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PE20050349A1 - Compuestos de aril o heteroaril amida - Google Patents

Compuestos de aril o heteroaril amida

Info

Publication number
PE20050349A1
PE20050349A1 PE2004000832A PE2004000832A PE20050349A1 PE 20050349 A1 PE20050349 A1 PE 20050349A1 PE 2004000832 A PE2004000832 A PE 2004000832A PE 2004000832 A PE2004000832 A PE 2004000832A PE 20050349 A1 PE20050349 A1 PE 20050349A1
Authority
PE
Peru
Prior art keywords
chloro
ethyl
amino
benzoic acid
aril
Prior art date
Application number
PE2004000832A
Other languages
English (en)
Inventor
Kazunari Nakao
Seiji Nukui
Yoshiyuki Okumara
Tatsuya Yamagishi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20050349A1 publication Critical patent/PE20050349A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE ARIL O HETEROARIL AMIDA DE FORMULA I, EN DONDE A ES UN GRUPO FENILO O PIRIDILO; B ES UN GRUPO ARILO O HETEROARILO; E ES 1,4-FENILENO; R1 Y R2 SON H, HALOGENO, ALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS; R3 Y R4 SON H, ALQUILO C1-C4, o R3 Y R4 SE UNEN FORMANDO UNA CADENA ALQUILENO C2-C6; R5 ES CO2H, CO2W, ENTRE OTROS; X ES METILENO, O o S; W ES UN ESTER FARMACEUTICAMENTE ACEPTABLE; CON LA CONDICION DE QUE R1 Y R2 NO SON H SIMULTANEAMENTE. SON COMPUESTOS PREFERIDOS: ACIDO 4-((1S)-1-{[5-CLORO-2-(4-FLUOROFENOXI)BENZOIL]AMINO}ETIL)BENZOICO; ACIDO 4-[(1S)-1-({[5-CLORO-2-(4-FLUOROFENOXI)PIRIDIN-3-IL]CARBONIL}AMINO)ETIL]BENZOICO; ACIDO 4-[(1S)-1-({[5-CLORO-2-(3-CIANOFENOXI)PIRIDIN-3-IL]CARBONIL}AMINO)ETIL]BENZOICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE PROSTAGLANDINA E2 Y SON UTILES EN EL TRATAMIENTO DEL DOLOR Y LA INFLAMACION
PE2004000832A 2003-09-03 2004-08-31 Compuestos de aril o heteroaril amida PE20050349A1 (es)

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