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PE20011267A1 - Carbamato como inhibidores de caspasa - Google Patents

Carbamato como inhibidores de caspasa

Info

Publication number
PE20011267A1
PE20011267A1 PE2001000296A PE2001000296A PE20011267A1 PE 20011267 A1 PE20011267 A1 PE 20011267A1 PE 2001000296 A PE2001000296 A PE 2001000296A PE 2001000296 A PE2001000296 A PE 2001000296A PE 20011267 A1 PE20011267 A1 PE 20011267A1
Authority
PE
Peru
Prior art keywords
carbamate
aryl
caspase inhibitors
aralkyl
heteroaryl
Prior art date
Application number
PE2001000296A
Other languages
English (en)
Inventor
Ronald Knegtel
David Bebbington
Jean-Damien Charrier
John Studley
David Kay
Michael Mortimore
Julian Golec
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PE20011267A1 publication Critical patent/PE20011267A1/es

Links

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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Abstract

SE REFIERE A CARBAMATO DE FORMULA I DONDE Z ES O, S; R1 ES H, -CHN2, -R, -CH2OR, -CH2SR, CH2Y; R ES ALIFATICO C1-C12, ARILO, ARALQUILO, HETEROCICLILO, HETEROCICLILALQUILO; Y ES UN GRUPO SALIENTE ELECTRONEGATIVO; R2 ES CO2H, CH2CO2H, ESTERES, AMIDAS; R3 ES UN GRUPO CAPAZ DE ENCAJAR EN UN SUBSITIO S2 DE UNA CASPASA; R4 ES H, ARILO, HETEROCICLILO, HETEROARILO, ENTRE OTROS; R5 ES ALQUILO C1-C12, ARILO, ARALQUILO, HETEROARILO, HETEROARALQUILO, CARBOCICLILO, ENTRE OTROS; R4 Y R5 JUNTO A N FORMAN UN HETEROCICLO CON 1-6 HETEROATOMOS. LOS COMPUESTOS DE CARBAMATO SON INHIBIDORES DE LAS CASPASAS E INTERVIENEN EN LA APOPTOSIS E INFLAMACION CELULAR
PE2001000296A 2000-03-29 2001-03-29 Carbamato como inhibidores de caspasa PE20011267A1 (es)

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Application Number Priority Date Filing Date Title
US19282600P 2000-03-29 2000-03-29

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PE20011267A1 true PE20011267A1 (es) 2001-12-15

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PE2001000296A PE20011267A1 (es) 2000-03-29 2001-03-29 Carbamato como inhibidores de caspasa

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US (2) US6689784B2 (es)
EP (1) EP1268425B1 (es)
JP (2) JP4298200B2 (es)
KR (1) KR100858640B1 (es)
CN (2) CN100358869C (es)
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AT (1) ATE384695T1 (es)
AU (2) AU4961901A (es)
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NO (1) NO325062B1 (es)
NZ (1) NZ521639A (es)
PE (1) PE20011267A1 (es)
PL (1) PL201081B1 (es)
PT (1) PT1268425E (es)
SK (1) SK13922002A3 (es)
TW (1) TWI318207B (es)
WO (1) WO2001072707A2 (es)
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ZA (1) ZA200207483B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01010127A (es) 1999-04-09 2002-08-20 Cytovia Inc Inhibidores de la caspasa y el uso de los mismos.
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