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PE20011030A1 - Combinaciones farmaceuticas que comprenden tegaserod y omeprazol - Google Patents

Combinaciones farmaceuticas que comprenden tegaserod y omeprazol

Info

Publication number
PE20011030A1
PE20011030A1 PE2000001312A PE0013122000A PE20011030A1 PE 20011030 A1 PE20011030 A1 PE 20011030A1 PE 2000001312 A PE2000001312 A PE 2000001312A PE 0013122000 A PE0013122000 A PE 0013122000A PE 20011030 A1 PE20011030 A1 PE 20011030A1
Authority
PE
Peru
Prior art keywords
alkyl
halogen
antagonists
receptor
anodycle
Prior art date
Application number
PE2000001312A
Other languages
English (en)
Inventor
Hans-Jurgen Pfannkuche
Stephan Anthony Billstein
Peter Dumovic
Nicola Franco
Mark Thomas Iwicki
Wilusz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20011030A1 publication Critical patent/PE20011030A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UNA COMBINACION QUE COMPRENDE: a) UN COMPUESTO AGONISTA PARCIAL DEL RECEPTOR 5-HT4 DE FORMULA I; DONDE R1 ES H, ALQUILO C1-C6, CARBONILO, BENZOILO, FENILALQUILCARBONILO C1-C4, R5 ES H, HALOGENO, ALQUILO C1-C6, OH, NITRO, AMINO, ALQUILAMINO C1-C6, ALQUILCARBONILAMINO, SO2NRaRb ; Ra Y Rb SON H, ALQUILO C1-C6, CIANO, TRIMETILSILILO, ALQUILO C1-C6, ENTRE OTROS; R6 ES H, CUANDO R5 ES OH R6 ES H, HALOGENO; Z ES -CR4=; R4 ES H, HALOGENO, OH, ALQUILO C1-C6; R7 ES H, HALOGENO, ALQUILO C1-C6; X-Y ES -CR8=N- o -CH(R8)-NH-; R8 ES H, ALQUILO C1-C6; B ES UN GRUPO a; n ES 1-2; A1 ES C=O, CH2; X1 ES S; NR11; R11 ES H, ALQUILO C1-C6 ENTRE OTROS; TAL COMO TEGASEROD (3-(5-METOXI-1H-INDOL-3-IL-METILEN)-N-PENTILCARBAZIMIDAMIDA); b) UN COAGENTE SELECCIONADO A PARTIR DE ANTAGONISTAS DEL RECEPTOR 5-HT3, AGONISTAS O ANTAGONISTAS DEL RECEPTOR 5-HT4, AGONISTAS DEL RECEPTOR DE SOMATOSTATINA, ANTAGONISTAS DEL RECEPTOR HISTAMINA H2, INHIBIDORES DE BOMBA DE PROTONES, AGENTES ANTIESPASMODICOS Y ANTIMUSCARINICOS, ANTIDEPRESIVOS TRICICLICOS, ANTAGONISTAS DEL RECEPTOR COLECISTOQUININA, ENTRE OTROS. LA COMBINACION PUEDE SER UTIL PARA REGULAR, ESTABILIZAR, NORMALIZAR LA MOVILIDAD GASTROINTESTINAL ALTERADA, DESORDENES ABDOMINALES
PE2000001312A 1999-12-10 2000-12-07 Combinaciones farmaceuticas que comprenden tegaserod y omeprazol PE20011030A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45838899A 1999-12-10 1999-12-10

Publications (1)

Publication Number Publication Date
PE20011030A1 true PE20011030A1 (es) 2001-10-31

Family

ID=23820591

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001312A PE20011030A1 (es) 1999-12-10 2000-12-07 Combinaciones farmaceuticas que comprenden tegaserod y omeprazol

Country Status (30)

Country Link
EP (3) EP1286668B1 (es)
JP (1) JP2003523324A (es)
KR (1) KR100765579B1 (es)
CN (2) CN1875966A (es)
AR (1) AR026916A1 (es)
AT (1) ATE293971T1 (es)
AU (2) AU778869B2 (es)
BR (1) BR0016275A (es)
CA (1) CA2388959A1 (es)
CO (1) CO5261535A1 (es)
CZ (1) CZ300690B6 (es)
DE (1) DE60019814T2 (es)
DK (1) DK1286668T3 (es)
ES (1) ES2240229T3 (es)
HU (1) HUP0301122A3 (es)
IL (2) IL149496A0 (es)
MX (1) MXPA02005695A (es)
MY (1) MY133423A (es)
NO (1) NO20022680L (es)
NZ (2) NZ566800A (es)
PE (1) PE20011030A1 (es)
PL (1) PL202201B1 (es)
PT (1) PT1286668E (es)
RU (1) RU2264215C2 (es)
SG (1) SG152025A1 (es)
SK (1) SK8062002A3 (es)
TR (1) TR200402293T2 (es)
TW (1) TWI263496B (es)
WO (1) WO2001041748A2 (es)
ZA (1) ZA200204493B (es)

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JP2003533482A (ja) * 2000-05-18 2003-11-11 グラクソ グループ リミテッド 機能性消化不良の治療方法
GB0209481D0 (en) * 2002-04-24 2002-06-05 Novartis Ag Organic compounds
MXPA05007379A (es) 2003-01-13 2006-02-10 Dynogen Pharmaceuticals Inc Metodo para tratar nauseas, vomito, esfuerzo por vomitar o cualquier combinacion de los mismos.
GB0307440D0 (en) * 2003-03-31 2003-05-07 Novartis Ag Organic compounds
RS20050868A (sr) * 2003-05-27 2007-08-03 Altana Pharma Ag., Farmaceutske kombinacije inhibotora protonske pumpe i jedinjenje koje modifikuje gastrointestinalni motilitet
US20050090554A1 (en) * 2003-09-12 2005-04-28 John Devane Treatment of gastroparesis and nonulcer dyspepsia with GABAB agonists
US7820690B2 (en) 2004-03-19 2010-10-26 Solvay Pharmaceuticals Gmbh Method of treating or inhibiting a non-digestive tract derived abdominal disorder associated with pain using a 5-HT, receptor antagonist
CA2573209A1 (en) * 2004-07-14 2006-01-19 Novartis Ag Combination of dpp-iv inhibitors and compounds modulating 5-ht3 and/or 5-ht4 receptors
KR20070107016A (ko) * 2005-01-31 2007-11-06 노파르티스 아게 양성자 펌프 억제제에 의해 유발될 수 있는 위 배출 지연을치료하기 위한 5-ht4 효능제의 용도
GB0506800D0 (en) * 2005-04-04 2005-05-11 Merck Sharp & Dohme New uses
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8354434B2 (en) 2006-01-30 2013-01-15 Purdue Pharma L.P. Cyclourea compounds as calcium channel blockers
AU2007257652A1 (en) * 2006-06-15 2007-12-21 Novartis Ag Compositions comprising tegaserod alone or in combination with a proton pump inhibitor for treating or preventing gastric injury
ES2604943T3 (es) 2007-02-09 2017-03-10 Ocera Therapeutics, Inc. Moduladores macrocíclicos del receptor de la grelina y procedimientos de uso de los mismos
WO2009064458A2 (en) 2007-11-13 2009-05-22 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
US20090143343A1 (en) 2007-11-13 2009-06-04 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
WO2018029474A2 (en) 2016-08-09 2018-02-15 Kymab Limited Anti-icos antibodies
SG11201810509PA (en) 2016-06-20 2018-12-28 Kymab Ltd Anti-pd-l1 antibodies
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
RU2764548C2 (ru) 2016-08-09 2022-01-18 Кимаб Лимитед Анти-icos антитела
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
GB201709808D0 (en) 2017-06-20 2017-08-02 Kymab Ltd Antibodies
GB201721338D0 (en) 2017-12-19 2018-01-31 Kymab Ltd Anti-icos Antibodies
EP3728314A1 (en) 2017-12-19 2020-10-28 Kymab Limited Bispecific antibody for icos and pd-l1
US20220396623A1 (en) 2021-05-18 2022-12-15 Kymab Limited Uses of anti-icos antibodies
GB202107994D0 (en) 2021-06-04 2021-07-21 Kymab Ltd Treatment of cancer
US20250340641A1 (en) 2022-05-18 2025-11-06 Kymab Limited Uses of anti-icos antibodies
FR3144752A1 (fr) 2023-01-10 2024-07-12 Song Huang Utilisation de polysulfate de pentosane pour le traitement de la toux seche

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Also Published As

Publication number Publication date
KR20030016208A (ko) 2003-02-26
HUP0301122A3 (en) 2005-03-29
CN1875966A (zh) 2006-12-13
DK1286668T3 (da) 2005-08-15
CO5261535A1 (es) 2003-03-31
PL202201B1 (pl) 2009-06-30
AU2005200797B2 (en) 2008-01-24
ATE293971T1 (de) 2005-05-15
DE60019814T2 (de) 2006-03-02
MXPA02005695A (es) 2002-09-18
PL355663A1 (en) 2004-05-04
WO2001041748A2 (en) 2001-06-14
WO2001041748A3 (en) 2002-12-19
KR100765579B1 (ko) 2007-10-09
TR200402293T2 (tr) 2004-10-21
EP1913944A1 (en) 2008-04-23
CN1409634A (zh) 2003-04-09
NO20022680D0 (no) 2002-06-06
ZA200204493B (en) 2003-09-29
HUP0301122A2 (hu) 2003-08-28
NZ531489A (en) 2005-09-30
TWI263496B (en) 2006-10-11
MY133423A (en) 2007-11-30
CZ300690B6 (cs) 2009-07-15
IL149496A (en) 2009-12-24
EP1286668B1 (en) 2005-04-27
SK8062002A3 (en) 2003-04-01
RU2002118316A (ru) 2004-02-20
IL149496A0 (en) 2002-11-10
AR026916A1 (es) 2003-03-05
PT1286668E (pt) 2005-08-31
SG152025A1 (en) 2009-05-29
DE60019814D1 (de) 2005-06-02
AU2005200797A1 (en) 2005-03-17
CN1310644C (zh) 2007-04-18
NZ566800A (en) 2009-11-27
EP1488788A1 (en) 2004-12-22
CZ20021967A3 (cs) 2002-08-14
JP2003523324A (ja) 2003-08-05
NO20022680L (no) 2002-08-12
RU2264215C2 (ru) 2005-11-20
AU778869B2 (en) 2004-12-23
EP1286668A2 (en) 2003-03-05
ES2240229T3 (es) 2005-10-16
AU2672801A (en) 2001-06-18
BR0016275A (pt) 2002-08-27
CA2388959A1 (en) 2001-06-14

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