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IL130900A0 - Atropisomers of 3-aryl-4(3H)- quinazolinones and their use as ampa-receptor antagonsts - Google Patents

Atropisomers of 3-aryl-4(3H)- quinazolinones and their use as ampa-receptor antagonsts

Info

Publication number
IL130900A0
IL130900A0 IL13090098A IL13090098A IL130900A0 IL 130900 A0 IL130900 A0 IL 130900A0 IL 13090098 A IL13090098 A IL 13090098A IL 13090098 A IL13090098 A IL 13090098A IL 130900 A0 IL130900 A0 IL 130900A0
Authority
IL
Israel
Prior art keywords
antagonsts
quinazolinones
ampa
atropisomers
receptor
Prior art date
Application number
IL13090098A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of IL130900A0 publication Critical patent/IL130900A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/91Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL13090098A 1997-02-28 1998-02-06 Atropisomers of 3-aryl-4(3H)- quinazolinones and their use as ampa-receptor antagonsts IL130900A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3890597P 1997-02-28 1997-02-28
PCT/IB1998/000150 WO1998038173A1 (en) 1997-02-28 1998-02-06 Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as ampa-receptor antagonists

Publications (1)

Publication Number Publication Date
IL130900A0 true IL130900A0 (en) 2001-01-28

Family

ID=21902563

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13090098A IL130900A0 (en) 1997-02-28 1998-02-06 Atropisomers of 3-aryl-4(3H)- quinazolinones and their use as ampa-receptor antagonsts

Country Status (40)

Country Link
US (1) US6306864B1 (is)
EP (1) EP0968194B1 (is)
JP (1) JP2000509731A (is)
KR (1) KR100358636B1 (is)
CN (1) CN1248248A (is)
AP (1) AP859A (is)
AR (1) AR011170A1 (is)
AT (1) ATE267817T1 (is)
AU (1) AU744028B2 (is)
BG (1) BG103689A (is)
BR (1) BR9807872A (is)
CA (1) CA2282277C (is)
DE (1) DE69824157T2 (is)
DK (1) DK0968194T3 (is)
DZ (1) DZ2440A1 (is)
EA (1) EA001963B1 (is)
ES (1) ES2219866T3 (is)
GT (1) GT199800038A (is)
HR (1) HRP980106A2 (is)
HU (1) HUP0000914A3 (is)
ID (1) ID22711A (is)
IL (1) IL130900A0 (is)
IS (1) IS1952B (is)
MA (1) MA24484A1 (is)
NO (1) NO313630B1 (is)
NZ (1) NZ336628A (is)
OA (1) OA11089A (is)
PA (1) PA8447001A1 (is)
PE (1) PE58399A1 (is)
PL (1) PL335418A1 (is)
PT (1) PT968194E (is)
SK (1) SK113299A3 (is)
TN (1) TNSN98035A1 (is)
TR (1) TR199902093T2 (is)
TW (1) TW504508B (is)
UA (1) UA61097C2 (is)
UY (1) UY24897A1 (is)
WO (1) WO1998038173A1 (is)
YU (1) YU41299A (is)
ZA (1) ZA981666B (is)

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EA002905B1 (ru) 1996-05-15 2002-10-31 Пфайзер Инк. 2,3-двузамещенные-4(3н)-хиназолиноны и содержащая их фармацевтическая композиция
US6323208B1 (en) 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
JPH11279158A (ja) * 1998-02-09 1999-10-12 Pfizer Prod Inc キナゾリン―4―オン誘導体の製造方法
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
US6518277B1 (en) * 2000-04-25 2003-02-11 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
EP1300396B1 (en) 2000-06-12 2009-01-14 Eisai R&D Management Co., Ltd. 1,2-dihydropyridine compounds, process for preparation of the same and use thereof
MXPA03001495A (es) 2000-08-18 2003-06-06 Ajinomoto Kk Derivados de fenilalanina novedosos.
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
US6939968B2 (en) * 2002-12-23 2005-09-06 Bristol-Myers Squibb Company Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives
US7410974B2 (en) * 2003-08-08 2008-08-12 Ulysses Pharmaceutical Products, Inc. Halogenated Quinazolinyl nitrofurans as antibacterial agents
US20080146562A1 (en) * 2003-08-08 2008-06-19 Ulysses Pharmaceutical Products Inc., Halogenated quinazolinyl nitrofurans as antibacterial agents
GB0325390D0 (en) * 2003-10-30 2003-12-03 Novartis Ag Organic compounds
KR101194176B1 (ko) 2003-12-22 2012-10-24 아지노모토 가부시키가이샤 신규한 페닐알라닌 유도체
WO2005113556A1 (en) 2004-05-13 2005-12-01 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
GB0416730D0 (en) * 2004-07-27 2004-09-01 Novartis Ag Organic compounds
CN101355946B (zh) 2005-11-04 2013-05-08 海德拉生物科学公司 调节trpv3功能的化合物
KR101129868B1 (ko) 2006-10-04 2012-04-12 화이자 프로덕츠 인코포레이티드 칼슘 수용체 길항제로서의 피리도[4,3-d]피리미딘-4(3H)-온 유도체
WO2008140750A1 (en) 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
CN101429166B (zh) * 2007-11-07 2013-08-21 上海特化医药科技有限公司 喹唑啉酮衍生物及其制备方法和用途
CA3092449A1 (en) 2008-11-13 2010-05-20 Gilead Calistoga Llc Therapies for hematologic malignancies
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
WO2010111432A1 (en) 2009-03-24 2010-09-30 Calistoga Pharmaceuticals Inc. Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use
CN102647987A (zh) 2009-07-21 2012-08-22 吉里德卡利斯托加公司 使用pi3k抑制剂治疗肝脏障碍
BR112014021935A2 (pt) 2012-03-05 2019-09-24 Gilead Calistoga Llc formas polimórficas de (s)-2(l-(9h-purin-6-ilamino)propil)-5-fluoro-3-fenilquinazolina-4(3h)ona
CN103275086B (zh) * 2013-05-30 2015-04-15 温州大学 一种6-取代喹唑啉并喹唑啉酮化合物及其合成方法和用途
WO2015095601A1 (en) 2013-12-20 2015-06-25 Gilead Calistoga Llc Process methods for phosphatidylinositol 3-kinase inhibitors
US9708327B2 (en) 2013-12-20 2017-07-18 Gilead Calistoga Llc Polymorphic forms of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
US9533909B2 (en) 2014-03-31 2017-01-03 Corning Incorporated Methods and apparatus for material processing using atmospheric thermal plasma reactor
AU2015274696B2 (en) 2014-06-13 2018-09-27 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
DE102014217021A1 (de) * 2014-08-27 2016-03-03 Skf Lubrication Systems Germany Ag Gehäuse für eine Vorrichtung zum dosierten Verteilen eines Mediums sowie eine Dosiereinrichtung zur Verwendung in dem Gehäuse
MA54460A (fr) 2018-12-14 2021-10-20 Eisai R&D Man Co Ltd Formulations pharmaceutiques à base d'eau de composés de 1,2-dihydropyridine
CN115335050B (zh) 2020-01-29 2024-05-17 卡玛瑞制药有限公司 用于治疗皮肤病症的化合物和组合物

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DE1195321B (de) * 1962-03-16 1965-06-24 Troponwerke Dinklage & Co Verfahren zur Herstellung von substituierten Chinazolon-(4)-derivaten
DE1670416A1 (de) * 1966-12-30 1971-02-11 Chem Fab Von Heyden Gmbh Muenc Verfahren zur Herstellung von aminosubstituierten Chinazolinonderivaten
US3748325A (en) * 1970-04-06 1973-07-24 Karamchand Premchand Private Process for the preparation of quinazolinone derivatives
US4183931A (en) * 1977-09-08 1980-01-15 Research Corporation 2-Ketoalkyl-4(3H)-quinazolinones
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US5777271A (en) * 1996-01-18 1998-07-07 Commscope, Inc. Cable having an at least partially oxidized armor layer
EA002905B1 (ru) * 1996-05-15 2002-10-31 Пфайзер Инк. 2,3-двузамещенные-4(3н)-хиназолиноны и содержащая их фармацевтическая композиция

Also Published As

Publication number Publication date
CA2282277C (en) 2005-10-11
IS5140A (is) 1999-07-30
ZA981666B (en) 1999-08-27
EP0968194A1 (en) 2000-01-05
NO313630B1 (no) 2002-11-04
DZ2440A1 (fr) 2003-01-11
PA8447001A1 (es) 2000-05-24
IS1952B (is) 2004-10-13
AR011170A1 (es) 2000-08-02
EA199900693A1 (ru) 2000-02-28
CA2282277A1 (en) 1998-09-03
GT199800038A (es) 1999-08-13
UY24897A1 (es) 2000-12-29
UA61097C2 (uk) 2003-11-17
EP0968194B1 (en) 2004-05-26
ES2219866T3 (es) 2004-12-01
PT968194E (pt) 2004-08-31
DK0968194T3 (da) 2004-08-16
US6306864B1 (en) 2001-10-23
TNSN98035A1 (fr) 2005-03-15
YU41299A (sh) 2002-09-19
MA24484A1 (fr) 1998-10-01
TR199902093T2 (xx) 1999-12-21
HRP980106A2 (en) 1999-02-28
NO994177L (no) 1999-08-27
BR9807872A (pt) 2000-03-21
HUP0000914A3 (en) 2001-09-28
HUP0000914A2 (hu) 2001-04-28
KR100358636B1 (ko) 2002-10-31
AP9801199A0 (en) 1998-03-31
ATE267817T1 (de) 2004-06-15
DE69824157D1 (de) 2004-07-01
JP2000509731A (ja) 2000-08-02
NZ336628A (en) 2001-03-30
AP859A (en) 2000-07-21
PL335418A1 (en) 2000-04-25
AU744028B2 (en) 2002-02-14
AU5676898A (en) 1998-09-18
OA11089A (en) 2003-09-22
WO1998038173A1 (en) 1998-09-03
EA001963B1 (ru) 2001-10-22
BG103689A (bg) 2000-11-30
CN1248248A (zh) 2000-03-22
DE69824157T2 (de) 2004-10-14
NO994177D0 (no) 1999-08-27
ID22711A (id) 1999-12-09
TW504508B (en) 2002-10-01
PE58399A1 (es) 1999-06-16
SK113299A3 (en) 2001-05-10
KR20000075814A (ko) 2000-12-26

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