AR021577A1 - Preparado con una amplitud terapeutica mejorada, que contiene inhibidores de la sintesis de los nucleotidos - Google Patents
Preparado con una amplitud terapeutica mejorada, que contiene inhibidores de la sintesis de los nucleotidosInfo
- Publication number
- AR021577A1 AR021577A1 ARP990106239A ARP990106239A AR021577A1 AR 021577 A1 AR021577 A1 AR 021577A1 AR P990106239 A ARP990106239 A AR P990106239A AR P990106239 A ARP990106239 A AR P990106239A AR 021577 A1 AR021577 A1 AR 021577A1
- Authority
- AR
- Argentina
- Prior art keywords
- synthesis
- nucleotides
- prepared
- improved therapeutic
- inhibitors
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 5
- 239000003112 inhibitor Substances 0.000 title abstract 5
- 239000002773 nucleotide Substances 0.000 title abstract 5
- 238000003786 synthesis reaction Methods 0.000 title abstract 5
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 2-morpholinoethyl- (E) - (1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl) -4- methyl-4-hexenoate Chemical compound 0.000 abstract 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 abstract 1
- HZQDCMWJEBCWBR-UUOKFMHZSA-N Mizoribine Chemical compound OC1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 HZQDCMWJEBCWBR-UUOKFMHZSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- PHEZJEYUWHETKO-UHFFFAOYSA-N brequinar Chemical compound N1=C2C=CC(F)=CC2=C(C(O)=O)C(C)=C1C(C=C1)=CC=C1C1=CC=CC=C1F PHEZJEYUWHETKO-UHFFFAOYSA-N 0.000 abstract 1
- 229950010231 brequinar Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 229960000485 methotrexate Drugs 0.000 abstract 1
- 229950000844 mizoribine Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
Preparado con una amplitud terapéutica mejorada, que contiene inhibidores de la síntesis de los nucleotidos. Un preparado que contiene por lo menos uncompuesto que esencialmente impide la circulacion entero-hepática de los inhibidores de la síntesisde los nucleotidos, o que, temporalmente desplazado,antagoniza el efecto de los inhibidores de la síntesis de los nucleotidos, y un inhibidor de la síntesis de los nucleotidos, tal como el Brequinar, elMicofenolatmofetil, el 2-morfolinoetil-(E)-(1,3-dihidro-4-hidroxi-6-metoxi-7-metil-3-oxoisobenzofuran-5-il)-4-metil-4-hexenoato), el Methotrexato, elMizoribine y los compuestos de las formulas (1) o (2): es adecuado para el tratamiento de enfermedades inmunologicas, del cáncer, o en transplantes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19857009A DE19857009A1 (de) | 1998-12-10 | 1998-12-10 | Zubereitung mit verbesserter therapeutischer Breite, enthaltend Nukleotidsyntheseinhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021577A1 true AR021577A1 (es) | 2002-07-24 |
Family
ID=7890633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106239A AR021577A1 (es) | 1998-12-10 | 1999-12-07 | Preparado con una amplitud terapeutica mejorada, que contiene inhibidores de la sintesis de los nucleotidos |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1137438B1 (es) |
| JP (1) | JP2002531525A (es) |
| KR (1) | KR20010080729A (es) |
| CN (1) | CN1189214C (es) |
| AR (1) | AR021577A1 (es) |
| AT (1) | ATE218370T1 (es) |
| AU (1) | AU766810B2 (es) |
| BG (1) | BG105548A (es) |
| BR (1) | BR9916006A (es) |
| CA (1) | CA2354266A1 (es) |
| CZ (1) | CZ20012029A3 (es) |
| DE (2) | DE19857009A1 (es) |
| DK (1) | DK1137438T3 (es) |
| EA (1) | EA005136B1 (es) |
| EE (1) | EE200100305A (es) |
| ES (1) | ES2178496T3 (es) |
| HK (1) | HK1041598B (es) |
| HR (1) | HRP20010429A2 (es) |
| HU (1) | HUP0104624A3 (es) |
| IL (1) | IL143586A0 (es) |
| MX (1) | MXPA01005861A (es) |
| NO (1) | NO20012719L (es) |
| NZ (1) | NZ511882A (es) |
| PL (1) | PL349336A1 (es) |
| PT (1) | PT1137438E (es) |
| SI (1) | SI1137438T1 (es) |
| SK (1) | SK284842B6 (es) |
| WO (1) | WO2000033876A1 (es) |
| YU (1) | YU39901A (es) |
| ZA (1) | ZA200104815B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4382354B2 (ja) * | 2001-03-13 | 2009-12-09 | ヴァルブルク・グリコムド・ゲーエムベーハー | １−ブタン酸誘導体およびその使用 |
| DE10112924A1 (de) * | 2001-03-13 | 2002-10-02 | Erich Eigenbrodt | 1-Butansäurederivate, pharmazeutische Zusammensetzungen enthaltend solche Derivate und Verwendungen solcher Derivate |
| GB0123571D0 (en) | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| US20040127435A1 (en) * | 2002-08-02 | 2004-07-01 | Regents Of The University Of California | Uses for inhibitors of inosine monophosphate dehydrogenase |
| AU2003258454A1 (en) | 2002-09-06 | 2004-04-30 | Schebo®Biotech Ag | Compounds for modulating the glycolosis enzyme complex and/or transaminase complex |
| WO2005060980A1 (ja) * | 2003-12-24 | 2005-07-07 | Masaakira Shonago | 疾患治療用医薬及び糖尿病治療用医薬 |
| DE102005017592A1 (de) * | 2005-04-16 | 2006-10-19 | Lindner, Jürgen, Dr. med. | Darreichungsformen und Kombinationspräparate von Pyrimidinbiosyntheseinhibitoren zur Erzielung zusätzlicher Wirkungen auf das Immunsystem |
| GEP20125379B (en) | 2007-05-03 | 2012-01-10 | Pfizer Ltd | 2 -pyridine carboxamide derivatives as sodium channel modulators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4127737A1 (de) * | 1991-08-22 | 1993-02-25 | Hoechst Ag | Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen |
| ATE128353T1 (de) * | 1991-10-23 | 1995-10-15 | Hoechst Ag | N-phenyl-2-cyano-3-hydroxycrotonsäureamidderiva e und deren verwendung als arzneimittel mit immunmodulatorischer eigenschaft. |
| IT1254519B (it) * | 1992-03-16 | 1995-09-25 | Chiesi Farma Spa | Associazioni di composti ad attivita' antivirale |
| DE19539638A1 (de) * | 1995-10-25 | 1997-04-30 | Hoechst Ag | Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen |
| AU4596097A (en) * | 1996-09-26 | 1998-04-17 | Williams, James W. | Improved therapeutic uses of 4-quinoline-carboxylic acid derivatives |
-
1998
- 1998-12-10 DE DE19857009A patent/DE19857009A1/de not_active Withdrawn
-
1999
- 1999-12-01 PT PT99961041T patent/PT1137438E/pt unknown
- 1999-12-01 JP JP2000586366A patent/JP2002531525A/ja not_active Withdrawn
- 1999-12-01 WO PCT/EP1999/009380 patent/WO2000033876A1/de not_active Ceased
- 1999-12-01 EA EA200100647A patent/EA005136B1/ru not_active IP Right Cessation
- 1999-12-01 CN CNB998142433A patent/CN1189214C/zh not_active Expired - Fee Related
- 1999-12-01 CA CA002354266A patent/CA2354266A1/en not_active Abandoned
- 1999-12-01 CZ CZ20012029A patent/CZ20012029A3/cs unknown
- 1999-12-01 DE DE59901681T patent/DE59901681D1/de not_active Expired - Fee Related
- 1999-12-01 BR BR9916006-4A patent/BR9916006A/pt not_active IP Right Cessation
- 1999-12-01 HK HK02103282.9A patent/HK1041598B/zh not_active IP Right Cessation
- 1999-12-01 AU AU17793/00A patent/AU766810B2/en not_active Ceased
- 1999-12-01 AT AT99961041T patent/ATE218370T1/de not_active IP Right Cessation
- 1999-12-01 MX MXPA01005861A patent/MXPA01005861A/es active IP Right Grant
- 1999-12-01 ES ES99961041T patent/ES2178496T3/es not_active Expired - Lifetime
- 1999-12-01 EP EP99961041A patent/EP1137438B1/de not_active Expired - Lifetime
- 1999-12-01 HR HR20010429A patent/HRP20010429A2/hr not_active Application Discontinuation
- 1999-12-01 KR KR1020017007176A patent/KR20010080729A/ko not_active Ceased
- 1999-12-01 YU YU39901A patent/YU39901A/sh unknown
- 1999-12-01 SK SK788-2001A patent/SK284842B6/sk unknown
- 1999-12-01 SI SI9930063T patent/SI1137438T1/xx unknown
- 1999-12-01 EE EEP200100305A patent/EE200100305A/xx unknown
- 1999-12-01 DK DK99961041T patent/DK1137438T3/da active
- 1999-12-01 HU HU0104624A patent/HUP0104624A3/hu unknown
- 1999-12-01 PL PL99349336A patent/PL349336A1/xx not_active Application Discontinuation
- 1999-12-01 NZ NZ511882A patent/NZ511882A/en unknown
- 1999-12-01 IL IL14358699A patent/IL143586A0/xx unknown
- 1999-12-07 AR ARP990106239A patent/AR021577A1/es not_active Application Discontinuation
-
2001
- 2001-05-30 BG BG105548A patent/BG105548A/xx unknown
- 2001-06-01 NO NO20012719A patent/NO20012719L/no not_active Application Discontinuation
- 2001-06-13 ZA ZA200104815A patent/ZA200104815B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |