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IL164004A0 - Piperazinyl-,pipertifinyl-and morpholinyl-derivatives as novel inhibitors of histone deacetylase - Google Patents

Piperazinyl-,pipertifinyl-and morpholinyl-derivatives as novel inhibitors of histone deacetylase

Info

Publication number
IL164004A0
IL164004A0 IL16400403A IL16400403A IL164004A0 IL 164004 A0 IL164004 A0 IL 164004A0 IL 16400403 A IL16400403 A IL 16400403A IL 16400403 A IL16400403 A IL 16400403A IL 164004 A0 IL164004 A0 IL 164004A0
Authority
IL
Israel
Prior art keywords
pipertifinyl
piperazinyl
morpholinyl
derivatives
histone deacetylase
Prior art date
Application number
IL16400403A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority claimed from PCT/EP2003/002510 external-priority patent/WO2003076438A1/en
Publication of IL164004A0 publication Critical patent/IL164004A0/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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IL16400503A IL164005A0 (en) 2002-03-13 2003-03-11 Carbonylamino-derivatives as novel inhibitiors of histone deacetylase
IL16400403A IL164004A0 (en) 2002-03-13 2003-03-11 Piperazinyl-,pipertifinyl-and morpholinyl-derivatives as novel inhibitors of histone deacetylase
IL16400703A IL164007A0 (en) 2002-03-13 2003-03-11 New inhibitors of histone deacetylase
IL164006A IL164006A (en) 2002-03-13 2004-09-09 Derivatives of piperazin (or piperidine) - 1 - yl - pyrimidine (phenyl, pyridine or [1,2,4] triazine) - 5 -carboxylic acid hydroxyamide, pharmaceutical compositions comprising them and a process for their preparation
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US7868204B2 (en) 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
US6897220B2 (en) 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
KR20100107509A (ko) 2001-09-14 2010-10-05 9222-9129 퀘벡 인코포레이티드 히스톤 데아세틸라아제의 억제제
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
ATE521592T1 (de) 2002-03-13 2011-09-15 Janssen Pharmaceutica Nv Histone-deacetylase-inhibitoren
EA007099B1 (ru) 2002-03-13 2006-06-30 Янссен Фармацевтика Н. В. Сульфонилпроизводные в качестве ингибиторов гистон-деацетилазы
KR20040090978A (ko) * 2002-03-13 2004-10-27 얀센 파마슈티카 엔.브이. 히스톤 디아세틸라제의 신규한 저해제로서의 설포닐-유도체
US7446109B2 (en) * 2002-03-13 2008-11-04 Janssen Pharmaceutica N.V. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
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