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PE109198A1 - Compuestos 1,4-heterociclicos inhibidores de metaloproteasas - Google Patents

Compuestos 1,4-heterociclicos inhibidores de metaloproteasas

Info

Publication number
PE109198A1
PE109198A1 PE1997000770A PE00077097A PE109198A1 PE 109198 A1 PE109198 A1 PE 109198A1 PE 1997000770 A PE1997000770 A PE 1997000770A PE 00077097 A PE00077097 A PE 00077097A PE 109198 A1 PE109198 A1 PE 109198A1
Authority
PE
Peru
Prior art keywords
alkyl
heteroaryl
aryl
heteroalkyl
alcoxi
Prior art date
Application number
PE1997000770A
Other languages
English (en)
Inventor
Randall Stryker Matthews
Biswanath De
Yetunde Olabisi Taiwo
Michael George Natchus
Stanislaw Pikul
Neil Gregory Almstead
Menyan Cheng
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE109198A1 publication Critical patent/PE109198A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
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    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
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  • AIDS & HIV (AREA)
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  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
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Abstract

SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: Ar ES COR3 o SO2R4; "W" ES H, ALQUILO o UN PUENTE (ALQUILENO, ARILENO o HETEROARILENO); "X" ES O, S, SO, SO2 o NR5; "Y" ES H, OH, SR10, SOR4, SO2R4, ALCOXI o NR11R12; "Z" ES UNA PORCION ESPIRO, UN GRUPO OXO o NO EXISTE; R1 ES H; R2 ES H, ALQUILO o ACILO; R3 ES ALCOXI, ARILOXI, HETEROARILOXI, ENTRE OTROS; R4 ES ALQUILO, HETEROALQUILO, ARILO o HETEROARILO; R5 ES H, ALQUILO, HETEROALQUILO, HETEROARILO, ARILO, SO2R6, COR7, CSR8, PO(R9)2 O FORMAN UN ANILLO CON "W"; R6 ES ALQUILO, ARILO, HETEROARILO, ENTRE OTROS; R7 ES H, ALCOXI, ARILOXI, ENTRE OTROS; R8 ES ALQUILO, ARILO, HETEROARILO, HETEROALQUILO, ENTRE OTROS; R9 ES ALQUILO, ARILO, HETEROARILO, HETEROALQUILO; R10 ES H, ALQUILO, ARILO, HETEROARILO; R11 Y R12 SON H, ALQUILO, HETEROALQUILO, ENTRE OTROS. LOS COMPUESTOS DE FORMULA (I) ACTUAN COMO INHIBIDORES DE LAS ENZIMAS METALOPROTEASAS DE MATRIZ, SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDEA, OSTEOARTRITIS, METASTASIS DE CELULAS TUMORALES, DESORDENES CARDIOVASCULARES, DESORDENES OCULARES Y LESIONES ULCERATIVAS, ENTRE OTROS
PE1997000770A 1996-08-28 1997-08-28 Compuestos 1,4-heterociclicos inhibidores de metaloproteasas PE109198A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2476496P 1996-08-28 1996-08-28

Publications (1)

Publication Number Publication Date
PE109198A1 true PE109198A1 (es) 1999-01-31

Family

ID=21822288

Family Applications (2)

Application Number Title Priority Date Filing Date
PE1997000770A PE109198A1 (es) 1996-08-28 1997-08-28 Compuestos 1,4-heterociclicos inhibidores de metaloproteasas
PE1997000766A PE108998A1 (es) 1996-08-28 1997-08-28 Compuestos heterociclicos inhibidores de metaloproteasas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE1997000766A PE108998A1 (es) 1996-08-28 1997-08-28 Compuestos heterociclicos inhibidores de metaloproteasas

Country Status (25)

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US (3) US6166005A (es)
EP (2) EP0923563A1 (es)
JP (2) JP2000515166A (es)
KR (2) KR20000035917A (es)
CN (2) CN1228773A (es)
AR (1) AR009356A1 (es)
AT (1) ATE231132T1 (es)
AU (2) AU731319B2 (es)
BR (2) BR9713185A (es)
CA (2) CA2264045A1 (es)
CO (2) CO4920241A1 (es)
CZ (2) CZ62399A3 (es)
DE (1) DE69718480T2 (es)
DK (1) DK0925287T3 (es)
HU (2) HUP0000591A3 (es)
ID (2) ID18142A (es)
IL (2) IL128663A0 (es)
NO (2) NO990760L (es)
NZ (2) NZ334253A (es)
PE (2) PE109198A1 (es)
PL (2) PL331856A1 (es)
SK (2) SK25199A3 (es)
TR (2) TR199900400T2 (es)
WO (2) WO1998008827A1 (es)
ZA (2) ZA977695B (es)

Families Citing this family (61)

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KR19990072009A (ko) * 1995-08-12 1999-09-27 게리 이. 프리드만 메탈로프로티나제 방해제, 그를 포함하는 약제 조성물 및 약제로서의 용도, 그리고 그의 제조방법 및 제조에 유용한 중간체
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
TR199900400T2 (xx) * 1996-08-28 1999-05-21 The Procter & Gamble Company Heterosiklik metaloproteaz inhibit�rleri.
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
EP0948489A1 (en) 1996-12-17 1999-10-13 Fujisawa Pharmaceutical Co., Ltd. Piperazine compounds as inhibitors of mmp or tnf
EA002546B1 (ru) 1997-02-11 2002-06-27 Пфайзер Инк. Производные арилсульфонилгидроксамовой кислоты
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
WO1998050348A1 (en) * 1997-05-09 1998-11-12 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
EP1009737A2 (en) 1997-07-31 2000-06-21 The Procter & Gamble Company Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors
US6403632B1 (en) * 2000-03-01 2002-06-11 Bristol Myers Squibb Pharma Co Lactam metalloprotease inhibitors
US6107291A (en) * 1997-12-19 2000-08-22 Amgen Inc. Azepine or larger medium ring derivatives and methods of use
EP1053226A1 (en) 1998-02-04 2000-11-22 Novartis AG Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
US6410580B1 (en) 1998-02-04 2002-06-25 Novartis Ag Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
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