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PE20020190A1 - Carboxamidas heterociclicas como agentes antivirales - Google Patents

Carboxamidas heterociclicas como agentes antivirales

Info

Publication number
PE20020190A1
PE20020190A1 PE2001000697A PE2001000697A PE20020190A1 PE 20020190 A1 PE20020190 A1 PE 20020190A1 PE 2001000697 A PE2001000697 A PE 2001000697A PE 2001000697 A PE2001000697 A PE 2001000697A PE 20020190 A1 PE20020190 A1 PE 20020190A1
Authority
PE
Peru
Prior art keywords
alkyl
formula
antiviral agents
heterocyclic carboxamides
chlorobenzyl
Prior art date
Application number
PE2001000697A
Other languages
English (en)
Inventor
Michael J Genin
Fred L Ciske
Scott D Larsen
Steven E Heasley
Byung Hyun Lee
Paul D May
John R Palmer
Mark E Schnute
Gordon L Bundy
Valerie A Vaillancourt
Atli Thonarensen
Allison J Wolf
David Wilhite
Nancy Anne Wicnienski
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20020190A1 publication Critical patent/PE20020190A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A CARBOXAMIDAS HETEROCICLICAS DE FORMULA I DONDE X ES Cl, F, Br, F, CN, NO2; G ES ALQUILO C1-C4; R1 ES ALQUILO C2-C7 SUSTITUIDO CON OH, ALCOXILO C1-C4, ARILO; R2 ES H, ALQUILO C1-C7; R1 Y R2 JUNTO CON N FORMAN MORFOLINA, PIRROLIDINA; W ES UN HETEROCICLO DE FORMULA W1, W3, W7, ENTRE OTROS; A ES CR4, N; B ES CR5, N; C ES CR6, N; D ES CR8, N; UNO DE E Y F ES O, EL OTRO ES CO; CUANDO W ES W3, UNO DE A, B, C ES N; R7 NO ES H, SI C ES N, ENTONCES A, B O A Y B SON N; R4 ES H, HALO, OR12, ENTRE OTROS; R6 ES H, HALO, ARILO, HETEROCICLO, ENTRE OTROS; R7 ES H, ALQUILO C1-C7, CICLOALQUILO C3-C8; R8 ES H, ALQUILO C1-C7; 1 ES EL PUNTO DE UNION ENTRE W Y G; 2 ES UN PUNTO DE UNION ENTRE W Y EL GRUPO CARBONILO DE FORMULA I. SON COMPUESTOS PREFERIDOS N-[4-CLOROBENCIL)-5-HIDROXI-3-(3-HIDROXI-1-PROPINIL)-2-OXO-2H-CROMEN-6-CARBOXAMIDA, 4,4-DIOXIDO DE N-(4-CLOROBENCIL)-1-METIL-6-(4-MORFOLINILMETIL)-1H-4,1,2-BENZOTIADIAZIN, ENTRE OTROS. EL COMPUESTO I ES UN INHIBIDOR DE POLIMERASA Y PUEDE SER UTIL COMO AGENTE ANTIVIRAL
PE2001000697A 2000-07-12 2001-07-12 Carboxamidas heterociclicas como agentes antivirales PE20020190A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21755800P 2000-07-12 2000-07-12
US27214201P 2001-02-28 2001-02-28

Publications (1)

Publication Number Publication Date
PE20020190A1 true PE20020190A1 (es) 2002-03-02

Family

ID=26912045

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000697A PE20020190A1 (es) 2000-07-12 2001-07-12 Carboxamidas heterociclicas como agentes antivirales

Country Status (7)

Country Link
US (3) US6559145B2 (es)
EP (1) EP1301493A2 (es)
JP (1) JP2004502770A (es)
AR (1) AR032165A1 (es)
AU (1) AU2001269700A1 (es)
PE (1) PE20020190A1 (es)
WO (1) WO2002004444A2 (es)

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Also Published As

Publication number Publication date
US6559145B2 (en) 2003-05-06
EP1301493A2 (en) 2003-04-16
AU2001269700A1 (en) 2002-01-21
US20030207880A1 (en) 2003-11-06
AR032165A1 (es) 2003-10-29
US20040142928A1 (en) 2004-07-22
WO2002004444A3 (en) 2002-05-30
US6903097B2 (en) 2005-06-07
JP2004502770A (ja) 2004-01-29
WO2002004444A2 (en) 2002-01-17
US20020025960A1 (en) 2002-02-28

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