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MXPA02012443A - Profarmaco en 3'' de 2'-desoxi-beta-l-nucleosidos. - Google Patents

Profarmaco en 3'' de 2'-desoxi-beta-l-nucleosidos.

Info

Publication number
MXPA02012443A
MXPA02012443A MXPA02012443A MXPA02012443A MXPA02012443A MX PA02012443 A MXPA02012443 A MX PA02012443A MX PA02012443 A MXPA02012443 A MX PA02012443A MX PA02012443 A MXPA02012443 A MX PA02012443A MX PA02012443 A MXPA02012443 A MX PA02012443A
Authority
MX
Mexico
Prior art keywords
nucleosides
deoxy
bgr
prodrugs
hepatitis
Prior art date
Application number
MXPA02012443A
Other languages
English (en)
Inventor
Martin L Bryant
Original Assignee
Indenix Cayman Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indenix Cayman Ltd filed Critical Indenix Cayman Ltd
Publication of MXPA02012443A publication Critical patent/MXPA02012443A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion concierne a compuestos, composiciones y metodos para el tratamiento de un huesped infectado con el virus de la hepatitis B. Especificamente, se describen compuestos y composiciones de 3'-esteres de 2-desoxi-??-L-nucleosidos, los cuales pueden ser administrados ya sea solos o en combinacion con otros agentes anti-hepatitis B. Se describen tambien compuestos y composiciones de 3',5'-esteres de 2'-desoxi-??-L- nucleosidos, los cuales pueden ser administrados ya sea solos o en combinacion con otros agentes anti-hepatitis B.
MXPA02012443A 2000-06-15 2001-06-15 Profarmaco en 3'' de 2'-desoxi-beta-l-nucleosidos. MXPA02012443A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21210000P 2000-06-15 2000-06-15
PCT/US2001/019147 WO2001096353A2 (en) 2000-06-15 2001-06-15 3'-PRODRUGS OF 2'-DEOXY-β-L-NUCLEOSIDES

Publications (1)

Publication Number Publication Date
MXPA02012443A true MXPA02012443A (es) 2004-09-10

Family

ID=22789563

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02012443A MXPA02012443A (es) 2000-06-15 2001-06-15 Profarmaco en 3'' de 2'-desoxi-beta-l-nucleosidos.

Country Status (27)

Country Link
EP (1) EP1296995B1 (es)
JP (1) JP4639032B2 (es)
KR (2) KR20030032967A (es)
CN (3) CN1295242C (es)
AP (1) AP1771A (es)
AR (1) AR035711A1 (es)
AT (1) ATE411332T1 (es)
AU (2) AU2001266927B2 (es)
BR (1) BR0111732A (es)
CA (1) CA2413163C (es)
CZ (1) CZ2003122A3 (es)
DE (1) DE60136181D1 (es)
EA (1) EA005774B1 (es)
ES (1) ES2317912T3 (es)
IL (3) IL153379A0 (es)
MA (1) MA27126A1 (es)
MX (1) MXPA02012443A (es)
MY (1) MY141594A (es)
NO (1) NO20026001L (es)
NZ (2) NZ535246A (es)
OA (1) OA12384A (es)
PE (1) PE20020216A1 (es)
PL (1) PL360404A1 (es)
UY (1) UY26779A1 (es)
WO (1) WO2001096353A2 (es)
YU (1) YU94802A (es)
ZA (2) ZA200300168B (es)

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AU2003300901A1 (en) 2002-12-12 2004-06-30 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
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PL2604620T5 (pl) 2003-05-30 2024-10-14 Gilead Pharmasset Llc Zmodyfikowane fluorowane analogi nukleozydu
KR20060035652A (ko) 2003-06-30 2006-04-26 이데닉스 (케이만) 리미티드 β-Ｌ-2-데옥시 뉴클레오시드의 합성
KR20070011451A (ko) 2004-05-05 2007-01-24 예일 유니버시티 신규의 항바이러스 헬리오크산틴 유사체
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AR054778A1 (es) 2005-06-17 2007-07-18 Novartis Ag Uso de sangliferina en hcv
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TW200946541A (en) 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
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TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
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MX2012011171A (es) 2010-03-31 2013-02-01 Gilead Pharmasset Llc Fosforamidatos de nucleosido.
AR094621A1 (es) 2010-04-01 2015-08-19 Idenix Pharmaceuticals Inc Compuestos y composiciones farmacéuticas para el tratamiento de infecciones virales
JP6069215B2 (ja) 2010-11-30 2017-02-01 ギリアド ファーマセット エルエルシー 化合物
CN103842369A (zh) 2011-03-31 2014-06-04 埃迪尼克斯医药公司 用于治疗病毒感染的化合物和药物组合物
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Also Published As

Publication number Publication date
AP1771A (en) 2007-08-23
NZ535246A (en) 2006-06-30
CN1900104A (zh) 2007-01-24
BR0111732A (pt) 2003-06-24
KR20070048277A (ko) 2007-05-08
NO20026001L (no) 2003-02-12
IL153379A (en) 2007-02-11
IL178864A0 (en) 2007-03-08
PL360404A1 (en) 2004-09-06
EP1296995A2 (en) 2003-04-02
JP2004533403A (ja) 2004-11-04
ATE411332T1 (de) 2008-10-15
CA2413163C (en) 2008-11-18
OA12384A (en) 2006-04-17
MY141594A (en) 2010-05-14
ZA200300168B (en) 2004-07-07
NO20026001D0 (no) 2002-12-13
DE60136181D1 (de) 2008-11-27
CA2413163A1 (en) 2001-12-20
UY26779A1 (es) 2001-12-28
PE20020216A1 (es) 2002-04-16
EA200300023A1 (ru) 2003-08-28
CN1452627A (zh) 2003-10-29
NZ523632A (en) 2005-03-24
CN101012259A (zh) 2007-08-08
CN1295242C (zh) 2007-01-17
WO2001096353A2 (en) 2001-12-20
MA27126A1 (fr) 2005-01-03
AP2003002713A0 (en) 2003-03-31
AU6692701A (en) 2001-12-24
YU94802A (sh) 2006-03-03
JP4639032B2 (ja) 2011-02-23
EP1296995B1 (en) 2008-10-15
CZ2003122A3 (cs) 2003-06-18
ES2317912T3 (es) 2009-05-01
AU2001266927B2 (en) 2006-12-14
KR20030032967A (ko) 2003-04-26
ZA200404306B (en) 2005-06-15
AR035711A1 (es) 2004-07-07
IL153379A0 (en) 2003-07-06
WO2001096353A3 (en) 2002-04-18
EA005774B1 (ru) 2005-06-30

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