HRP20031007A2 - Benzoxazepine derivatives and their use as ampa receptor stimulators - Google Patents

Benzoxazepine derivatives and their use as ampa receptor stimulators

Info

Publication number: HRP20031007A2
Authority: HR; Croatia
Prior art keywords: ampa receptor; benzoxazepine derivatives; receptor stimulators; stimulators; benzoxazepine
Prior art date: 2001-06-11

Application number

HR20031007A

Other languages

English (en)

Inventor

James Anthony Grove Simon

Zhang Mingqiang

Shahid Mohammad

Original Assignee

Akzo Nobel N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-11

Filing date

2002-06-05

Publication date

2005-10-31

2002-06-05 Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.

2005-10-31 Publication of HRP20031007A2 publication Critical patent/HRP20031007A2/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

HR20031007A 2001-06-11 2002-06-05 Benzoxazepine derivatives and their use as ampa receptor stimulators HRP20031007A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01202215		2001-06-11
PCT/EP2002/006185 WO2002100865A1 (en)	2001-06-11	2002-06-05	Benzoxazepine derivatives and their use as ampa receptor stimulators

Publications (1)

Publication Number	Publication Date
HRP20031007A2 true HRP20031007A2 (en)	2005-10-31

Family

ID=8180450

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20031007A HRP20031007A2 (en)	2001-06-11	2002-06-05	Benzoxazepine derivatives and their use as ampa receptor stimulators

Country Status (29)

Country	Link
US (2)	US7307073B2 (is)
EP (1)	EP1399450B1 (is)
JP (1)	JP4435561B2 (is)
KR (1)	KR100863255B1 (is)
CN (1)	CN1257908C (is)
AR (1)	AR036092A1 (is)
AT (1)	ATE389659T1 (is)
AU (1)	AU2002314144B2 (is)
BR (1)	BR0210222A (is)
CA (1)	CA2450274C (is)
CO (1)	CO5550447A2 (is)
CZ (1)	CZ300052B6 (is)
DE (1)	DE60225689T2 (is)
EC (1)	ECSP034891A (is)
ES (1)	ES2301651T3 (is)
HR (1)	HRP20031007A2 (is)
HU (1)	HUP0400154A3 (is)
IL (2)	IL158905A0 (is)
IS (1)	IS2526B (is)
MX (1)	MXPA03011563A (is)
NO (1)	NO328705B1 (is)
NZ (1)	NZ529670A (is)
PE (1)	PE20030097A1 (is)
PL (1)	PL366721A1 (is)
RU (1)	RU2279434C2 (is)
SK (1)	SK287150B6 (is)
TW (1)	TWI232863B (is)
WO (1)	WO2002100865A1 (is)
ZA (1)	ZA200309382B (is)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0400196A3 (en)	2001-06-14	2007-05-02	Organon Nv	(pyrido/thieno)[f]oxazepin-5-one derivatives, their use and pharmaceutical compositions containing them
US20110218190A1 (en) *	2008-11-10	2011-09-08	The Regents Of The University Of California	Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
SI2483278T1 (sl) *	2009-09-28	2014-03-31	F. Hoffmann-La Roche Ag	Inhibitorske spojine benzoksazepina pi3k in njihova uporaba pri zdravljenju raka
FR2964969B1 (fr) *	2010-09-16	2012-08-24	Servier Lab	Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BR112015031249A2 (pt)	2013-06-13	2017-07-25	Veroscience Llc	método de tratamento, método para tratar um distúrbio metabólico ou um elemento chave do mesmo, método para normalizar um ritmo diário de liberação de dopamina no sumn, método para estimular a liberação de dopamina de neurônios dopaminérgicos no sumn de um indivíduo e composição farmacêutica
WO2018085619A1 (en)	2016-11-07	2018-05-11	Arbutus Biopharma, Inc.	Substituted pyridinone-containing tricyclic compounds, and methods using same
TWI801517B (zh)	2018-03-12	2023-05-11	加拿大商愛彼特生物製藥公司	經取代的2-吡啶酮三環化合物、其類似物及其使用方法
US11505551B2 (en)	2018-04-12	2022-11-22	Arbutus Biopharma Corporation	Methods for preparing substituted pyridinone-containing tricyclic compounds
JP7138246B2 (ja)	2018-11-22	2022-09-15	福建▲広▼生中霖生物科技有限公司	Ｂ型肝炎表面抗原阻害剤の結晶形
WO2021188911A1 (en) *	2020-03-20	2021-09-23	Amathus Therapeutics, Inc.	Cyclic sulfonamide derivatives as trap1 modulators and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1238719A (is)	1968-11-01	1971-07-07
PT651746E (pt)	1992-07-24	2002-09-30	Univ California	Drogas que intensificam as respostas sinapticas mediadas por receptores de ampa
EP0801651B1 (de)	1995-01-06	2001-07-11	F. Hoffmann-La Roche Ag	Hydroxymethyl-imidazodiazepine und deren ester
US5650409A (en) *	1995-06-02	1997-07-22	Cortex Pharmaceuticals, Inc.	Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) *	1996-04-03	1998-04-07	The Regents Of The University Of California	Benzoxazines for enhancing synaptic response
ES2245015T3 (es)	1997-06-09	2005-12-16	Pfizer Products Inc.	Quinazolin-4-onas como antagonistas de ampa.
US5985871A (en)	1997-12-24	1999-11-16	Cortex Pharmaceuticals, Inc.	Benzoxazine compounds for enhancing synaptic response
HUP0101280A3 (en) *	1998-02-18	2003-02-28	Neurosearch As	Positive ampa receptor modulator compounds and their use
US6124278A (en)	1998-04-03	2000-09-26	The Regents Of The University Of California	Acylbenzoxazines for enhancing synaptic response

2002
- 2002-05-31 TW TW091111746A patent/TWI232863B/zh not_active IP Right Cessation
- 2002-06-05 PL PL02366721A patent/PL366721A1/xx not_active IP Right Cessation
- 2002-06-05 KR KR1020037016150A patent/KR100863255B1/ko not_active Expired - Fee Related
- 2002-06-05 EP EP02740691A patent/EP1399450B1/en not_active Expired - Lifetime
- 2002-06-05 MX MXPA03011563A patent/MXPA03011563A/es active IP Right Grant
- 2002-06-05 HU HU0400154A patent/HUP0400154A3/hu unknown
- 2002-06-05 JP JP2003503632A patent/JP4435561B2/ja not_active Expired - Lifetime
- 2002-06-05 ES ES02740691T patent/ES2301651T3/es not_active Expired - Lifetime
- 2002-06-05 US US10/480,623 patent/US7307073B2/en not_active Expired - Lifetime
- 2002-06-05 AU AU2002314144A patent/AU2002314144B2/en not_active Expired
- 2002-06-05 AT AT02740691T patent/ATE389659T1/de active
- 2002-06-05 WO PCT/EP2002/006185 patent/WO2002100865A1/en not_active Ceased
- 2002-06-05 CN CNB028116410A patent/CN1257908C/zh not_active Expired - Lifetime
- 2002-06-05 HR HR20031007A patent/HRP20031007A2/xx not_active Application Discontinuation
- 2002-06-05 BR BR0210222-6A patent/BR0210222A/pt not_active Application Discontinuation
- 2002-06-05 CA CA2450274A patent/CA2450274C/en not_active Expired - Lifetime
- 2002-06-05 IL IL15890502A patent/IL158905A0/xx unknown
- 2002-06-05 RU RU2004100310/04A patent/RU2279434C2/ru not_active IP Right Cessation
- 2002-06-05 SK SK1518-2003A patent/SK287150B6/sk not_active IP Right Cessation
- 2002-06-05 NZ NZ529670A patent/NZ529670A/en unknown
- 2002-06-05 CZ CZ20033376A patent/CZ300052B6/cs not_active IP Right Cessation
- 2002-06-05 DE DE60225689T patent/DE60225689T2/de not_active Expired - Lifetime
- 2002-06-10 PE PE2002000495A patent/PE20030097A1/es not_active Application Discontinuation
- 2002-06-10 AR ARP020102171A patent/AR036092A1/es unknown
2003
- 2003-11-13 IS IS7036A patent/IS2526B/is unknown
- 2003-11-17 IL IL158905A patent/IL158905A/en not_active IP Right Cessation
- 2003-12-02 ZA ZA200309382A patent/ZA200309382B/en unknown
- 2003-12-04 CO CO03107046A patent/CO5550447A2/es not_active Application Discontinuation
- 2003-12-10 NO NO20035486A patent/NO328705B1/no not_active IP Right Cessation
- 2003-12-11 EC EC2003004891A patent/ECSP034891A/es unknown
2007
- 2007-10-25 US US11/924,451 patent/US7504390B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SK287150B6 (sk)	2010-01-07
ATE389659T1 (de)	2008-04-15
AR036092A1 (es)	2004-08-11
CA2450274C (en)	2010-12-21
IL158905A0 (en)	2004-05-12
ES2301651T3 (es)	2008-07-01
US7504390B2 (en)	2009-03-17
RU2004100310A (ru)	2005-06-10
ECSP034891A (es)	2004-01-28
TWI232863B (en)	2005-05-21
JP2004533466A (ja)	2004-11-04
HK1061858A1 (en)	2004-10-08
US7307073B2 (en)	2007-12-11
KR100863255B1 (ko)	2008-10-15
US20040171605A1 (en)	2004-09-02
KR20040006030A (ko)	2004-01-16
CZ300052B6 (cs)	2009-01-21
BR0210222A (pt)	2004-04-13
DE60225689D1 (de)	2008-04-30
JP4435561B2 (ja)	2010-03-17
IL158905A (en)	2008-12-29
SK15182003A3 (sk)	2004-05-04
EP1399450B1 (en)	2008-03-19
HUP0400154A3 (en)	2007-05-02
IS2526B (is)	2009-07-15
EP1399450A1 (en)	2004-03-24
DE60225689T2 (de)	2008-07-17
US20080139529A1 (en)	2008-06-12
MXPA03011563A (es)	2004-03-18
CZ20033376A3 (en)	2004-04-14
CN1257908C (zh)	2006-05-31
AU2002314144B2 (en)	2008-01-31
CA2450274A1 (en)	2002-12-19
PE20030097A1 (es)	2003-02-08
ZA200309382B (en)	2005-03-02
HUP0400154A2 (hu)	2004-07-28
WO2002100865A1 (en)	2002-12-19
CO5550447A2 (es)	2005-08-31
CN1514835A (zh)	2004-07-21
NO20035486D0 (no)	2003-12-10
RU2279434C2 (ru)	2006-07-10
NZ529670A (en)	2006-02-24
IS7036A (is)	2003-11-13
PL366721A1 (en)	2005-02-07
NO328705B1 (no)	2010-05-03

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TWI371450B (en)	2012-09-01	Novel substituted dihydro 3-halo-1h-pyrazole-5-carboxylates,their preparation and use
PL377239A1 (pl)	2006-01-23	Nowe amino-podstawione pochodne dihydropirymido [4,5-d]-pirymidynonu, ich wytwarzanie i zastosowanie jako środków framaceutycznych
IL159832A0 (en)	2004-06-20	4-amino-6-phenyl-pyrrolo[2,3-d] pyrimidine derivatives
PL373223A1 (en)	2005-08-22	7,8,9,10-tetrahydro-6h-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2h-pyrrolo[2,1-b]-quinazolinone derivatives
IL159275A0 (en)	2004-06-01	Phenylsulfonyl-1, 3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use
HUP0402171A3 (en)	2008-08-28	Pyrazolopyrimidinone derivatives having pde7-inhibitory activity
AU2002359126A8 (en)	2003-06-30	Benzodiazepine derivatives, preparation thereof and use thereof
PL356990A1 (en)	2004-07-12	Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists
DE60002821D1 (en)	2003-06-26	Reversibel photokuppelnde nukleinsäure und phosphoramidit
TWI318974B (en)	2010-01-01	Acylaminothiazole derivatives, their preparation and their therapeutic use
IL166821A0 (en)	2006-01-15	Novel 1,4-diazabicycloalkane derivatives their preparation and use
DE60013243D1 (en)	2004-09-30	Immunochromatographisches teststück und chromatographische analysenmethode
IL158905A0 (en)	2004-05-12	Benzoxazepine derivatives and their use as ampa receptor stimulators
PL375709A1 (en)	2005-12-12	Derivatives of [6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide
HUP0600238A3 (en)	2009-12-28	Benzothiazole- and benzoxazole-4,7-dione derivatives and their use
GB0112802D0 (en)	2001-07-18	Pyrimidine derivatives
DE50010914D1 (en)	2005-09-15	Emissionsarme und hydrolysestabile polyurethan-schaumstoffe
PL365342A1 (en)	2004-12-27	Mikanolide derivatives, their preparation and therapeutic uses
IL142362A0 (en)	2002-03-10	Ureidopiperidine derivatives as selective human nk3 receptor antagonists
EP1279384A4 (en)	2006-04-26	STIMULATOR OF EROGEN ZONES
GB0027548D0 (en)	2000-12-27	Bicyclic amide derivatives
HK1036795A (en)	2002-01-18	Ureidopiperidine derivatives as selective human nk3 receptor antagonists
GB0111047D0 (en)	2001-06-27	Pacemaker
GB0107878D0 (en)	2001-05-23	Pacemaker
AU2002363642A1 (en)	2003-05-26	Nk1 antagonists

Legal Events

Date	Code	Title	Description
2005-10-31	A1OB	Publication of a patent application
2006-04-04	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2006-12-11	PPPP	Transfer of rights	Owner name: N.V. ORGANON, NL
2011-05-26	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20110526 Year of fee payment: 10
2012-01-13	ODBC	Application rejected