PE20020216A1 - PRODROGAS 3' DE 2' -DESOXI-ß-L-NUCLEOSIDOS - Google Patents
PRODROGAS 3' DE 2' -DESOXI-ß-L-NUCLEOSIDOSInfo
- Publication number
- PE20020216A1 PE20020216A1 PE2001000584A PE2001000584A PE20020216A1 PE 20020216 A1 PE20020216 A1 PE 20020216A1 PE 2001000584 A PE2001000584 A PE 2001000584A PE 2001000584 A PE2001000584 A PE 2001000584A PE 20020216 A1 PE20020216 A1 PE 20020216A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- refers
- nucleoside
- aryl
- substituted
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 abstract 5
- -1 NUCLEOSIDE COMPOUND Chemical class 0.000 abstract 2
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 235000011178 triphosphate Nutrition 0.000 abstract 1
- 239000001226 triphosphate Substances 0.000 abstract 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A PRODROGAS 3' DE 2' DESOXI-ß-L-NUCLEOSIDOS DONDE EL TERMINO 2'- DESOXI SE REFIERE A UN NUCLEOSIDO QUE NO TIENE SUSTITUYENTES EN POSICION 2' Y EL TERMINO PRODROGA 3' SE REFIERE A UN DESOXI-ß-L-NUCLEOSIDO QUE TIENE UNA PORCION SEPARABLE EN LA POSICION 3' INCLUYENDO ACILO Y UN L-AMINOACIDO. SE REFIERE A UN ß-L NUCLEOSIDO 3'-O-SUSTITUIDO DE FORMULA I DONDE R1 ES H, ALQUILO, CO-ALQUILO, CO-ARILO, CO-ALCOXIALQUILO, ENTRE OTROS; R2 ES ALQUILO, CO-ALQUILO, CO-ARILO, CO-ALCOXIALQUILO, CO-ARILOXIALQUILO, ENTRE OTROS; X ES O, S, SO2, CH2. EL COMPUESTO ß-L NUCLEOSIDO 3'-O-SUSTITUIDO ES UNA ß-L-2'-DESOXIPURINA DE FORMULA II DONDE R1 ES H, ALQUILO, CO-ALQUILO, CO-ARILO, CO-ALCOXIALQUILO, ENTRE OTROS; R2 ES ALQUILO, CO-ALQUILO, CO-ARILO, RESIDUO AMINOACIDO, MONO, DI, O TRIFOSFATO; Y ES OR3, NR3R4, SR3; X1 Y X2 SON H, ALQUILO, CO-ALQUILO, ENTRE OTROS; R3-R6 SON H, ALQUILO, DIALQUILAMINOALQUILENO DE PREFERENCIA DIMETILAMINOMETILENO, CO-ALQUILO ENTRE OTROS.I ADEMAS A COMPUESTOS DE B-L NUCLEOSIDO 3'-O-SUSTITUIDO TAL COMO B-L-2'-DESOXIPURINA, ß-L-2'-DESOXIADENOSINA, B-L-2'-DESO-GUANIDINA, B-L-2'-DESOXIINOSINA, B-L-2'-DESOXIPIRIMIDINA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA PARA EL TRATAMIENTO DE UNA INFECCION POR VIRUS DE HEPATITIS B
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21210000P | 2000-06-15 | 2000-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020216A1 true PE20020216A1 (es) | 2002-04-16 |
Family
ID=22789563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000584A PE20020216A1 (es) | 2000-06-15 | 2001-06-15 | PRODROGAS 3' DE 2' -DESOXI-ß-L-NUCLEOSIDOS |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1296995B1 (es) |
| JP (1) | JP4639032B2 (es) |
| KR (2) | KR20070048277A (es) |
| CN (3) | CN1900104A (es) |
| AP (1) | AP1771A (es) |
| AR (1) | AR035711A1 (es) |
| AT (1) | ATE411332T1 (es) |
| AU (2) | AU6692701A (es) |
| BR (1) | BR0111732A (es) |
| CA (1) | CA2413163C (es) |
| CZ (1) | CZ2003122A3 (es) |
| DE (1) | DE60136181D1 (es) |
| EA (1) | EA005774B1 (es) |
| ES (1) | ES2317912T3 (es) |
| IL (3) | IL153379A0 (es) |
| MA (1) | MA27126A1 (es) |
| MX (1) | MXPA02012443A (es) |
| MY (1) | MY141594A (es) |
| NO (1) | NO20026001L (es) |
| NZ (2) | NZ523632A (es) |
| OA (1) | OA12384A (es) |
| PE (1) | PE20020216A1 (es) |
| PL (1) | PL360404A1 (es) |
| UY (1) | UY26779A1 (es) |
| WO (1) | WO2001096353A2 (es) |
| YU (1) | YU94802A (es) |
| ZA (2) | ZA200300168B (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1284741B1 (en) | 2000-04-13 | 2008-11-19 | Pharmasset, Inc. | 3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of viral infections |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| US6787526B1 (en) | 2000-05-26 | 2004-09-07 | Idenix Pharmaceuticals, Inc. | Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides |
| NZ547204A (en) | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
| US7138376B2 (en) | 2001-09-28 | 2006-11-21 | Idenix Pharmaceuticals, Inc. | Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides |
| AU2003248748A1 (en) | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| MY140819A (en) | 2002-06-28 | 2010-01-29 | Idenix Caymans Ltd | Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae |
| AU2003263412A1 (en) * | 2002-06-28 | 2004-01-19 | Centre National De La Recherche Scientifique (Cnrs) | 1'-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections |
| BR0314259A (pt) | 2002-09-13 | 2005-07-26 | Idenix Cayman Ltd | ß-l-2'-desoxinucleosìdeos para o tratamento de cepas de hbv resistentes e terapias combinadas |
| US7824851B2 (en) | 2002-11-15 | 2010-11-02 | Idenix Pharmaceuticals, Inc. | 2′-branched nucleosides and Flaviviridae mutation |
| KR20050109918A (ko) | 2002-12-12 | 2005-11-22 | 이데닉스 (케이만) 리미티드 | 2'-분지형 뉴클레오시드의 제조 방법 |
| US7582748B2 (en) | 2003-03-20 | 2009-09-01 | Microbiologica Quimica E Farmaceutical Ltd. | Methods of manufacture of 2′-deoxy-β-L-nucleosides |
| WO2004096149A2 (en) | 2003-04-28 | 2004-11-11 | Idenix (Cayman) Limited | Industrially scalable nucleoside synthesis |
| CA2734052A1 (en) | 2003-05-30 | 2005-01-13 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
| RU2361875C2 (ru) | 2003-06-30 | 2009-07-20 | Айденикс (Кайман) Лимитед | СИНТЕЗ β-L-2'-ДЕЗОКСИНУКЛЕОЗИДОВ |
| CN1980657A (zh) | 2004-05-05 | 2007-06-13 | 耶鲁大学 | 新颖的抗病毒赛菊宁黄质类似物 |
| CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| BRPI0515279A (pt) | 2004-09-14 | 2008-07-15 | Pharmasset Inc | preparação de ribofuranosil pirimidinas e purinas 2'fluoro-2'-alquil- substituìdas ou outras opcionalmente substituìdas e seus derivados |
| US7524831B2 (en) | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
| CN101242842A (zh) | 2005-06-17 | 2008-08-13 | 诺瓦提斯公司 | Sanglifehrin在hcv中的用途 |
| GB0609178D0 (en) | 2006-05-09 | 2006-06-21 | Univ Cardiff | Novel compounds |
| US7897737B2 (en) | 2006-12-05 | 2011-03-01 | Lasergen, Inc. | 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| TW200946541A (en) | 2008-03-27 | 2009-11-16 | Idenix Pharmaceuticals Inc | Solid forms of an anti-HIV phosphoindole compound |
| CA2727709C (en) | 2008-06-11 | 2017-11-14 | Lasergen, Inc. | Nucleotides and nucleosides and methods for their use in dna sequencing |
| WO2010075554A1 (en) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Synthesis of purine nucleosides |
| EP2376514A2 (en) | 2008-12-23 | 2011-10-19 | Pharmasset, Inc. | Nucleoside analogs |
| US8716262B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| RS54368B1 (sr) | 2010-03-31 | 2016-04-28 | Gilead Pharmasset Llc | Kristalni (s)-izopropil 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-diokso-3,4-dihidropirimidin-1-(2h)-il)-4-fluoro-3-hidroksi-4-metiltetrahidrofuran-2-il)metoksi)(fenoksi)fosforil)amino)propanoat |
| MX2012011222A (es) | 2010-04-01 | 2013-01-18 | Centre Nat Rech Scient | Compuestos y composiciones farmaceuticas para el tratamiento de infecciones virales. |
| CA2818853A1 (en) | 2010-11-30 | 2012-06-07 | Gilead Pharmasset Llc | 2'-spirocyclo-nucleosides for use in therapy of hcv or dengue virus |
| EP2691409B1 (en) | 2011-03-31 | 2018-02-21 | Idenix Pharmaceuticals LLC. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| CA2847892A1 (en) | 2011-09-12 | 2013-03-21 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| WO2013040257A1 (en) | 2011-09-13 | 2013-03-21 | Lasergen, Inc. | 5-methoxy. 3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing |
| UA116087C2 (uk) | 2011-09-16 | 2018-02-12 | Гіліад Фармассет Елелсі | Композиція для лікування вірусу гепатиту c |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| AR090699A1 (es) * | 2012-04-18 | 2014-12-03 | Biocryst Pharm Inc | Compuestos inhibidores de la actividad de la arn polimerasa viral |
| MY172166A (en) | 2013-01-31 | 2019-11-15 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
| SG11201600919UA (en) | 2013-08-27 | 2016-03-30 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
| JP7620781B2 (ja) | 2018-04-12 | 2025-01-24 | ユーシービー バイオサイエンシズ，インコーポレイテッド | 不均衡なヌクレオチドプールによって引き起こされた疾患を治療するためのデオキシヌクレオシドのプロドラッグ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4958013A (en) * | 1989-06-06 | 1990-09-18 | Northwestern University | Cholesteryl modified oligonucleotides |
| IT1246983B (it) * | 1990-11-13 | 1994-12-12 | Consiglio Nazionale Ricerche | L-2'-desossiuridine e composizioni farmaceutiche che le contengono. |
| US5559101A (en) * | 1994-10-24 | 1996-09-24 | Genencor International, Inc. | L-ribofuranosyl nucleosides |
| SE9603178L (sv) * | 1996-08-30 | 1997-09-22 | Scania Cv Ab | Anordning vid ett fordon för monterbar anfästning av en förarplatsmodul |
| SG132498A1 (en) * | 1998-08-10 | 2007-06-28 | Idenix Pharmaceuticals Inc | Beta-l-2æ-deoxy-nucleosides for the treatment of hepatitis b |
-
2001
- 2001-06-14 MY MYPI20012807A patent/MY141594A/en unknown
- 2001-06-15 NZ NZ523632A patent/NZ523632A/en unknown
- 2001-06-15 AT AT01944522T patent/ATE411332T1/de not_active IP Right Cessation
- 2001-06-15 YU YU94802A patent/YU94802A/sh unknown
- 2001-06-15 EA EA200300023A patent/EA005774B1/ru not_active IP Right Cessation
- 2001-06-15 CA CA002413163A patent/CA2413163C/en not_active Expired - Lifetime
- 2001-06-15 CN CNA2006100741038A patent/CN1900104A/zh active Pending
- 2001-06-15 NZ NZ535246A patent/NZ535246A/en unknown
- 2001-06-15 EP EP01944522A patent/EP1296995B1/en not_active Expired - Lifetime
- 2001-06-15 WO PCT/US2001/019147 patent/WO2001096353A2/en not_active Ceased
- 2001-06-15 UY UY26779A patent/UY26779A1/es not_active Application Discontinuation
- 2001-06-15 CN CNA2006101495863A patent/CN101012259A/zh active Pending
- 2001-06-15 IL IL15337901A patent/IL153379A0/xx active IP Right Grant
- 2001-06-15 AU AU6692701A patent/AU6692701A/xx active Pending
- 2001-06-15 AR ARP010102881A patent/AR035711A1/es not_active Application Discontinuation
- 2001-06-15 DE DE60136181T patent/DE60136181D1/de not_active Expired - Lifetime
- 2001-06-15 KR KR1020077009124A patent/KR20070048277A/ko not_active Ceased
- 2001-06-15 MX MXPA02012443A patent/MXPA02012443A/es active IP Right Grant
- 2001-06-15 CN CNB018138020A patent/CN1295242C/zh not_active Expired - Fee Related
- 2001-06-15 CZ CZ2003122A patent/CZ2003122A3/cs unknown
- 2001-06-15 PE PE2001000584A patent/PE20020216A1/es not_active Application Discontinuation
- 2001-06-15 PL PL36040401A patent/PL360404A1/xx not_active Application Discontinuation
- 2001-06-15 AP APAP/P/2003/002713A patent/AP1771A/en active
- 2001-06-15 AU AU2001266927A patent/AU2001266927B2/en not_active Ceased
- 2001-06-15 JP JP2002510494A patent/JP4639032B2/ja not_active Expired - Lifetime
- 2001-06-15 ES ES01944522T patent/ES2317912T3/es not_active Expired - Lifetime
- 2001-06-15 BR BR0111732-7A patent/BR0111732A/pt not_active IP Right Cessation
- 2001-06-15 KR KR1020027017018A patent/KR20030032967A/ko not_active Abandoned
- 2001-06-15 OA OA1200200374A patent/OA12384A/en unknown
-
2002
- 2002-12-11 IL IL153379A patent/IL153379A/en not_active IP Right Cessation
- 2002-12-13 NO NO20026001A patent/NO20026001L/no unknown
-
2003
- 2003-01-02 MA MA26989A patent/MA27126A1/fr unknown
- 2003-01-07 ZA ZA200300168A patent/ZA200300168B/en unknown
-
2004
- 2004-06-01 ZA ZA200404306A patent/ZA200404306B/xx unknown
-
2006
- 2006-10-25 IL IL178864A patent/IL178864A0/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |