PE20001050A1 - Benzamidas sustituidas y medicamento que las comprende - Google Patents
Benzamidas sustituidas y medicamento que las comprendeInfo
- Publication number
- PE20001050A1 PE20001050A1 PE1999000942A PE00094299A PE20001050A1 PE 20001050 A1 PE20001050 A1 PE 20001050A1 PE 1999000942 A PE1999000942 A PE 1999000942A PE 00094299 A PE00094299 A PE 00094299A PE 20001050 A1 PE20001050 A1 PE 20001050A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- benzamides
- medication
- substitute
- formula
- Prior art date
Links
- 229940054066 benzamide antipsychotics Drugs 0.000 title abstract 2
- 150000003936 benzamides Chemical class 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 102000004127 Cytokines Human genes 0.000 abstract 2
- 108090000695 Cytokines Proteins 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 230000002584 immunomodulator Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIERE A BENZAMIDAS DE FORMULA I, DONDE; R1 ES ES UN GRUPO DE FORMULA C00R4; R4 ES ALQUILO C1-C6, CONR5R6; R5 Y R6 SON ALQUILO C1-C6 O JUNTO CON N FORMAN UN ANILLO DE PIRROLIDINA, PIPERIDINA, HEXAMETILENIMINA, MORFOLINA; R2 ES CLORO, FLUOR, CF3, ALQUILO C1-C3, H; R3 ES OH, ALQUILO C1-C6, ALCOXI C1-C6, CH2-NR5R6. EL COMPUESTO I ES UN INMUNOMODULADOR QUE MANTIENE EN EQUILIBRIO LAS CITOCINAS INDUCTORAS DE INFLAMACION Y LAS CITOCINAS INHIBIDORAS DE LA INFLAMACION
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843793A DE19843793C2 (de) | 1998-09-24 | 1998-09-24 | Substituierte Benzamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001050A1 true PE20001050A1 (es) | 2000-11-18 |
Family
ID=7882078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000942A PE20001050A1 (es) | 1998-09-24 | 1999-09-17 | Benzamidas sustituidas y medicamento que las comprende |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6080742A (es) |
| EP (1) | EP0989121B1 (es) |
| JP (1) | JP2000095761A (es) |
| KR (1) | KR20000023339A (es) |
| CN (1) | CN1126741C (es) |
| AR (1) | AR021814A1 (es) |
| AT (1) | ATE309987T1 (es) |
| AU (1) | AU750919B2 (es) |
| BR (1) | BR9906070A (es) |
| CA (1) | CA2283021A1 (es) |
| CO (1) | CO5160263A1 (es) |
| CZ (1) | CZ295496B6 (es) |
| DE (2) | DE19843793C2 (es) |
| DK (1) | DK0989121T3 (es) |
| ES (1) | ES2251143T3 (es) |
| HU (1) | HUP9903216A3 (es) |
| IL (1) | IL132012A (es) |
| NO (1) | NO312671B1 (es) |
| NZ (1) | NZ337531A (es) |
| PE (1) | PE20001050A1 (es) |
| PL (1) | PL194897B1 (es) |
| RU (1) | RU2221783C2 (es) |
| SI (1) | SI0989121T1 (es) |
| SK (1) | SK283316B6 (es) |
| UY (1) | UY25712A1 (es) |
| ZA (1) | ZA996133B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10002509A1 (de) | 2000-01-21 | 2001-07-26 | Gruenenthal Gmbh | Substituierte Glutarimide |
| AU2001252196A1 (en) * | 2000-03-20 | 2001-10-03 | Grunenthal G.M.B.H. | Substituted benzamides |
| US20050118138A1 (en) * | 2000-07-19 | 2005-06-02 | Chih-Ping Liu | Method of treatment using interferon-tau |
| US7431920B2 (en) * | 2000-07-19 | 2008-10-07 | Pepgen Corporation | Method of treating IL-10 deficiency |
| US20040247565A1 (en) * | 2000-07-19 | 2004-12-09 | Chih-Ping Liu | Method of treatment using interferon-tau |
| US20050201981A1 (en) * | 2004-03-10 | 2005-09-15 | Chih-Ping Liu | Method of optimizing treatment with interferon-tau |
| US20050118137A1 (en) * | 2000-07-19 | 2005-06-02 | Chih-Ping Liu | Method of treatment using interferon-tau |
| US20050226845A1 (en) * | 2004-03-10 | 2005-10-13 | Chih-Ping Liu | Method of treatment using interferon-tau |
| US20050084478A1 (en) * | 2000-10-17 | 2005-04-21 | Chih-Ping Liu | Combination therapy using interferon-tau |
| EP1199074A1 (en) * | 2000-09-15 | 2002-04-24 | Warner-Lambert Company | Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production |
| EP1188438A1 (en) * | 2000-09-15 | 2002-03-20 | Warner-Lambert Company | Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production |
| JP4361273B2 (ja) * | 2001-02-27 | 2009-11-11 | アメリカ合衆国 | 潜在的な血管形成阻害剤としてのサリドマイド類似体 |
| US6479493B1 (en) | 2001-08-23 | 2002-11-12 | Cell Pathways, Inc. | Methods for treatment of type I diabetes |
| WO2003037365A1 (en) * | 2001-11-01 | 2003-05-08 | The Johns Hopkins University | Methods and compositions for treating vascular leak using hepatocyte growth factor |
| DE10163595A1 (de) * | 2001-12-21 | 2003-08-07 | Gruenenthal Gmbh | In 3-Position heterocyclisch substituierte Piperidin-2,6-dione |
| JP4943845B2 (ja) * | 2003-09-17 | 2012-05-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンティッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | サリドマイド類似体 |
| US8952895B2 (en) | 2011-06-03 | 2015-02-10 | Apple Inc. | Motion-based device operations |
| US20060078942A1 (en) * | 2004-03-10 | 2006-04-13 | Pepgen Corporation | Method of treatment using interferon-tau |
| US20080025948A1 (en) * | 2004-03-10 | 2008-01-31 | Chih-Ping Liu | Methods of Treatment Using Interferon-Tau |
| DE102004026703A1 (de) * | 2004-05-28 | 2005-12-29 | Grünenthal GmbH | Verfahren zur Herstellung von in 3-Position heterocyclisch substituierten Piperidin-2,6-dionen |
| CA2648216C (en) * | 2006-04-13 | 2016-06-07 | Michael Gutschow | Tetrahalogenated compounds useful as inhibitors of angiogenesis |
| CN112079769A (zh) | 2008-04-23 | 2020-12-15 | 里格尔药品股份有限公司 | 用于治疗代谢障碍的甲酰胺化合物 |
| US8927725B2 (en) | 2011-12-02 | 2015-01-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
| KR102316961B1 (ko) * | 2020-01-29 | 2021-10-26 | 프라비바이오 주식회사 | 면역억제제로서의 벤젠 유도체의 면역억제용 약학적 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1545672B2 (de) * | 1965-05-08 | 1974-11-07 | Chemie Gruenenthal Gmbh, 5190 Stolberg | Dikarbonsäureimidderivate und Verfahren zu ihrer Herstellung |
| GB8928043D0 (en) * | 1989-12-12 | 1990-02-14 | Pfizer Ltd | Muscarinic receptor antagonists |
-
1998
- 1998-09-24 DE DE19843793A patent/DE19843793C2/de not_active Expired - Fee Related
-
1999
- 1999-08-27 NZ NZ337531A patent/NZ337531A/xx not_active IP Right Cessation
- 1999-09-03 EP EP99117319A patent/EP0989121B1/de not_active Expired - Lifetime
- 1999-09-03 DK DK99117319T patent/DK0989121T3/da active
- 1999-09-03 ES ES99117319T patent/ES2251143T3/es not_active Expired - Lifetime
- 1999-09-03 SI SI9930863T patent/SI0989121T1/sl unknown
- 1999-09-03 AT AT99117319T patent/ATE309987T1/de active
- 1999-09-03 DE DE59912795T patent/DE59912795D1/de not_active Expired - Lifetime
- 1999-09-15 UY UY25712A patent/UY25712A1/es unknown
- 1999-09-17 AR ARP990104701A patent/AR021814A1/es unknown
- 1999-09-17 PE PE1999000942A patent/PE20001050A1/es not_active Application Discontinuation
- 1999-09-21 KR KR1019990040635A patent/KR20000023339A/ko not_active Ceased
- 1999-09-21 CO CO99059817A patent/CO5160263A1/es unknown
- 1999-09-22 JP JP11269084A patent/JP2000095761A/ja not_active Withdrawn
- 1999-09-22 AU AU48861/99A patent/AU750919B2/en not_active Ceased
- 1999-09-22 HU HU9903216A patent/HUP9903216A3/hu unknown
- 1999-09-22 CA CA002283021A patent/CA2283021A1/en not_active Abandoned
- 1999-09-23 RU RU99120663/04A patent/RU2221783C2/ru not_active IP Right Cessation
- 1999-09-23 CN CN99120232A patent/CN1126741C/zh not_active Expired - Fee Related
- 1999-09-23 CZ CZ19993386A patent/CZ295496B6/cs not_active IP Right Cessation
- 1999-09-23 BR BR9906070-1A patent/BR9906070A/pt not_active IP Right Cessation
- 1999-09-23 NO NO19994626A patent/NO312671B1/no not_active IP Right Cessation
- 1999-09-23 IL IL13201299A patent/IL132012A/en not_active IP Right Cessation
- 1999-09-23 PL PL335555A patent/PL194897B1/pl not_active IP Right Cessation
- 1999-09-23 SK SK1308-99A patent/SK283316B6/sk not_active IP Right Cessation
- 1999-09-23 ZA ZA9906133A patent/ZA996133B/xx unknown
- 1999-09-24 US US09/405,180 patent/US6080742A/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20001050A1 (es) | Benzamidas sustituidas y medicamento que las comprende | |
| CO4970728A1 (es) | 2-aminopiridinas que contienen sustituyentes de anillos condensados | |
| PE20020235A1 (es) | Derivados de nor-seco himbacina como antagonistas de los receptores de trombina | |
| ES2095860T3 (es) | Derivados de 4-(1'-oxociclohex-2'-il)azetidin-2-ona. | |
| DE68920482D1 (de) | 1-Indolylalkyl-4-(substituierte Pyridinyl)-Piperazine. | |
| YU17092A (sh) | Derivati 2,4-diaminohinazolina | |
| ES2062320T3 (es) | Fungicidas. | |
| EA200201057A1 (ru) | Новый способ синтеза периндоприла и его фармацевтически приемлемых солей | |
| EA199800923A1 (ru) | Новые 2,3-двузамещенные 4(3н)-хиназолины | |
| SE7503157L (sv) | Sett att framstella 4-(polyalkoxifenyl)-2-pyrrolidoner. | |
| ES2125927T3 (es) | Nuevo metodo de producir 9-((glicilo substituido)amino)-6-desmetil-6-desoxitetraciclinas substituidas en la posicion 7. | |
| AR015763A1 (es) | Indolinonas sustituidas y sus sales fisiologicamente compatibles, un procedimiento para su preparacion, su empleo para la preparacion de un medicamento, losmedicamentos que las contienen y un procedimiento para la preparacion de estos medicamentos | |
| DK1485359T3 (da) | Natriumkanalblokkere | |
| PE20011228A1 (es) | Derivados de piridopirimidina o iminopirimidina utiles para el tratamiento de enfermedades neurodegenerativas | |
| NO302572B1 (no) | Piperidinforbindelser, og farmasöytiske preparater inneholdende slike | |
| ES2109218T3 (es) | Bis-(hidroximetil)ciclobutil-purinas y -pirimidinas. | |
| DK249089D0 (da) | Benzamid-forbindelser, der er nyttige som protease-inhibitorer | |
| PE20040349A1 (es) | Beta-aminoacidos con afinidad por la proteina alfa-2-delta | |
| ES2055791T3 (es) | Compuestos heterociclicos. | |
| DK0657422T3 (da) | Naphthyloxyeddikesyrederivater som PEG2-agonister og -antagonister | |
| EA200000094A1 (ru) | Способ получения замещенного пергидроизоиндола | |
| ES2172173T3 (es) | 2-aminopiridinas con sustituyentes alcoxi ramificados como inhibidores de la nos. | |
| ES2086341T3 (es) | Derivados de aminoacidos con propiedades inhibidoras de la renina, procedimiento para su preparacion, agentes que los contienen y su utilizacion. | |
| ES2077998T3 (es) | Derivados de 2-aminopirimidina-4-carboxamida, su preparacion y su aplicacion terapeutica. | |
| DE69324212D1 (de) | Indol-7-carboxamide Derivate als Analgetika |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |