PE20000988A1 - Agonistas y antagonistas muscarinicos - Google Patents
Agonistas y antagonistas muscarinicosInfo
- Publication number
- PE20000988A1 PE20000988A1 PE1999000838A PE00083899A PE20000988A1 PE 20000988 A1 PE20000988 A1 PE 20000988A1 PE 1999000838 A PE1999000838 A PE 1999000838A PE 00083899 A PE00083899 A PE 00083899A PE 20000988 A1 PE20000988 A1 PE 20000988A1
- Authority
- PE
- Peru
- Prior art keywords
- benzoyl
- dec
- phenyl
- ring
- azatriciclo
- Prior art date
Links
- 239000000472 muscarinic agonist Substances 0.000 title 1
- 239000003149 muscarinic antagonist Substances 0.000 title 1
- -1 PHENOXY, BENZOYL Chemical class 0.000 abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical class C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 1
- 108010009685 Cholinergic Receptors Proteins 0.000 abstract 1
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 abstract 1
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 abstract 1
- 102000034337 acetylcholine receptors Human genes 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical class O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN ANILLO AZACICLICO (AZADAMANTANOS, AZANORADAMANTANOS AZAHOMOADAMANTANOS) DE FORMULA I, DONDE Q ES UN ANILLO DE FORMULA a, b, c, ENTRE OTROS; X ES CH2, NH, O o S; V, W, Y, Z SON CH, N; n Y m SON 0-4; R1 Y R2 SON H, OH, HALOGENO, NH2, CARBOXI, ALQUILO C1-C10, OR3, NR3R4, FENIL, FENOXI, BENZOIL, ENTRE OTROS; R ES H, HALOGENO, CN, CHO, OH, OR3, FENIL, FENOXI, BENZOIL, ANILLO HETEROCICLICO DE 5-6 MIEMBROS, ENTRE OTROS; R3 Y R4 SON ALQUILO C1-C15, ALQUENIL C2-C15, FENIL, FENOXI, BENZOIL, BENCIL, BENCILOXICARBONIL, ANILLOS HETEROCICLICOS DE 5-6 MIEMBROS. SON COMPUESTOS PREFERIDOS 2-(5-AZATRICICLO[3.3.1.1]DEC-2-ILIDENO)-2-CIANOACETATO DE ETILO, 2-(5-AZATRICICLO[3.3.1.1]DEC-2-IL)-2-CIANOACETATO DE ETILO, 3-(5-AZA-2-CLOROTRICICLO[3.3.1.1]DEC-2-IL)-4-CLORO-1,2,5-TIADIAZOL, ENTRE OTROS. EL COMPUESTO I ES UN AGONISTA O ANTAGONISTA DEL RECEPTOR COLINERGICO O RECEPTORES MUSCARINICOS M4 POR LO QUE PUEDE SER UTIL PARA INDUCIR ANALGESIA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9697798P | 1998-08-18 | 1998-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000988A1 true PE20000988A1 (es) | 2000-09-30 |
Family
ID=22260061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000838A PE20000988A1 (es) | 1998-08-18 | 1999-08-18 | Agonistas y antagonistas muscarinicos |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US6093724A (es) |
| EP (1) | EP1112272B1 (es) |
| JP (1) | JP2002523416A (es) |
| KR (1) | KR20010072784A (es) |
| CN (1) | CN1312812A (es) |
| AR (1) | AR020199A1 (es) |
| AT (1) | ATE227724T1 (es) |
| AU (1) | AU750566B2 (es) |
| BG (1) | BG105256A (es) |
| BR (1) | BR9913072A (es) |
| CA (1) | CA2340946A1 (es) |
| CO (1) | CO5130018A1 (es) |
| DE (1) | DE69903961T2 (es) |
| EE (1) | EE200100096A (es) |
| ES (1) | ES2191455T3 (es) |
| HK (1) | HK1038918A1 (es) |
| HU (1) | HUP0103203A3 (es) |
| ID (1) | ID27544A (es) |
| IL (1) | IL141050A0 (es) |
| IS (1) | IS5827A (es) |
| NO (1) | NO20010804L (es) |
| NZ (1) | NZ509762A (es) |
| PE (1) | PE20000988A1 (es) |
| PL (1) | PL346247A1 (es) |
| RU (1) | RU2219179C2 (es) |
| SK (1) | SK1892001A3 (es) |
| TR (1) | TR200100462T2 (es) |
| WO (1) | WO2000011001A1 (es) |
| YU (1) | YU13301A (es) |
| ZA (1) | ZA200100978B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2423789A1 (en) * | 2000-10-19 | 2002-04-25 | Pfizer Products Inc. | Bridged piperazine derivatives |
| GB0117950D0 (en) * | 2001-02-16 | 2001-09-19 | Aventis Pharma Inc | Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands |
| WO2002094827A1 (en) * | 2001-05-23 | 2002-11-28 | Neurosearch A/S | Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US20030064979A1 (en) * | 2001-06-29 | 2003-04-03 | Hansen Thomas Kruse | Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48 |
| US6828328B1 (en) * | 2002-03-01 | 2004-12-07 | Ucb S.A. | Analgesic combination of muscarinic agonists |
| US7897766B2 (en) | 2005-09-23 | 2011-03-01 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
| US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| US8076350B2 (en) * | 2006-12-22 | 2011-12-13 | Abbott Laboratories | Spirocyclic azaadamantane derivatives and methods of use |
| CN101641356B (zh) * | 2007-03-23 | 2012-09-05 | 雅培制药有限公司 | 氮杂金刚烷的乙酰胺和甲酰胺衍生物及其使用方法 |
| WO2008118745A1 (en) * | 2007-03-23 | 2008-10-02 | Abbott Laboratories | 4-substituted azaadamantane derivatives and methods of use thereof |
| JP2012530084A (ja) * | 2009-06-19 | 2012-11-29 | アボット・ラボラトリーズ | ジアザホモアダマンタン誘導体およびこの使用方法 |
| EP3061821B1 (en) | 2009-07-22 | 2019-07-10 | Puretech Health LLC | Compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| US10265311B2 (en) | 2009-07-22 | 2019-04-23 | PureTech Health LLC | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| WO2011133920A1 (en) | 2010-04-23 | 2011-10-27 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| CA2809675A1 (en) | 2010-09-23 | 2012-03-29 | Shuang Chen | Monohydrate of an azaadamantane derivative |
| US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
| US11325896B2 (en) | 2017-12-20 | 2022-05-10 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor M4 |
| EP3856182B1 (en) | 2018-09-28 | 2025-12-24 | Karuna Therapeutics, Inc. | Compositions and methods for treating disorders ameliorated by muscarnic receptor activation |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4739074A (en) * | 1986-01-22 | 1988-04-19 | Pennwalt Corporation | Adamantane spiro-pyrrolidine derivatives |
| IL88156A (en) * | 1987-11-13 | 1997-02-18 | Novo Nordisk As | Azacyclic compounds their preparation and pharmaceutical compositions containing them |
| US5527813A (en) * | 1990-08-21 | 1996-06-18 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
| WO1992011261A1 (en) * | 1990-12-21 | 1992-07-09 | Merck Sharp & Dohme Limited | 4-azatricyclo[2.2.1.02,6]heptanes and pharmaceutical compositions |
| US5955470A (en) * | 1991-06-11 | 1999-09-21 | Merrell Pharmaceuticals, Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
| US5641791A (en) * | 1991-08-13 | 1997-06-24 | Novo Nordisk A.S | Heterocyclic compounds and their preparation and use |
| EE03566B1 (et) * | 1995-11-02 | 2001-12-17 | Neurosearch A/S | Kondenseerunud tropaanderivaadid, nende valmistamine ja kasutamine |
| US5914338A (en) * | 1996-04-02 | 1999-06-22 | Novo Nordisk | Heterocyclic compounds and their preparation and use |
| US6057446A (en) * | 1998-04-02 | 2000-05-02 | Crooks; Peter Anthony | Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds |
| US5952339A (en) * | 1998-04-02 | 1999-09-14 | Bencherif; Merouane | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
| US5986100A (en) * | 1998-04-02 | 1999-11-16 | Crooks; Peter Anthony | Pharmaceutical compositions and methods for use |
-
1999
- 1999-08-16 ID IDW20010377A patent/ID27544A/id unknown
- 1999-08-16 US US09/375,149 patent/US6093724A/en not_active Expired - Fee Related
- 1999-08-16 NZ NZ509762A patent/NZ509762A/xx unknown
- 1999-08-16 EP EP99945064A patent/EP1112272B1/en not_active Expired - Lifetime
- 1999-08-16 ES ES99945064T patent/ES2191455T3/es not_active Expired - Lifetime
- 1999-08-16 EE EEP200100096A patent/EE200100096A/xx unknown
- 1999-08-16 HU HU0103203A patent/HUP0103203A3/hu unknown
- 1999-08-16 HK HK02100409.3A patent/HK1038918A1/zh unknown
- 1999-08-16 WO PCT/US1999/018570 patent/WO2000011001A1/en not_active Ceased
- 1999-08-16 TR TR2001/00462T patent/TR200100462T2/xx unknown
- 1999-08-16 AU AU57758/99A patent/AU750566B2/en not_active Ceased
- 1999-08-16 CN CN99809775A patent/CN1312812A/zh active Pending
- 1999-08-16 RU RU2001107139/04A patent/RU2219179C2/ru not_active IP Right Cessation
- 1999-08-16 PL PL99346247A patent/PL346247A1/xx not_active Application Discontinuation
- 1999-08-16 DE DE69903961T patent/DE69903961T2/de not_active Expired - Fee Related
- 1999-08-16 JP JP2000566274A patent/JP2002523416A/ja active Pending
- 1999-08-16 BR BR9913072-6A patent/BR9913072A/pt not_active IP Right Cessation
- 1999-08-16 YU YU13301A patent/YU13301A/sh unknown
- 1999-08-16 AT AT99945064T patent/ATE227724T1/de not_active IP Right Cessation
- 1999-08-16 IL IL14105099A patent/IL141050A0/xx unknown
- 1999-08-16 SK SK189-2001A patent/SK1892001A3/sk unknown
- 1999-08-16 CA CA002340946A patent/CA2340946A1/en not_active Abandoned
- 1999-08-16 KR KR1020017002128A patent/KR20010072784A/ko not_active Withdrawn
- 1999-08-17 AR ARP990104100A patent/AR020199A1/es unknown
- 1999-08-18 PE PE1999000838A patent/PE20000988A1/es not_active Application Discontinuation
- 1999-08-18 CO CO99052330A patent/CO5130018A1/es unknown
-
2000
- 2000-05-09 US US09/567,785 patent/US6251916B1/en not_active Expired - Fee Related
- 2000-10-17 US US09/690,494 patent/US6323194B1/en not_active Expired - Fee Related
-
2001
- 2001-01-26 IS IS5827A patent/IS5827A/is unknown
- 2001-02-05 ZA ZA200100978A patent/ZA200100978B/xx unknown
- 2001-02-14 BG BG105256A patent/BG105256A/xx unknown
- 2001-02-16 NO NO20010804A patent/NO20010804L/no not_active Application Discontinuation
- 2001-10-05 US US09/972,415 patent/US6423842B1/en not_active Expired - Fee Related
-
2002
- 2002-03-27 US US10/108,046 patent/US6555550B1/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20000988A1 (es) | Agonistas y antagonistas muscarinicos | |
| PE20011212A1 (es) | Compuestos para el tratamiento de la fibromialgia y el sindrome de fatiga cronica | |
| PE20010854A1 (es) | USO DE DERIVADOS DE PIRIMIDINA 4 SUSTITUIDOS COMO ANTAGONISTAS DE LOS RECEPTORES DE GLUTAMATO mGluR1 | |
| PE20010683A1 (es) | Nuevos derivados de biarileter utiles como inhibidores de la recaptacion de monoaminas | |
| PE20010930A1 (es) | Bifenil sulfonamidas como antagonistas de receptores de angiotensina endotelina duales | |
| EA200100058A1 (ru) | 4-бензилпиперидиналкилсульфоксидные гетероциклические соединения и их применение в качестве подтип-избирательных антагонистов nmda-рецепторов | |
| PE20011035A1 (es) | Ureas ciclicas sustituidas como antagonistas de los receptores de neuroquinina | |
| PE20011030A1 (es) | Combinaciones farmaceuticas que comprenden tegaserod y omeprazol | |
| PT776893E (pt) | Compostos azaciclicos com actividade antagonista do receptor de taquiquinina; nk1 e nk2 | |
| PE20020753A1 (es) | Heteroaromaticos fusionados como activadores de la glucoquinasa | |
| PE20050420A1 (es) | Fenacilo 2-hidroxi-3-diaminoalcanos | |
| DE60025189D1 (de) | Cyanopyrrole als progesteronrezeptoragonisten | |
| DE3850203D1 (de) | Benzimidazolin-2-oxo-1-carboxylsäure-Derivate, verwendbar als Antagonisten von 5-HT-Rezeptoren. | |
| ATE260912T1 (de) | Oxazol ppar antagonisten | |
| EA200200649A1 (ru) | Комбинация ингибитора обратного захвата серотонина и антагониста, обратного агониста или неполного агониста 5-нт2с-рецептора | |
| PE79599A1 (es) | Derivados de 5'-desoxicitidina | |
| BG101110A (bg) | Заместени пиримидинови съединения и тяхното използване | |
| PE20001084A1 (es) | Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas | |
| DE69623799D1 (de) | Kondensierte tropanderivate als neurotransmitter-reuptake-inhibitoren | |
| CO5510023A1 (es) | Uso de antagonistas del canal de sodio neuronal para el control de ectoparasitos en animales homeotermicos | |
| PE20100093A1 (es) | Derivados de acetileno | |
| EA200400748A1 (ru) | Агонисты рецепторов, активируемых пероксисомным пролифератором | |
| PT93687A (pt) | Processo para a preparacao de antagonistas de serotonina de tetra-hidrobenz,d}indole | |
| PE20050587A1 (es) | Derivados de diazindol-dicarbonilo-piperazinilo como agentes antivirales | |
| PE20010166A1 (es) | Nuevas oxazolidinonas biciclicas como agentes antibacterianos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |