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PE20030186A1 - FUSED CYCLIC COMPOUNDS AS MODULATORS OF THE NUCLEAR HORMONE RECEPTOR - Google Patents

FUSED CYCLIC COMPOUNDS AS MODULATORS OF THE NUCLEAR HORMONE RECEPTOR

Info

Publication number
PE20030186A1
PE20030186A1 PE2001000651A PE2001000651A PE20030186A1 PE 20030186 A1 PE20030186 A1 PE 20030186A1 PE 2001000651 A PE2001000651 A PE 2001000651A PE 2001000651 A PE2001000651 A PE 2001000651A PE 20030186 A1 PE20030186 A1 PE 20030186A1
Authority
PE
Peru
Prior art keywords
cr7r7
alkyl
link
modulators
heterocycle
Prior art date
Application number
PE2001000651A
Other languages
Spanish (es)
Inventor
James Aaron Balog
Weifang Shan
Mark E Salvati
Soren Giese
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20030186A1 publication Critical patent/PE20030186A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS CICLICOS FUSIONADOS DE FORMULA I DONDE G ES ARILO, HETEROCICLO, HETEROARILO OPCIONALMENTE SUSTITUIDO CON H, CN, R1R2NC=O, HOCR3R3', R1R1'P=O, ENTRE OTROS; E ES C=Z2, CR7R7', SO2, P=OR2; Z1 Y Z2 SON O, S, NH, NR6; A1 Y A2 SON CR7, N; Y ES J-J'-J"; J Y J" SON (CR7R7')n; n ES 0-3; J' ES UN ENLACE, O, S, SO, SO2, NH, NR6, NR1C0, CR7R7', C=CR8R8', R2P=O, OPOOR2, ENTRE OTROS; W ES CR7R7'-CR7R7', R8C=CR8', N=CR8, N=N, ENTRE OTROS; Q ES H, ALQUILO, ALQUENILO, ENTRE OTROS; M ES UN ENLACE, O, CR7R7', NR10, M' ES UN ENLACE, NR10, AL MENOS UNO DE M Y M' ES UN ENLACE; L ES UN ENLACE, (CR7R7')n, NH, NR5, N(CR7R7')n, n ES 0-3; R1 Y R1' SON H, ALQUILO, HETEROCICLO, ENTRE OTROS; R2 ES ALQUILO, CICLOALQUILO, HETEROCICLO, ENTRE OTROS; R6 ES ALQUILO, CICLOALQUILO, HETEROCICLO, ENTRE OTROS; R7 Y R7' SON H, ALQUILO, CICLOALQUILO, HETEROCILO, ENTRE OTROS; R8 Y R8' SON H, ALQUILO, HETEROCICLO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS (5O,8O,8aO)-8,8a-DIHIDRO-2-[3-(TRIFLUOROMETIL)FENIL]-5,8-METANOIMIDAZO[1,5-a]PIRIDIN-1,3(2H,5H)-DIONA, (5O,8O,8aO)-8,8a-DIHIDRO-2-[1-NAFTALENIL]-5,8-METANOIMIDAZO[1,5-a]PIRIDIN-1,3(2H,5H)-DIONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS OTRO AGENTE ANTICANCEROSO. LOS COMPUESTOS SON MIMETICOS ESTEROIDES Y MODULADORES DE LA FUNCION DEL RECEPTOR DE HORMONAS NUCLEARES DE ENLACE A ESTEROIDES Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS, CANCER, HIPERTROFIA BENIGNA DE PROSTATA, ENFERMEDAD CARDIACA,REFERS TO FUSED CYCLICAL COMPOUNDS OF FORMULA I WHERE G IS ARYL, HETEROCICLO, HETEROARYL OPTIONALLY SUBSTITUTED WITH H, CN, R1R2NC = O, HOCR3R3 ', R1R1'P = O, AMONG OTHERS; E IS C = Z2, CR7R7 ', SO2, P = OR2; Z1 AND Z2 ARE O, S, NH, NR6; A1 AND A2 ARE CR7, N; Y IS J-J'-J "; J AND J" ARE (CR7R7 ') n; n IS 0-3; J 'IS A LINK, O, S, SO, SO2, NH, NR6, NR1C0, CR7R7', C = CR8R8 ', R2P = O, OPOOR2, AMONG OTHERS; W IS CR7R7'-CR7R7 ', R8C = CR8', N = CR8, N = N, AMONG OTHERS; Q IS H, RENTAL, ALKENYL, AMONG OTHERS; M IS A LINK, OR, CR7R7 ', NR10, M' IS A LINK, NR10, AT LEAST ONE OF M AND M 'IS A LINK; L IS A LINK, (CR7R7 ') n, NH, NR5, N (CR7R7') n, n IS 0-3; R1 AND R1 'ARE H, ALKYL, HETEROCYCLE, AMONG OTHERS; R2 IS ALKYL, CYCLOALKYL, HETEROCYCLE, AMONG OTHERS; R6 IS ALKYL, CYCLOALKYL, HETEROCYCLE, AMONG OTHERS; R7 AND R7 'ARE H, ALKYL, CYCLOALKYL, HETEROCYL, AMONG OTHERS; R8 AND R8 'ARE H, ALKYL, HETEROCICLO, AMONG OTHERS. PREFERRED COMPOUNDS ARE (5O, 8O, 8aO) -8,8a-DIHYDRO-2- [3- (TRIFLUOROMETHYL) PHENYL] -5,8-METHANOIMIDAZO [1,5-a] PYRIDIN-1,3 (2H, 5H) -DIONA, (5O, 8O, 8aO) -8,8a-DIHYDRO-2- [1-NAPHTHALENYL] -5,8-METHANOIMIDAZO [1,5-a] PYRIDIN-1,3 (2H, 5H) -DIONA, AMONG OTHERS. IT ALSO REFERS TO A COMPOSITION THAT ALSO INCLUDES ANOTHER ANTI-CANCER AGENT. THE COMPOUNDS ARE STEROID MIMETICS AND MODULATORS OF THE FUNCTION OF THE STEROID-BINDING NUCLEAR HORMONE RECEPTOR AND MAY BE USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES, CANCER, BENIGN PRADOSTATE HYPERTROPHY, ILLNESS

PE2001000651A 2000-06-28 2001-08-23 FUSED CYCLIC COMPOUNDS AS MODULATORS OF THE NUCLEAR HORMONE RECEPTOR PE20030186A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21439200P 2000-06-28 2000-06-28
US28443801P 2001-04-18 2001-04-18
US28461701P 2001-04-18 2001-04-18

Publications (1)

Publication Number Publication Date
PE20030186A1 true PE20030186A1 (en) 2003-03-23

Family

ID=27395986

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000651A PE20030186A1 (en) 2000-06-28 2001-08-23 FUSED CYCLIC COMPOUNDS AS MODULATORS OF THE NUCLEAR HORMONE RECEPTOR

Country Status (9)

Country Link
KR (1) KR20030014407A (en)
CN (1) CN1443187A (en)
AR (1) AR031709A1 (en)
CZ (1) CZ20024250A3 (en)
IL (1) IL152890A0 (en)
PE (1) PE20030186A1 (en)
PL (1) PL366565A1 (en)
TR (1) TR200202702T2 (en)
UY (1) UY26809A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
EP2455362A1 (en) * 2005-11-28 2012-05-23 GTX, Inc. Nuclear receptor binding agents
US8546451B2 (en) 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
CN102875556B (en) * 2011-07-12 2016-03-30 天津药明康德新药开发有限公司 (4S)-1-replaces-2,5-diazabicyclos [2,2,1] heptane derivative and preparation method
CN110184346A (en) * 2019-07-11 2019-08-30 德阳市人民医院 The diagnosis marker of Male Osteoporosis

Also Published As

Publication number Publication date
UY26809A1 (en) 2002-01-31
TR200202702T2 (en) 2004-12-21
IL152890A0 (en) 2003-06-24
CN1443187A (en) 2003-09-17
KR20030014407A (en) 2003-02-17
CZ20024250A3 (en) 2003-10-15
PL366565A1 (en) 2005-02-07
AR031709A1 (en) 2003-10-01

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