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PE109098A1 - Amina ciclica sustituida util como inhibidor de metaloproteasas - Google Patents

Amina ciclica sustituida util como inhibidor de metaloproteasas

Info

Publication number
PE109098A1
PE109098A1 PE1997000768A PE00076897A PE109098A1 PE 109098 A1 PE109098 A1 PE 109098A1 PE 1997000768 A PE1997000768 A PE 1997000768A PE 00076897 A PE00076897 A PE 00076897A PE 109098 A1 PE109098 A1 PE 109098A1
Authority
PE
Peru
Prior art keywords
alkyl
alcoxi
heteroaryl
aryl
disorders
Prior art date
Application number
PE1997000768A
Other languages
English (en)
Inventor
Biswanath De
Yetunde Olabisi Taiwo
Michael George Natchus
Neil Gregory Almstead
Stanislaw Pikul
Menyan Cheng
Roger Gunnard Bookland
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE109098A1 publication Critical patent/PE109098A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/42—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Confectionery (AREA)
  • Peptides Or Proteins (AREA)
  • Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIEREN A COMPUESTOS DE FORMULA (I) SU ISOMERO, DIASTEROISOMERO O ENANTIOMERO OPTICO, O SU SAL, ESTER, AMIDA O IMIDA BIOHIDROLIZABLE, EN DONDE: Ar ES ALQUILO, HETEROALQUILO, ARILO O HETEROARILO, DE PREFERENCIA ES FENILO SUSTITUIDO CON METOXI, NITRO o BUTOXI; "W" ES H, ALQUILO INFERIOR o UN PUENTE ALQUILENO; "Y" ES OH, SO2R5, ALCOXI o NR6R7; "Z" ES H, OH, ALQUILO, ALQUILENO o HETEROALQUILENO; R1 ES OH, ALCOXI, NHOR2; R2 ES H o ALQUILO; R6 Y R7 SON H, ALQUILO, HETEROARILO, ARILO, SO2R8, COR9, ENTRE OTROS; R8 ES ALQUILO, ARILO, HETEROARILO, ENTRE OTROS; R9 ES H, ALCOXI, ARILOXI, ENTRE OTROS; n ES 1; 2 o 3; UN COMPUESTO (I) PREFERIDO ES (1N)-(4-METOXIFENILSULFONIL)-(2 -R o -S)-N-HIDROXICARBOXAMIDO-(4 -R o -S)-HIDROXIPIRROLIDINA. LOS COMPUESTOS DE FORMULA (I) ACTUAN COMO INHIBIDORES DE LAS ENZIMAS METALOPROTEASAS, SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDEA, OSTEOARTRITIS, METASTASIS DE CELULAS TUMORALES, DESORDENES CARDIOVASCULARES, DESORDENES OCULARES Y CONDICIONES ULCERATIVAS, ENTRE OTROS
PE1997000768A 1996-08-28 1997-08-28 Amina ciclica sustituida util como inhibidor de metaloproteasas PE109098A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2484296P 1996-08-28 1996-08-28

Publications (1)

Publication Number Publication Date
PE109098A1 true PE109098A1 (es) 1999-02-19

Family

ID=21822685

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000768A PE109098A1 (es) 1996-08-28 1997-08-28 Amina ciclica sustituida util como inhibidor de metaloproteasas

Country Status (29)

Country Link
US (6) US6417219B1 (es)
EP (1) EP0927161B1 (es)
JP (2) JP3541043B2 (es)
KR (1) KR100323272B1 (es)
CN (1) CN1232451A (es)
AT (1) ATE226193T1 (es)
AU (1) AU741893B2 (es)
BR (1) BR9713465A (es)
CA (1) CA2263928A1 (es)
CO (1) CO4900036A1 (es)
CZ (1) CZ63199A3 (es)
DE (1) DE69716449T2 (es)
DK (1) DK0927161T3 (es)
ES (1) ES2201318T3 (es)
HU (1) HUP0000478A3 (es)
ID (1) ID18143A (es)
IL (1) IL128666A (es)
MY (1) MY116959A (es)
NO (1) NO315371B1 (es)
NZ (1) NZ334256A (es)
PE (1) PE109098A1 (es)
PL (1) PL331802A1 (es)
PT (1) PT927161E (es)
RU (1) RU2221782C2 (es)
SK (1) SK25099A3 (es)
TR (1) TR199900431T2 (es)
TW (1) TWI232218B (es)
WO (1) WO1998008815A1 (es)
ZA (1) ZA977698B (es)

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ZA977698B (en) 1998-02-23
PL331802A1 (en) 1999-08-02
PT927161E (pt) 2003-12-31
TR199900431T2 (xx) 1999-04-21
US20020061877A1 (en) 2002-05-23
IL128666A0 (en) 2000-01-31
JP3541043B2 (ja) 2004-07-07
NO990855L (no) 1999-04-23
ID18143A (id) 1998-03-05
JP2004115531A (ja) 2004-04-15
NO990855D0 (no) 1999-02-23
WO1998008815A1 (en) 1998-03-05
US6569855B2 (en) 2003-05-27
EP0927161B1 (en) 2002-10-16
JP2000516955A (ja) 2000-12-19
US20020072517A1 (en) 2002-06-13
CN1232451A (zh) 1999-10-20
HUP0000478A3 (en) 2000-10-30
DK0927161T3 (da) 2003-02-17
MY116959A (en) 2004-04-30
TWI232218B (en) 2005-05-11
HUP0000478A2 (hu) 2000-09-28
CZ63199A3 (cs) 1999-08-11
ATE226193T1 (de) 2002-11-15
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EP0927161A1 (en) 1999-07-07
US20030191163A1 (en) 2003-10-09
AU741893B2 (en) 2001-12-13
NO315371B1 (no) 2003-08-25
IL128666A (en) 2005-09-25
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US6858628B2 (en) 2005-02-22
DE69716449D1 (de) 2002-11-21
NZ334256A (en) 2000-11-24
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US20050101567A1 (en) 2005-05-12
AU4074197A (en) 1998-03-19
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US6417219B1 (en) 2002-07-09
BR9713465A (pt) 2000-03-28
RU2221782C2 (ru) 2004-01-20
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US20050154019A1 (en) 2005-07-14
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