[go: up one dir, main page]

BG103096A - Thrombin inhibitors - Google Patents

Thrombin inhibitors

Info

Publication number
BG103096A
BG103096A BG103096A BG10309699A BG103096A BG 103096 A BG103096 A BG 103096A BG 103096 A BG103096 A BG 103096A BG 10309699 A BG10309699 A BG 10309699A BG 103096 A BG103096 A BG 103096A
Authority
BG
Bulgaria
Prior art keywords
thrombin inhibitors
compounds
formulawhere
thetreatment
aswell
Prior art date
Application number
BG103096A
Other languages
Bulgarian (bg)
English (en)
Inventor
Dorit Baucke
Udo Lange
Helmut Mack
Werner Seitz
Thomas Zierke
Hans HOEFFKEN
Wilfried Hornberger
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of BG103096A publication Critical patent/BG103096A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
BG103096A 1996-08-14 1999-01-19 Thrombin inhibitors BG103096A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19632773A DE19632773A1 (de) 1996-08-14 1996-08-14 Neue Thrombininhibitoren
PCT/EP1997/004104 WO1998006741A1 (de) 1996-08-14 1997-07-29 Thrombininhibitoren

Publications (1)

Publication Number Publication Date
BG103096A true BG103096A (en) 1999-09-30

Family

ID=7802624

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103096A BG103096A (en) 1996-08-14 1999-01-19 Thrombin inhibitors

Country Status (30)

Country Link
US (1) US6114358A (xx)
EP (1) EP0956294B1 (xx)
JP (1) JP4089981B2 (xx)
KR (1) KR20000030002A (xx)
CN (1) CN1228783A (xx)
AR (1) AR009070A1 (xx)
AT (1) ATE268781T1 (xx)
AU (1) AU735364B2 (xx)
BG (1) BG103096A (xx)
BR (1) BR9711191A (xx)
CA (1) CA2263220A1 (xx)
CO (1) CO4900030A1 (xx)
CZ (1) CZ299634B6 (xx)
DE (2) DE19632773A1 (xx)
DK (1) DK0956294T3 (xx)
ES (1) ES2221062T3 (xx)
HR (1) HRP970441B1 (xx)
HU (1) HUP0001826A3 (xx)
ID (1) ID17873A (xx)
IL (1) IL127751A0 (xx)
MY (1) MY132820A (xx)
NO (1) NO990662L (xx)
NZ (1) NZ333679A (xx)
PL (1) PL188411B1 (xx)
PT (1) PT956294E (xx)
RU (1) RU2175328C2 (xx)
SK (1) SK284915B6 (xx)
TR (1) TR199900310T2 (xx)
WO (1) WO1998006741A1 (xx)
ZA (1) ZA977239B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
DE19632773A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
WO1999037668A1 (de) * 1998-01-26 1999-07-29 Basf Aktiengesellschaft Thrombininhibitoren
AU2424499A (en) * 1998-01-26 1999-08-09 Basf Aktiengesellschaft Heterocyclic amidines as callicrein protease inhibitors
EP1054886B1 (en) * 1998-02-09 2002-09-04 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines as protease inhibitors, in particular as urokinase inhibitors
BR9917036A (pt) * 1999-02-09 2002-07-30 Dimensional Pharm Inc Amidinas heteroarila, metilamidinas e guanidinas como inibidores de protease
CZ20013577A3 (cs) * 1999-04-09 2002-07-17 Basf Aktiengesellschaft Inhibitory komplementních proteáz s nízkou molekulovou hmotností
AU3559000A (en) * 1999-04-09 2000-11-14 Basf Aktiengesellschaft Method for producing amidines
WO2000061609A2 (de) * 1999-04-09 2000-10-19 Basf Aktiengesellschaft Prodrugs von thrombininhibitoren
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
KR20010002891A (ko) * 1999-06-18 2001-01-15 성재갑 아릴 또는 헤테로아릴 그룹을 갖는 트롬빈 억제제 및 그 제조 방법
DE19933861A1 (de) 1999-07-23 2001-01-25 Basf Ag Verfahren zur Herstellung von 2-Aminomethyl-4-cyano-thiazol
DE10049937A1 (de) * 2000-10-06 2002-04-11 Knoll Ag Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
FI122575B (fi) 2006-12-04 2012-03-30 Dieffenbacher Panelboard Oy Laitteisto kuitujen, kuten lastujen sirottelemiseksi
SG10201502484SA (en) 2010-03-30 2015-05-28 Verseon Corp Multisubstituted aromatic compounds as inhibitors of thrombin
CN110101699A (zh) 2013-03-15 2019-08-09 维颂公司 作为丝氨酸蛋白酶抑制剂的多取代芳族化合物
HK1214252A1 (zh) 2013-03-15 2016-07-22 Verseon Corporation 作為凝血酶抑制劑的鹵代吡唑
CN103520160B (zh) * 2013-10-17 2015-04-22 广东药学院 三棱中肽类化合物的应用
BR112017004704A2 (pt) 2014-09-17 2018-01-23 Verseon Corp composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio em um indivíduo
PL3261639T3 (pl) 2015-02-27 2022-12-19 Verseon International Corporation Podstawione związki pirazolowe jako inhibitory proteazy serynowej

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
GB9007751D0 (en) * 1990-04-05 1990-06-06 Ciba Geigy Ag Novel platelet-aggregation inhibitors
EP0503203A1 (en) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Novel thrombin inhibitors
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) * 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
IL112795A (en) * 1994-03-04 2001-01-28 Astrazeneca Ab Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
DE4443390A1 (de) * 1994-12-06 1996-06-13 Basf Ag Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
JPH11500120A (ja) * 1995-02-17 1999-01-06 ビーエーエスエフ アクチェンゲゼルシャフト 新規なトロンビンインヒビター
DE19632773A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
DE19632772A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine

Also Published As

Publication number Publication date
ID17873A (id) 1998-02-05
EP0956294B1 (de) 2004-06-09
NO990662D0 (no) 1999-02-12
WO1998006741A1 (de) 1998-02-19
HRP970441B1 (en) 2005-04-30
PL331540A1 (en) 1999-07-19
US6114358A (en) 2000-09-05
AU3941797A (en) 1998-03-06
JP4089981B2 (ja) 2008-05-28
ZA977239B (en) 1999-02-15
HUP0001826A2 (hu) 2000-09-28
BR9711191A (pt) 1999-08-17
EP0956294A1 (de) 1999-11-17
NZ333679A (en) 1999-09-29
HUP0001826A3 (en) 2002-01-28
RU2175328C2 (ru) 2001-10-27
SK899A3 (en) 1999-06-11
SK284915B6 (sk) 2006-02-02
JP2000516598A (ja) 2000-12-12
CZ48699A3 (cs) 1999-05-12
NO990662L (no) 1999-02-12
CA2263220A1 (en) 1998-02-19
CO4900030A1 (es) 2000-03-27
DE19632773A1 (de) 1998-02-19
AR009070A1 (es) 2000-03-08
CZ299634B6 (cs) 2008-10-01
CN1228783A (zh) 1999-09-15
PL188411B1 (pl) 2005-01-31
ATE268781T1 (de) 2004-06-15
DK0956294T3 (da) 2004-10-11
DE59711714D1 (de) 2004-07-15
KR20000030002A (ko) 2000-05-25
ES2221062T3 (es) 2004-12-16
HRP970441A2 (en) 1998-06-30
PT956294E (pt) 2004-10-29
AU735364B2 (en) 2001-07-05
MY132820A (en) 2007-10-31
IL127751A0 (en) 1999-10-28
TR199900310T2 (xx) 1999-04-21

Similar Documents

Publication Publication Date Title
BG103096A (en) Thrombin inhibitors
BG102425A (en) (methylsulphonyl)phenyl-2-(5h)-furanons as cyclooxygenase-2-inhibitors
BG104056A (en) Triazole compounds and their use as dopamine-d3-ligands
BG105783A (en) Triazole compounds with dopamine-d3-receptor affinity
BG103310A (en) Benzonaphthyridins as bronchial therapeutical means
MY132115A (en) Novel thrombin inhibitors
TR200001603T2 (tr) Yeni bileşikler
BG103251A (bg) Оксадиазоли, методи за получаването им и приложението им като лекарствени средства
MX9702658A (es) Derivados novedosos de acido carboxilico, su preparacion y uso.
MX9700886A (es) Nuevas oxazolidinonas sustituidas.
GB9406857D0 (en) Improvements in or relating to organic compounds
IL112495A0 (en) Phenylacetic acid derivatives, their preparation and compositions containing them
MY115662A (en) Novel compounds with analgesic effect
GR3023233T3 (en) Inhibitors of dipeptidyl-aminopeptidase type iv
MY107158A (en) 3-arylcarbonyl; -1h-indoles useful as therapeutic agents.
MX9700885A (es) Nuevas heteroariloxazolidinonas.
MX9704030A (es) 1,1-dioxidos de 2-heterocicliloxi y tiometil-1,2,5-tiadiazolidin-3-ona y composiciones y metodo de uso de los mismos.
AU7650294A (en) Aminocyclohexylesters and uses thereof
MX9804588A (es) Uso de composiciones que comprenden blanqueador de halogeno para suavidad mejorada a la piel.
MY106202A (en) Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof.
AU8974298A (en) 1,4,7,10-tetraazabicyclo{8.2.2}tetradecan-2-one, a process for the preparation thereof and the use thereof for the preparation of tetraazamacrocycles
CA2047744A1 (en) Method for the synthesis of huperzine a and analogs thereof and compounds useful therein
BG103558A (en) Sulphonic acid or sulphonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds
UA49884C2 (uk) ПОХІДНІ <font face="Symbol">a</font>-ГІДРОКСИКАРБОНОВОЇ КИСЛОТИ ТА ЛІКАРСЬКИЙ ЗАСІБ НА ЇХ ОСНОВІ
BG102814A (en) New derivatives of carboxylic acid, their preparation and application