IL127751A0 - Thrombin inhibitors - Google Patents

Thrombin inhibitors

Info

Publication number: IL127751A0
Authority: IL; Israel
Prior art keywords: thrombin inhibitors; thrombin; inhibitors
Prior art date: 1996-08-14

Application number

IL12775197A

Other languages

English (en)

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-14

Filing date

1997-07-29

Publication date

1999-10-28

1997-07-29 Application filed by Basf Ag filed Critical Basf Ag

1999-10-28 Publication of IL127751A0 publication Critical patent/IL127751A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Rheumatology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)

IL12775197A 1996-08-14 1997-07-29 Thrombin inhibitors IL127751A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19632773A DE19632773A1 (de)	1996-08-14	1996-08-14	Neue Thrombininhibitoren
PCT/EP1997/004104 WO1998006741A1 (fr)	1996-08-14	1997-07-29	Inhibiteurs de la thrombine

Publications (1)

Publication Number	Publication Date
IL127751A0 true IL127751A0 (en)	1999-10-28

Family

ID=7802624

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12775197A IL127751A0 (en)	1996-08-14	1997-07-29	Thrombin inhibitors

Country Status (30)

Country	Link
US (1)	US6114358A (fr)
EP (1)	EP0956294B1 (fr)
JP (1)	JP4089981B2 (fr)
KR (1)	KR20000030002A (fr)
CN (1)	CN1228783A (fr)
AR (1)	AR009070A1 (fr)
AT (1)	ATE268781T1 (fr)
AU (1)	AU735364B2 (fr)
BG (1)	BG103096A (fr)
BR (1)	BR9711191A (fr)
CA (1)	CA2263220A1 (fr)
CO (1)	CO4900030A1 (fr)
CZ (1)	CZ299634B6 (fr)
DE (2)	DE19632773A1 (fr)
DK (1)	DK0956294T3 (fr)
ES (1)	ES2221062T3 (fr)
HR (1)	HRP970441B1 (fr)
HU (1)	HUP0001826A3 (fr)
ID (1)	ID17873A (fr)
IL (1)	IL127751A0 (fr)
MY (1)	MY132820A (fr)
NO (1)	NO990662D0 (fr)
NZ (1)	NZ333679A (fr)
PL (1)	PL188411B1 (fr)
PT (1)	PT956294E (fr)
RU (1)	RU2175328C2 (fr)
SK (1)	SK284915B6 (fr)
TR (1)	TR199900310T2 (fr)
WO (1)	WO1998006741A1 (fr)
ZA (1)	ZA977239B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9602263D0 (sv)	1996-06-07	1996-06-07	Astra Ab	New amino acid derivatives
SE9602646D0 (sv)	1996-07-04	1996-07-04	Astra Ab	Pharmaceutically-useful compounds
DE19632772A1 (de)	1996-08-14	1998-02-19	Basf Ag	Neue Benzamidine
DE19632773A1 (de) *	1996-08-14	1998-02-19	Basf Ag	Neue Thrombininhibitoren
AR013084A1 (es)	1997-06-19	2000-12-13	Astrazeneca Ab	Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv)	1997-12-05	1997-12-05	Astra Ab	New compounds
BR9907112A (pt) *	1998-01-26	2000-10-24	Basf Ag	Composto, medicamento, e, uso de um composto
JP2002501044A (ja) *	1998-01-26	2002-01-15	ビーエーエスエフアクチェンゲゼルシャフト	カリクレインプロテアーゼ阻害剤としての複素環アミジン
EP1054886B1 (fr) *	1998-02-09	2002-09-04	3-Dimensional Pharmaceuticals, Inc.	Heteroaryl amidines, methylamidines et guanidines utiles en tant qu'inhibiteurs de protease et plus particulierement en tant qu'inhibiteurs d'urokinase
JP2002536446A (ja) *	1999-02-09	2002-10-29	３−ディメンショナルファーマシューティカルズ，インコーポレイテッド	プロテアーゼ阻害剤としての、ヘテロアリールアミジン類、メチルアミジン類およびグアニジン類
CN1355810A (zh) *	1999-04-09	2002-06-26	巴斯福股份公司	凝血酶抑制剂的前体药物
EP1169315A2 (fr) *	1999-04-09	2002-01-09	Basf Aktiengesellschaft	Procede de production d'amidines
ATE281466T1 (de) *	1999-04-09	2004-11-15	Abbott Gmbh & Co Kg	Niedermolekulare inhibitoren von komplementproteasen
AR023510A1 (es)	1999-04-21	2002-09-04	Astrazeneca Ab	Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
KR20010002891A (ko) *	1999-06-18	2001-01-15	성재갑	아릴 또는 헤테로아릴 그룹을 갖는 트롬빈 억제제 및 그 제조 방법
DE19933861A1 (de)	1999-07-23	2001-01-25	Basf Ag	Verfahren zur Herstellung von 2-Aminomethyl-4-cyano-thiazol
DE10049937A1 (de) *	2000-10-06	2002-04-11	Knoll Ag	Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten
DE10064797A1 (de) *	2000-12-22	2002-06-27	Knoll Ag	Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
FI122575B (fi)	2006-12-04	2012-03-30	Dieffenbacher Panelboard Oy	Laitteisto kuitujen, kuten lastujen sirottelemiseksi
NZ700332A (en)	2010-03-30	2017-06-30	Verseon Corp	Multisubstituted aromatic compounds as inhibitors of thrombin
ES2853483T3 (es)	2013-03-15	2021-09-16	Verseon Int Corporation	Compuestos aromáticos multisustituidos como inhibidores de la serina proteasa
JP6479749B2 (ja)	2013-03-15	2019-03-06	ヴァーセオンコーポレイション	トロンビン阻害剤としてのハロゲノピラゾール
CN103520160B (zh) *	2013-10-17	2015-04-22	广东药学院	三棱中肽类化合物的应用
US10189810B2 (en)	2014-09-17	2019-01-29	Verseon Corporation	Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
CA2977993A1 (fr)	2015-02-27	2016-09-01	Verseon Corporation	Composes pyrazole substitues a utiliser en tant qu'inhibiteurs de serine protease

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4879313A (en) *	1988-07-20	1989-11-07	Mosanto Company	Novel platelet-aggregation inhibitors
US5332726A (en) *	1989-09-29	1994-07-26	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Antithrombotic peptides and pseudopeptides
GB9007751D0 (en) *	1990-04-05	1990-06-06	Ciba Geigy Ag	Novel platelet-aggregation inhibitors
EP0503203A1 (fr) *	1991-03-15	1992-09-16	Merrell Dow Pharmaceuticals Inc.	Nouveaux inhibiteurs de la thrombine
AU675981B2 (en) *	1992-12-02	1997-02-27	Bristol-Myers Squibb Company	Guanidinyl-substituted heterocyclic thrombin inhibitors
SE9301916D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	New peptides derivatives
EP0648780A1 (fr) *	1993-08-26	1995-04-19	Bristol-Myers Squibb Company	Inhibiteurs hétérocycliques de thrombine
IL112795A (en) *	1994-03-04	2001-01-28	Astrazeneca Ab	Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them
DE4421052A1 (de) *	1994-06-17	1995-12-21	Basf Ag	Neue Thrombininhibitoren, ihre Herstellung und Verwendung
DE4443390A1 (de) *	1994-12-06	1996-06-13	Basf Ag	Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
CN1198839C (zh) *	1995-02-17	2005-04-27	艾伯特有限及两合公司	作为凝血酶抑制剂的新的二肽脒类
DE19632772A1 (de) *	1996-08-14	1998-02-19	Basf Ag	Neue Benzamidine
DE19632773A1 (de) *	1996-08-14	1998-02-19	Basf Ag	Neue Thrombininhibitoren

1996
- 1996-08-14 DE DE19632773A patent/DE19632773A1/de not_active Withdrawn
1997
- 1997-07-29 CN CN97197391A patent/CN1228783A/zh active Pending
- 1997-07-29 TR TR1999/00310T patent/TR199900310T2/xx unknown
- 1997-07-29 EP EP97936672A patent/EP0956294B1/fr not_active Expired - Lifetime
- 1997-07-29 PT PT97936672T patent/PT956294E/pt unknown
- 1997-07-29 DK DK97936672T patent/DK0956294T3/da active
- 1997-07-29 ES ES97936672T patent/ES2221062T3/es not_active Expired - Lifetime
- 1997-07-29 JP JP50934098A patent/JP4089981B2/ja not_active Expired - Fee Related
- 1997-07-29 HU HU0001826A patent/HUP0001826A3/hu unknown
- 1997-07-29 US US09/242,289 patent/US6114358A/en not_active Expired - Lifetime
- 1997-07-29 DE DE59711714T patent/DE59711714D1/de not_active Expired - Fee Related
- 1997-07-29 KR KR1019997001279A patent/KR20000030002A/ko not_active Withdrawn
- 1997-07-29 PL PL97331540A patent/PL188411B1/pl not_active IP Right Cessation
- 1997-07-29 AT AT97936672T patent/ATE268781T1/de not_active IP Right Cessation
- 1997-07-29 IL IL12775197A patent/IL127751A0/xx unknown
- 1997-07-29 NZ NZ333679A patent/NZ333679A/en unknown
- 1997-07-29 CZ CZ0048699A patent/CZ299634B6/cs not_active IP Right Cessation
- 1997-07-29 SK SK8-99A patent/SK284915B6/sk not_active IP Right Cessation
- 1997-07-29 RU RU99104925/04A patent/RU2175328C2/ru not_active IP Right Cessation
- 1997-07-29 AU AU39417/97A patent/AU735364B2/en not_active Ceased
- 1997-07-29 BR BR9711191A patent/BR9711191A/pt not_active IP Right Cessation
- 1997-07-29 CA CA002263220A patent/CA2263220A1/fr not_active Abandoned
- 1997-07-29 WO PCT/EP1997/004104 patent/WO1998006741A1/fr not_active Ceased
- 1997-08-11 HR HR970441A patent/HRP970441B1/xx not_active IP Right Cessation
- 1997-08-13 CO CO97046533A patent/CO4900030A1/es unknown
- 1997-08-13 ZA ZA977239A patent/ZA977239B/xx unknown
- 1997-08-13 AR ARP970103680A patent/AR009070A1/es not_active Application Discontinuation
- 1997-08-13 MY MYPI97003700A patent/MY132820A/en unknown
- 1997-08-14 ID IDP972839A patent/ID17873A/id unknown
1999
- 1999-01-19 BG BG103096A patent/BG103096A/xx unknown
- 1999-02-12 NO NO990662A patent/NO990662D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20000030002A (ko)	2000-05-25
BG103096A (en)	1999-09-30
ZA977239B (en)	1999-02-15
JP4089981B2 (ja)	2008-05-28
DK0956294T3 (da)	2004-10-11
NO990662L (no)	1999-02-12
HRP970441A2 (en)	1998-06-30
HUP0001826A3 (en)	2002-01-28
AR009070A1 (es)	2000-03-08
EP0956294A1 (fr)	1999-11-17
RU2175328C2 (ru)	2001-10-27
NZ333679A (en)	1999-09-29
PL188411B1 (pl)	2005-01-31
JP2000516598A (ja)	2000-12-12
MY132820A (en)	2007-10-31
NO990662D0 (no)	1999-02-12
DE19632773A1 (de)	1998-02-19
CN1228783A (zh)	1999-09-15
SK899A3 (en)	1999-06-11
ATE268781T1 (de)	2004-06-15
HUP0001826A2 (hu)	2000-09-28
EP0956294B1 (fr)	2004-06-09
CZ48699A3 (cs)	1999-05-12
ES2221062T3 (es)	2004-12-16
WO1998006741A1 (fr)	1998-02-19
SK284915B6 (sk)	2006-02-02
PL331540A1 (en)	1999-07-19
CO4900030A1 (es)	2000-03-27
AU3941797A (en)	1998-03-06
PT956294E (pt)	2004-10-29
DE59711714D1 (de)	2004-07-15
US6114358A (en)	2000-09-05
CA2263220A1 (fr)	1998-02-19
TR199900310T2 (xx)	1999-04-21
HRP970441B1 (en)	2005-04-30
ID17873A (id)	1998-02-05
CZ299634B6 (cs)	2008-10-01
AU735364B2 (en)	2001-07-05
BR9711191A (pt)	1999-08-17

Publication	Publication Date	Title
HRP960075B1 (en)	2004-10-31	New thrombin inhibitors
PL331338A1 (en)	1999-07-05	Thiosulphonamidic metaloprotease inhibitors
AU3832895A (en)	1996-05-06	Thrombin inhibitors
HUP0001826A3 (en)	2002-01-28	Thrombin inhibitors
PL328307A1 (en)	1999-01-18	Serinic protease inhibitors
PL331803A1 (en)	1999-08-02	Bidonoric metaloprotease inhibitors
PL328875A1 (en)	1999-03-01	Serinic protease inhibitors
PL328223A1 (en)	1999-01-18	Aspartil protease inhibitors
IL136139A0 (en)	2001-05-20	Thrombin inhibitors
AU3396697A (en)	1998-04-14	Thrombin inhibitor
GB9613718D0 (en)	1996-08-28	Thrombin inhibitors
IL117437A0 (en)	1996-10-16	Novel thrombin inhibitors
IL121474A0 (en)	1998-02-08	Thrombin inhibitors
GB9624817D0 (en)	1997-01-15	Metalloproteinase inhibitors
ZA974779B (en)	1997-12-01	Thrombin inhibitors.
EP1027333A4 (fr)	2000-11-08	Inhibiteurs de thrombine
GB9624292D0 (en)	1997-01-08	Thrombin inhibitors
GB9625311D0 (en)	1997-01-22	Thrombin inhibitors
GB9605163D0 (en)	1996-05-15	Thrombin inhibitors
GB9624278D0 (en)	1997-01-08	Thrombin inhibitors
GB9624319D0 (en)	1997-01-08	Thrombin inhibitors
SI0956294T1 (en)	2004-10-31	Thrombin inhibitors
GB9704209D0 (en)	1997-04-16	Thrombin inhibitors
GB9716872D0 (en)	1997-10-15	Thrombin Inhibitors
ZA968922B (en)	1997-05-28	Thrombin inhibitors

Legal Events

Date	Code	Title	Description
2003-05-29	HP	Change in proprietorship