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NO990855L - Substituerte sykliske amin-metallprotease-inhibitorer - Google Patents

Substituerte sykliske amin-metallprotease-inhibitorer

Info

Publication number
NO990855L
NO990855L NO990855A NO990855A NO990855L NO 990855 L NO990855 L NO 990855L NO 990855 A NO990855 A NO 990855A NO 990855 A NO990855 A NO 990855A NO 990855 L NO990855 L NO 990855L
Authority
NO
Norway
Prior art keywords
protease inhibitors
cyclic amine
substituted cyclic
metal protease
amine metal
Prior art date
Application number
NO990855A
Other languages
English (en)
Other versions
NO990855D0 (no
NO315371B1 (no
Inventor
Michael George Natchus
Biswanath De
Stanislaw Pikul
Neil Gregory Almstead
Roger Gunnard Bookland
Yetunde Olabisi Taiwo
Menyan Cheng
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO990855D0 publication Critical patent/NO990855D0/no
Publication of NO990855L publication Critical patent/NO990855L/no
Publication of NO315371B1 publication Critical patent/NO315371B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/42—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Confectionery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Catalysts (AREA)
  • Peptides Or Proteins (AREA)
NO19990855A 1996-08-28 1999-02-23 Substituerte sykliske amin-metallprotease-inhibitorer NO315371B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2484296P 1996-08-28 1996-08-28
PCT/US1997/014555 WO1998008815A1 (en) 1996-08-28 1997-08-22 Substituted cyclic amine metalloprotease inhibitors

Publications (3)

Publication Number Publication Date
NO990855D0 NO990855D0 (no) 1999-02-23
NO990855L true NO990855L (no) 1999-04-23
NO315371B1 NO315371B1 (no) 2003-08-25

Family

ID=21822685

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19990855A NO315371B1 (no) 1996-08-28 1999-02-23 Substituerte sykliske amin-metallprotease-inhibitorer

Country Status (29)

Country Link
US (6) US6417219B1 (no)
EP (1) EP0927161B1 (no)
JP (2) JP3541043B2 (no)
KR (1) KR100323272B1 (no)
CN (1) CN1232451A (no)
AT (1) ATE226193T1 (no)
AU (1) AU741893B2 (no)
BR (1) BR9713465A (no)
CA (1) CA2263928A1 (no)
CO (1) CO4900036A1 (no)
CZ (1) CZ63199A3 (no)
DE (1) DE69716449T2 (no)
DK (1) DK0927161T3 (no)
ES (1) ES2201318T3 (no)
HU (1) HUP0000478A3 (no)
ID (1) ID18143A (no)
IL (1) IL128666A (no)
MY (1) MY116959A (no)
NO (1) NO315371B1 (no)
NZ (1) NZ334256A (no)
PE (1) PE109098A1 (no)
PL (1) PL331802A1 (no)
PT (1) PT927161E (no)
RU (1) RU2221782C2 (no)
SK (1) SK25099A3 (no)
TR (1) TR199900431T2 (no)
TW (1) TWI232218B (no)
WO (1) WO1998008815A1 (no)
ZA (1) ZA977698B (no)

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US6872742B2 (en) * 1996-08-28 2005-03-29 The Procter & Gamble Company Substituted cyclic amine metalloprotease inhibitors
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US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
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KR20140072894A (ko) * 2011-10-04 2014-06-13 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 신규의 세포사멸 유도 화합물
TW201825458A (zh) 2016-09-20 2018-07-16 英商葛蘭素史克智慧財產（第二）有限公司 Ｔｒｐｖ４拮抗劑
EP3515889A1 (en) 2016-09-20 2019-07-31 GlaxoSmithKline Intellectual Property (No. 2) Limited Trpv4 antagonists
CN109790116B (zh) 2016-09-20 2022-10-28 葛兰素史密斯克莱知识产权（第2 号）有限公司 Trpv4拮抗剂
CN110709096B (zh) 2017-05-05 2023-10-31 泽兰德制药公司 细胞间隙连接通讯调节剂及其在糖尿病性眼病治疗中的应用

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Also Published As

Publication number Publication date
US6417219B1 (en) 2002-07-09
DE69716449T2 (de) 2003-08-07
US20030191163A1 (en) 2003-10-09
WO1998008815A1 (en) 1998-03-05
KR20000035922A (ko) 2000-06-26
PE109098A1 (es) 1999-02-19
US6858628B2 (en) 2005-02-22
US20020072517A1 (en) 2002-06-13
NZ334256A (en) 2000-11-24
HK1020962A1 (en) 2000-05-26
ID18143A (id) 1998-03-05
IL128666A (en) 2005-09-25
NO990855D0 (no) 1999-02-23
ZA977698B (en) 1998-02-23
US20020061877A1 (en) 2002-05-23
ES2201318T3 (es) 2004-03-16
MY116959A (en) 2004-04-30
ATE226193T1 (de) 2002-11-15
KR100323272B1 (ko) 2002-02-06
TWI232218B (en) 2005-05-11
EP0927161B1 (en) 2002-10-16
US20050101567A1 (en) 2005-05-12
PL331802A1 (en) 1999-08-02
US20050154019A1 (en) 2005-07-14
AU4074197A (en) 1998-03-19
RU2221782C2 (ru) 2004-01-20
DE69716449D1 (de) 2002-11-21
PT927161E (pt) 2003-12-31
HUP0000478A3 (en) 2000-10-30
NO315371B1 (no) 2003-08-25
TR199900431T2 (xx) 1999-04-21
AU741893B2 (en) 2001-12-13
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CZ63199A3 (cs) 1999-08-11
HUP0000478A2 (hu) 2000-09-28
CO4900036A1 (es) 2000-03-27
JP2000516955A (ja) 2000-12-19
US6569855B2 (en) 2003-05-27
DK0927161T3 (da) 2003-02-17
CN1232451A (zh) 1999-10-20
JP2004115531A (ja) 2004-04-15
CA2263928A1 (en) 1998-03-05
IL128666A0 (en) 2000-01-31
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EP0927161A1 (en) 1999-07-07
BR9713465A (pt) 2000-03-28

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