PE20030741A1 - Imidazolidinas sustituidas y procedimientos para su preparacion - Google Patents
Imidazolidinas sustituidas y procedimientos para su preparacionInfo
- Publication number
- PE20030741A1 PE20030741A1 PE2002001194A PE2002001194A PE20030741A1 PE 20030741 A1 PE20030741 A1 PE 20030741A1 PE 2002001194 A PE2002001194 A PE 2002001194A PE 2002001194 A PE2002001194 A PE 2002001194A PE 20030741 A1 PE20030741 A1 PE 20030741A1
- Authority
- PE
- Peru
- Prior art keywords
- cycloalkyl
- alkyl
- iliden
- alkenyl
- amine
- Prior art date
Links
- WRYCSMQKUKOKBP-UHFFFAOYSA-N Imidazolidine Chemical compound C1CNCN1 WRYCSMQKUKOKBP-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 150000001412 amines Chemical class 0.000 abstract 3
- -1 2-CHLORO-6-TRIFLUOROMETHYLPHENYL Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 206010041235 Snoring Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000037356 lipid metabolism Effects 0.000 abstract 1
- 230000003387 muscular Effects 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A IMIDAZOLIDINAS SUSTITUIDAS DE FORMULA I DONDE R1 Y R2 SON CH, ALQUILO C1-C5, ALQUENILO C2-C5, ALQUINILO C2-C5, CICLOALQUILO C3-C6, CICLOALQUENILO C4-C6, ENTRE OTROS; R1 Y R2 JUNTO CON LOS DOS ATOMOS DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN ANILLO CARBONADO SATURADO O INSATURADO DE 5-8 MIEMBROS; R3 ES F, Cl, Br, I, ALQUILO C1-C4, ALQUENILO C1-C4, CICLOALQUILO C3-C6, OH, ENTRE OTROS; R4 A R6 SON H, F, Cl, Br, I, ALQUILO C1-C4, ALQUENILO C1-C4, CICLOALQUILO C3-C6, OH, ALCOXI C1-C4, ENTRE OTROS; R7 ES H, F, Cl, Br, I, ALQUILO C1-C4, ALQUENILO C1-C4, CICLOALQUILO C3-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS HIDROCLORURO DE TRANS-(2-CLORO-6-TRIFLUOROMETILFENIL)-OCTAHIDROBENCIMIDAZOL-2-ILIDEN)AMINA, SAL DEL ACIDO TRIFLUOROACETICO Y (S,S)-(2,6-DICLOROFENIL)-(OCTAHIDROBENCIMIDAZOL-2-ILIDEN)AMINA, SAL DEL ACIDO TRILUOROACETICO Y CIS-(2,6-DICLOROFENIL)-(OCTAHIDROBENCIMIDAZOL-2-ILIDEN)AMINA, HIDROCLORURO DE TRANS-(OCTAHIDROBENCIMIDAZOL-2-ILIDEN)-2-(2-FENOXIFENIL)AMINA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL, METABOLISMO DE LIPIDOS, AUMENTAN EL TONO MUSCULAR DEL TRACTO RESPIRATORIO Y REDUCEN EL RONQUIDO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10163239A DE10163239A1 (de) | 2001-12-21 | 2001-12-21 | Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030741A1 true PE20030741A1 (es) | 2003-09-29 |
Family
ID=7710363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002001194A PE20030741A1 (es) | 2001-12-21 | 2002-12-11 | Imidazolidinas sustituidas y procedimientos para su preparacion |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1461034B1 (es) |
| JP (1) | JP4571803B2 (es) |
| KR (1) | KR100959031B1 (es) |
| CN (1) | CN100339079C (es) |
| AR (1) | AR037932A1 (es) |
| AT (1) | ATE345797T1 (es) |
| AU (1) | AU2002361990B2 (es) |
| BR (1) | BR0215154A (es) |
| CA (1) | CA2470856A1 (es) |
| CO (1) | CO5590925A2 (es) |
| DE (2) | DE10163239A1 (es) |
| DK (1) | DK1461034T3 (es) |
| ES (1) | ES2275945T3 (es) |
| HR (1) | HRP20040573A2 (es) |
| HU (1) | HUP0600836A2 (es) |
| IL (2) | IL162562A0 (es) |
| MA (1) | MA27149A1 (es) |
| MX (1) | MXPA04005388A (es) |
| MY (1) | MY134344A (es) |
| NO (1) | NO20043009L (es) |
| PE (1) | PE20030741A1 (es) |
| PL (1) | PL368940A1 (es) |
| RS (1) | RS53204A (es) |
| RU (1) | RU2004122415A (es) |
| TW (1) | TW200305408A (es) |
| WO (1) | WO2003053434A1 (es) |
| ZA (1) | ZA200404149B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10323701A1 (de) | 2003-05-22 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Verfahren zur Synthese heterocyclischer Verbindungen |
| ES2545903T3 (es) | 2003-06-30 | 2015-09-16 | Sumitomo Chemical Company, Limited | Compuestos de urea asimétricos y procedimiento para producir compuestos asimétricos por reacción de adición asimétrica de conjugado usando dichos compuestos como catalizador |
| DE10341240A1 (de) * | 2003-09-08 | 2005-04-07 | Aventis Pharma Deutschland Gmbh | Substituierte Thienoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| KR102386666B1 (ko) | 2014-07-25 | 2022-04-15 | 다이쇼 세이야꾸 가부시끼가이샤 | 헤테로아릴로 치환된 페닐테트라히드로이소퀴놀린 화합물 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3236857A (en) * | 1961-10-09 | 1966-02-22 | Boehringer Sohn Ingelheim | 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products |
| US3190802A (en) * | 1961-10-09 | 1965-06-22 | Boehringer Sohn Ingelheim | Shaving composition and method of using same |
| EP0070084A3 (en) * | 1981-04-24 | 1983-02-16 | Beecham Group Plc | Imidazoline derivatives |
| DE3712385A1 (de) * | 1987-04-11 | 1988-10-27 | Boehringer Ingelheim Kg | 2-(phenylimino)imidazolidine |
| GB9313330D0 (en) * | 1993-06-28 | 1993-08-11 | Fujisawa Pharmaceutical Co | New compound and its preparation |
| EP0639573A1 (de) * | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
| DE4328869A1 (de) * | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| KR100257129B1 (ko) * | 1993-09-11 | 2000-05-15 | 성재갑 | 신규 세팔로스포린계 항생제 및 이의 제조방법 |
| US5552415A (en) * | 1993-12-21 | 1996-09-03 | Eli Lilly And Company | Method of inhibiting Alzheimer's Disease |
| DE19548812A1 (de) * | 1995-12-27 | 1997-07-03 | Hoechst Ag | Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikaments zur Atemstimulation |
| DE19633966A1 (de) * | 1996-08-22 | 1998-02-26 | Hoechst Ag | Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| ATE244717T1 (de) * | 1997-03-14 | 2003-07-15 | Vertex Pharma | Inhibitoren des impdh-enzyms |
| DE19945302A1 (de) * | 1999-09-22 | 2001-03-29 | Merck Patent Gmbh | Biphenylderivate als NHE-3-Inhibitoren |
| DE19950898A1 (de) * | 1999-10-22 | 2001-04-26 | Aventis Pharma Gmbh | Heterocyclisch substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19960204A1 (de) * | 1999-12-14 | 2001-06-28 | Aventis Pharma Gmbh | Substituierte Norlbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10015248A1 (de) * | 2000-03-28 | 2001-10-04 | Merck Patent Gmbh | Bisamidino-Verbindungen als NHE-3 Inhibitoren |
| DE10019062A1 (de) * | 2000-04-18 | 2001-10-25 | Merck Patent Gmbh | 2-Guanidino-4-aryl-chinazoline als NHE-3 Inhibitoren |
| DE10060292A1 (de) * | 2000-12-05 | 2002-06-20 | Aventis Pharma Gmbh | Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament |
-
2001
- 2001-12-21 DE DE10163239A patent/DE10163239A1/de not_active Withdrawn
-
2002
- 2002-12-09 ES ES02796586T patent/ES2275945T3/es not_active Expired - Lifetime
- 2002-12-09 WO PCT/EP2002/013921 patent/WO2003053434A1/de not_active Ceased
- 2002-12-09 DK DK02796586T patent/DK1461034T3/da active
- 2002-12-09 CN CNB028258177A patent/CN100339079C/zh not_active Expired - Fee Related
- 2002-12-09 KR KR1020047009820A patent/KR100959031B1/ko not_active Expired - Fee Related
- 2002-12-09 RS YU53204A patent/RS53204A/sr unknown
- 2002-12-09 PL PL02368940A patent/PL368940A1/xx not_active Application Discontinuation
- 2002-12-09 CA CA002470856A patent/CA2470856A1/en not_active Abandoned
- 2002-12-09 EP EP02796586A patent/EP1461034B1/de not_active Expired - Lifetime
- 2002-12-09 HR HR20040573A patent/HRP20040573A2/hr not_active Application Discontinuation
- 2002-12-09 AU AU2002361990A patent/AU2002361990B2/en not_active Ceased
- 2002-12-09 BR BR0215154-5A patent/BR0215154A/pt not_active IP Right Cessation
- 2002-12-09 AT AT02796586T patent/ATE345797T1/de not_active IP Right Cessation
- 2002-12-09 RU RU2004122415/04A patent/RU2004122415A/ru not_active Application Discontinuation
- 2002-12-09 IL IL16256202A patent/IL162562A0/xx unknown
- 2002-12-09 JP JP2003554191A patent/JP4571803B2/ja not_active Expired - Fee Related
- 2002-12-09 DE DE50208809T patent/DE50208809D1/de not_active Expired - Lifetime
- 2002-12-09 MX MXPA04005388A patent/MXPA04005388A/es active IP Right Grant
- 2002-12-09 HU HU0600836A patent/HUP0600836A2/hu unknown
- 2002-12-11 PE PE2002001194A patent/PE20030741A1/es not_active Application Discontinuation
- 2002-12-19 TW TW091136596A patent/TW200305408A/zh unknown
- 2002-12-19 AR ARP020105018A patent/AR037932A1/es unknown
- 2002-12-20 MY MYPI20024821A patent/MY134344A/en unknown
-
2004
- 2004-05-27 ZA ZA200404149A patent/ZA200404149B/en unknown
- 2004-06-01 MA MA27709A patent/MA27149A1/fr unknown
- 2004-06-16 IL IL162562A patent/IL162562A/en not_active IP Right Cessation
- 2004-06-17 CO CO04056920A patent/CO5590925A2/es not_active Application Discontinuation
- 2004-07-15 NO NO20043009A patent/NO20043009L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MY134344A (en) | 2007-12-31 |
| ZA200404149B (en) | 2006-05-31 |
| MA27149A1 (fr) | 2005-01-03 |
| IL162562A0 (en) | 2005-11-20 |
| WO2003053434A1 (de) | 2003-07-03 |
| JP4571803B2 (ja) | 2010-10-27 |
| ATE345797T1 (de) | 2006-12-15 |
| ES2275945T3 (es) | 2007-06-16 |
| KR100959031B1 (ko) | 2010-05-20 |
| TW200305408A (en) | 2003-11-01 |
| BR0215154A (pt) | 2004-10-19 |
| CO5590925A2 (es) | 2005-12-30 |
| EP1461034A1 (de) | 2004-09-29 |
| AR037932A1 (es) | 2004-12-22 |
| CN100339079C (zh) | 2007-09-26 |
| HRP20040573A2 (en) | 2004-10-31 |
| DK1461034T3 (da) | 2007-03-26 |
| RU2004122415A (ru) | 2005-03-27 |
| DE10163239A1 (de) | 2003-07-10 |
| RS53204A (sr) | 2006-10-27 |
| JP2005516947A (ja) | 2005-06-09 |
| MXPA04005388A (es) | 2004-10-11 |
| PL368940A1 (en) | 2005-04-04 |
| CN1606440A (zh) | 2005-04-13 |
| AU2002361990B2 (en) | 2008-10-09 |
| IL162562A (en) | 2009-12-24 |
| HUP0600836A2 (en) | 2008-04-28 |
| CA2470856A1 (en) | 2003-07-03 |
| DE50208809D1 (de) | 2007-01-04 |
| NO20043009L (no) | 2004-07-15 |
| KR20040068322A (ko) | 2004-07-30 |
| EP1461034B1 (de) | 2006-11-22 |
| AU2002361990A1 (en) | 2003-07-09 |
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