|
JPH0193801A
(ja)
*
|
1987-10-05 |
1989-04-12 |
Fanuc Ltd |
コントロールプログラムのローディング装置
|
|
GB9114760D0
(en)
*
|
1991-07-09 |
1991-08-28 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9119704D0
(en)
*
|
1991-09-14 |
1991-10-30 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9121028D0
(en)
*
|
1991-10-03 |
1991-11-13 |
Pfizer Ltd |
Therapeutic agents
|
|
US5294612A
(en)
*
|
1992-03-30 |
1994-03-15 |
Sterling Winthrop Inc. |
6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
|
|
DE4211239C2
(de)
*
|
1992-04-03 |
1995-11-16 |
Max Planck Gesellschaft |
Arzneimittel gegen Herz-Kreislauf-Erkrankungen
|
|
GB9218322D0
(en)
*
|
1992-08-28 |
1992-10-14 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9311920D0
(en)
*
|
1993-06-09 |
1993-07-28 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9312853D0
(en)
|
1993-06-22 |
1993-08-04 |
Euro Celtique Sa |
Chemical compounds
|
|
US6143746A
(en)
*
|
1994-01-21 |
2000-11-07 |
Icos Corporation |
Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
|
|
GB9514465D0
(en)
*
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Chemical compounds
|
|
JP3726306B2
(ja)
*
|
1994-04-27 |
2005-12-14 |
日産化学工業株式会社 |
ピラゾールカルボン酸誘導体および植物病害防除剤
|
|
US5922751A
(en)
|
1994-06-24 |
1999-07-13 |
Euro-Celtique, S.A. |
Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
|
|
US5591776A
(en)
|
1994-06-24 |
1997-01-07 |
Euro-Celtique, S.A. |
Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
|
|
US5696159A
(en)
*
|
1994-08-03 |
1997-12-09 |
Cell Pathways, Inc. |
Lactone compounds for treating patients with precancerous lesions
|
|
US5776962A
(en)
*
|
1994-08-03 |
1998-07-07 |
Cell Pathways, Inc. |
Lactone compounds for treating patient with precancerous lesions
|
|
GB9423911D0
(en)
|
1994-11-26 |
1995-01-11 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9423910D0
(en)
|
1994-11-26 |
1995-01-11 |
Pfizer Ltd |
Therapeutic agents
|
|
WO1996028448A1
(en)
*
|
1995-03-10 |
1996-09-19 |
Sanofi Winthrop, Inc. |
6-ARYL PYRAZOLO[3,4-d]PYRIMIDIN-4-ONES AND COMPOSITIONS AND METHODS OF USE THEREOF
|
|
US5656629A
(en)
*
|
1995-03-10 |
1997-08-12 |
Sanofi Winthrop, Inc. |
6-substituted pyrazolo (3,4-d)pyrimidin-4-ones and compositions and methods of use thereof
|
|
US6046206A
(en)
*
|
1995-06-07 |
2000-04-04 |
Cell Pathways, Inc. |
Method of treating a patient having a precancerous lesions with amide quinazoline derivatives
|
|
US6262059B1
(en)
|
1995-06-07 |
2001-07-17 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with quinazoline derivatives
|
|
US6200980B1
(en)
|
1995-06-07 |
2001-03-13 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl purinone derivatives
|
|
US6046216A
(en)
*
|
1995-06-07 |
2000-04-04 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives
|
|
US5874440A
(en)
*
|
1995-06-07 |
1999-02-23 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl pyrimidinone derivatives
|
|
US6232312B1
(en)
|
1995-06-07 |
2001-05-15 |
Cell Pathways, Inc. |
Method for treating patient having precancerous lesions with a combination of pyrimidopyrimidine derivatives and esters and amides of substituted indenyl acetic acides
|
|
US6060477A
(en)
*
|
1995-06-07 |
2000-05-09 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
|
|
GB9514473D0
(en)
*
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Chemical compounds
|
|
GB9514464D0
(en)
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Medicaments
|
|
US6166041A
(en)
|
1995-10-11 |
2000-12-26 |
Euro-Celtique, S.A. |
2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
|
|
US6075016A
(en)
|
1996-04-10 |
2000-06-13 |
Euro-Celtique S.A. |
6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
|
|
SK154498A3
(en)
|
1996-05-10 |
2000-01-18 |
Icos Corp |
Carboline derivatives, process for the preparation thereof, pharmaceutical compositions containing same and use of mentioned derivatives as drugs
|
|
GB9612514D0
(en)
*
|
1996-06-14 |
1996-08-14 |
Pfizer Ltd |
Novel process
|
|
HRP970348A2
(en)
*
|
1996-07-17 |
1998-04-30 |
Bayer Ag |
New nitropyrazole esters, process for their preparation and their use for the preparation of nytropyrazolamides
|
|
US6331543B1
(en)
|
1996-11-01 |
2001-12-18 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
|
|
USRE37234E1
(en)
*
|
1996-11-01 |
2001-06-19 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
|
|
US5958926A
(en)
|
1996-11-01 |
1999-09-28 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
|
|
AU722480B2
(en)
*
|
1996-11-01 |
2000-08-03 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
|
|
DE19701277A1
(de)
*
|
1997-01-16 |
1998-07-23 |
Bayer Ag |
Verfahren zur Herstellung von 1-Alkyl-pyrazol-5-carbonsäureestern
|
|
KR100390612B1
(ko)
|
1997-04-25 |
2003-07-07 |
화이자 인코포레이티드 |
타입 5 시클릭 구아노신 3',5'-모노포스페이트포스포디에스테라제를 억제하는 성기능 장애 치료용피라졸로피리미디논 제조용 중간체의 제조 방법
|
|
US5858694A
(en)
*
|
1997-05-30 |
1999-01-12 |
Cell Pathways, Inc. |
Method for identifying compounds for inhibition of cancerous lesions
|
|
CA2238283C
(en)
|
1997-05-30 |
2002-08-20 |
Cell Pathways, Inc. |
Method for identifying compounds for inhibition of neoplastic lesions, pharmaceutical compositions from such compounds and uses of such compounds and compositions for treating neoplastic lesions
|
|
US20020025969A1
(en)
*
|
1997-07-09 |
2002-02-28 |
Wolf-Georg Forssmann |
Use of phosphordiesterase inhibitors in the treatment of prostatic diseases
|
|
GB9722520D0
(en)
|
1997-10-24 |
1997-12-24 |
Pfizer Ltd |
Compounds
|
|
US6472425B1
(en)
|
1997-10-31 |
2002-10-29 |
Nitromed, Inc. |
Methods for treating female sexual dysfunctions
|
|
DE19750085A1
(de)
*
|
1997-11-12 |
1999-05-20 |
Bayer Ag |
2-Phenyl-substituierte Imidazotriazinone
|
|
IL135462A0
(en)
*
|
1997-11-12 |
2001-05-20 |
Bayer Ag |
2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
|
|
US5852035A
(en)
*
|
1997-12-12 |
1998-12-22 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to substituted N- arylmethyl and heterocyclmethyl-1H-pyrazolo (3,4-B) quinolin-4-amines
|
|
US6410584B1
(en)
|
1998-01-14 |
2002-06-25 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells with indole derivatives
|
|
US6046199A
(en)
*
|
1998-01-14 |
2000-04-04 |
Cell Pathways, Inc. |
Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives
|
|
US5942520A
(en)
*
|
1998-01-27 |
1999-08-24 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines
|
|
US5990117A
(en)
*
|
1998-04-15 |
1999-11-23 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives
|
|
SK15532000A3
(sk)
|
1998-04-20 |
2001-12-03 |
Pfizer Inc. |
Pyrazolopyrimidínové inhibítory cgmp pde5 na použitie na liečbu sexuálnych dysfunkcií, spôsob ich prípravy, medziprodukty a farmaceutický prostriedok s ich obsahom
|
|
CA2235642C
(en)
|
1998-05-15 |
2007-11-13 |
Torcan Chemical Ltd. |
Processes for preparing sildenafil
|
|
US6087368A
(en)
*
|
1998-06-08 |
2000-07-11 |
Bristol-Myers Squibb Company |
Quinazolinone inhibitors of cGMP phosphodiesterase
|
|
US6200591B1
(en)
*
|
1998-06-25 |
2001-03-13 |
Anwar A. Hussain |
Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
|
|
DE19829616A1
(de)
|
1998-07-02 |
2000-01-05 |
Bayer Ag |
Verfahren zur Herstellung von 1-Alkyl-pyrazol-5-carbonsäureestern
|
|
DE19834507A1
(de)
*
|
1998-07-31 |
2000-02-03 |
Hexal Ag |
Pharmazeutische, wasserlösliche Tablettenformulierung zur Anwendung von Sildenafil
|
|
DE19834506A1
(de)
*
|
1998-07-31 |
2000-02-03 |
Hexal Ag |
Transmucosales therapeutisches System zur Anwendung von Sildenafil
|
|
US6180629B1
(en)
|
1998-08-14 |
2001-01-30 |
Cell Pathways, Inc. |
[4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia
|
|
US6268372B1
(en)
|
1998-09-11 |
2001-07-31 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones
|
|
US6124303A
(en)
*
|
1998-09-11 |
2000-09-26 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 9-substituted 2-(2-N-aloxyphenyl) purin-6-ones
|
|
GB9822238D0
(en)
*
|
1998-10-12 |
1998-12-09 |
Pfizer Ltd |
Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
|
|
US6200771B1
(en)
|
1998-10-15 |
2001-03-13 |
Cell Pathways, Inc. |
Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
|
|
US6130053A
(en)
*
|
1999-08-03 |
2000-10-10 |
Cell Pathways, Inc. |
Method for selecting compounds for inhibition of neoplastic lesions
|
|
GB9823101D0
(en)
|
1998-10-23 |
1998-12-16 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
AU5995699A
(en)
*
|
1998-10-23 |
2000-05-15 |
Bunnage, Mark Edward |
Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction
|
|
GB9823103D0
(en)
|
1998-10-23 |
1998-12-16 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
GB9823102D0
(en)
|
1998-10-23 |
1998-12-16 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
UA67802C2
(uk)
|
1998-10-23 |
2004-07-15 |
Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. |
Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції
|
|
KR100353014B1
(ko)
*
|
1998-11-11 |
2002-09-18 |
동아제약 주식회사 |
발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물
|
|
RU2220145C2
(ru)
*
|
1998-11-11 |
2003-12-27 |
Донг А Фарм. Ко., Лтд. |
Производные пиразолопиримидинона для лечения импотенции и способ их получения
|
|
US6133271A
(en)
*
|
1998-11-19 |
2000-10-17 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
|
|
EP1002798A1
(en)
*
|
1998-11-20 |
2000-05-24 |
Orchid Chemicals & Pharmaceuticals Ltd. |
An improved process for preparing a therapeutically active pyrazolopyrimidinone derivative
|
|
US6187779B1
(en)
|
1998-11-20 |
2001-02-13 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
|
|
US6369092B1
(en)
|
1998-11-23 |
2002-04-09 |
Cell Pathways, Inc. |
Method for treating neoplasia by exposure to substituted benzimidazole derivatives
|
|
US6034099A
(en)
*
|
1998-11-24 |
2000-03-07 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
|
|
US6077842A
(en)
*
|
1998-11-24 |
2000-06-20 |
Cell Pathways, Inc. |
Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives
|
|
US6486155B1
(en)
|
1998-11-24 |
2002-11-26 |
Cell Pathways Inc |
Method of inhibiting neoplastic cells with isoquinoline derivatives
|
|
AU3347300A
(en)
*
|
1999-01-28 |
2000-08-18 |
Sepracor, Inc. |
Desmethylsildenafil compositions and methods
|
|
US6025394A
(en)
|
1999-01-29 |
2000-02-15 |
Cell Pathways, Inc. |
Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
|
|
US6020379A
(en)
*
|
1999-02-19 |
2000-02-01 |
Cell Pathways, Inc. |
Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
|
|
JP2002538121A
(ja)
*
|
1999-03-03 |
2002-11-12 |
メルク エンド カムパニー インコーポレーテッド |
プレニルタンパク質トランスフェラーゼの阻害剤
|
|
WO2000078760A1
(en)
*
|
1999-06-21 |
2000-12-28 |
The Biochemical Pharmaceutical Factory Of Zhuhai Sez |
Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
|
|
CN1094492C
(zh)
*
|
1999-06-21 |
2002-11-20 |
杭州神鹰医药化工有限公司 |
西地那非的制备方法
|
|
US7235625B2
(en)
|
1999-06-29 |
2007-06-26 |
Palatin Technologies, Inc. |
Multiple agent therapy for sexual dysfunction
|
|
CN1077108C
(zh)
*
|
1999-07-13 |
2002-01-02 |
成都地奥制药集团有限公司 |
用于制备药物昔多芬的前体化合物
|
|
IL130968A
(en)
|
1999-07-15 |
2002-12-01 |
Shmuel Simon |
Pharmaceutical composition comprising sildenafil or its analogs, useful for the treatment of tinnitus and hearing loss
|
|
ES2166270B1
(es)
*
|
1999-07-27 |
2003-04-01 |
Almirall Prodesfarma Sa |
Derivados de 8-fenil-6,9-dihidro-(1,2,4,)triazolo(3,4-i)purin-5-ona.
|
|
EP1077214A1
(en)
*
|
1999-08-16 |
2001-02-21 |
Orchid Chemicals & Pharmaceuticals Ltd. |
An improved process for preparing a pyrazolopyrimidinone derivative
|
|
WO2001019827A1
(en)
*
|
1999-09-13 |
2001-03-22 |
Cipla Ltd. |
A novel process for the synthesis of sildenafil citrate
|
|
TWI265925B
(en)
*
|
1999-10-11 |
2006-11-11 |
Pfizer |
Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
|
|
GB9924020D0
(en)
|
1999-10-11 |
1999-12-15 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
NZ517324A
(en)
*
|
1999-10-11 |
2003-09-26 |
Pfizer |
5-(2-substituted-5-heterocyclylsulphonylpyrid-3-YL)- dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors
|
|
WO2001047934A1
(de)
|
1999-12-24 |
2001-07-05 |
Bayer Aktiengesellschaft |
Isoxazolopyrimidinone und ihre verwendung
|
|
CN1434825A
(zh)
|
1999-12-24 |
2003-08-06 |
拜尔公司 |
咪唑并[1,3,5]三嗪酮及其应用
|
|
ES2231311T3
(es)
|
1999-12-24 |
2005-05-16 |
Bayer Healthcare Ag |
Triazolotriazinonas y su uso.
|
|
KR100358083B1
(ko)
*
|
2000-02-17 |
2002-10-25 |
에스케이케미칼주식회사 |
피롤로피리미디논 유도체와 이의 제조방법, 그리고 이의용도
|
|
US6555547B1
(en)
|
2000-02-28 |
2003-04-29 |
Cell Pathways, Inc. |
Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative
|
|
US6569638B1
(en)
|
2000-03-03 |
2003-05-27 |
Cell Pathways, Inc |
Method for screening compounds for the treatment of neoplasia
|
|
AU2000254308A1
(en)
*
|
2000-05-17 |
2001-11-26 |
Sk Chemicals Co., Ltd. |
Pyrazolopyrimidinone derivatives, process for their preparation and their use
|
|
GB0015462D0
(en)
*
|
2000-06-22 |
2000-08-16 |
Pfizer Ltd |
Novel process for the preparation of pyrazolopyrimidinones
|
|
JP2004501154A
(ja)
*
|
2000-06-22 |
2004-01-15 |
ファイザー・インク |
ピラゾロピリミジノン製造のための新規方法
|
|
US6667398B2
(en)
|
2000-06-22 |
2003-12-23 |
Pfizer Inc |
Process for the preparation of pyrazolopyrimidinones
|
|
US6730786B2
(en)
|
2000-06-22 |
2004-05-04 |
Pfizer Inc |
Process for the preparation of pyrazolopyrimidinones
|
|
KR100377782B1
(ko)
*
|
2000-06-23 |
2003-03-29 |
동아제약 주식회사 |
발기부전 치료에 효과를 갖는 피라졸로피리미디논화합물의 제조방법
|
|
US6809200B2
(en)
|
2000-07-28 |
2004-10-26 |
Pfizer Inc. |
Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-one compounds and intermediates thereof
|
|
US6407259B1
(en)
|
2000-07-28 |
2002-06-18 |
Pfizer Inc. |
Process for the preparation of pyrazoles
|
|
EP1176142A1
(en)
*
|
2000-07-28 |
2002-01-30 |
Pfizer Inc. |
Process for the preparation of pyrazoles
|
|
EP1176147A1
(en)
*
|
2000-07-28 |
2002-01-30 |
Pfizer Limited |
Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof
|
|
WO2002013798A2
(en)
*
|
2000-08-11 |
2002-02-21 |
Pfizer Limited |
Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors
|
|
PE20020394A1
(es)
|
2000-08-18 |
2002-06-21 |
Agouron Pharma |
Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
|
|
WO2002016364A1
(en)
*
|
2000-08-23 |
2002-02-28 |
Lg Life Sciences Ltd. |
Polyethoxylated pyrazolo pyrimidinone derivatives, process for preparation thereof and pharmaceutical compositions comprising the same for the treatment of impotence
|
|
CN1642973A
(zh)
*
|
2000-09-06 |
2005-07-20 |
奥索-麦克尼尔药品公司 |
治疗变态反应的方法
|
|
US6821978B2
(en)
|
2000-09-19 |
2004-11-23 |
Schering Corporation |
Xanthine phosphodiesterase V inhibitors
|
|
US6548508B2
(en)
|
2000-10-20 |
2003-04-15 |
Pfizer, Inc. |
Use of PDE V inhibitors for improved fecundity in mammals
|
|
EP1211313A3
(en)
*
|
2000-11-01 |
2003-04-23 |
Pfizer Limited |
Modulation of PDE11A activity
|
|
US6828473B2
(en)
|
2000-11-01 |
2004-12-07 |
Pfizer Inc. |
Modulation of PDE11A activity
|
|
SE0004780D0
(sv)
|
2000-12-22 |
2000-12-22 |
Jordanian Pharmaceutical Mfg & |
Novel compunds
|
|
DE10118306A1
(de)
|
2001-04-12 |
2002-10-17 |
Bayer Ag |
Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation
|
|
CN1127506C
(zh)
|
2001-06-29 |
2003-11-12 |
刘宝顺 |
一种治疗阳痿的新化合物
|
|
DE10135815A1
(de)
*
|
2001-07-23 |
2003-02-06 |
Bayer Ag |
Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
|
|
RU2278863C2
(ru)
*
|
2001-08-10 |
2006-06-27 |
Орто-Макнейл Фармасьютикал, Инк. |
Замещенные пиразолы, фармацевтическая композиция и способ ингибирования активности катепсина s
|
|
RU2286343C2
(ru)
*
|
2001-08-10 |
2006-10-27 |
Орто-Макнейл Фармасьютикал, Инк. |
Замещенные пиразолы
|
|
US6479493B1
(en)
|
2001-08-23 |
2002-11-12 |
Cell Pathways, Inc. |
Methods for treatment of type I diabetes
|
|
AR036674A1
(es)
|
2001-08-28 |
2004-09-29 |
Schering Corp |
Inhibidores de fosfodiesterasa v de guanina de policiclicos, composicion farmaceutica, y el uso de dichos compuestos para la preparacion de medicamentos para tratar desordenes fisiologicos
|
|
DE10155018A1
(de)
*
|
2001-11-07 |
2003-07-10 |
Berolina Drug Dev Ab Svedala |
Deuterierte Pyrazolopyrimidinone sowie diese Verbindungen enthaltende Arzneimittel
|
|
EP1442042A1
(en)
|
2001-11-09 |
2004-08-04 |
Schering Corporation |
Polycyclic guanine derivative phosphodiesterase v inhibitors
|
|
ES2294189T3
(es)
|
2001-12-13 |
2008-04-01 |
Asubio Pharma Co., Ltd. |
Derivados de pirazolopirimidinona que tienen accion inhibidora de pde7.
|
|
CA2469075C
(en)
|
2001-12-20 |
2011-09-13 |
Applied Research Systems Ars Holding N.V. |
Pyrrolidine derivatives as prostaglandin modulators
|
|
GB0202282D0
(en)
|
2002-01-31 |
2002-03-20 |
Pfizer Ltd |
Treatment of male sexual dysfunction
|
|
US6962940B2
(en)
|
2002-03-20 |
2005-11-08 |
Celgene Corporation |
(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
|
|
US7893101B2
(en)
|
2002-03-20 |
2011-02-22 |
Celgene Corporation |
Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
|
|
US7208516B2
(en)
|
2002-03-20 |
2007-04-24 |
Celgene Corporation |
Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
|
US7276529B2
(en)
|
2002-03-20 |
2007-10-02 |
Celgene Corporation |
Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
|
KR100435514B1
(ko)
*
|
2002-03-22 |
2004-06-10 |
한미약품 주식회사 |
실데나필 젖산염의 속효제형
|
|
EP1348707B1
(en)
*
|
2002-03-28 |
2010-08-25 |
Ustav Experimentalni Botaniky AV CR, v.v.i. (Institute of Experimental Botany Academy of Sciences of the Czech Republic, PRO) |
Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy
|
|
DE10220570A1
(de)
|
2002-05-08 |
2003-11-20 |
Bayer Ag |
Carbamat-substituierte Pyrazolopyridine
|
|
JP2005529927A
(ja)
*
|
2002-05-23 |
2005-10-06 |
ファイザー インコーポレイテッド |
新規な組み合わせ
|
|
GB0214784D0
(en)
*
|
2002-06-26 |
2002-08-07 |
Pfizer Ltd |
Novel combination
|
|
DE10232113A1
(de)
|
2002-07-16 |
2004-01-29 |
Bayer Ag |
Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
|
|
GB0219961D0
(en)
|
2002-08-28 |
2002-10-02 |
Pfizer Ltd |
Oxytocin inhibitors
|
|
US7119200B2
(en)
*
|
2002-09-04 |
2006-10-10 |
Schering Corporation |
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
|
US7323462B2
(en)
|
2002-12-10 |
2008-01-29 |
Pfizer Inc. |
Morpholine dopamine agonists
|
|
PT1572173E
(pt)
|
2002-12-13 |
2010-05-10 |
Warner Lambert Co |
Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
WO2004072079A1
(en)
*
|
2003-02-11 |
2004-08-26 |
Pfizer Limited |
Hydrated and anhydrous sildenafil hemi-citrate compound
|
|
CA2525946C
(en)
|
2003-05-22 |
2013-01-29 |
Altana Pharma Ag |
Composition comprising a pde4 inhibitor and a pde5 inhibitor
|
|
JP2006219373A
(ja)
|
2003-06-13 |
2006-08-24 |
Daiichi Asubio Pharma Co Ltd |
Pde7阻害作用を有するピリジニルピラゾロピリミジノン誘導体
|
|
JP2007504243A
(ja)
*
|
2003-09-03 |
2007-03-01 |
ニューロジェン・コーポレーション |
5−アリール−ピラゾロ[4,3−d]ピリミジン類、ピリジン類、ピラジン類及び関連化合物
|
|
EP1779852A3
(en)
*
|
2004-01-05 |
2007-05-09 |
Teva Pharmaceutical Industries Ltd. |
Processes for the production of sildenafil base and citrate salt
|
|
EP1633364B1
(en)
*
|
2004-01-05 |
2008-02-27 |
Teva Pharmaceutical Industries Ltd. |
Processes for the production of sildenafil base and citrate salt
|
|
WO2005079808A1
(en)
|
2004-01-22 |
2005-09-01 |
Pfizer Limited |
Triazole derivatives which inhibit vasopressin antagonistic activity
|
|
CN101106997A
(zh)
*
|
2004-08-17 |
2008-01-16 |
约翰·霍普金斯大学 |
Pde5抑制剂组合物及治疗心脏病征候的方法
|
|
DE102005009240A1
(de)
|
2005-03-01 |
2006-09-07 |
Bayer Healthcare Ag |
Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
|
|
UA84688C2
(uk)
*
|
2005-04-15 |
2008-11-25 |
Виктор Павлович Кутняк |
Засіб для лікування еректильної дисфункції
|
|
EP2366393B1
(en)
|
2005-04-19 |
2013-08-07 |
Takeda GmbH |
Roflumilast for the treatment of pulmonary hypertension
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
DE102006043443A1
(de)
|
2006-09-15 |
2008-03-27 |
Bayer Healthcare Ag |
Neue aza-bicyclische Verbindungen und ihre Verwendung
|
|
CN101563348B
(zh)
*
|
2006-12-21 |
2011-08-24 |
上海特化医药科技有限公司 |
西地那非的制备方法及其中间体
|
|
WO2008151257A2
(en)
|
2007-06-04 |
2008-12-11 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
ES2310144B1
(es)
|
2007-06-15 |
2010-01-12 |
Galenicum Health, S.L. |
Intermedios para la preparacion de un inhibidor de la fosfodiesterasa tipo 5.
|
|
KR20100058660A
(ko)
|
2007-10-23 |
2010-06-03 |
테바 파마슈티컬 인더스트리즈 리미티드 |
다사티닙 다형체 및 이의 제조 방법
|
|
WO2009149279A2
(en)
|
2008-06-04 |
2009-12-10 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
CA2730603C
(en)
|
2008-07-16 |
2019-09-24 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
WO2010067140A1
(es)
|
2008-12-12 |
2010-06-17 |
Siegfried Rhein S.A. De C.V. |
Composicion de liberacion pulsatil de sildenafil y proceso para prepararla
|
|
DE102008063992A1
(de)
|
2008-12-19 |
2010-09-02 |
Lerner, Zinoviy, Dipl.-Ing. |
Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
|
|
WO2010074783A1
(en)
|
2008-12-23 |
2010-07-01 |
The Trustees Of Columbia University In The City Of New York |
Phosphodiesterase inhibitors and uses thereof
|
|
GB0903493D0
(en)
|
2009-02-27 |
2009-04-08 |
Vantia Ltd |
New compounds
|
|
ES2553035T3
(es)
|
2009-11-27 |
2015-12-03 |
Adverio Pharma Gmbh |
Procedimiento para la preparación de {4,6-diamino-2-[1-(2-fluorobencil)-1H-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}-metilcarbamato de metilo y su purificación para el uso como principio activo farmacéutico
|
|
UY33041A
(es)
|
2009-11-27 |
2011-06-30 |
Bayer Schering Pharma Aktienegesellschaft |
Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico
|
|
CN101870699B
(zh)
*
|
2010-04-06 |
2013-11-20 |
漆又毛 |
苯磺酰基哌嗪衍生物
|
|
DE102010021637A1
(de)
|
2010-05-26 |
2011-12-01 |
Bayer Schering Pharma Aktiengesellschaft |
Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
|
|
MX2010006227A
(es)
|
2010-06-07 |
2011-12-14 |
World Trade Imp Exp Wtie Ag |
Nuevos derivados 1,4-diazepanos, inhibidores de pde-5.
|
|
WO2012000634A1
(de)
|
2010-06-29 |
2012-01-05 |
Georg Bambach |
Pharmazeutische zusammensetzung zur behandlung von erektiler dysfunktion
|
|
CN101891747B
(zh)
*
|
2010-07-02 |
2012-04-25 |
张南 |
抑制5型磷酸二酯酶的化合物及制备方法
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
CN102134242B
(zh)
*
|
2011-01-21 |
2013-08-28 |
浙江大德药业集团有限公司 |
一种用于治疗阳痿的快速长效的化合物
|
|
KR102034748B1
(ko)
|
2011-03-01 |
2019-10-21 |
시너지 파마슈티컬즈 인코포레이티드 |
구아닐레이트 사이클라제 c 작용제의 제조 방법
|
|
US9402877B2
(en)
|
2011-11-04 |
2016-08-02 |
Xion Pharmaceuticals Corporation |
Methods and compositions for oral administration of melanocortin receptor agonist compounds
|
|
EA031602B1
(ru)
|
2011-11-25 |
2019-01-31 |
Адверио Фарма Гмбх |
Способы получения альдегидов
|
|
US20150239889A1
(en)
*
|
2012-08-23 |
2015-08-27 |
Mitsubishi Tanabe Pharma Corporation |
Pyrazolopyrimidine compound
|
|
HK1217488A1
(zh)
|
2013-02-21 |
2017-01-13 |
Adverio Pharma Gmbh |
{4,6-二氨基-2-[1-(2-氟苄基)-1h-吡唑并[3,4-b]吡啶-3-基]嘧啶-5-基}甲基氨基甲酸甲酯的形式
|
|
US9545446B2
(en)
|
2013-02-25 |
2017-01-17 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase and their uses
|
|
EP2970384A1
(en)
|
2013-03-15 |
2016-01-20 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase and their uses
|
|
WO2014151200A2
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
|
AU2014274812B2
(en)
|
2013-06-05 |
2018-09-27 |
Bausch Health Ireland Limited |
Ultra-pure agonists of guanylate cyclase C, method of making and using same
|
|
WO2015021358A2
(en)
|
2013-08-09 |
2015-02-12 |
Dominique Charmot |
Compounds and methods for inhibiting phosphate transport
|
|
CN103755709B
(zh)
*
|
2014-01-15 |
2016-05-25 |
广东药学院 |
西地那非衍生物的微波辅助制备方法
|
|
CN105017255A
(zh)
*
|
2014-04-25 |
2015-11-04 |
浙江泰康药业集团有限公司 |
西地那非制备工艺
|
|
JP6687550B2
(ja)
|
2014-06-23 |
2020-04-22 |
セルジーン コーポレイション |
肝疾患又は肝機能異常を治療するためのアプレミラスト
|
|
CN107722020A
(zh)
*
|
2015-07-23 |
2018-02-23 |
青岛华之草医药科技有限公司 |
一种治疗男性勃起功能障碍的枸橼酸西地那非化合物
|
|
EP3377495B1
(en)
*
|
2015-11-16 |
2022-03-16 |
Topadur Pharma AG |
2-phenyl-3,4-dihydropyrrolo[2,1-f] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof
|
|
WO2017168174A1
(en)
|
2016-04-02 |
2017-10-05 |
N4 Pharma Uk Limited |
New pharmaceutical forms of sildenafil
|
|
WO2018069316A2
(en)
|
2016-10-10 |
2018-04-19 |
Transgene Sa |
Immunotherapeutic product and mdsc modulator combination therapy
|
|
KR20240113607A
(ko)
|
2017-06-21 |
2024-07-22 |
트랜스진 |
개인 맞춤형 백신
|
|
CA3093093A1
(en)
|
2018-03-07 |
2019-09-12 |
Transgene |
Parapoxvirus vectors
|
|
KR102836746B1
(ko)
|
2018-08-06 |
2025-07-21 |
니콕스 에스아 |
산화질소 방출 포스포디에스테라제 타입 5 억제제
|
|
SE542968C2
(en)
|
2018-10-26 |
2020-09-22 |
Lindahl Anders |
Treatment of osteoarthritis
|
|
CN113166157B
(zh)
|
2018-11-28 |
2024-08-27 |
托帕杜制药公司 |
双作用模式可溶性鸟苷酸环化酶活化剂和磷酸二酯酶抑制剂及其用途
|
|
CA3124773A1
(en)
|
2018-12-28 |
2020-07-02 |
Transgene |
M2-defective poxvirus
|
|
CN114340631A
(zh)
|
2019-05-21 |
2022-04-12 |
阿德利克斯股份有限公司 |
用于降低患者的血清磷酸盐的组合
|
|
CN118878542A
(zh)
*
|
2024-07-16 |
2024-11-01 |
西安市食品药品检验所 |
一种豪莫西地那非衍生物及其合成方法和应用
|