DE60136181D1 - 3'-prodrugs von 2'-deoxy-beta-l-nukleosiden - Google Patents

3'-prodrugs von 2'-deoxy-beta-l-nukleosiden

Info

Publication number: DE60136181D1
Authority: DE; Germany
Prior art keywords: nucleosides; deoxy; prodrugs; beta
Prior art date: 2000-06-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60136181T

Other languages

English (en)

Inventor

Martin L Bryant

Gilles Gosselin

Jean-Louis Imbach

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Centre National de la Recherche Scientifique CNRS

Universite de Montpellier

Idenix Cayman Ltd

Original Assignee

Centre National de la Recherche Scientifique CNRS

Universite de Montpellier

Idenix Cayman Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-15

Filing date

2001-06-15

Publication date

2008-11-27

2001-06-15 Application filed by Centre National de la Recherche Scientifique CNRS, Universite de Montpellier, Idenix Cayman Ltd filed Critical Centre National de la Recherche Scientifique CNRS

2008-11-27 Application granted granted Critical

2008-11-27 Publication of DE60136181D1 publication Critical patent/DE60136181D1/de

2021-06-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biotechnology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE60136181T 2000-06-15 2001-06-15 3'-prodrugs von 2'-deoxy-beta-l-nukleosiden Expired - Lifetime DE60136181D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US21210000P	2000-06-15	2000-06-15
PCT/US2001/019147 WO2001096353A2 (en)	2000-06-15	2001-06-15	3'-PRODRUGS OF 2'-DEOXY-β-L-NUCLEOSIDES

Publications (1)

Publication Number	Publication Date
DE60136181D1 true DE60136181D1 (de)	2008-11-27

Family

ID=22789563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60136181T Expired - Lifetime DE60136181D1 (de)	2000-06-15	2001-06-15	3'-prodrugs von 2'-deoxy-beta-l-nukleosiden

Country Status (27)

Country	Link
EP (1)	EP1296995B1 (de)
JP (1)	JP4639032B2 (de)
KR (2)	KR20030032967A (de)
CN (3)	CN1295242C (de)
AP (1)	AP1771A (de)
AR (1)	AR035711A1 (de)
AT (1)	ATE411332T1 (de)
AU (2)	AU2001266927B2 (de)
BR (1)	BR0111732A (de)
CA (1)	CA2413163C (de)
CZ (1)	CZ2003122A3 (de)
DE (1)	DE60136181D1 (de)
EA (1)	EA005774B1 (de)
ES (1)	ES2317912T3 (de)
IL (3)	IL153379A0 (de)
MA (1)	MA27126A1 (de)
MX (1)	MXPA02012443A (de)
MY (1)	MY141594A (de)
NO (1)	NO20026001L (de)
NZ (2)	NZ535246A (de)
OA (1)	OA12384A (de)
PE (1)	PE20020216A1 (de)
PL (1)	PL360404A1 (de)
UY (1)	UY26779A1 (de)
WO (1)	WO2001096353A2 (de)
YU (1)	YU94802A (de)
ZA (2)	ZA200300168B (de)

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ATE414520T1 (de)	2000-04-13	2008-12-15	Pharmasset Inc	3 oder 2 hydroxymethyl substituierte nucleoside derivate und ihre verwendung zur behandlung von virusinfektionen
MY164523A (en)	2000-05-23	2017-12-29	Univ Degli Studi Cagliari	Methods and compositions for treating hepatitis c virus
MXPA02011691A (es)	2000-05-26	2004-05-17	Idenix Cayman Ltd	Metodos y composiciones para el tratamiento de flavivirus y pestivirus.
US6787526B1 (en)	2000-05-26	2004-09-07	Idenix Pharmaceuticals, Inc.	Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
JP2005504087A (ja)	2001-09-28	2005-02-10	イデニクス（ケイマン）リミテツド	４’が修飾されたヌクレオシドを使用するｃ型肝炎ウイルス治療のための方法および組成物
US7608600B2 (en)	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
MY140819A (en) *	2002-06-28	2010-01-29	Idenix Caymans Ltd	Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae
JP2005533824A (ja)	2002-06-28	2005-11-10	イデニクス（ケイマン）リミテツド	フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン
CN101172993A (zh)	2002-06-28	2008-05-07	埃迪尼克斯(开曼)有限公司	用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
EP1525209B1 (de)	2002-06-28	2017-11-15	Idenix Pharmaceuticals LLC	1'-, 2'- und 3'-modifizierte nukleosidderivate zur behandlung von flaviviridae infektionen
US7186700B2 (en)	2002-09-13	2007-03-06	Idenix Pharmaceuticals, Inc.	β-L-2′-deoxynucleosides for the treatment of resistant HBV strains and combination therapies
PL377342A1 (pl)	2002-11-15	2006-01-23	Idenix (Cayman) Limited	Nukleozydy rozgałęzione w pozycji 2' oraz mutacja Flaviviridae
AU2003300901A1 (en)	2002-12-12	2004-06-30	Idenix (Cayman) Limited	Process for the production of 2'-branched nucleosides
CN101415719A (zh)	2003-03-20	2009-04-22	微生物化学及药品有限公司	生产2’-脱氧-β-L-核苷的方法
EP1620451A4 (de) *	2003-04-28	2009-02-18	Novartis Ag	Im grosstechnischen massstab durchführbare nukleosidsynthese
PL2604620T5 (pl)	2003-05-30	2024-10-14	Gilead Pharmasset Llc	Zmodyfikowane fluorowane analogi nukleozydu
KR20060035652A (ko)	2003-06-30	2006-04-26	이데닉스 (케이만) 리미티드	β-Ｌ-2-데옥시 뉴클레오시드의 합성
KR20070011451A (ko)	2004-05-05	2007-01-24	예일 유니버시티	신규의 항바이러스 헬리오크산틴 유사체
CN101023094B (zh)	2004-07-21	2011-05-18	法莫赛特股份有限公司	烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
NZ554442A (en)	2004-09-14	2011-05-27	Pharmasset Inc	Preparation of 2'fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
US7524831B2 (en)	2005-03-02	2009-04-28	Schering Corporation	Treatments for Flaviviridae virus infection
AR054778A1 (es)	2005-06-17	2007-07-18	Novartis Ag	Uso de sangliferina en hcv
GB0609178D0 (en) *	2006-05-09	2006-06-21	Univ Cardiff	Novel compounds
US7897737B2 (en)	2006-12-05	2011-03-01	Lasergen, Inc.	3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
US7964580B2 (en)	2007-03-30	2011-06-21	Pharmasset, Inc.	Nucleoside phosphoramidate prodrugs
TW200946541A (en)	2008-03-27	2009-11-16	Idenix Pharmaceuticals Inc	Solid forms of an anti-HIV phosphoindole compound
KR101677772B1 (ko)	2008-06-11	2016-11-18	레이저젠, 인코퍼레이티드	뉴클레오타이드 및 뉴클레오사이드 그리고 시퀀싱에서의 이들의 이용 방법
US8716263B2 (en)	2008-12-23	2014-05-06	Gilead Pharmasset Llc	Synthesis of purine nucleosides
EA201100851A1 (ru)	2008-12-23	2012-04-30	Фармассет, Инк.	Аналоги нуклеозидов
EA019341B1 (ru)	2008-12-23	2014-02-28	Джилид Фармассет, Ллс.	Фосфорамидаты нуклеозидов
TWI576352B (zh)	2009-05-20	2017-04-01	基利法瑪席特有限責任公司	核苷磷醯胺
US8618076B2 (en)	2009-05-20	2013-12-31	Gilead Pharmasset Llc	Nucleoside phosphoramidates
MX2012011171A (es)	2010-03-31	2013-02-01	Gilead Pharmasset Llc	Fosforamidatos de nucleosido.
AR094621A1 (es)	2010-04-01	2015-08-19	Idenix Pharmaceuticals Inc	Compuestos y composiciones farmacéuticas para el tratamiento de infecciones virales
JP6069215B2 (ja)	2010-11-30	2017-02-01	ギリアドファーマセットエルエルシー	化合物
CN103842369A (zh)	2011-03-31	2014-06-04	埃迪尼克斯医药公司	用于治疗病毒感染的化合物和药物组合物
CA2847892A1 (en)	2011-09-12	2013-03-21	Idenix Pharmaceuticals, Inc.	Compounds and pharmaceutical compositions for the treatment of viral infections
EP2755984B1 (de)	2011-09-13	2020-02-12	Agilent Technologies, Inc.	5-methoxy. 3 '-oh-unblockierte, schnell photospaltbare endgruppennukleotide und verfahren zur nukleinsäuresequenzierung
SG11201400664WA (en)	2011-09-16	2014-04-28	Gilead Pharmassett Llc	Methods for treating hcv
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
AR090699A1 (es) *	2012-04-18	2014-12-03	Biocryst Pharm Inc	Compuestos inhibidores de la actividad de la arn polimerasa viral
US20140212491A1 (en)	2013-01-31	2014-07-31	Gilead Pharmasset Llc	Combination formulation of two antiviral compounds
EP3038601B1 (de)	2013-08-27	2020-04-08	Gilead Pharmasset LLC	Kombinationsformulierung zweier antiviraler verbindungen
WO2019200340A1 (en)	2018-04-12	2019-10-17	Modis Therapeutics Inc.	Prodrugs of deoxynucleosides for treatment of diseases cased by unbalanced nucleotide pools

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US4958013A (en) *	1989-06-06	1990-09-18	Northwestern University	Cholesteryl modified oligonucleotides
IT1246983B (it) *	1990-11-13	1994-12-12	Consiglio Nazionale Ricerche	L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
US5559101A (en) *	1994-10-24	1996-09-24	Genencor International, Inc.	L-ribofuranosyl nucleosides
SE505648C2 (sv) *	1996-08-30	1997-09-22	Scania Cv Ab	Anordning vid ett fordon för monterbar anfästning av en förarplatsmodul
ES2579903T3 (es) *	1998-08-10	2016-08-17	Centre National De La Recherche Scientifique (Cnrs)	Beta-L-2'-desoxi-nucleósidos para el tratamiento de la hepatitis B

2001
- 2001-06-14 MY MYPI20012807A patent/MY141594A/en unknown
- 2001-06-15 BR BR0111732-7A patent/BR0111732A/pt not_active IP Right Cessation
- 2001-06-15 ES ES01944522T patent/ES2317912T3/es not_active Expired - Lifetime
- 2001-06-15 CN CNB018138020A patent/CN1295242C/zh not_active Expired - Fee Related
- 2001-06-15 DE DE60136181T patent/DE60136181D1/de not_active Expired - Lifetime
- 2001-06-15 CN CNA2006101495863A patent/CN101012259A/zh active Pending
- 2001-06-15 CZ CZ2003122A patent/CZ2003122A3/cs unknown
- 2001-06-15 CA CA002413163A patent/CA2413163C/en not_active Expired - Lifetime
- 2001-06-15 AT AT01944522T patent/ATE411332T1/de not_active IP Right Cessation
- 2001-06-15 WO PCT/US2001/019147 patent/WO2001096353A2/en not_active Ceased
- 2001-06-15 UY UY26779A patent/UY26779A1/es not_active Application Discontinuation
- 2001-06-15 EA EA200300023A patent/EA005774B1/ru not_active IP Right Cessation
- 2001-06-15 NZ NZ535246A patent/NZ535246A/en unknown
- 2001-06-15 NZ NZ523632A patent/NZ523632A/en unknown
- 2001-06-15 AR ARP010102881A patent/AR035711A1/es not_active Application Discontinuation
- 2001-06-15 AU AU2001266927A patent/AU2001266927B2/en not_active Ceased
- 2001-06-15 JP JP2002510494A patent/JP4639032B2/ja not_active Expired - Lifetime
- 2001-06-15 IL IL15337901A patent/IL153379A0/xx active IP Right Grant
- 2001-06-15 OA OA1200200374A patent/OA12384A/en unknown
- 2001-06-15 PL PL36040401A patent/PL360404A1/xx not_active Application Discontinuation
- 2001-06-15 YU YU94802A patent/YU94802A/sh unknown
- 2001-06-15 KR KR1020027017018A patent/KR20030032967A/ko not_active Abandoned
- 2001-06-15 KR KR1020077009124A patent/KR20070048277A/ko not_active Ceased
- 2001-06-15 PE PE2001000584A patent/PE20020216A1/es not_active Application Discontinuation
- 2001-06-15 MX MXPA02012443A patent/MXPA02012443A/es active IP Right Grant
- 2001-06-15 CN CNA2006100741038A patent/CN1900104A/zh active Pending
- 2001-06-15 AP APAP/P/2003/002713A patent/AP1771A/en active
- 2001-06-15 AU AU6692701A patent/AU6692701A/xx active Pending
- 2001-06-15 EP EP01944522A patent/EP1296995B1/de not_active Expired - Lifetime
2002
- 2002-12-11 IL IL153379A patent/IL153379A/en not_active IP Right Cessation
- 2002-12-13 NO NO20026001A patent/NO20026001L/no unknown
2003
- 2003-01-02 MA MA26989A patent/MA27126A1/fr unknown
- 2003-01-07 ZA ZA200300168A patent/ZA200300168B/en unknown
2004
- 2004-06-01 ZA ZA200404306A patent/ZA200404306B/xx unknown
2006
- 2006-10-25 IL IL178864A patent/IL178864A0/en unknown

Also Published As

Publication number	Publication date
AP1771A (en)	2007-08-23
NZ535246A (en)	2006-06-30
CN1900104A (zh)	2007-01-24
BR0111732A (pt)	2003-06-24
KR20070048277A (ko)	2007-05-08
NO20026001L (no)	2003-02-12
IL153379A (en)	2007-02-11
IL178864A0 (en)	2007-03-08
PL360404A1 (en)	2004-09-06
EP1296995A2 (de)	2003-04-02
JP2004533403A (ja)	2004-11-04
ATE411332T1 (de)	2008-10-15
CA2413163C (en)	2008-11-18
OA12384A (en)	2006-04-17
MY141594A (en)	2010-05-14
ZA200300168B (en)	2004-07-07
NO20026001D0 (no)	2002-12-13
MXPA02012443A (es)	2004-09-10
CA2413163A1 (en)	2001-12-20
UY26779A1 (es)	2001-12-28
PE20020216A1 (es)	2002-04-16
EA200300023A1 (ru)	2003-08-28
CN1452627A (zh)	2003-10-29
NZ523632A (en)	2005-03-24
CN101012259A (zh)	2007-08-08
CN1295242C (zh)	2007-01-17
WO2001096353A2 (en)	2001-12-20
MA27126A1 (fr)	2005-01-03
AP2003002713A0 (en)	2003-03-31
AU6692701A (en)	2001-12-24
YU94802A (sh)	2006-03-03
JP4639032B2 (ja)	2011-02-23
EP1296995B1 (de)	2008-10-15
CZ2003122A3 (cs)	2003-06-18
ES2317912T3 (es)	2009-05-01
AU2001266927B2 (en)	2006-12-14
KR20030032967A (ko)	2003-04-26
ZA200404306B (en)	2005-06-15
AR035711A1 (es)	2004-07-07
IL153379A0 (en)	2003-07-06
WO2001096353A3 (en)	2002-04-18
EA005774B1 (ru)	2005-06-30

Publication	Publication Date	Title
ATE411332T1 (de)	2008-10-15	3'-prodrugs von 2'-deoxy-beta-l-nukleosiden
NO20031268D0 (no)	2003-03-19	4-aminokinazoliner
DE69928195D1 (de)	2005-12-15	Komplettierung von Untrerdruck-Bohrlöchern
ID30590A (id)	2002-01-03	Celana sekali pakai jenis-celana pendek
CY2012029I2 (el)	2015-08-05	Nεα μορφη της 5-ομεπραζολης
EP1294513A4 (de)	2005-11-23	Lokalisationsspezifische kovalente biokonjugation von proteinen
CY2006003I2 (el)	2009-11-04	Χρηση δαπτομυκινης
DE60126814D1 (de)	2007-04-05	Inhalation von stickoxid
ID30187A (id)	2001-11-15	Dongkrak jenis pantagraf
DE60142051D1 (de)	2010-06-17	Herstellung von perfluorolefinen
DE60132362D1 (de)	2008-02-21	Herstellung von ultradünnwandigen cordierit-strukturen
NO20031267L (no)	2003-05-19	4-aminokinazoliner
ID28032A (id)	2001-05-03	TRISIKLIK PIPERIDIN-Δ3-SEBAGAI ANTAGONIS-α2
DE60007360D1 (de)	2004-01-29	Amorphe modifikation von torasemid
DE60031450D1 (de)	2006-11-30	Polymorph v von torasemid
EP1192168A4 (de)	2003-04-16	Galektin
EP1314428A4 (de)	2006-10-18	Oct-zubereitungen
ID30381A (id)	2001-11-29	Penggunaan arilalkanoilpiridazina
DE60207900D1 (de)	2006-01-19	"Suspend"-Paketübertrager
ITRC20000004V0 (it)	2000-07-17	Deodorante - souvenir "i calandreddhi"
ITRC20010003A1 (it)	2001-05-22	"fumanello"
PT9613T (pt)	2001-09-27	Vysor 3 d
UA4579S (uk)	2001-02-15	Дозиметр-радіометр гамма-бета-випромінювань
SE0002629D0 (sv)	2000-07-12	Novel compounds and their use
ITSA20000021A0 (it)	2000-11-29	Eufrasia 2000

Legal Events

Date	Code	Title	Description
2009-11-05	8364	No opposition during term of opposition
2012-06-19	R082	Change of representative	Ref document number: 1296995 Country of ref document: EP Representative=s name: JONES DAY RECHTSANWAELTE PATENTANWAELTE, DE

Date

Code

Title

Description

2009-11-05

8364

No opposition during term of opposition

2012-06-19

R082

Change of representative

Ref document number: 1296995

Country of ref document: EP

Representative=s name: JONES DAY RECHTSANWAELTE PATENTANWAELTE, DE