081967A1 (en) 2006-05-26
IL164909A0 (en) 2005-12-18
DOP2003000638A (es) 2003-11-30
IS7512A (is) 2004-10-18
KR100754760B1 (ko) 2007-09-04
KR20050000413A (ko) 2005-01-03
NO20045235L (no) 2004-11-29
MA27119A1 (fr) 2004-12-20
HRP20041023A2 (en) 2005-02-28
AU2003234251A1 (en) 2003-11-17
TWI262077B (en) 2006-09-21
US7786305B2 (en) 2010-08-31
BR0309650A (pt) 2005-04-26
US20050101628A1 (en) 2005-05-12
UA75828C2 (en) 2006-05-15
PE20040598A1 (es) 2004-10-05
ECSP045392A (es) 2005-01-03
TW200307543A (en) 2003-12-16
RU2004134604A (ru) 2005-05-27
RU2285004C2 (ru) 2006-10-10
IL164909A (en) 2010-04-15
PL373401A1 (en) 2005-08-22
JO2479B1 (en) 2009-01-20
MXPA04010702A (es) 2005-02-17
CN1310917C (zh) 2007-04-18
MY129850A (en) 2007-05-31
CN1662532A (zh) 2005-08-31

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