EE200000289A - Asendatud 4-amino-tiasool-2-üüli ühendid kui tsükliinisõltuvusega kinaaside inhibiitorid - Google Patents
Asendatud 4-amino-tiasool-2-üüli ühendid kui tsükliinisõltuvusega kinaaside inhibiitoridInfo
- Publication number
- EE200000289A EE200000289A EEP200000289A EEP200000289A EE200000289A EE 200000289 A EE200000289 A EE 200000289A EE P200000289 A EEP200000289 A EE P200000289A EE P200000289 A EEP200000289 A EE P200000289A EE 200000289 A EE200000289 A EE 200000289A
- Authority
- EE
- Estonia
- Prior art keywords
- aminothiazol
- cyclin
- inhibitors
- substituted
- compounds
- Prior art date
Links
- -1 4-Aminothiazol-2-yl Compounds Chemical class 0.000 title 1
- 108091007914 CDKs Proteins 0.000 title 1
- 102000003903 Cyclin-dependent kinases Human genes 0.000 title 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6363497P | 1997-10-27 | 1997-10-27 | |
| US6366697P | 1997-10-28 | 1997-10-28 | |
| PCT/US1998/022809 WO1999021845A2 (en) | 1997-10-27 | 1998-10-27 | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE200000289A true EE200000289A (et) | 2001-06-15 |
Family
ID=26743609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200000289A EE200000289A (et) | 1997-10-27 | 1998-10-27 | Asendatud 4-amino-tiasool-2-üüli ühendid kui tsükliinisõltuvusega kinaaside inhibiitorid |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US6569878B1 (et) |
| EP (1) | EP1056732B1 (et) |
| JP (1) | JP2004500304A (et) |
| KR (1) | KR20010082501A (et) |
| CN (1) | CN1158269C (et) |
| AP (1) | AP1445A (et) |
| AT (2) | ATE332896T1 (et) |
| AU (1) | AU738792B2 (et) |
| BG (1) | BG64195B1 (et) |
| BR (1) | BR9815200A (et) |
| CA (1) | CA2306082A1 (et) |
| DE (2) | DE69835241T2 (et) |
| EA (1) | EA003527B1 (et) |
| EE (1) | EE200000289A (et) |
| ES (2) | ES2256968T3 (et) |
| GE (1) | GEP20032896B (et) |
| HR (1) | HRP20000222A2 (et) |
| HU (1) | HUP0004512A3 (et) |
| ID (1) | ID24372A (et) |
| IL (1) | IL135574A0 (et) |
| IS (1) | IS5462A (et) |
| LT (1) | LT4855B (et) |
| LV (1) | LV12592B (et) |
| NO (1) | NO20001955L (et) |
| NZ (1) | NZ503788A (et) |
| OA (1) | OA11352A (et) |
| PL (1) | PL342447A1 (et) |
| RO (1) | RO119463B1 (et) |
| SI (1) | SI20324A (et) |
| SK (1) | SK5212000A3 (et) |
| TR (1) | TR200001081T2 (et) |
| UA (1) | UA66810C2 (et) |
| WO (1) | WO1999021845A2 (et) |
| YU (1) | YU22400A (et) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69835241T2 (de) * | 1997-10-27 | 2007-05-31 | Agouron Pharmaceuticals, Inc., La Jolla | 4-Aminothiazol Derivate, deren Herstellung und deren Verwendung als Inhibitoren Cyclin-abhängiger Kinasen |
| UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
| JP3390744B2 (ja) * | 1998-09-22 | 2003-03-31 | 山之内製薬株式会社 | シアノフェニル誘導体 |
| US6214852B1 (en) | 1998-10-21 | 2001-04-10 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
| US6414156B2 (en) | 1998-10-21 | 2002-07-02 | Bristol-Myers Squibb Company | Process for preparing azacycloalkanoylaminothiazoles |
| HUP0202708A3 (en) | 1999-04-15 | 2004-12-28 | Bristol Myers Squibb Co | Cyclic protein tyrosine kinase inhibitors, pharmaceutical compositions containing them and their use |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| UA71971C2 (en) * | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
| TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
| PE20010306A1 (es) * | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| US7141581B2 (en) | 1999-07-02 | 2006-11-28 | Agouron Pharmaceuticals, Inc. | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use |
| US6114365A (en) * | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
| US6515004B1 (en) | 1999-12-15 | 2003-02-04 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
| US6392053B2 (en) | 1999-12-15 | 2002-05-21 | Bristol-Myers Squibb Company | Process for preparing arylacetylaminothiazoles |
| YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| AU2001230026A1 (en) * | 2000-02-04 | 2001-08-14 | Novo-Nordisk A/S | 2,4-diaminothiazole derivatives |
| MXPA02010222A (es) | 2000-04-18 | 2003-05-23 | Agouron Pharma | Pirazoles para inhibir proteina cinasa. |
| KR100423899B1 (ko) * | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
| HK1052354A1 (zh) * | 2000-08-09 | 2003-09-11 | Agouron Pharmaceuticals, Inc. | 吡唑-噻唑化合物，包括它们的药物组分，和他们在抑制细胞周期蛋白依赖性激酶用途的方法 |
| AU2001279090A1 (en) | 2000-08-18 | 2002-03-04 | Agouron Pharmaceuticals, Inc. | Heterocyclic-hydroxyimino-fluorenes and their use for inhibiting protein kinases |
| EP1712550A3 (en) * | 2000-12-22 | 2009-07-15 | Ortho-McNeil Pharmaceutical, Inc. | Substituted triazole diamine derivatives as kinase inhibitors |
| EP1355889B1 (en) * | 2000-12-22 | 2006-06-07 | Ortho-McNeil Pharmaceutical, Inc. | Substituted triazole diamine derivatives as kinase inhibitors |
| US6756374B2 (en) * | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
| CA2450562A1 (en) * | 2001-06-22 | 2003-01-03 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| HN2002000156A (es) * | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización. |
| EP1724270A3 (en) | 2001-07-19 | 2007-01-03 | Pfizer Italia S.r.l. | Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents |
| WO2003011843A1 (en) * | 2001-08-03 | 2003-02-13 | Novo Nordisk A/S | Novel 2,4-diaminothiazole derivatives |
| GEP20063909B (en) | 2002-01-22 | 2006-08-25 | Warner Lambert Co | 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d] PYRIMIDIN-7-ONES |
| US6818663B2 (en) * | 2002-05-17 | 2004-11-16 | Hoffmann-La Roches | Diaminothiazoles |
| UA77303C2 (en) | 2002-06-14 | 2006-11-15 | Pfizer | Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use |
| US6872724B2 (en) | 2002-07-24 | 2005-03-29 | Merck & Co., Inc. | Polymorphs with tyrosine kinase activity |
| AU2003281664A1 (en) | 2002-07-25 | 2004-02-16 | Pfizer Products Inc. | Isothiazole derivatives useful as anticancer agents |
| RU2324685C2 (ru) * | 2002-08-07 | 2008-05-20 | Ф.Хоффманн-Ля Рош Аг | Производные тиазола, способ их получения и применение, фармацевтическая композиция, обладающая свойствами антагонистов рецепторов npy |
| US7157455B2 (en) | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
| WO2004072070A1 (en) * | 2003-02-12 | 2004-08-26 | Pfizer Inc. | Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives |
| CA2516234A1 (en) * | 2003-02-21 | 2004-09-02 | Pfizer Inc. | N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors |
| ATE439837T1 (de) | 2003-06-03 | 2009-09-15 | Novartis Ag | 5-gliedrige heterocyclische p-38 inhibitoren |
| PT1641764E (pt) | 2003-06-26 | 2011-10-27 | Novartis Ag | Inibidores de p38 quinase a base de heterociclo de 5 elementos |
| TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| WO2005012256A1 (en) | 2003-07-22 | 2005-02-10 | Astex Therapeutics Limited | 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
| AU2004259263B2 (en) | 2003-07-29 | 2010-12-16 | High Point Pharmaceuticals, Llc | Pyridazinyl- piperazines and their use as histamine H3 receptor ligands |
| WO2005047504A1 (en) * | 2003-11-07 | 2005-05-26 | The Board Of Trustees Of The University Of Illinois | Induction of cellular senescence by cdk4 disruption for tumor suppression and regression |
| US20050171182A1 (en) * | 2003-12-11 | 2005-08-04 | Roger Briesewitz | Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases |
| EP1550372A1 (en) * | 2003-12-24 | 2005-07-06 | Bayer CropScience GmbH | Plant growth regulation |
| EP1711497A1 (en) * | 2004-01-30 | 2006-10-18 | AB Science | 2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine kinase inhibitors |
| WO2005097766A1 (en) * | 2004-03-31 | 2005-10-20 | Lexicon Genetics, Inc. | 2-aminomethylthiazole-5-carboxamides as protein kinase modulators |
| US7211576B2 (en) * | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
| AU2005325271A1 (en) | 2004-05-06 | 2006-07-27 | Plexxikon, Inc. | PDE4B inhibitors and uses therefor |
| US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
| US7423053B2 (en) * | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 4-Aminothiazole derivatives |
| US7423051B2 (en) * | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 2,6-diaminopyridine derivatives |
| JP2008512380A (ja) | 2004-09-03 | 2008-04-24 | プレキシコン，インコーポレーテッド | Ｐｄｅ４ｂ阻害剤 |
| US7253285B2 (en) * | 2004-09-17 | 2007-08-07 | Hoffmann-La Roche Inc. | Thiazolinone 4-monosubstituted quinolines |
| US7241893B2 (en) * | 2004-09-17 | 2007-07-10 | Hoffman-La Roche Inc. | Thiazolinone 2-substituted quinolines |
| CN100569773C (zh) | 2004-10-14 | 2009-12-16 | 霍夫曼-拉罗奇有限公司 | 作为抗癌剂的新型吖吲哚噻唑啉酮 |
| US8110573B2 (en) | 2004-12-30 | 2012-02-07 | Astex Therapeutics Limited | Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases |
| WO2006070192A1 (en) | 2004-12-30 | 2006-07-06 | Astex Therapeutics Limited | Thiazole and isothiazole derivatives that modulate the acivity of cdk, gsk and aurora kynases |
| JP5475234B2 (ja) | 2005-01-21 | 2014-04-16 | アステックス・セラピューティクス・リミテッド | 医薬化合物 |
| ES2552338T3 (es) | 2005-01-21 | 2015-11-27 | Astex Therapeutics Limited | Compuestos farmacéuticos |
| US7304074B2 (en) | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
| KR101286569B1 (ko) | 2005-07-04 | 2013-07-23 | 하이 포인트 파마슈티칼스, 엘엘씨 | 신규 약제 |
| WO2007015064A1 (en) | 2005-07-30 | 2007-02-08 | Astrazeneca Ab | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders |
| US7705009B2 (en) * | 2005-11-22 | 2010-04-27 | Hoffman-La Roche Inc. | 4-aminopyrimidine-5-thione derivatives |
| AU2007229492B2 (en) | 2006-03-28 | 2011-11-03 | High Point Pharmaceuticals, Llc | Benzothiazoles having histamine H3 receptor activity |
| JP2009537596A (ja) | 2006-05-23 | 2009-10-29 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | ６−（４−シクロプロピルピペリジン−１−イル）−２’−メチル−［３，４’］−ビピリジン及びその医薬としての使用 |
| CN102295606A (zh) | 2006-05-29 | 2011-12-28 | 高点制药有限责任公司 | 合成3-（1，3-苯并间二氧杂环戊烯-5-基）-6-（4-环丙基哌嗪-1-基）-哒嗪的方法及其适用的中间体 |
| PL2366703T3 (pl) * | 2007-02-13 | 2015-02-27 | Ab Science | Postać polimorficzna pochodnej 2-amino-(nitroarylo)-tiazolu |
| RU2009140182A (ru) * | 2007-05-11 | 2011-06-20 | Ф. Хоффманн-Ля Рош Аг (Ch) | Гетариланилины в качестве модуляторов для бета-амилоида |
| EP2014656A3 (en) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
| ES2986590T3 (es) | 2010-06-14 | 2024-11-12 | Scripps Research Inst | Reprogramación de células hacia un nuevo destino |
| GEP201706688B (en) * | 2012-02-02 | 2017-06-26 | Senex Biotechnology Inc | Cdk8/cdk19 selective inhibitors and their use in anti- metastatic and chemopreventative methods for cancer |
| CN102977049A (zh) * | 2012-11-26 | 2013-03-20 | 盛世泰科生物医药技术(苏州)有限公司 | 一种2-氨基-4-环丙基-5-羧酸乙酯噻唑的合成方法 |
| US9783515B2 (en) | 2013-05-07 | 2017-10-10 | The Regents Of The University Of California | Radiomitigating pharmaceutical formulations |
| CN104628627A (zh) * | 2014-12-23 | 2015-05-20 | 安徽德信佳生物医药有限公司 | 一种1-boc-4-氨基哌啶的合成方法 |
| CN106854200B (zh) * | 2015-12-08 | 2019-05-21 | 上海复星星泰医药科技有限公司 | 色瑞替尼及其中间体的制备方法 |
| WO2018089902A1 (en) * | 2016-11-13 | 2018-05-17 | Apogee Biotechnology Corporation | Diaminothiazole compounds, compositions and methods of use |
| CA3048376A1 (en) | 2016-12-27 | 2018-07-05 | Riken | Bmp-signal-inhibiting compound |
| EP3571196B1 (en) * | 2017-01-19 | 2023-01-04 | Temple University Of The Commonwealth System Of Higher Education | Novel bridged bicycloalkyl-substituted aminothizoles and their methods of use |
| EP3749654B1 (en) | 2018-02-06 | 2025-04-23 | The Board of Trustees of the University of Illinois | Substituted benzothiophene analogs as selective estrogen receptor degraders |
| TWI787523B (zh) | 2018-06-15 | 2022-12-21 | 漢達生技醫藥股份有限公司 | 達沙替尼十二烷基硫酸鹽之結晶 |
| CN109897014A (zh) * | 2019-04-17 | 2019-06-18 | 成都睿智化学研究有限公司 | 一种1-（取代苯基）-4-甲基哌嗪的工艺制备方法 |
| CN118453591A (zh) * | 2020-09-01 | 2024-08-09 | 苏州灵希生物科技有限公司 | 化合物作为cyp2e1抑制剂的应用 |
| CN114805432A (zh) * | 2022-03-03 | 2022-07-29 | 西北工业大学 | 新型可光催化剪切的羧酸保护基及其氨基酸衍生物的制备方法 |
| KR102820358B1 (ko) * | 2022-08-30 | 2025-06-12 | 한국화학연구원 | Mkk3 키나아제 억제 화합물을 함유한 천포창 개선 또는 치료용 조성물 |
| WO2025128616A1 (en) * | 2023-12-12 | 2025-06-19 | Genesis Therapeutics, Inc. | Compounds for treating cancer |
| WO2026024674A1 (en) | 2024-07-22 | 2026-01-29 | Genesis Therapeutics, Inc. | Methods of treating skp2-associated cancers |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3530161A (en) | 1968-08-19 | 1970-09-22 | Shell Oil Co | Aromatic isothiocyanate production |
| BE792402A (fr) | 1971-12-07 | 1973-06-07 | Ciba Geigy | Composes heterocycliques azotes et medicaments anthelminthiqueset antimicrobiens qui en contiennent |
| CH593806A5 (et) | 1974-11-14 | 1977-12-15 | Ciba Geigy Ag | |
| US4086239A (en) | 1977-07-01 | 1978-04-25 | Stauffer Chemical Company | Thiazole bis-phosphates and phosphonates, intermediates, and insecticidal compositions and methods |
| US4649146A (en) | 1983-01-31 | 1987-03-10 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives and pharmaceutical composition comprising the same |
| DE3804531A1 (de) | 1988-02-13 | 1989-08-24 | Bayer Ag | 5-cyano-2,4-diamino-thiazol-derivate |
| IE68593B1 (en) | 1989-12-06 | 1996-06-26 | Sanofi Sa | Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them |
| US5620963A (en) | 1991-10-15 | 1997-04-15 | Isis Pharmaceuticals, Inc. | Oligonucleotides for modulating protein kinase C having phosphorothioate linkages of high chiral purity |
| US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| EP0584222B1 (en) * | 1991-05-10 | 1997-10-08 | Rhone-Poulenc Rorer International (Holdings) Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
| US5721237A (en) * | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
| US5449755A (en) | 1991-09-20 | 1995-09-12 | Fred Hutchinson Cancer Research Center | Human cyclin E |
| US5262409A (en) | 1991-10-11 | 1993-11-16 | Fred Hutchinson Cancer Research Center | Binary tumor therapy |
| US5441880A (en) | 1991-11-18 | 1995-08-15 | Cold Spring Harbor Laboratory | Human cdc25 genes, encoded products and uses thereof |
| US5302706A (en) | 1991-12-16 | 1994-04-12 | Baylor College Of Medicine | Senescent cell derived inhibitors of DNA synthesis |
| US5596079A (en) | 1991-12-16 | 1997-01-21 | Smith; James R. | Mimetics of senescent cell derived inhibitors of DNA synthesis |
| WO1993021230A1 (en) | 1992-04-10 | 1993-10-28 | Dana-Farber Cancer Institute, Inc. | Activation-state-specific phosphoprotein immunodetection |
| AU5168393A (en) | 1992-09-30 | 1994-04-26 | Yale University | Therapeutic and diagnostic methods and compositions based on transducin-like enhancer of split proteins and nucleic acids |
| US5543291A (en) | 1993-01-29 | 1996-08-06 | Dana Farber Cancer Institute | Method of detecting carcinoma |
| WO1994026303A1 (en) | 1993-05-13 | 1994-11-24 | Neorx Corporation | Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells |
| US5443962A (en) | 1993-06-04 | 1995-08-22 | Mitotix, Inc. | Methods of identifying inhibitors of cdc25 phosphatase |
| US5514571A (en) | 1993-08-05 | 1996-05-07 | University Technologies International Inc. | Cyclin D1 negative regulatory activity |
| US5473056A (en) | 1993-10-13 | 1995-12-05 | Merck & Co., Inc. | E2F-2, a novel mammalian transcription factor |
| US5532167A (en) | 1994-01-07 | 1996-07-02 | Beth Israel Hospital | Substrate specificity of protein kinases |
| US5484710A (en) | 1994-01-14 | 1996-01-16 | La Jolla Cancer Research Foundation | Method of down-regulating a gene linked to a P-53 responsive element |
| US5625031A (en) | 1994-02-08 | 1997-04-29 | Bristol-Myers Squibb Company | Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein |
| CA2162150C (en) | 1994-03-18 | 2010-03-30 | Mark H. Skolnick | Germline mutations in the mts gene and method for detecting predisposition to cancer at the mts gene |
| US5496831A (en) | 1994-05-13 | 1996-03-05 | The General Hospital Corporation | Inhibition of insulin-induced adiposis |
| US5631156A (en) | 1994-06-21 | 1997-05-20 | The University Of Michigan | DNA encoding and 18 KD CDK6 inhibiting protein |
| US5571523A (en) | 1995-03-09 | 1996-11-05 | President And Fellows Of Harvard College | Antioxidant-induced apoptosis in vascular smooth muscle cells |
| US5733920A (en) | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
| BR9611157A (pt) | 1995-11-01 | 1999-03-30 | Novartis Ag | Derivados de purina e processos para sua preparação |
| US5849733A (en) | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
| TW513418B (en) | 1996-07-31 | 2002-12-11 | Otsuka Pharma Co Ltd | Thiazole derivatives, their production and use |
| DZ2285A1 (fr) | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
| GB9621757D0 (en) | 1996-10-18 | 1996-12-11 | Ciba Geigy Ag | Phenyl-substituted bicyclic heterocyclyl derivatives and their use |
| BR9807305A (pt) * | 1997-02-05 | 2000-05-02 | Warner Lambert Co | Pirido [2,3-d] pirimidinas e 4-aminopirimidinas como inibidores de proliferação celular. |
| DE69835241T2 (de) * | 1997-10-27 | 2007-05-31 | Agouron Pharmaceuticals, Inc., La Jolla | 4-Aminothiazol Derivate, deren Herstellung und deren Verwendung als Inhibitoren Cyclin-abhängiger Kinasen |
| UA71971C2 (en) * | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
-
1998
- 1998-10-27 DE DE69835241T patent/DE69835241T2/de not_active Expired - Fee Related
- 1998-10-27 US US09/179,744 patent/US6569878B1/en not_active Expired - Fee Related
- 1998-10-27 EA EA200000464A patent/EA003527B1/ru not_active IP Right Cessation
- 1998-10-27 GE GEAP19985301A patent/GEP20032896B/en unknown
- 1998-10-27 RO ROA200000423A patent/RO119463B1/ro unknown
- 1998-10-27 NZ NZ503788A patent/NZ503788A/xx unknown
- 1998-10-27 ES ES98957393T patent/ES2256968T3/es not_active Expired - Lifetime
- 1998-10-27 KR KR1020007004392A patent/KR20010082501A/ko not_active Ceased
- 1998-10-27 AT AT02001881T patent/ATE332896T1/de not_active IP Right Cessation
- 1998-10-27 HR HR20000222A patent/HRP20000222A2/hr not_active Application Discontinuation
- 1998-10-27 BR BR9815200-9A patent/BR9815200A/pt not_active Application Discontinuation
- 1998-10-27 JP JP2000517957A patent/JP2004500304A/ja active Pending
- 1998-10-27 HU HU0004512A patent/HUP0004512A3/hu unknown
- 1998-10-27 TR TR2000/01081T patent/TR200001081T2/xx unknown
- 1998-10-27 CA CA002306082A patent/CA2306082A1/en not_active Abandoned
- 1998-10-27 AT AT98957393T patent/ATE315553T1/de not_active IP Right Cessation
- 1998-10-27 SK SK521-2000A patent/SK5212000A3/sk unknown
- 1998-10-27 YU YU22400A patent/YU22400A/sh unknown
- 1998-10-27 UA UA2000042107A patent/UA66810C2/uk unknown
- 1998-10-27 IL IL13557498A patent/IL135574A0/xx unknown
- 1998-10-27 SI SI9820068A patent/SI20324A/sl unknown
- 1998-10-27 WO PCT/US1998/022809 patent/WO1999021845A2/en not_active Ceased
- 1998-10-27 AP APAP/P/2000/001795A patent/AP1445A/en active
- 1998-10-27 DE DE69833223T patent/DE69833223T2/de not_active Expired - Fee Related
- 1998-10-27 ES ES02001881T patent/ES2267873T3/es not_active Expired - Lifetime
- 1998-10-27 PL PL98342447A patent/PL342447A1/xx not_active Application Discontinuation
- 1998-10-27 AU AU13664/99A patent/AU738792B2/en not_active Ceased
- 1998-10-27 CN CNB988104741A patent/CN1158269C/zh not_active Expired - Fee Related
- 1998-10-27 EE EEP200000289A patent/EE200000289A/et unknown
- 1998-10-27 EP EP98957393A patent/EP1056732B1/en not_active Expired - Lifetime
- 1998-10-27 ID IDW20000740A patent/ID24372A/id unknown
-
2000
- 2000-04-14 LT LT2000033A patent/LT4855B/lt not_active IP Right Cessation
- 2000-04-14 NO NO20001955A patent/NO20001955L/no not_active Application Discontinuation
- 2000-04-19 IS IS5462A patent/IS5462A/is unknown
- 2000-04-25 OA OA1200000120A patent/OA11352A/en unknown
- 2000-05-03 LV LVP-00-51A patent/LV12592B/en unknown
- 2000-05-26 BG BG104478A patent/BG64195B1/bg unknown
-
2003
- 2003-03-13 US US10/388,851 patent/US20030220326A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EE200000289A (et) | Asendatud 4-amino-tiasool-2-üüli ühendid kui tsükliinisõltuvusega kinaaside inhibiitorid | |
| DK1042307T3 (da) | Aminothiazolinhibitorer af cyclinafhængige kinaser | |
| ID22982A (id) | PIRAZOL-PIRAZOL TERSUBSTITUSI SEBAGAI INHIBITOR KINASE p38 | |
| EE04616B1 (et) | Bitsüklilised heteroaromaatsed ühendid kui valgu türosiini kinaasi inhibiitorid | |
| NO20005673L (no) | Heterocykliske inhibitorer av P38 | |
| DK1183033T3 (da) | Pyrrolotriazininhibitorer af kinaser | |
| NO992960D0 (no) | Substituerte nitrogen-inneholdende heterocykliske forbindelser som inhibitorer for p38 protein-kinase | |
| DK1114051T3 (da) | Inhibitorer for p38 | |
| EE200200140A (et) | Pteridinoonid kui kinaasi inhibiitorid | |
| NO20022864L (no) | Aminotiazol inhibitorer av syklin uavhengig kinase | |
| PL331154A1 (en) | Bicyclic heteroaromatic compounds as inhibitors of proteinous tyrosine kinase | |
| NO20006483D0 (no) | Forbindelser av ustabile dipeptidyl peptidase IV-inhibitorer | |
| EE9800351A (et) | Asendatud benseensulfoonamiidi derivaadid kui COX-2 inhibiitorite eelravimid | |
| ATE251160T1 (de) | Purin-derivative inhibitoren der tyrosi-protein kinase syk | |
| FI963228A7 (fi) | Substituoituja bifenyylijohdannaisia fosfodiesteraasi-inhibiittoreina | |
| EE200100044A (et) | Heterotsüklilised ühendid kui rotamaasensüümide inhibiitorid | |
| PT1049695E (pt) | Imidazotriazinonas 2-fenil substituidas enquanto inibidores de fosfodiesterase | |
| EE200300227A (et) | P38 kinaasiga seotud haigusseisundite ravimeetodid ja kinaasi inhibiitoritena kasulikud pürrolotriasiiniühendid | |
| PL325122A1 (en) | Bicyclic derivatives of 4-aralkylamino pyrididine as inhibitors of thyrosinic kinase | |
| DE69831950D1 (de) | Inhibitoren des hitzeschock-faktors | |
| PL339186A1 (en) | Derivatives of pyrrolopyrrolone as inhibitors of neutrophilic elastase | |
| GB9706652D0 (en) | Inhibitors of FPT as anti-inflammatories |