IE38383L - Doxycycline parenteral composition - Google Patents
Doxycycline parenteral compositionInfo
- Publication number
- IE38383L IE38383L IE731845A IE184573A IE38383L IE 38383 L IE38383 L IE 38383L IE 731845 A IE731845 A IE 731845A IE 184573 A IE184573 A IE 184573A IE 38383 L IE38383 L IE 38383L
- Authority
- IE
- Ireland
- Prior art keywords
- doxycycline
- salt
- composition
- water
- ascorbate
- Prior art date
Links
- 229960003722 doxycycline Drugs 0.000 title abstract 4
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 6
- WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 abstract 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 abstract 2
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 abstract 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical compound [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910000318 alkali metal phosphate Inorganic materials 0.000 abstract 2
- 229940072107 ascorbate Drugs 0.000 abstract 2
- 235000010323 ascorbic acid Nutrition 0.000 abstract 2
- 239000011668 ascorbic acid Substances 0.000 abstract 2
- TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Chemical compound OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 abstract 2
- 159000000003 magnesium salts Chemical class 0.000 abstract 2
- -1 oxide Chemical compound 0.000 abstract 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 abstract 1
- DPZHKLJPVMYFCU-UHFFFAOYSA-N 2-(5-bromopyridin-2-yl)acetonitrile Chemical compound BrC1=CC=C(CC#N)N=C1 DPZHKLJPVMYFCU-UHFFFAOYSA-N 0.000 abstract 1
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 abstract 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 abstract 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 abstract 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 229940001468 citrate Drugs 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 1
- 235000011180 diphosphates Nutrition 0.000 abstract 1
- 229940044170 formate Drugs 0.000 abstract 1
- 229940050410 gluconate Drugs 0.000 abstract 1
- 229940097042 glucuronate Drugs 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 229940049906 glutamate Drugs 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 229940005740 hexametaphosphate Drugs 0.000 abstract 1
- TWBYWOBDOCUKOW-UHFFFAOYSA-M isonicotinate Chemical compound [O-]C(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-M 0.000 abstract 1
- 229940001447 lactate Drugs 0.000 abstract 1
- 229960004194 lidocaine Drugs 0.000 abstract 1
- 229910001629 magnesium chloride Inorganic materials 0.000 abstract 1
- 125000005341 metaphosphate group Chemical group 0.000 abstract 1
- 229940014662 pantothenate Drugs 0.000 abstract 1
- 235000019161 pantothenic acid Nutrition 0.000 abstract 1
- 239000011713 pantothenic acid Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960004919 procaine Drugs 0.000 abstract 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 abstract 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 abstract 1
- 229960001860 salicylate Drugs 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 235000019832 sodium triphosphate Nutrition 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 abstract 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1350196 Doxycycline parenteral composition PFIZER Inc 27 Dec 1972 [26 Oct 1972] 59710/72 Heading A5B Aqueous pharmaceutical compositions for parenteral administration comprise a solution in water of from 1 to 10% by weight of a pharmaceutically acceptable acid addition salt of doxycycline, together with at least 3 molar proportions of a water-soluble alkali metal phosphate salt, and at least 3 molar proportions of a pharmaceutically acceptable watersoluble magnesium salt, said composition having a pH value in the range of from 1.0 to 3.5 The doxycycline acid addition salt may be the hydrochloride, hydrochloride hemiethanolate hemihydrate, hydrobromide, sulphate, nitrate, ascorbate, citrate, gluconate, lactate, isonicotinate, gentisinate, pantothenate, salicylate, glucuronate, formate, or glutamate. The alkali metal phosphate salt may be sodium or potassium orthophosphate, metaphosphate, pyrophosphate, tripolyphosphate or hexametaphosphate and the magnesium salt may be magnesium chloride, glyconate, oxide, ascorbate or lactate. The pH value may be adjusted by ascorbic, tartaric, gluconic, glucuronic, citric, gentisic, isonicotinic or glutamic acid. The composition may also contain a water-soluble local anaesthetic such as procaine and lidocaine hydrochlorides.
[GB1350196A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30123672A | 1972-10-26 | 1972-10-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38383L true IE38383L (en) | 1974-04-26 |
| IE38383B1 IE38383B1 (en) | 1978-03-01 |
Family
ID=23162536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1845/73A IE38383B1 (en) | 1972-10-26 | 1973-10-16 | Doxycline parenteral composition |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS531815B2 (en) |
| AR (1) | AR200582A1 (en) |
| BE (1) | BE806261A (en) |
| CA (1) | CA1005760A (en) |
| CH (1) | CH583563A5 (en) |
| DE (1) | DE2352910A1 (en) |
| DK (1) | DK133084C (en) |
| FI (1) | FI52269B (en) |
| FR (1) | FR2204402B1 (en) |
| GB (1) | GB1350196A (en) |
| IE (1) | IE38383B1 (en) |
| KE (1) | KE2568A (en) |
| MY (1) | MY7500201A (en) |
| NL (1) | NL162836C (en) |
| PH (1) | PH9547A (en) |
| SE (1) | SE411424B (en) |
| ZA (1) | ZA738187B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0052404B1 (en) * | 1980-11-19 | 1987-05-27 | THE PROCTER & GAMBLE COMPANY | Non-yellowing topical pharmaceutical composition |
| US5124317A (en) | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.P.A. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| US5977082A (en) | 1985-08-02 | 1999-11-02 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| CN115844842B (en) * | 2022-12-28 | 2024-09-13 | 江西省保灵动物保健品有限公司 | Doxycycline hydrochloride tablet and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1767891C3 (en) * | 1968-06-28 | 1980-10-30 | Pfizer | Process for the preparation of aqueous medicinal solutions for parenteral, peroral and local use containing a tetracycline derivative |
| ES396132A1 (en) * | 1970-10-30 | 1972-12-01 | Villax | Complexes of a-6-deoxy-5-hydroxy tetracycline and their preparation |
-
1972
- 1972-12-27 GB GB5971072A patent/GB1350196A/en not_active Expired
-
1973
- 1973-10-16 CA CA183,513A patent/CA1005760A/en not_active Expired
- 1973-10-16 IE IE1845/73A patent/IE38383B1/en unknown
- 1973-10-19 BE BE1005441A patent/BE806261A/en not_active IP Right Cessation
- 1973-10-19 FR FR7337347A patent/FR2204402B1/fr not_active Expired
- 1973-10-22 PH PH15133*UA patent/PH9547A/en unknown
- 1973-10-22 DE DE19732352910 patent/DE2352910A1/en not_active Ceased
- 1973-10-23 CH CH1495773A patent/CH583563A5/xx not_active IP Right Cessation
- 1973-10-23 ZA ZA738187A patent/ZA738187B/en unknown
- 1973-10-24 FI FI3299/73A patent/FI52269B/fi active
- 1973-10-24 NL NL7314596.A patent/NL162836C/en not_active IP Right Cessation
- 1973-10-25 JP JP11949073A patent/JPS531815B2/ja not_active Expired
- 1973-10-25 DK DK578073A patent/DK133084C/en active
- 1973-10-25 AR AR250701A patent/AR200582A1/en active
- 1973-10-25 SE SE7314529A patent/SE411424B/en unknown
-
1975
- 1975-09-15 KE KE2568*UA patent/KE2568A/en unknown
- 1975-12-30 MY MY201/75A patent/MY7500201A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1005760A (en) | 1977-02-22 |
| BE806261A (en) | 1974-04-19 |
| AU6158973A (en) | 1975-04-24 |
| FI52269B (en) | 1977-05-02 |
| GB1350196A (en) | 1974-04-18 |
| DK133084C (en) | 1976-08-16 |
| KE2568A (en) | 1975-09-26 |
| MY7500201A (en) | 1975-12-31 |
| PH9547A (en) | 1976-01-16 |
| FR2204402A1 (en) | 1974-05-24 |
| JPS4980226A (en) | 1974-08-02 |
| NL162836B (en) | 1980-02-15 |
| IE38383B1 (en) | 1978-03-01 |
| JPS531815B2 (en) | 1978-01-23 |
| DE2352910A1 (en) | 1974-05-09 |
| ZA738187B (en) | 1974-11-27 |
| SE411424B (en) | 1979-12-27 |
| FR2204402B1 (en) | 1976-08-13 |
| DK133084B (en) | 1976-03-22 |
| NL162836C (en) | 1980-07-15 |
| NL7314596A (en) | 1974-05-01 |
| AR200582A1 (en) | 1974-11-22 |
| CH583563A5 (en) | 1977-01-14 |
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