LT4855B - Pakeisti 4-amino-tiazol-2-il junginiai kaip nuo ciklino priklausomų kinazių inhibitoriai - Google Patents

Pakeisti 4-amino-tiazol-2-il junginiai kaip nuo ciklino priklausomų kinazių inhibitoriai Download PDF

Info

Publication number: LT4855B
Authority: LT; Lithuania
Prior art keywords: group; fused; compound; amino; nmr
Prior art date: 1997-10-27

Application number

LT2000033A

Other languages

English (en)

Lithuanian (lt)

Other versions

LT2000033A (en

Inventor

Wesley K.M. Chong

Song Shao Chu

Rohit R. Duvadie

Lin Li

Wei Xiao

Yi Yang

Original Assignee

Agouron Pharmaceuticals,Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-27

Filing date

2000-04-14

Publication date

2001-11-26

2000-04-14 Application filed by Agouron Pharmaceuticals,Inc. filed Critical Agouron Pharmaceuticals,Inc.

2001-06-25 Publication of LT2000033A publication Critical patent/LT2000033A/xx

2001-11-26 Publication of LT4855B publication Critical patent/LT4855B/lt

Links

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XIFJZJPMHNUGRA-UHFFFAOYSA-N n-methyl-4-nitroaniline Chemical compound CNC1=CC=C([N+]([O-])=O)C=C1 XIFJZJPMHNUGRA-UHFFFAOYSA-N 0.000 description 1
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235000019254 sodium formate Nutrition 0.000 description 1
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WERLWDBLJLNYAC-OKILXGFUSA-N tert-butyl (2s,6r)-4-(4-isothiocyanatophenyl)-2,6-dimethylpiperazine-1-carboxylate Chemical compound C1[C@@H](C)N(C(=O)OC(C)(C)C)[C@@H](C)CN1C1=CC=C(N=C=S)C=C1 WERLWDBLJLNYAC-OKILXGFUSA-N 0.000 description 1
RNLQHMIDSCYLAK-UHFFFAOYSA-N tert-butyl 2-(methylamino)acetate;hydron;chloride Chemical compound Cl.CNCC(=O)OC(C)(C)C RNLQHMIDSCYLAK-UHFFFAOYSA-N 0.000 description 1
MHYOKZQFAQMTSH-UHFFFAOYSA-N tert-butyl 4-(4-aminophenyl)-3,5-dimethylpiperazine-1-carboxylate Chemical compound CC1CN(C(=O)OC(C)(C)C)CC(C)N1C1=CC=C(N)C=C1 MHYOKZQFAQMTSH-UHFFFAOYSA-N 0.000 description 1
LORCKFPWKRKGLV-UHFFFAOYSA-N tert-butyl 4-[4-[[4-amino-5-(2,4,6-trifluorobenzoyl)-1,3-thiazol-2-yl]amino]phenyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C(C=C1)=CC=C1NC1=NC(N)=C(C(=O)C=2C(=CC(F)=CC=2F)F)S1 LORCKFPWKRKGLV-UHFFFAOYSA-N 0.000 description 1
NKURRHIZOJJPSC-UHFFFAOYSA-N tert-butyl 4-[4-[[4-amino-5-(2,6-dichlorobenzoyl)-1,3-thiazol-2-yl]amino]phenyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C(C=C1)=CC=C1NC1=NC(N)=C(C(=O)C=2C(=CC=CC=2Cl)Cl)S1 NKURRHIZOJJPSC-UHFFFAOYSA-N 0.000 description 1
MFHZMCHOPGVYFZ-UHFFFAOYSA-N tert-butyl 4-[4-[[4-amino-5-(2,6-difluorobenzoyl)-1,3-thiazol-2-yl]amino]phenyl]-2,6-dimethylpiperazine-1-carboxylate Chemical compound C1C(C)N(C(=O)OC(C)(C)C)C(C)CN1C(C=C1)=CC=C1NC1=NC(N)=C(C(=O)C=2C(=CC=CC=2F)F)S1 MFHZMCHOPGVYFZ-UHFFFAOYSA-N 0.000 description 1
LSCMLXOVDHNIDO-UHFFFAOYSA-N tert-butyl 4-[4-[[4-amino-5-(2,6-difluorobenzoyl)-1,3-thiazol-2-yl]amino]phenyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C(C=C1)=CC=C1NC1=NC(N)=C(C(=O)C=2C(=CC=CC=2F)F)S1 LSCMLXOVDHNIDO-UHFFFAOYSA-N 0.000 description 1
YWTDFUNSVBPYRK-UHFFFAOYSA-N tert-butyl 4-[4-[[4-amino-5-(3-methylthiophene-2-carbonyl)-1,3-thiazol-2-yl]amino]phenyl]piperazine-1-carboxylate Chemical compound C1=CSC(C(=O)C2=C(N=C(NC=3C=CC(=CC=3)N3CCN(CC3)C(=O)OC(C)(C)C)S2)N)=C1C YWTDFUNSVBPYRK-UHFFFAOYSA-N 0.000 description 1
AKFYUFMDMIBCQW-UHFFFAOYSA-N tert-butyl 4-[[(4-isothiocyanatophenyl)sulfonylamino]methyl]piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1CNS(=O)(=O)C1=CC=C(N=C=S)C=C1 AKFYUFMDMIBCQW-UHFFFAOYSA-N 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
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210000001519 tissue Anatomy 0.000 description 1
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VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000001262 western blot Methods 0.000 description 1
229910052727 yttrium Inorganic materials 0.000 description 1
229910000166 zirconium phosphate Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)

LT2000033A 1997-10-27 2000-04-14 Pakeisti 4-amino-tiazol-2-il junginiai kaip nuo ciklino priklausomų kinazių inhibitoriai LT4855B (lt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6363497P	1997-10-27	1997-10-27
US6366697P	1997-10-28	1997-10-28

Publications (2)

Publication Number	Publication Date
LT2000033A LT2000033A (en)	2001-06-25
LT4855B true LT4855B (lt)	2001-11-26

Family

ID=26743609

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LT2000033A LT4855B (lt)	1997-10-27	2000-04-14	Pakeisti 4-amino-tiazol-2-il junginiai kaip nuo ciklino priklausomų kinazių inhibitoriai

Country Status (34)

Country	Link
US (2)	US6569878B1 (et)
EP (1)	EP1056732B1 (et)
JP (1)	JP2004500304A (et)
KR (1)	KR20010082501A (et)
CN (1)	CN1158269C (et)
AP (1)	AP1445A (et)
AT (2)	ATE332896T1 (et)
AU (1)	AU738792B2 (et)
BG (1)	BG64195B1 (et)
BR (1)	BR9815200A (et)
CA (1)	CA2306082A1 (et)
DE (2)	DE69835241T2 (et)
EA (1)	EA003527B1 (et)
EE (1)	EE200000289A (et)
ES (2)	ES2256968T3 (et)
GE (1)	GEP20032896B (et)
HR (1)	HRP20000222A2 (et)
HU (1)	HUP0004512A3 (et)
ID (1)	ID24372A (et)
IL (1)	IL135574A0 (et)
IS (1)	IS5462A (et)
LT (1)	LT4855B (et)
LV (1)	LV12592B (et)
NO (1)	NO20001955L (et)
NZ (1)	NZ503788A (et)
OA (1)	OA11352A (et)
PL (1)	PL342447A1 (et)
RO (1)	RO119463B1 (et)
SI (1)	SI20324A (et)
SK (1)	SK5212000A3 (et)
TR (1)	TR200001081T2 (et)
UA (1)	UA66810C2 (et)
WO (1)	WO1999021845A2 (et)
YU (1)	YU22400A (et)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69835241T2 (de) *	1997-10-27	2007-05-31	Agouron Pharmaceuticals, Inc., La Jolla	4-Aminothiazol Derivate, deren Herstellung und deren Verwendung als Inhibitoren Cyclin-abhängiger Kinasen
UA60365C2 (uk)	1998-06-04	2003-10-15	Пфайзер Продактс Інк.	Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
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LT2000033A (en)	2001-06-25
RO119463B1 (ro)	2004-11-30
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JP2004500304A (ja)	2004-01-08
HRP20000222A2 (en)	2001-02-28
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PL342447A1 (en)	2001-06-04
CA2306082A1 (en)	1999-05-06
US6569878B1 (en)	2003-05-27
UA66810C2 (uk)	2004-06-15
DE69833223D1 (de)	2006-04-06
DE69833223T2 (de)	2006-09-14
OA11352A (en)	2003-12-23
DE69835241D1 (de)	2006-08-24
ATE315553T1 (de)	2006-02-15
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EA200000464A1 (ru)	2000-12-25
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US20030220326A1 (en)	2003-11-27
AP1445A (en)	2005-07-10
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MXPA00003812A (en)	2001-05-07	4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases
CZ20001285A3 (cs)	2001-01-17	Substituované 4-aminothiazol-2-ylové sloučeniny jako inhibitory cyklin-dependentních kinas
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