JP2012036128A - Collagen production promoter and skin-beautifying composition comprising the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a novel component that exhibits a retinoid-like action and a collagen production-promoting action and inhibits formation of wrinkles by increasing the thickness of the dermis.SOLUTION: (1) The collagen production promoter contains an extract from a plant belonging to the genus Fragaria of the family Rosaceae as an effective ingredient. (2) The collagen production promoter as described in (1), where a seed is used as a portion of the plant belonging to the genus Fragaria of the family Rosaceae. (3) The collagen production promoter contains an extract from a seed of a litchi as an effective ingredient. (4) The collagen production promoter contains an extract from a plant belonging to the genus Juglans of the family Juglandaceae as an effective ingredient. (5) The retinoid-like action-activating agent contains an extract from a plant belonging to the genus Juglans of the family Juglandaceae as an effective ingredient. (6) The dermis growth promoter contains an extract from a seed of a plant belonging to the genus Fragaria of the family Rosaceae as an effective ingredient.

Description

  The present invention relates to a skin-beautifying composition that uses a novel ingredient as an active ingredient, has a retinoid-like action, and further promotes collagen production.

  Compounds having retinoid-like activity are well known in the art and are described in many patents in the United States and other countries, as well as in the scientific literature. In general in the art, retinoid-like activity is known and recognized to be useful for treating and alleviating the signs and symptoms of many diseases and conditions to treat mammals, including humans. In other words, pharmaceutical compositions containing retinoid-like compounds as active ingredients are used as regulators of cell proliferation and differentiation, and in particular for skin diseases such as acne, Darier's disease, psoriasis, ichthyosis, eczema and atopic dermatitis. ), Therapeutic and preventive agents for malignant hyperproliferative diseases (e.g. epithelial cancer, breast cancer, prostate cancer, head and neck cancer, and myeloid leukemia), atherosclerosis and recurrent stenosis (Shinnai) Therapeutic and prophylactic agents (by membrane hyperproliferation), other non-malignant hyperproliferative diseases (e.g. endometrial hyperplasia, benign prostatic hyperplasia, proliferative vitreoretinopathy and dysplasia), autoimmune diseases And treatment of immune diseases (e.g. lupus erythematosus), treatment of chronic inflammatory diseases (e.g. pulmonary fibrosis), treatment and prevention of diseases involved in lipid metabolism and transport (e.g. lipemia), wound healing Promoter, an agent for treating dry eye syndrome and when it is useful as therapeutic and prophylactic agents of skin sun damage, it is generally recognized in the art.

  Skin aging symptoms such as wrinkles, spots, and skin elasticity due to external stress such as aging and ultraviolet rays include functional deterioration of skin dermal fibroblasts, degeneration and reduction of collagen, hyaluronic acid and other factors. Decrease in mucopolysaccharides is an important factor. However, as with conventional cosmetics, it is clear that skin aging symptoms cannot be sufficiently prevented simply by trying to retain moisture by combining biochemical products such as mucopolysaccharides and collagen and synthetic polymer products. It has become. Therefore, in order to obtain an external preparation for skin having anti-aging and improving effects on skin, cell activation, collagen production promoting action, hyaluronic acid production promoting action and antioxidant action, etc., or a plurality of these actions Attempts have been made to search for and contain ingredients, but there are still not enough in terms of stability, side effects and effects.

Human skin undergoes certain aging effects, some aging effects are due to intrinsic effects (eg, aging), and some aging effects are exogenous (For example, aging by light). In addition, acne, oily or dry skin, keratosis, rosacea, photosensitivity, inflammation, erythema, and allergic or autoimmune reactive reactions such as dermatosis and photodermatoses. , Temporary or permanent changes in the skin may occur.

The results of the aging effects described above may include thinning the skin, weakening the binding force between the epidermis and dermis, and reducing the number of cells and blood supply of blood vessels. This result often results in the formation of fine lines and wrinkles and can result in pigment deficiencies.

  Thus, retinoids have been used to treat skin conditions caused by endogenous aging, exogenous factors, or skin diseases. However, despite the effectiveness of treatment with retinoids, retinoids are irritating to the skin, so their efficacy is limited. Such side effects of retinoids can limit the use of retinoids.

To date, research on alternative compounds for retinoids has been conducted on the treatment of skin diseases related to aging such as skin atrophy, acne, light aging, and on the reduction of the incidence of wrinkles, fine lines, stretched lines, or cellulite. Has brought some success.

“BIO INDUSTRY”, 1991, Vol. 8, p. 346 “J. Invest. Dermatol”, 1994, Vol. 102, p. 385 “Skin (increased by 5)”, 1997, Vol. 51, p. 53 “Nagoya Med. J.”, 1997, Vol. 41, p. 27 “Arthritis Rheumatism”, 1967, Vol. 10, p. 357 “Connective tissue”, 1984, Kanehara Publishing, p. 481 “Inflammation”, 1991, Vol. 11, p. 16 “Connective tissues and diseases”, 1980, Kodansha, p. 246 “Connective tissues and diseases”, 1980, Kodansha, p. 153 “Biochimica Biophysica Acta”, 1989, Vol. 1014, p. 305 “Journal of Japan Society of Obstetrics and Gynecology”, 1989, Volume 41, p. 1943 “Experimental Cell Research”, 1983, 148, p. 377

Against this background, the extract of Rosaceae Fragaria L., the extract of lychee, the extract of Walnut family (Juglans) retinoid-like action and the action of promoting collagen production The present invention was completed.
In other words, the present invention has a retinoid-like action, has an action of promoting collagen production, and is capable of suppressing wrinkle formation by increasing the thickness by promoting the growth of the dermis. The object is to provide ingredients.

The features of the present invention for solving the above-described problems are as follows.
1. Collagen production promoter comprising as an active ingredient an extract of Rosaceae Fragaria L.
2. The collagen production promoter according to claim 1, wherein seeds are used as a part of the Rosaceae Fragaria L ..
3. Collagen production promoter comprising lychee seed extract as an active ingredient.
4). A collagen production promoter comprising an extract of the genus Juglans as an active ingredient.
5. A retinoid-like activator comprising as an active ingredient an extract of the genus Juglans.
6). A dermal growth promoter containing an extract of the seeds of the genus Rosaceae Fragaria L. as an active ingredient.

It is a graph which shows the retinoid like action of a strawberry seed extract, a lychee seed extract, and a walnut extract. It is a graph which shows the collagen production promotion effect in a strawberry seed extract, a lychee seed extract, and a walnut extract. It is a graph which shows the growth promotion effect | action of the dermis in the artificial dermis in a strawberry seed extract.

The present invention is described in detail below.
The collagen production promoter, retinoid-like activator of the present invention, and skin thickness increasing agent (hereinafter simply referred to as “collagen production promoter etc.”) are referred to as Rosaceae of the Rosaceae family. Fragaria L.), a lychee, and an extract of the genus Juglans is an active ingredient.
The kind of Rosaceae Fragaria L. used as a raw material of the present invention is not particularly limited, and examples thereof include Fragaria daltoniana, Fragaria iinumae (Fragaria iinumae), Fragaria nilgerrensis, Fragaria nipponica (Frosaria snake strawberry), Fragaria nipponica f. . Rosea (Safflower Snake Strawberry), Fragaria nipponica var. yakusimensis (Yakushima Shirobana Snake Strawberry), Fragaria nubicola, Fragaria vesca (Ezosnake Strawberry) Fragaria viridis, Fragaria yezoensis (Ezoxosa strawberry), Fragaria
moupinensis, Fragaria
orientalis, Fragaria
moschata, Fragaria
× ananassa
Examples include DUCHESNE (Netherlands strawberry), Fragaria chiloensis (Chile strawberry), Fragaria iturupensis Staudt, Fragaria virginiana (Virginia strawberry), Fragaria × Potentilla (intergeneric hybrid), Fragaria × vescana and the like.
These may be used alone or in combination of two or more. Of these, Fragaria x ananassa DUCHESNE (Netherlands strawberry) is particularly preferable.

  The cultivar of Fragaria x ananassa DUCHESNE (Dutch strawberry) used at this time is not particularly limited. For example, Toyono, Nyoho, Tochiotome, Sahonoka, Akihime, Asuka Ascalby, Iberry, Tochihime, Red Pearl, Sachinoka, Amaou, Hoho Early Childhood, Benihoppe Momoichigo, Natsumi, Summer Princess, Pettika, Natsumusume (Karenya), Echigohime (Echigo) Hime) and the like, but not limited thereto. These may be used alone or in combination of two or more.

  The part of Rosaceae Fragaria L. used as a raw material is not particularly limited, but leaves, stems, fruits, flowers, seeds, etc. can be used, especially using seeds. preferable. It contains a high concentration of polyphenols such as tyrilloside, and thereby has an excellent collagen production promoting action, retinoid-like action active action, and skin thickness increasing action (hereinafter simply referred to as “collagen production promoting action”). ).

  It is preferable that tiriloside is contained as a component of Rosaceae Fragaria L .. This is because it has an excellent collagen production promoter action and the like.

At this time, the content of tyrilloside is not particularly limited. However, when the total mass of the collagen production accelerator and the like is 100% by mass, 0.01-15% by mass, preferably 0.5-10% by mass. preferable. This is because it has a superior collagen production promoting action and the like.
It is preferable to contain kaempferol 3-O-glucoside as a component of the genus Rosaceae Fragaria L.

  The fruit tree of evergreen tree of lychee (Litchi chinensis). Also called litchi. In the present invention, lychee seeds are used.

The invention is characterized by the use of an extract of the genus Juglans.
Further, the walnut genus used in the present invention is not particularly limited. For example, walnut (Juglans regia), walnut (J. aulantifolia), walnut (J. ailantifolia var. Cordiformis), walnut (J. regia var. Orientis) ) And the like. The whole walnut part may be used as a raw material, but seeds from which the outer skin and inner skin have been removed are preferably used. More preferably, only the seed coat is peeled from the seed and the seed is removed. This is because polyphenols, which are active ingredients, are not contained in the seeds at all, and the polyphenol content in the seed coat is extremely high.

  Moreover, although the manufacturing method of collagen production promoter etc. is not specifically limited, Polar solvent extraction, supercritical extraction, etc. are mentioned. In the present invention, only one of these may be used, or both of them may be used.

Here, when extracting with a polar solvent, strawberry seeds, lychee seeds, and walnuts (hereinafter simply referred to as “plant raw materials”) may be used as they are as raw materials for extraction, or defatted plant raw materials may be used. It is because an active ingredient can be extracted easily.
At this time, as a degreasing method, for example, the plant raw material may be squeezed to separate the oil, and after separating the oil, the residual oil of the pressed product is extracted and separated with a degreasing solvent (fat-soluble organic solvent). You may do it. Further, the plant raw material may be pulverized and extracted and separated using a degreasing solvent (fat-soluble organic solvent).

  At this time, preferable degreasing solvents include n-hexane, acetone and the like. In particular, it is preferable to use n-hexane. This is because the extracted oil can be used as an edible oil, and the extract of the defatted plant material can be easily used as a food material. These degreasing solvents may be used alone or in combination of two or more.

  Furthermore, when extracting by polar solvent extraction, the polar solvent to be used is not particularly limited. For example, water, methanol, ethanol, isopropanol, acetone, 1,3-butylene glycol, ethylene glycol, propylene glycol, glycerin, acetic acid, acetic acid are used. Examples include ethyl, ether, hexane and the like. Of these, water and ethanol are preferred. In particular, it is preferable to use hydrous ethanol. These may be used alone or in combination of two or more.

  When water is used as the extraction solvent, the extraction temperature is 20 to 100 ° C., preferably about 80 to 100 ° C. This is because if the extraction temperature is too low, it is difficult to extract active ingredients. The kind of water for extraction is not particularly limited, and tap water, distilled water, mineral water, alkaline ionized water and the like can be used.

  When hydrous ethanol is used as the extraction solvent, the ethanol concentration is preferably 30 to 90 wt%. This is because if the amount is less than about 30 wt% or exceeds 90 wt%, the extraction amount of the active ingredient tends to decrease. The extraction temperature is 20 to 80 ° C, preferably about 50 to 80 ° C. In addition, the water-containing ethanol extraction may be repeated at various concentrations in order to improve the content of the active ingredient.

  In addition, when extracting with a polar solvent, any extraction method such as continuous extraction, immersion extraction, countercurrent extraction, etc. can be employed as the extraction method, and any apparatus can be used at room temperature or under reflux heating. Can do. Moreover, you may combine the said extraction method etc.

  As a specific method, an extraction raw material is put into a treatment tank filled with an extraction solvent, and an active ingredient is eluted while stirring. For example, when water or water-containing ethanol is used as the extraction solvent, the extraction is performed for about 30 minutes to 5 hours using a polar solvent of about 5 to 100 times (weight ratio) of the extraction raw material. The active ingredient is eluted in the solvent, and then filtered to remove the extraction residue to obtain an extract. Thereafter, the extract is subjected to treatments such as dilution, concentration, drying and purification according to a conventional method to obtain a collagen production promoter.

  Examples of the purification method include activated carbon treatment, resin adsorption treatment, ion exchange resin, liquid-liquid countercurrent distribution, and the like, but they are not used in large quantities when added to foods. It may be used unpurified.

  Moreover, when extracting by supercritical extraction, the supercritical fluid to be used is not specifically limited, For example, a carbon dioxide, water, etc. are mentioned. In addition, these may use only 1 type and may use 2 or more types together. Of these, carbon dioxide is particularly preferred. It is because an active ingredient can be extracted more easily. The extraction method at this time may be performed by a known method.

  The collagen production promoter of the present invention can be used as a material for various foods and drinks. Examples of the food and drink include edible oil (salad oil), confectionery (gum, candy, caramel, chocolate, cookie, snack, jelly, gummy, tablet confection etc.), noodles (soba, udon, ramen etc.), and dairy products ( Milk, ice cream, yogurt, etc.), seasonings (miso, soy sauce, etc.), soups, beverages (juice, coffee, tea, tea, carbonated drinks, sports drinks, etc.) and health foods (tablets , Capsules, etc.) and nutritional supplements (nutrient drinks, etc.). The collagen production promoter of the present invention and the like may be appropriately blended with these foods and drinks.

These foods and drinks can be blended with various ingredients depending on the type, for example, glucose, fructose, sucrose, maltose, sorbitol, stevioside, corn syrup, lactose, citric acid, tartaric acid, malic acid, succinic acid. Acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, gum arabic, Food materials such as carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinic acid amide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances and preservatives can be used. In addition, collagen production promoters with health maintenance functions include other antioxidants and health food ingredients such as antioxidants, reduced ascorbic acid (vitamin C), vitamin E, and reduced forms. Glutatin, tocotrienol, vitamin A derivative, lycopene, β-cryptoxanthin, astaxanthin, zeaxanthin, fucoxanthin, uric acid, ubiquinone, coenzyme Q10, folic acid, garlic extract, allicin, sezamin, lignans, catechins, isoflavones, chalcones, tannins, Flavonoids, coumarins, isocoumarins, blueberry extract, arbutin, tannin, anthocyanin, apple polyphenol, grape seed extract, ellagic acid, kojic acid, surge extract health food material, V. (vitamin) A, V.B1, V. B2, V.B6, V.B12, VC, VD, VE , VP, choline, niacin, pantothenic acid, calcium folate, EPA, oligosaccharide, dietary fiber, squalene, soy lecithin, taurine, donariella, protein, octacosanol, DHA, egg yolk lecithin, linoleic acid, lactoferrin, magnesium, zinc, chromium, Selenium, potassium, heme iron, oyster meat extract, chitosan, chitin oligosaccharide, collagen, chondroitin, turmeric, licorice, kukoshi, keihi, hawthorn, ginger, ganoderma, shijimi extract, suppon, plantain, chamomile, chamomile, dandelion, hibiscus , Honey, Boren, Royal Jelly, Lime, Lavender, Rosehip, Rosemary, Sage, Bifidobacterium, Facaris, Lacris, Wheat Germ Oil, Sesame Oil, Perilla Oil, Soybean Oil, Medium Chain Fatty Acid, Agaricus, Ichi Wu leaf extract, turmeric, chondroitin, brown rice germ extract, litchi, onion, DHA, EPA, DPA, green tea, cordyceps, garlic, bee, papaya, puer, propolis, megsuri tree, yabushitake, royal jelly, saw palmetto, hyaluron Acid, Collagen, Gabba, Harpseal Oil, Shark Cartilage, Glucosamine, Lecithin, Phosphatidylserine, Tabuchi Carrot, Mulberry Leaf, Soybean Extract, Echinacea, Ezoukogi, Barley Extract, Olive Leaf, Olive Seed, Gymnema, Banaba, Salacia , Garcinia, Chitosan, St. John's wort, jujube, carrot, passion flower, broccoli, placenta, pearl barley, grape seed, peanut seed coat, bilberry, black cohosh, maria thistle, laurel, sage, rosemary, rafma, Black vinegar, bitter gourd, maca, safflower, flax, oolong tea, flower spine, caffeine, capsaicin, xylo-oligosaccharide, glucosamine, buckwheat, citrus, dietary fiber, protein, prunes, spirulina, barley young leaves, nucleic acid, yeast, shiitake mushroom, plum meat , Amino acids, deep sea bream extract, noni, oyster meat, suppon, champignon, plantain, acerola, pineapple, banana, peach, apricot, melon, strawberry, raspberry, orange, fucoidan, mesimacob, cranberry, chondroitin sulfate, zinc, iron, Ceramide, Silk Peptide, Glycine, Niacin, Chest Tree, Ceramide, L-Cysteine, L-Carnitine, Red Wine Leaf, Millet, Horsetail, Biotin, Centella Asiatica, Hascup, Pycnogenol, Fuqui, Rhubarb, Clove, Rosemary, Catechin, Puaru, Citric acid, Beer yeast, Merirot, Black zinger, Ginger, Gadju, Nattokinase, Benikouji, Tocotrienol, Lactoferrin, Cinnamon, Buckwheat, Cocoa, Yuzu seed extract, Perilla seed extract, Lychee seed extract, Evening primrose extract, Black rice extract, α-lipoic acid, GABA, fresh coffee bean extract, Japanese bursa extract, kiwi seed extract, Unshu mandarin orange extract, red ginger extract, red rice extract, lingonberry extract, kankanikujuyo extract, white jellyfish extract, resveratrol, A cherry blossom extract can also be blended.

  As a specific production method, the collagen production promoter of the present invention is used as it is, and in the case of an extract, it is spray-dried or freeze-dried together with powdered dextrin, and this is made into a powder, granule, tablet, or solution for easy food production. (Instant food, etc.) If necessary, it can also be mixed with a binder such as gum arabic to form a powder or granules, and added to a solid food. In the case of an extract, it can also be added to a beverage as it is or after being dispersed and dissolved in water, ethanol, glycerin or a mixture thereof.

  The collagen production promoter or the like of the present invention may be used as a raw material for drugs (including pharmaceuticals and quasi drugs). It can be produced by appropriately blending the collagen production promoter of the present invention with a raw material for a pharmaceutical preparation. In addition, the said chemical | medical agent may be used for a human and may be used for mammals other than a human. Examples of pharmaceutical raw materials that can be blended in the collagen production promoter of the present invention include, for example, excipients (glucose, lactose, sucrose, sodium chloride, starch, calcium carbonate, kaolin, crystalline cellulose, cacao butter, hydrogenated vegetable oil, kaolin, Talc, etc.), binder (distilled water, physiological saline, ethanol water, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethylcellulose, potassium phosphate, polyvinylpyrrolidone, etc.), disintegrant (sodium alginate, agar, carbonate) Sodium hydride, calcium carbonate, sodium lauryl sulfate, stearic acid monoglyceride, starch, lactose, gum arabic powder, gelatin, ethanol, etc.), disintegration inhibitors (sucrose, stearin, cocoa butter, hydrogenated oil, etc.), absorption enhancers (No. Quaternary ammonium base, sodium lauryl sulfate Um, etc.), adsorbents (glycerin, starch, lactose, kaolin, bentonite, silicic acid, etc.), lubricants (purified talc, stearates, polyethylene glycol, and the like) and the like.

  The administration method of the collagen production promoter and the like according to the present invention can be generally administered orally in the form of tablets, pills, soft / hard capsules, fine granules, powders, granules and the like. The water-soluble preparation can be administered orally as a liquid. Furthermore, parenteral administration may be used. When administered as a parenteral agent, the collagen production promoter of the present invention is dispersed in a suitable solubilizer such as ethanol or water, and then an agent such as a poultice, lotion, ointment, tincture or cream. Can be applied in form. Water-soluble preparations such as collagen production promoters can be used as they are or in the form of a poultice, lotion, ointment, tincture, cream, etc. with a dispersant, suspension, stabilizer, etc. added. Can be applied.

  The dose may vary depending on the administration method, medical condition, age of the patient, etc., but for adults, it can be generally administered in an amount of about 5 to 200 mg as an active ingredient per day and usually about 0.5 to 100 mg for children.

  The compounding ratio when using the collagen production promoter or the like of the present invention as a drug can be appropriately changed depending on the dosage form, but is usually about 0.01 to 10 wt.% When administered orally or by mucosal absorption. %, In the case of parenteral administration, it should be about 0.01 to 20 wt%. In addition, since the dose varies depending on various conditions, a dose smaller than the above dose may be sufficient, or it may be necessary to administer beyond the range. In addition to the collagen production promoter and the like, the pharmaceutical composition may include other known compounds commonly used in the pharmaceutical field, and compounds necessary for molding into a form suitable for oral administration. Examples of such compounds include lactose, starch, hydroxypropyl cellulose, kaolin, talc, calcium carbonate and the like.

Moreover, the collagen production promoter of this invention etc. can be contained in the animal feed for mammals. The animal feed can be contained in the same manner as the food and drink. The animal feed is not particularly limited. For example, it is used for domestic animals such as cattle and pigs, companion animals such as dogs, cats and hamsters (animals kept as pets). can do.
For example, flour, meat, etc. can be used as companion animal feed. At this time, examples of the flour include wheat flour, rice flour, rye flour, corn flour, millet flour, bubble flour, corn flour, and soybean flour, and these flours may be used in combination of two or more. By using flour, nutrients such as carbohydrates can be supplied to companion animals. Among the above flours, it is most preferable to use flour, and as flour, strong flour, medium flour, thin flour can be used alone or in combination, and even when such flour and other flour are used in combination Good. Furthermore, in order to adjust the elasticity of the animal feed after the heat treatment, wheat flour, wheat gluten, soybean protein and the like may be combined. In addition, the network structure derived from gluten contained in wheat flour can constitute a puffed tissue structure when heat-treated, which contributes to improving the texture.

  The meat used in the present invention is not particularly limited, and chicken, pork, beef, mutton, goat meat, salmon, turkey meat, horse meat, etc. can be used, but chicken is preferably used from the point of flavor. The The above meat is obtained by slaughtering and demolishing livestock in the usual way. In addition, since the deterioration of the quality of a product with intermediate moisture or low moisture is mainly caused by fat oxidation, the meat to be used is preferably red meat from which the fat content is low or fat is removed. In addition, the coexistence of meat can improve the palatability of companion animals as well as strengthening high-quality animal proteins.

Even when the collagen production promoter of the present invention is used as an external preparation for skin (including cosmetics, pharmaceuticals and quasi drugs), it can be expected to promote collagen production. In addition, the said skin external preparation may be used for a human and may be used for mammals other than a human.
Examples of skin external preparations that can contain the collagen production promoter of the present invention include, for example, emulsion, soap, facial cleanser, bath preparation, cream, emulsion, lotion, eau de cologne, shave cream, shave lotion. , Cosmetic oil, suntan / sunscreen lotion, powder, foundation, perfume, pack, nail cream, enamel, enamel remover, eyebrow, blusher, eye cream, eye shadow, mascara, eyeliner, lipstick, lip balm, shampoo, Rinse, hair dye, dispersion liquid, cleaning agent and the like can be mentioned.
Examples of the form of pharmaceuticals or quasi drugs that can contain the collagen production promoter of the present invention include ointments, creams, and liquids for external use.

In addition to the collagen production promoter according to the present invention, the external preparation for skin of the above-described form includes components, oils, and the like that are blended in skin external preparations such as cosmetics and quasi-drugs as long as the collagen production promotion action and the like are not impaired. Higher alcohols, fatty acids, ultraviolet absorbers, powders, pigments, surfactants, polyhydric alcohols / sugars, polymers, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, and the like.
Examples are listed below, but the present invention is not limited to these examples.

(1) Examples of oil components Ester-based oil phase components: glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isostearic acid Isocetyl, butyl stearate, butyl myristate, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine Diisopropyl acid, isoaralkyl neopentanoate, glyceryl tri (capryl / caprate), trimethylolpropane tri-2-ethylhexanoate, trimethylol triisostearate Propane, pentaerythritol tetra-2-ethylhexanoate, cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinoleate, isolaurate Stearyl, isotridecyl myristate, isocetyl myristate, isostearyl myristate, isocetyl palmitate, isostearyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl linoleate, octyldodecyl isoleate, isopropyl isostearate Cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethyleneglycol dioctanoate , Ethylene glycol dioleate, propylene glycol dicaprate, propylene glycol di (capryl / capric acid), propylene glycol dicaprylate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, triisopalmitine Glyceryl acid, glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate, octyl isononanoate, hexyl decyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerin oleic acid Ester, polyglycerol isostearate, dipropyl carbonate, charcoal Dialkyl (C12-18), triisocetyl citrate, triisoaralkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyl decyl lactate, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, Trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, olein Cholesteryl acid, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, 12-stearoyl hydroxystearate Cetyl, 12-stearoyl-hydroxystearic acid stearyl 12-stearoyl-hydroxystearic acid isostearate, and the like.
Hydrocarbon oil phase components: squalane, liquid paraffin, α-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, petrolatum and the like.
Animal and vegetable oils and their hydrogenated oils, and naturally occurring waxes: beef tallow, hydrogenated beef tallow, lard, hydrogenated tallow, horse oil, hydrogenated horse oil, mink oil, orange luffy oil, fish oil, hydrogenated fish oil, egg yolk oil and other animal oils and Its hardened oil, avocado oil, almond oil, olive oil, cacao butter, kiwi seed oil, apricot oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, safflower oil, shea butter, soybean oil, evening primrose oil , Perilla oil, tea seed oil, camellia oil, corn oil, rapeseed oil, hydrogenated rapeseed oil, palm kernel oil, hydrogenated palm kernel oil, palm oil, hydrogenated palm oil, peanut oil, hydrogenated peanut oil, castor oil, hydrogenated castor oil , Vegetable oils such as sunflower oil, grape seed oil, jojoba oil, hardened jojoba oil, macadamia nut oil, medhome oil, cottonseed oil, hardened cottonseed oil, coconut oil, hardened coconut oil and its hardened , Beeswax, high acid value beeswax, lanolin, reduced lanolin, hydrogenated lanolin, liquid lanolin, carnauba wax and montan wax.
Silicone oil phase components: dimethylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, methylhydrogenpolysiloxane, polyether-modified organopolysiloxane, dimethyl Siloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, amino-modified silicone oil, amino-modified organopolysiloxane, dimethiconol, silicone gel, acrylic Examples include silicone, trimethylsiloxysilicic acid, and silicone RTV rubber.
Fluorine oil phase components: perfluoropolyether, fluorine-modified organopolysiloxane, fluorinated pitch, fluorocarbon, fluoroalcohol, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane, and the like.

(2) Examples of higher alcohols Lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, 2-ethylhexanol, hexadecyl alcohol, octyldodecanol and the like can be mentioned.

(3) Examples of fatty acids Caprylic acid, capric acid, undecylenic acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid, behenic acid , Erucic acid, 2-ethylhexanoic acid and the like.

(4) Examples of UV absorbers Paraaminobenzoic acid, amyl paraaminobenzoate, ethyldihydroxypropyl paraaminobenzoate, glyceryl paraaminobenzoate, ethyl paraaminobenzoate, octyl paraaminobenzoate, octyldimethyl paraaminobenzoate, ethylene glycol salicylate, salicylic acid Octyl, triethanolamine salicylate, phenyl salicylate, butylphenyl salicylate, benzyl salicylate, homomenthyl salicylate, benzyl cinnamate, octyl paramethoxycinnamate, 2-ethylhexyl paramethoxycinnamate, mono-2-diparamethoxycinnamate Glyceryl ethylhexanoate, isopropyl paramethoxycinnamate, diethanolamine salt of paramethoxyhydrocinnamic acid, diisopropyl diisopropylcinnamic acid Stealth mixture, urocanic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its salts, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, hydroxyoctoxybenzophenone, tetrahydroxybenzophenone, Butylmethoxydibenzoylmethane, 2,4,6-trianilino-p- (carbo-2-ethylhexyl-1-oxy) -1,3,5-triazine, 2- (2-hydroxy-5-methylphenyl) benzotriazole , Methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3, 3-diphenyl acrylate, phenylbenzimidazole sulfate, 3- (4-methylbenzylidene) can Examples include full, isopropyldibenzoylmethane, 4- (3,4-dimethoxyphenylmethylene) -2, 5-dioxo-1-imidazolidinepropionate 2-ethylhexyl, and the like, polymer derivatives, silane derivatives, and the like.

(5) Examples of powders and pigments Red 104, Red 201, Yellow 4, Blue 1, Black 401 and other dyes, Yellow 4 AL lake, Yellow 203 BA lake and other lake dyes, nylon powder , Silk powder, urethane powder, Teflon (registered trademark) powder, silicone powder, polymethyl methacrylate powder, cellulose powder, starch, silicone elastomer spherical powder, polyethylene powder, yellow iron oxide, red iron oxide, black Colored pigments such as iron oxide, chromium oxide, carbon black, ultramarine and bitumen, white pigments such as zinc oxide, titanium oxide and cerium oxide, extender pigments such as talc, mica, sericite, kaolin and barium sulfate plate, titanium mica Pearl pigments such as barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, metal salts such as magnesium silicate, Inorganic powders such as Rica and alumina, metal soaps such as aluminum stearate, magnesium stearate, zinc palmitate, zinc myristate, magnesium myristate, zinc laurate, zinc undecylenate, bentonite, smectite, boron nitride, etc. It is done. There are no particular restrictions on the shape of these powders (spherical, rod-like, needle-like, plate-like, irregular shape, flake-like, spindle-like, etc.) and particle diameter. These powders are conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, The surface treatment may or may not be performed in advance by polyacrylic acid treatment, metal soap treatment, amino acid treatment, lecithin treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment or the like.

(6) Examples of surfactants Anionic surfactants: fatty acid soap, α-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate , Alkylamide sulfate, alkyl phosphate, POE alkyl phosphate, alkylamide phosphate, alkyloylalkyl taurine salt, N-acyl amino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate, alkyl sulfoacetic acid Sodium, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphate, etc. are mentioned.
Cationic surfactant: alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, benzalkonium chloride , Behenic acid amidopropyldimethylhydroxypropylammonium chloride, stearic acid diethylaminoethylamide, stearic acid dimethylaminopropylamide, lanolin derivative quaternary ammonium salts, and the like.
Amphoteric surfactants: carboxybetaine type, amide betaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amidoamine type and the like.
Nonionic surfactant: propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE sorbitol fatty acid ester, POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE cured castor Oil, POE castor oil, POE / POP copolymer, POE / POP alkyl ether, polyether-modified silicone lauric acid alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, and the like.
Natural surfactant: lecithin, saponin, sugar surfactant and the like.

(7) Examples of polyhydric alcohols and sugars Ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1, 3 -Butylene glycol, sorbitol, mannitol, raffinose, erythritol, glucose, sucrose, fructose, xylitol, lactose, maltose, maltitol, trehalose, alkylated trehalose, mixed isomerized sugar, sulfated trehalose, pullulan and the like. These chemically modified compounds can also be used.

(8) Examples of polymers Acrylic ester / methacrylic acid ester copolymer (plus size, manufactured by Kyoyo Chemical), vinyl acetate / crotonic acid copolymer (resin 28-1310, manufactured by NSC), vinyl acetate / croton Acid / vinyl neodecanate copolymer (28-2930, manufactured by NSC), methyl vinyl ether maleic acid half ester (Gantrez ES, manufactured by ISP), T-butyl acrylate / ethyl acrylate / methacrylic acid copolymer (rubymer) , BASF), vinyl pyrrolidone / vinyl acetate / vinyl propionate copolymer (Rubicol VAP, BASF), vinyl acetate / crotonic acid copolymer (Rubiset CA, BASF), vinyl acetate / croton Acid / vinyl pyrrolidone copolymer (Rubiset CAP, manufactured by BASF), vinyl pyrrolidone / acrylate copolymer (Rubiflex, BA SF), acrylate / acrylamide copolymer (Ultrahold, BASF), vinyl acetate / butyl maleate / isobornyl acrylate copolymer (Advantage, ISP), carboxy vinyl polymer (Carbopol, BF Goodrich), anionic polymer compounds such as acrylic acid / alkyl methacrylate copolymer (Pemulene, BF Goodrich), and acetic acid amphoteric products of dialkylaminoethyl methacrylate polymers (Yukaformer, Mitsubishi Chemical) Amphoteric polymer compounds such as octyl acrylate acrylate / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer (AMPHOMER, NSC), quaternized vinylpyrrolidone / dimethylaminoethyl methacrylate (GAFQUAT, ISP) , Methyl vinyl imidazolium chloride Cationic polymer compounds such as vinyl / vinylpyrrolidone copolymer (rubicoat, manufactured by BASF), polyvinylpyrrolidone (rubiscol K, manufactured by BASF), vinylpyrrolidone / vinyl acetate copolymer (rubiscol VA, manufactured by BASF) ), Nonionic polymer compounds such as vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer 937, manufactured by ISP), vinylcaprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer VC713, manufactured by ISP), etc. There is. Cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar, gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabino Naturally derived polymer compounds such as galactan, gum karaya, gum tragacanth, alginic acid, albumin, casein, curdlan, gellan gum and dextran can also be suitably used.

(9) Examples of physiologically active ingredients Examples of physiologically active ingredients include substances that impart some physiological activity to the skin when applied to the skin. For example, whitening ingredients, immunostimulants, anti-aging agents, UV protection agents, slimming agents, tanning agents, antioxidants, hair growth agents, hair restorers, moisturizers, blood circulation promoters, antibacterial agents, bactericides, desiccants, A cooling sensation agent, a warming sensation agent, vitamins, an amino acid, a wound healing promoter, an irritation relaxation agent, an analgesic agent, a cell activator, an enzyme component, etc. are mentioned. Examples of these suitable ingredients include, for example, ashitaba extract, avocado extract, amateur extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract, fennel extract, turmeric extract, oolong tea extract, ages Extract, Echinacea leaf extract, Ogon extract, Oat extract, Oen extract, Barley extract, Hypericum extract, Oyster extract, Dutch mustard extract, Orange extract, Seawater dried product, Seaweed extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk , Chamomile extract, Carrot extract, Kawara mugwort extract, Licorice extract, Calcade extract, Oyster extract, Kina extract, Cucumba extract, Guanosine, Gardenia extract, Kumazasa extract, Clarae Kiss, walnut extract, grapefruit extract, clematis extract, chlorella extract, mulberry extract, gentian extract, tea extract, yeast extract, burdock extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, bilberry extract, saicin extract, psycho extract Extract Kizuta extract, hawthorn extract, elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, senki Sue extract, assembly extract, soybean extract, tiso extract, thyme extract, tea extract, clove extract, chigaya extract, chimpi extract, touki extract, toshinsen extract, tonin extract, spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, Novara extract, hibiscus extract, bacmond extract, parsley extract, honey, hamamelis extract, parietalia extract, toad extract, bisabolol, loquat extract, dandelion extract, burdock extract, bukuro extract, butcher bloom extract, grape extract, propolis, loofah extract, Safflower extract, peppermint extract, bodaige extract, button extract, hop extract, pine extract, marronnier extract, mizubasho Kiss, Mukuroji extract, Melissa extract, Peach extract, Cornflower extract, Eucalyptus extract, Yukinoshita extract, Yokuinin extract, Artemisia extract, Lavender extract, Apple extract, Lettuce extract, Lemon extract, Lotus root extract, Rose extract, Rosemary extract, Roman chamomile extract And royal jelly extract.
Biopolymers such as deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes, amino acids, hydrolyzed peptides, sodium lactate, urea, sodium pyrrolidonecarboxylate , Moisturizing ingredients such as betaine, whey, trimethylglycine, oily ingredients such as sphingolipid, ceramide, phytosphingosine, cholesterol, cholesterol derivatives, phospholipids, ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, Immunostimulants such as hydrocortisone, vitamin A, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, calcium pantothenate, biotin, nicotinamide, vitamin C ester Vitamins, active ingredients such as allantoin, diisopropylamine dichloroacetate, 4-aminomethylcyclohexanecarboxylic acid, antioxidants such as tocopherol, carotenoid, flavonoid, tannin, lignan, saponin, α-hydroxy acid, β-hydroxy acid, etc. Cell activators, blood circulation promoters such as γ-oryzanol and vitamin E derivatives, wound healing agents such as retinol and retinol derivatives, arbutin, kojic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid, glutathione, etc. Whitening agent, cephalanthin, licorice extract, red pepper tincture, hinokitiol, garlic iodide extract, pyridoxine hydrochloride, DL-α-tocopherol, nicotinic acid, nicotinic acid derivative, calcium pantothenate, D-pantothenyl alcohol, aceto Chilpanthenyl ethyl ether, biotin, allantoin, isopropylmethylphenol, estradiol, ethinyl estradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, takanal, camphor, salicylic acid, nonyl acid vanillylamide, nonanoic acid vanillylamide, piroctone olamine, pentadecane Glyceryl acid, L-menthol, mononitroguaiacol, resorcin, γ-aminobutyric acid, benzethonium chloride, mexiletine hydrochloride, auxin, female hormone, cantharis tincture, cyclosporine, zinc pyrithione, hydrocortisone, minoxidil, polyoxyethylene sorbitan monostearate , Hair growth agents such as mint oil and Sasanishiki extract.

(10) Examples of antioxidants Sodium bisulfite, sodium sulfite, erythorbic acid, sodium erythorbate, dilauryl thiodipropionate, tocopherol, tolyl biguanide, nordihydroguaiaretic acid, parahydroxyanisole, butylhydroxyanisole, dibutylhydroxy Examples include plant extracts having an antioxidant effect such as toluene, ascorbyl stearate, ascorbyl palmitate, octyl gallate, propyl gallate, carotenoid, flavonoid, tannin, lignan, saponin, apple extract and clove extract.

(11) Examples of solvents Purified water, ethanol, lower alcohol, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, volatile linear silicone, next-generation chlorofluorocarbon and the like.

Example 1
Production of strawberry seed extract The ground Dutch strawberry seeds were defatted with hexane and extracted with stirring with 70% ethanol (70 ° C, 1 hour). Thereafter, the obtained extract was concentrated and dried to obtain a strawberry seed extract powder (strawberry seed extract).
The polyphenol content was determined by HPLC using the foreign dennis method, and the tyriloside content was determined by HPLC under the following conditions. As a result, the polyphenol content (gallic acid equivalent) of the strawberry seed extract of this example was 10.8%, and tiliroside was 2.1%.

HPLC conditions Eluent: 37.5% acetonitrile Flow rate: 1 mL / min
Detection: UV 254 nm
Column: Shiseido capcelpack C18 (4.6 × 250 mm)

Example 2
Production of lychee seed extract Lychee was stirred and extracted with 40% ethanol (75 ° C., 4 hours). Thereafter, the obtained extract was concentrated and dried to obtain a lychee seed extract powder.

Example 3
Production of walnut extract The seed coat of walnut was extracted by stirring with 50% ethanol (50 ° C., 1 hour). Thereafter, the resulting extract was concentrated and dried to obtain a walnut extract powder.

Test Example 1: Test of retinoid-like action in strawberry seed extract, lychee seed extract, and walnut extract
Using a RARγ ligand assay kit (manufactured by Microsystems), RARγ binding activity (retinoid-like action) of strawberry seed extract, lychee seed extract, and walnut extract was measured according to the attached instructions. The result is shown in FIG.
According to FIG. 1, it was confirmed that the walnut extract has a retinoid-like action.

Test Example 2: Evaluation of Collagen Production Promoting Action in Strawberry Seed Extract, Lychee Seed Extract, and Walnut Extract Human fibroblasts were seeded at a rate of 2.0 × 10 ⁴ on a 24-well plate, and MEM alpha / 10% FBS / The cells were cultured for 72 hours using 1% PS. Thereafter, the strawberry was extracted with each concentration of strawberry seed extract, lychee seed extract, and walnut extract shown in FIG. 2 and replaced with MEM alpha / 1% FBS / 1% PS, followed by further culturing for 24 hours. The collagen production function was evaluated by measuring the amount of procollagen in the cell culture supernatant by ELISA. The result is shown in FIG. According to FIG. 2, it was confirmed that the strawberry seed extract, the lychee seed extract, and the walnut extract have a collagen production promoting action.

Test Example 3: Evaluation of dermal growth promoting action using an artificial dermis model An artificial dermis model (TOYOBO) was cultured in a medium containing 3% of strawberry seed extract at 37 ° C for 72 hours, and then sections were prepared and stained with HE. The dermal growth promoting effect was evaluated by comparing the thickness of the dermis with an optical microscope. The result is shown in FIG.
According to FIG. 3, it was confirmed that the strawberry seed extract has an action of increasing the thickness of the dermis. Thereby, it was confirmed that the strawberry seed extract has a dermal growth action.

Examples of blending the collagen production promoter and the like of this example are shown below. These do not limit the present invention.
Formulation Example 1: Cosmetic cream
Squalane 20.0wt%
Beeswax 5.0
Refined jojoba oil 5.0
Glycerin 5.0
Glycerol monostearate 2.0
Polyoxyethylene (20) sorbitan-
Monostearate 2.0
Collagen production promoter 2.0
Preservative appropriate amount
Perfume
Purified water residue
100.0wt%

Formulation Example 2: Lotion
Ethanol 5.0wt%
Glycerin 2.0
1,3-butylene glycol 2.0
Polyethylene oleyl ether 0.5
Sodium citrate 0.1
Citric acid 0.1
Collagen production promoter 0.1
Purified water residue
100.0wt%

Formulation Example 3: Body Gel
Macadamia nut oil 2.0wt%
Octyldodecyl myristate 10.0
Methylphenylpolysiloxane 5.0
Behenyl alcohol 3.0
Stearic acid 3.0
Batyl alcohol 1.0
Glyceryl monostearate 1.0
Tetraoleic acid polyoxyethylene sorbit 2.0
Hydrogenated soybean phospholipid 1.0
Ceramide 0.1
Retinol palmitate 0.1
Preservative appropriate amount
Centella extract 1.0
Collagen production promoter 1.0
1,3-butylene glycol 5.0
Purified water residue
100.0wt%

Formulation Example 4: Latex
Squalane 4.0wt%
Vaseline 2.5
Cetanol 2.0
Glycerin 2.0
Lipophilic glyceryl monostearate 1.0
Stearic acid 1.0
L-Arginine 1.0
Collagen production promoter 0.5
Potassium hydroxide 0.1
Perfume
Purified water residue
100.0wt%

Formulation Example 5: Bath agent (liquid)
Propylene glycol 50.0wt%
Ethanol 20.0
Sodium sulfate 5.0
Collagen production promoter 0.5
Lanolin 0.5
Avocado oil 0.5
Dye 1.5
Fragrance 22.0
100.0wt%
Formulation Example 6: Chewing gum
53.0wt% sugar
Gum base 20.0
Glucose 10.0
Minamata 16.0
Fragrance 0.5
Collagen production promoter 0.5
100.0wt%

Formulation Example 7: Gummy
Reduced water tank 40.0wt%
Granulated sugar 20.0
Glucose 20.0
Gelatin 4.7
Water 9.68
Strawberry juice 4.0
Grape flavor 0.6
Dye 0.02
Collagen production promoter 1.0
100.0wt%

Formulation Example 8: Candy
50.0 wt% sugar
Minamata 33.0
Water 14.4
Organic acid 2.0
Fragrance 0.2
Collagen production promoter 0.4
100.0wt%

Formulation Example 9: Yogurt (Hard / Soft)
Milk 41.5wt%
Nonfat dry milk 5.8
Sugar 8.0
Agar 0.15
Gelatin 0.1
Lactic acid bacteria 0.005
Collagen production promoter 0.4
Perfume
Water residue
100.0wt%

Formulation Example 10: Soft drink
Fructose glucose liquid sugar 30.0wt%
Emulsifier 0.5
Collagen production promoter, etc.0.05
Perfume
Purified water residue
100.0wt%

Formulation Example 11: Tablets
76.4 wt% sugar
Glucose 19.0
Sucrose fatty acid ester 0.2
Collagen production promoter 0.5
Purified water 3.9
100.0wt%

Formulation Example 12: Soft capsule
Strawberry seed oil 87.0wt%
Emulsifier 12.0
Collagen production promoter 1.0
100.0wt%

Formulation Example 13: Tablet
Lactose 54.0wt%
Crystalline cellulose 30.0
Starch degradation product 10.0
Glycerin fatty acid ester 5.0
Collagen production promoter 1.0
100.0wt%

Formulation Example 14: Oral granules (pharmaceuticals)
Collagen production promoter 1.0wt%
Lactose 30.0
Cornstarch 60.0
Crystalline cellulose 8.0
Polyvinylpyrrolidone 1.0
100.0wt%

Formulation Example 15: Cat food
Corn 34.0wt%
Flour 35.0
Meat meal 15.0
Beef tallow 8.9
Salt 1.0
Skipjack extract 4.0
Collagen production promoter 1.0
Taurine 0.1
Vitamins 0.5
Minerals 0.5
100.0wt%

Formulation Example 16: Dog food
Corn 30.0wt%
Meat (chicken) 15.0
Defatted soybean 10.0
Flour 25.0
Mosses 5.0
Collagen production promoter 5.0
Animal fats and oils 8.9
Oligosaccharide 0.1
Vitamin 0.5
Mineral 0.5
100.0wt%

  As described above, the present invention can provide a retinoid-like action promoter, a collagen production promoter, and a dermal growth promoter containing a novel component as an active ingredient.

Claims (6)

  Collagen production promoter comprising as an active ingredient an extract of Rosaceae Fragaria L.   The collagen production promoter according to claim 1, wherein seeds are used as a part of the Rosaceae Fragaria L ..   Collagen production promoter comprising lychee seed extract as an active ingredient.   A collagen production promoter comprising an extract of the genus Juglans as an active ingredient.   A retinoid-like activator comprising as an active ingredient an extract of the genus Juglans.   A dermal growth promoter containing an extract of the seeds of the genus Rosaceae Fragaria L. as an active ingredient.

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