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KR880004814A - 이포스파미드 동결건조물 및 이의 제조방법 - Google Patents

이포스파미드 동결건조물 및 이의 제조방법 Download PDF

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Publication number
KR880004814A
KR880004814A KR870012077A KR870012077A KR880004814A KR 880004814 A KR880004814 A KR 880004814A KR 870012077 A KR870012077 A KR 870012077A KR 870012077 A KR870012077 A KR 870012077A KR 880004814 A KR880004814 A KR 880004814A
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KR
South Korea
Prior art keywords
weight
phosphamide
hexitol
ifosfamide
parts
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Granted
Application number
KR870012077A
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English (en)
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KR900003491B1 (ko
Inventor
자우에르비어 디이터
담만 우베-페터
이작 오토
Original Assignee
게르하르트 노바크,귄터 스타인메츠
아스타 파마 아크티엔게젤샤프트
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Application filed by 게르하르트 노바크,귄터 스타인메츠, 아스타 파마 아크티엔게젤샤프트 filed Critical 게르하르트 노바크,귄터 스타인메츠
Publication of KR880004814A publication Critical patent/KR880004814A/ko
Application granted granted Critical
Publication of KR900003491B1 publication Critical patent/KR900003491B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
  • Control Of El Displays (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Amplifiers (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

내용 없음

Description

이포스파미드 동결건조물 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 이포스파미드(Ifosfamide), 이포스파미드 1중량부를 기준으로 하여 0.1 내지 17중량부의 헥시톨 및 임의로 다른 통상의 약제학적 보조물질을 함유하는 동결건조제제.
  2. 제1항에 있어서, 헥시톨이 만니톨임을 특징으로 하는 동결건조제제.
  3. 이포스파미드 1내지 13중량%, 이스파미드 1중량부를 기준으로 하여 헥시톨 0.1내지 17중량부 및, 임의로 이포스파미드 1중량부를 기준으로 하여 다른 약제학적 보조물질 0내지 16.9중량부를 함유하는 이포스파미드 수성 또는 수성-에탄올성 용액을 -70° 내지 0℃에서 동결시키고 ; 동결상태에서 이와 같이 수득한 생성물로부터 물을 제거함을 특징으로 하여, 이포스파미드 동결건조물을 제조하는 방법.
  4. 제3항에 있어서, 초기에 비-흡수성 결합수를 -30 내지 40℃의 온도 및 10-3내지 10mbar의 압력에서 먼저 제거하고 ; 이어서 흡수성 결합수를 0내지 40℃의 온도 및 10-4내지 10-1mbar의 압력에서 제거함을 특징으로 하는 방법.
  5. 제3 또는 4항에 있어서, 핵시톨이 만니톨임을 특징으로 하는 방법.
  6. 제3 내지 5항중 어느 한 항에 따라 수득한 이포스파미드 동결건조물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870012077A 1986-10-31 1987-10-30 이포스파미드 동결건조물 및 이의 제조방법 Expired KR900003491B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3637089 1986-10-31
DEP3637089.4 1986-10-31

Publications (2)

Publication Number Publication Date
KR880004814A true KR880004814A (ko) 1988-06-27
KR900003491B1 KR900003491B1 (ko) 1990-05-21

Family

ID=6312873

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870012077A Expired KR900003491B1 (ko) 1986-10-31 1987-10-30 이포스파미드 동결건조물 및 이의 제조방법

Country Status (25)

Country Link
EP (1) EP0265812B1 (ko)
JP (1) JPS63159319A (ko)
KR (1) KR900003491B1 (ko)
AT (1) ATE55250T1 (ko)
AU (1) AU598602B2 (ko)
CA (1) CA1314231C (ko)
DD (1) DD262582A5 (ko)
DE (1) DE3764235D1 (ko)
DK (1) DK169308B1 (ko)
EG (1) EG18333A (ko)
ES (1) ES2017982B3 (ko)
FI (1) FI87140C (ko)
GE (1) GEP19971025B (ko)
GR (1) GR3000708T3 (ko)
HU (1) HU197987B (ko)
IL (1) IL84312A (ko)
IN (1) IN168119B (ko)
LV (1) LV10051B (ko)
MX (1) MX8958A (ko)
NO (1) NO873860L (ko)
PT (1) PT86032B (ko)
RU (1) RU1836079C (ko)
UA (1) UA11075A (ko)
YU (1) YU197387A (ko)
ZA (1) ZA878183B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0334083B1 (de) * 1988-03-19 1991-07-24 ASTA Pharma Aktiengesellschaft Ifosfamid-Mesna-Lyophilisat und Verfahren zu dessen Herstellung
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
WO1995007083A1 (en) * 1993-09-10 1995-03-16 F.H. Faulding & Co. Limited Ifosfamide lyophilisate composition
DE19529057B4 (de) * 1995-08-08 2007-12-13 Baxter Healthcare S.A. Ifosfamid-Lyophilisat-Zubereitungen
JP2002505282A (ja) * 1998-03-03 2002-02-19 塩野義製薬株式会社 ホスホリパーゼ阻害剤の［［３−（２−アミノ−１，２−ジオキソエチル）−２−エチル−１−フェニルメチル）−１ｈ−インドール−４−イル］オキシ］酢酸ナトリウムを含む薬学的組成物
BR0314068A (pt) * 2002-09-05 2005-07-05 Bharat Serums & Vaccines Ltd Processo para a preparação de uma composição estável com baixo nìvel de toxicidade; composição estável que contém oxazafosforina; uso de uma composição estável que contém oxazafosforina; e método de tratamento de uma doença maligna
KR101066181B1 (ko) * 2002-12-02 2011-09-20 바라트 쎄럼스 앤드 백신스 리미티드 비경구 투여용 아이포스파마이드 조성물 및 이의 제조방법
US8436190B2 (en) * 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
BRPI0715279A2 (pt) * 2006-09-29 2013-06-11 Infa Sa sistema de embalagem, sistema de embalagem para uma composiÇço farmacÊutica, mÉtodo para transferir uma composiÇço farmcÊutica para administraÇço por infusço intravenosa, uso de um sistema de embalagem, kit para administraÇço parenteral de fÁrmacos com um acesso intravenoso e kit admnistraÇço parenteral de princÍpios ativos
CN105900385B (zh) * 2014-12-04 2019-08-27 华为技术有限公司 在数据通信网中的负载分配

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732340A (en) * 1966-07-11 1973-05-08 Asta Werke Ag Chem Fab N',o-propylene phosphoric acid ester diamides
DE2750207A1 (de) * 1977-05-09 1978-11-16 Walton J Smith Gefriergetrocknete zusammensetzungen, insbesondere gefriergetrocknete pharmazeutische praeparate und verfahren zu deren herstellung
DE3279834D1 (en) * 1981-12-31 1989-08-31 Asta Pharma Ag 4-sulfido-oxaza phosphorines and their use in the treatment of cancer, and in immunosuppression
US4537883A (en) * 1982-11-12 1985-08-27 Mead Johnson & Company Lyophilized cyclophosphamide

Also Published As

Publication number Publication date
FI87140B (fi) 1992-08-31
UA11075A (uk) 1996-12-25
MX8958A (es) 1993-12-01
ATE55250T1 (de) 1990-08-15
DE3764235D1 (de) 1990-09-13
EP0265812A1 (de) 1988-05-04
GR3000708T3 (en) 1991-10-10
ES2017982B3 (es) 1991-03-16
DK569687A (da) 1988-05-01
CA1314231C (en) 1993-03-09
EG18333A (en) 1993-12-30
FI874727L (fi) 1988-05-01
AU8052987A (en) 1988-05-05
DK169308B1 (da) 1994-10-10
LV10051B (en) 1995-06-20
IL84312A0 (en) 1988-03-31
HU197987B (en) 1989-07-28
NO873860L (no) 1988-05-02
RU1836079C (ru) 1993-08-23
IL84312A (en) 1991-11-21
PT86032A (de) 1987-11-01
KR900003491B1 (ko) 1990-05-21
JPH0543684B2 (ko) 1993-07-02
DK569687D0 (da) 1987-10-30
DD262582A5 (de) 1988-12-07
GEP19971025B (en) 1997-04-06
JPS63159319A (ja) 1988-07-02
FI87140C (fi) 1992-12-10
ZA878183B (en) 1988-05-02
LV10051A (lv) 1994-05-10
AU598602B2 (en) 1990-06-28
HUT44932A (en) 1988-05-30
IN168119B (ko) 1991-02-09
EP0265812B1 (de) 1990-08-08
PT86032B (pt) 1990-08-31
FI874727A0 (fi) 1987-10-27
YU197387A (en) 1988-12-31
NO873860D0 (no) 1987-09-15

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