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GB1346014A - Derivatives of alpha-ketoglutaric acid and their preparation - Google Patents

Derivatives of alpha-ketoglutaric acid and their preparation

Info

Publication number
GB1346014A
GB1346014A GB4712172A GB1346014DA GB1346014A GB 1346014 A GB1346014 A GB 1346014A GB 4712172 A GB4712172 A GB 4712172A GB 1346014D A GB1346014D A GB 1346014DA GB 1346014 A GB1346014 A GB 1346014A
Authority
GB
United Kingdom
Prior art keywords
alpha
derivatives
ketoglutaric acid
preparation
pyridoxamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4712172A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Made SA
Original Assignee
Laboratorios Made SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Made SA filed Critical Laboratorios Made SA
Publication of GB1346014A publication Critical patent/GB1346014A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1346014 α-Ketoglutaric acid derivatives LABORATORIOS MADE SA 12 Oct 1972 47121/72 Heading C2C The invention comprises pyridoxal alphaketoglutarate and pyridoxamine alpha-ketoglutarates of the formulµ They may be prepared by dissolving alphaketoglutaric acid and pyridoxal or pyridoxamine separately and mixing the solutions. If desired the salt may be used as such in pharmaceutical compositions or neutralized with an organic or inorganic base and used in the form of a double salt.
GB4712172A 1972-10-09 1972-10-12 Derivatives of alpha-ketoglutaric acid and their preparation Expired GB1346014A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH30674A CH561183A5 (en) 1972-10-09 1972-10-09
GB4712172 1972-10-12
BE790118 1972-10-13

Publications (1)

Publication Number Publication Date
GB1346014A true GB1346014A (en) 1974-02-06

Family

ID=27159418

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4712172A Expired GB1346014A (en) 1972-10-09 1972-10-12 Derivatives of alpha-ketoglutaric acid and their preparation

Country Status (3)

Country Link
BE (1) BE790118A (en)
CH (1) CH561183A5 (en)
GB (1) GB1346014A (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
EP1169322B8 (en) 1999-03-08 2006-09-13 Medicure Inc. Pyridoxal analogues for the treatment of disorders caused by a deficiency in vitamin b6
WO2001003682A2 (en) 1999-07-13 2001-01-18 Medicure Inc. Use of pyridoxin derivatives for the treatment of diabetes and related complications
CA2383252A1 (en) 1999-08-24 2001-03-01 Medicure International Inc. Treatment of cardiovascular related pathologies
US7442689B2 (en) 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
DE60133323T2 (en) 2000-02-29 2009-03-05 Medicure International Inc. Cardioprotective phosphonates
AU784840B2 (en) 2000-03-28 2006-07-06 Medicure International Inc. Treatment of cerebrovascular disease
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
US6897228B2 (en) 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
ATE364595T1 (en) 2000-07-07 2007-07-15 Medicure Int Inc PYRIDOXINE AND PYRIDOXAL ANALOGS AS CARDIOVASCULAR THERAPEUTICS
US7459468B2 (en) 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
JP2008517956A (en) 2004-10-28 2008-05-29 メディキュア・インターナショナル・インコーポレーテッド Dual antiplatelet / anticoagulant pyridoxine analogues

Also Published As

Publication number Publication date
BE790118A (en) 1973-02-01
CH561183A5 (en) 1975-04-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee