PE20010166A1 - Nuevas oxazolidinonas biciclicas como agentes antibacterianos - Google Patents
Nuevas oxazolidinonas biciclicas como agentes antibacterianosInfo
- Publication number
- PE20010166A1 PE20010166A1 PE2000000486A PE0004862000A PE20010166A1 PE 20010166 A1 PE20010166 A1 PE 20010166A1 PE 2000000486 A PE2000000486 A PE 2000000486A PE 0004862000 A PE0004862000 A PE 0004862000A PE 20010166 A1 PE20010166 A1 PE 20010166A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- methyl
- oxazolidinones
- oxazolidin
- indol
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 2-FLUOROETHYL Chemical class 0.000 abstract 1
- XIPUIGPNIDKXJU-UHFFFAOYSA-N [CH]1CC1 Chemical class [CH]1CC1 XIPUIGPNIDKXJU-UHFFFAOYSA-N 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A OXAZOLIDINONAS BICICLICAS DE FORMULA I, DONDE: W ES O, S; X ES S(=O)m, NR3; Y ES O, NH, CH2, S(=O)m; R1 ES ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON R5; R2 ES H, ALQUILO C1-C6, CICLOPROPILO, NH2, NH-ALQUILO C1-C6, ENTRE OTROS; R3 ES ALQUILO C1-C8, C(=O)R4, C(=S)NHALQUILO C1-4; R4 ES H, ALQUILO C1-C6, CH2OC(=O)ALQUILO C1-C4; R5 ES HALOGENO, CN, OH, SH, NH2, OR6, ENTRE OTROS; R6 ES ALQUILO C1-C6, C(=O)ALQUILO C1-C4; C(=O)OALQUILO C1-C4, C(=O)NH2, C(=O)NHALQUILO C1-C4, SO2-ALQUILO C1-C4; m ES 0-2; n ES 0-1; CON LA CONDICION QUE CUANDO n ES 0, Y ES -CH2-. SON COMPUESTOS PREFERIDOS N-({(5S)-3-[(2R)-1-(2-FLUOROETIL)-2-METIL-2,3-DIHIDRO-1H-INDOL-5-IL]-2-OXO-1,3-OXAZOLIDIN-5-IL}METIL)ACETAMIDA; N-{[(5S)-3-((2R)-1-GLICOLIL-2-METIL-2,3-DIHIDRO-1H-INDOL-5-IL)-2-OXO-1,3-OXAZOLIDIN-5-IL]METIL}ACETAMIDA, N-({(5S)-3-[(2R)-1-FORMIL-2-METIL-2,3-DIHIDRO-1H-INDOL-5-IL]-2-OXO-1,3-OXAZOLIDIN-5-IL}METIL)ETANOTIOAMIDA, ENTRE OTROS. EL COMPUESTO I ES UN ANTIMICROBIANO, UTILIZANDOSE 0,1 mg/Kg A 100 mg/kg DE PESO CORPORAL/DIA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE INFECCIONES MICROBIANAS CUTANEAS, OCULARES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13625099P | 1999-05-27 | 1999-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010166A1 true PE20010166A1 (es) | 2001-02-03 |
Family
ID=22472021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000486A PE20010166A1 (es) | 1999-05-27 | 2000-05-23 | Nuevas oxazolidinonas biciclicas como agentes antibacterianos |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6387896B1 (es) |
| EP (1) | EP1181288B1 (es) |
| JP (1) | JP2003501351A (es) |
| KR (1) | KR20020012245A (es) |
| CN (1) | CN1142162C (es) |
| AR (1) | AR024118A1 (es) |
| AT (1) | ATE246189T1 (es) |
| AU (1) | AU767380B2 (es) |
| BR (1) | BR0010982A (es) |
| CA (1) | CA2372233A1 (es) |
| DE (1) | DE60004207T2 (es) |
| DK (1) | DK1181288T3 (es) |
| ES (1) | ES2203473T3 (es) |
| HK (1) | HK1046680B (es) |
| MX (1) | MXPA01012167A (es) |
| NZ (1) | NZ515754A (es) |
| PE (1) | PE20010166A1 (es) |
| PT (1) | PT1181288E (es) |
| WO (1) | WO2000073301A1 (es) |
| ZA (1) | ZA200109384B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0010982A (pt) * | 1999-05-27 | 2002-03-05 | Upjohn Co | Novas oxazolidinonas bicìclicas como agentes antibacterianos |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| US6642238B2 (en) | 2000-02-10 | 2003-11-04 | Pharmacia And Upjohn Company | Oxazolidinone thioamides with piperazine amide substituents |
| WO2001058885A1 (en) * | 2000-02-10 | 2001-08-16 | Pharmacia & Upjohn Company | Oxazolidinone thioamides with piperazine amide substituents |
| US6514529B2 (en) | 2000-03-22 | 2003-02-04 | Pharmacia & Upjohn Company | Oxazolidinone tablet formulation |
| HK1054325B (zh) * | 2000-03-22 | 2006-01-13 | 法玛西雅厄普约翰美国公司 | 恶唑烷酮片剂的配方 |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| PE20020689A1 (es) | 2000-11-17 | 2002-08-03 | Upjohn Co | Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno |
| US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| US7304050B2 (en) | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| AU2005270951A1 (en) * | 2004-08-06 | 2006-02-16 | Pharmacia & Upjohn Company Llc | Oxazolidinones containing oxindoles as antibacterial agents |
| AU2006231919A1 (en) | 2005-04-06 | 2006-10-12 | Pharmacia & Upjohn Company Llc | 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents |
| KR20070116989A (ko) * | 2005-04-06 | 2007-12-11 | 파마시아 앤드 업존 캄파니 엘엘씨 | 항균제로서의 옥신돌 옥사졸리디논 |
| TW200804288A (en) * | 2005-12-12 | 2008-01-16 | Astrazeneca Ab | Alkylsulphonamide quinolines |
| RU2522582C2 (ru) | 2008-11-20 | 2014-07-20 | Панацеа Биотек Лтд. | Новые противомикробные средства |
| RU2012102094A (ru) | 2009-06-26 | 2013-08-10 | Панацеа Биотек Лтд. | Новые азабициклогексаны |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8506659A1 (es) * | 1983-06-07 | 1985-08-01 | Du Pont | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
| US5032605A (en) | 1987-10-09 | 1991-07-16 | Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents |
| US4801600A (en) | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| US5036093A (en) | 1987-10-09 | 1991-07-30 | Du Pont Merck Pharmaceutical | Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents |
| US5039690A (en) | 1987-10-09 | 1991-08-13 | Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents |
| US4965268A (en) | 1987-10-09 | 1990-10-23 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| US5036092A (en) | 1987-10-09 | 1991-07-30 | Du Pont Merck Pharmaceutical | Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents |
| EP0609905B1 (en) | 1988-09-15 | 2001-06-06 | PHARMACIA & UPJOHN COMPANY | 3-(Nitrogen substituted)phenyl-5beta-amidomethyloxazolidin-2-ones |
| US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
| DE4425609A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
| ZA968661B (en) | 1995-11-17 | 1998-04-14 | Upjohn Co | Oxazolidinone antibacterial agent with tricyclic substituents. |
| DE19604223A1 (de) * | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
| DE19802239A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
| BR0010982A (pt) * | 1999-05-27 | 2002-03-05 | Upjohn Co | Novas oxazolidinonas bicìclicas como agentes antibacterianos |
-
2000
- 2000-05-17 BR BR0010982-7A patent/BR0010982A/pt not_active IP Right Cessation
- 2000-05-17 AT AT00930095T patent/ATE246189T1/de not_active IP Right Cessation
- 2000-05-17 JP JP2001500626A patent/JP2003501351A/ja active Pending
- 2000-05-17 AU AU47975/00A patent/AU767380B2/en not_active Ceased
- 2000-05-17 DE DE60004207T patent/DE60004207T2/de not_active Expired - Fee Related
- 2000-05-17 KR KR1020017015142A patent/KR20020012245A/ko not_active Withdrawn
- 2000-05-17 WO PCT/US2000/008224 patent/WO2000073301A1/en not_active Ceased
- 2000-05-17 US US09/572,167 patent/US6387896B1/en not_active Expired - Fee Related
- 2000-05-17 DK DK00930095T patent/DK1181288T3/da active
- 2000-05-17 CN CNB008081565A patent/CN1142162C/zh not_active Expired - Fee Related
- 2000-05-17 EP EP00930095A patent/EP1181288B1/en not_active Expired - Lifetime
- 2000-05-17 CA CA002372233A patent/CA2372233A1/en not_active Abandoned
- 2000-05-17 NZ NZ515754A patent/NZ515754A/en unknown
- 2000-05-17 PT PT00930095T patent/PT1181288E/pt unknown
- 2000-05-17 HK HK02107873.5A patent/HK1046680B/zh unknown
- 2000-05-17 MX MXPA01012167A patent/MXPA01012167A/es active IP Right Grant
- 2000-05-17 ES ES00930095T patent/ES2203473T3/es not_active Expired - Lifetime
- 2000-05-23 PE PE2000000486A patent/PE20010166A1/es not_active Application Discontinuation
- 2000-05-26 AR ARP000102587A patent/AR024118A1/es unknown
-
2001
- 2001-11-14 ZA ZA200109384A patent/ZA200109384B/en unknown
-
2002
- 2002-03-04 US US10/090,400 patent/US20020143009A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR0010982A (pt) | 2002-03-05 |
| ATE246189T1 (de) | 2003-08-15 |
| WO2000073301A1 (en) | 2000-12-07 |
| HK1046680A1 (en) | 2003-01-24 |
| AU767380B2 (en) | 2003-11-06 |
| PT1181288E (pt) | 2003-12-31 |
| EP1181288B1 (en) | 2003-07-30 |
| EP1181288A1 (en) | 2002-02-27 |
| KR20020012245A (ko) | 2002-02-15 |
| CN1353709A (zh) | 2002-06-12 |
| ZA200109384B (en) | 2003-02-14 |
| JP2003501351A (ja) | 2003-01-14 |
| DE60004207D1 (de) | 2003-09-04 |
| ES2203473T3 (es) | 2004-04-16 |
| CN1142162C (zh) | 2004-03-17 |
| DK1181288T3 (da) | 2003-11-17 |
| CA2372233A1 (en) | 2000-12-07 |
| AU4797500A (en) | 2000-12-18 |
| AR024118A1 (es) | 2002-09-04 |
| US6387896B1 (en) | 2002-05-14 |
| DE60004207T2 (de) | 2004-06-03 |
| NZ515754A (en) | 2003-10-31 |
| US20020143009A1 (en) | 2002-10-03 |
| MXPA01012167A (es) | 2002-06-21 |
| HK1046680B (zh) | 2004-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |