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PE20020235A1 - Derivados de nor-seco himbacina como antagonistas de los receptores de trombina - Google Patents

Derivados de nor-seco himbacina como antagonistas de los receptores de trombina

Info

Publication number
PE20020235A1
PE20020235A1 PE2001000558A PE2001000558A PE20020235A1 PE 20020235 A1 PE20020235 A1 PE 20020235A1 PE 2001000558 A PE2001000558 A PE 2001000558A PE 2001000558 A PE2001000558 A PE 2001000558A PE 20020235 A1 PE20020235 A1 PE 20020235A1
Authority
PE
Peru
Prior art keywords
alkyl
seco
derivatives
antagonists
himbacin
Prior art date
Application number
PE2001000558A
Other languages
English (en)
Inventor
Samuel Chackalamannil
Yan Xia
Mariappan Chelliah
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20020235A1 publication Critical patent/PE20020235A1/es

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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A DERIVADOS DE NOR-SECO HIMBACINA (UN ALCALOIDE DE PIPERIDINA) DE FORMULA I DONDE Z ES -(CH2)n-, GRUPO a, GRUPO b DONDE R10 ESTA AUSENTE; LA LINEA DE PUNTOS REPRESENTA UN DOBLE ENLACE OPCIONAL, LA LINEA DOBLE DE PUNTOS REPRESENTA UN ENLACE SIMPLE OPCIONAL; n ES 0-2; R1 Y R2 SON H, ALQUILO C1-C6, FLUOR(C1-C6)ALQUILO, DIFLUOR(C1-C6)ALQUILO, TRIFLUOR(C1-C6)ALQUILO, ENTRE OTROS; R3 ES H, HIDROXI, ALCOXI C1-C6, ENTRE OTROS; R34 ES (H, R3), (H,R43), ENTRE OTROS; R8, R10, R11 SON R1 Y OR1 CON LA CONDICION DE QUE CUANDO EL DOBLE ENLACE ESTA PRESENTE R10 ESTA AUSENTE; R9 ES H, OH, ALCOXI, ENTRE OTROS; B ES -(CH2)n3, -CH2-O, ENTRE OTROS; X ES O, NR6, ENTRE OTROS; Y ES O, X, (H, H), ENTRE OTROS; R6 ES H, ALQUILO C1-C6, FENILO, ENTRE OTROS; R15 ES H, ALQUILO C1-C6, ENTRE OTROS; R22 Y R23 SON H, R24-ALQUILO C1-C10, ENTRE OTROS; R24 ES H, HALO, OH, ENTRE OTROS. LOS DERIVADOS DE NOR-SECO HIMBACINA SON ANTAGONISTAS DE LOS RECEPTORES DE TROMBINA Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON TROMBOSIS, ATEROESCLEROSIS, RESTENOSIS, HIPERTENSION, ANGINA PECTORIS
PE2001000558A 2000-06-15 2001-06-13 Derivados de nor-seco himbacina como antagonistas de los receptores de trombina PE20020235A1 (es)

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US21172400P 2000-06-15 2000-06-15

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US (2) US6645987B2 (es)
EP (2) EP1294714B1 (es)
JP (2) JP4642318B2 (es)
KR (1) KR100604742B1 (es)
CN (1) CN1203070C (es)
AR (1) AR028952A1 (es)
AT (1) ATE368659T1 (es)
AU (2) AU2001266900B2 (es)
BR (1) BR0111991A (es)
CA (1) CA2410177C (es)
CY (1) CY1106947T1 (es)
CZ (1) CZ20024098A3 (es)
DE (1) DE60129698T2 (es)
DK (1) DK1294714T3 (es)
EC (1) ECSP024390A (es)
ES (1) ES2291323T3 (es)
HU (1) HUP0303081A3 (es)
IL (2) IL153308A0 (es)
MX (1) MXPA02012447A (es)
MY (1) MY130642A (es)
NO (1) NO325690B1 (es)
NZ (1) NZ523075A (es)
PE (1) PE20020235A1 (es)
PL (1) PL359822A1 (es)
PT (1) PT1294714E (es)
RU (1) RU2293735C2 (es)
SK (1) SK287026B6 (es)
TW (1) TWI302913B (es)
WO (1) WO2001096330A2 (es)
ZA (1) ZA200210099B (es)

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