HRP20031007A2 - Benzoxazepine derivatives and their use as ampa receptor stimulators - Google Patents

Benzoxazepine derivatives and their use as ampa receptor stimulators

Info

Publication number: HRP20031007A2
Authority: HR; Croatia
Prior art keywords: ampa receptor; benzoxazepine derivatives; receptor stimulators; stimulators; benzoxazepine
Prior art date: 2001-06-11

Application number

HR20031007A

Other languages

English (en)

Inventor

James Anthony Grove Simon

Zhang Mingqiang

Shahid Mohammad

Original Assignee

Akzo Nobel N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-11

Filing date

2002-06-05

Publication date

2005-10-31

2002-06-05 Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.

2005-10-31 Publication of HRP20031007A2 publication Critical patent/HRP20031007A2/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Cardiology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

HR20031007A 2001-06-11 2002-06-05 Benzoxazepine derivatives and their use as ampa receptor stimulators HRP20031007A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01202215		2001-06-11
PCT/EP2002/006185 WO2002100865A1 (en)	2001-06-11	2002-06-05	Benzoxazepine derivatives and their use as ampa receptor stimulators

Publications (1)

Publication Number	Publication Date
HRP20031007A2 true HRP20031007A2 (en)	2005-10-31

Family

ID=8180450

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20031007A HRP20031007A2 (en)	2001-06-11	2002-06-05	Benzoxazepine derivatives and their use as ampa receptor stimulators

Country Status (29)

Country	Link
US (2)	US7307073B2 (xx)
EP (1)	EP1399450B1 (xx)
JP (1)	JP4435561B2 (xx)
KR (1)	KR100863255B1 (xx)
CN (1)	CN1257908C (xx)
AR (1)	AR036092A1 (xx)
AT (1)	ATE389659T1 (xx)
AU (1)	AU2002314144B2 (xx)
BR (1)	BR0210222A (xx)
CA (1)	CA2450274C (xx)
CO (1)	CO5550447A2 (xx)
CZ (1)	CZ300052B6 (xx)
DE (1)	DE60225689T2 (xx)
EC (1)	ECSP034891A (xx)
ES (1)	ES2301651T3 (xx)
HR (1)	HRP20031007A2 (xx)
HU (1)	HUP0400154A3 (xx)
IL (2)	IL158905A0 (xx)
IS (1)	IS2526B (xx)
MX (1)	MXPA03011563A (xx)
NO (1)	NO328705B1 (xx)
NZ (1)	NZ529670A (xx)
PE (1)	PE20030097A1 (xx)
PL (1)	PL366721A1 (xx)
RU (1)	RU2279434C2 (xx)
SK (1)	SK287150B6 (xx)
TW (1)	TWI232863B (xx)
WO (1)	WO2002100865A1 (xx)
ZA (1)	ZA200309382B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7345036B2 (en)	2001-06-14	2008-03-18	N.V. Organon	(Pyrido/thieno)—[f]—oxazepine-5-one derivatives
WO2010054336A2 (en) *	2008-11-10	2010-05-14	The Regents Of The University Of California	Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
DK2483278T3 (da) *	2009-09-28	2014-01-13	Hoffmann La Roche	Benzoxazepin pi3k-inhibitorforbindelser og deres anvendelse i behandlingen af cancer
FR2964969B1 (fr)	2010-09-16	2012-08-24	Servier Lab	Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP3008167A4 (en)	2013-06-13	2017-06-07	VeroScience LLC	Compositions and methods for treating metabolic disorders
WO2018009256A1 (en)	2016-03-29	2018-01-11	Respirerx Pharmaceuticals, Inc.	Compositions and methods for treating attention deficit disorders
US10821103B2 (en)	2016-11-07	2020-11-03	Arbutus Biopharma Corporation	Substituted pyridinone-containing trycyclic compounds, and methods using same
WO2019177937A1 (en)	2018-03-12	2019-09-19	Arbutus Biopharma, Inc.	Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same
KR20200142529A (ko)	2018-04-12	2020-12-22	아뷰터스 바이오파마 코포레이션	치환된 피리디논-함유 트리사이클릭 화합물의 제조 방법
AU2019382521B2 (en)	2018-11-22	2023-11-16	Fujian Akeylink Biotechnology Co., Ltd.	Crystal form of hepatitis B surface antigen inhibitor
EP4121072A1 (en) *	2020-03-20	2023-01-25	Amathus Therapeutics, Inc.	Cyclic sulfonamide derivatives as trap1 modulators and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1238719A (xx)	1968-11-01	1971-07-07
CA2138533C (en)	1992-07-24	2009-04-14	Gary S. Lynch	Drugs that enhance synaptic responses mediated by ampa receptors
CN1168140A (zh)	1995-01-06	1997-12-17	弗·哈夫曼-拉罗切有限公司	羟甲基咪唑并二氮杂䓬及其酯
US5650409A (en) *	1995-06-02	1997-07-22	Cortex Pharmaceuticals, Inc.	Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) *	1996-04-03	1998-04-07	The Regents Of The University Of California	Benzoxazines for enhancing synaptic response
DE69831446T2 (de)	1997-06-09	2006-06-14	Pfizer Prod Inc	Chinazolin-4-on AMPA Antagonisten
US5985871A (en)	1997-12-24	1999-11-16	Cortex Pharmaceuticals, Inc.	Benzoxazine compounds for enhancing synaptic response
CA2320354A1 (en) *	1998-02-18	1999-08-26	Neurosearch A/S	Novel compounds and their use as positive ampa receptor modulators
US6124278A (en)	1998-04-03	2000-09-26	The Regents Of The University Of California	Acylbenzoxazines for enhancing synaptic response

2002
- 2002-05-31 TW TW091111746A patent/TWI232863B/zh not_active IP Right Cessation
- 2002-06-05 WO PCT/EP2002/006185 patent/WO2002100865A1/en not_active Ceased
- 2002-06-05 JP JP2003503632A patent/JP4435561B2/ja not_active Expired - Lifetime
- 2002-06-05 SK SK1518-2003A patent/SK287150B6/sk not_active IP Right Cessation
- 2002-06-05 KR KR1020037016150A patent/KR100863255B1/ko not_active Expired - Fee Related
- 2002-06-05 CN CNB028116410A patent/CN1257908C/zh not_active Expired - Lifetime
- 2002-06-05 CZ CZ20033376A patent/CZ300052B6/cs not_active IP Right Cessation
- 2002-06-05 HU HU0400154A patent/HUP0400154A3/hu unknown
- 2002-06-05 US US10/480,623 patent/US7307073B2/en not_active Expired - Lifetime
- 2002-06-05 DE DE60225689T patent/DE60225689T2/de not_active Expired - Lifetime
- 2002-06-05 MX MXPA03011563A patent/MXPA03011563A/es active IP Right Grant
- 2002-06-05 IL IL15890502A patent/IL158905A0/xx unknown
- 2002-06-05 HR HR20031007A patent/HRP20031007A2/xx not_active Application Discontinuation
- 2002-06-05 RU RU2004100310/04A patent/RU2279434C2/ru not_active IP Right Cessation
- 2002-06-05 PL PL02366721A patent/PL366721A1/xx not_active IP Right Cessation
- 2002-06-05 AT AT02740691T patent/ATE389659T1/de active
- 2002-06-05 EP EP02740691A patent/EP1399450B1/en not_active Expired - Lifetime
- 2002-06-05 CA CA2450274A patent/CA2450274C/en not_active Expired - Lifetime
- 2002-06-05 NZ NZ529670A patent/NZ529670A/en unknown
- 2002-06-05 BR BR0210222-6A patent/BR0210222A/pt not_active Application Discontinuation
- 2002-06-05 AU AU2002314144A patent/AU2002314144B2/en not_active Expired
- 2002-06-05 ES ES02740691T patent/ES2301651T3/es not_active Expired - Lifetime
- 2002-06-10 PE PE2002000495A patent/PE20030097A1/es not_active Application Discontinuation
- 2002-06-10 AR ARP020102171A patent/AR036092A1/es unknown
2003
- 2003-11-13 IS IS7036A patent/IS2526B/is unknown
- 2003-11-17 IL IL158905A patent/IL158905A/en not_active IP Right Cessation
- 2003-12-02 ZA ZA200309382A patent/ZA200309382B/en unknown
- 2003-12-04 CO CO03107046A patent/CO5550447A2/es not_active Application Discontinuation
- 2003-12-10 NO NO20035486A patent/NO328705B1/no not_active IP Right Cessation
- 2003-12-11 EC EC2003004891A patent/ECSP034891A/es unknown
2007
- 2007-10-25 US US11/924,451 patent/US7504390B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AR036092A1 (es)	2004-08-11
EP1399450B1 (en)	2008-03-19
SK287150B6 (sk)	2010-01-07
JP4435561B2 (ja)	2010-03-17
CZ20033376A3 (en)	2004-04-14
CZ300052B6 (cs)	2009-01-21
CA2450274C (en)	2010-12-21
CA2450274A1 (en)	2002-12-19
ATE389659T1 (de)	2008-04-15
TWI232863B (en)	2005-05-21
SK15182003A3 (sk)	2004-05-04
CO5550447A2 (es)	2005-08-31
PL366721A1 (en)	2005-02-07
CN1257908C (zh)	2006-05-31
BR0210222A (pt)	2004-04-13
US7504390B2 (en)	2009-03-17
RU2004100310A (ru)	2005-06-10
US7307073B2 (en)	2007-12-11
EP1399450A1 (en)	2004-03-24
IL158905A (en)	2008-12-29
AU2002314144B2 (en)	2008-01-31
HUP0400154A2 (hu)	2004-07-28
JP2004533466A (ja)	2004-11-04
WO2002100865A1 (en)	2002-12-19
US20040171605A1 (en)	2004-09-02
KR100863255B1 (ko)	2008-10-15
NO328705B1 (no)	2010-05-03
NZ529670A (en)	2006-02-24
PE20030097A1 (es)	2003-02-08
ZA200309382B (en)	2005-03-02
ECSP034891A (es)	2004-01-28
NO20035486D0 (no)	2003-12-10
HK1061858A1 (en)	2004-10-08
DE60225689T2 (de)	2008-07-17
CN1514835A (zh)	2004-07-21
DE60225689D1 (de)	2008-04-30
KR20040006030A (ko)	2004-01-16
MXPA03011563A (es)	2004-03-18
ES2301651T3 (es)	2008-07-01
IS2526B (is)	2009-07-15
RU2279434C2 (ru)	2006-07-10
HUP0400154A3 (en)	2007-05-02
IL158905A0 (en)	2004-05-12
US20080139529A1 (en)	2008-06-12
IS7036A (is)	2003-11-13

Publication	Publication Date	Title
TWI371450B (en)	2012-09-01	Novel substituted dihydro 3-halo-1h-pyrazole-5-carboxylates,their preparation and use
PL377239A1 (pl)	2006-01-23	Nowe amino-podstawione pochodne dihydropirymido [4,5-d]-pirymidynonu, ich wytwarzanie i zastosowanie jako środków framaceutycznych
IL159832A0 (en)	2004-06-20	4-amino-6-phenyl-pyrrolo[2,3-d] pyrimidine derivatives
PL373223A1 (en)	2005-08-22	7,8,9,10-tetrahydro-6h-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2h-pyrrolo[2,1-b]-quinazolinone derivatives
IL148997A0 (en)	2002-11-10	Bicyclic imidazo-3-yl-amine derivatives
PL366829A1 (en)	2005-02-07	Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use
HUP0402171A3 (en)	2008-08-28	Pyrazolopyrimidinone derivatives having pde7-inhibitory activity
AU2002359126A8 (en)	2003-06-30	Benzodiazepine derivatives, preparation thereof and use thereof
IL149010A0 (en)	2002-11-10	Bicyclic imidazo-5-yl-amine derivatives
PL356990A1 (en)	2004-07-12	Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists
DE60002821D1 (en)	2003-06-26	Reversibel photokuppelnde nukleinsäure und phosphoramidit
TWI318974B (en)	2010-01-01	Acylaminothiazole derivatives, their preparation and their therapeutic use
HRP20031007A2 (en)	2005-10-31	Benzoxazepine derivatives and their use as ampa receptor stimulators
IL166821A0 (en)	2006-01-15	Novel 1,4-diazabicycloalkane derivatives their preparation and use
DE60013243D1 (en)	2004-09-30	Immunochromatographisches teststück und chromatographische analysenmethode
PL375709A1 (en)	2005-12-12	Derivatives of [6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide
HUP0600238A3 (en)	2009-12-28	Benzothiazole- and benzoxazole-4,7-dione derivatives and their use
DE50010914D1 (en)	2005-09-15	Emissionsarme und hydrolysestabile polyurethan-schaumstoffe
GB0112803D0 (en)	2001-07-18	Pyrimidine derivatives
IL142362A0 (en)	2002-03-10	Ureidopiperidine derivatives as selective human nk3 receptor antagonists
EP1279384A4 (en)	2006-04-26	STIMULATOR OF EROGEN ZONES
GB0027548D0 (en)	2000-12-27	Bicyclic amide derivatives
GB0119477D0 (en)	2001-10-03	Pyrimidine derivatives
HK1036795A (en)	2002-01-18	Ureidopiperidine derivatives as selective human nk3 receptor antagonists
GB0111047D0 (en)	2001-06-27	Pacemaker

Legal Events

Date	Code	Title	Description
2005-10-31	A1OB	Publication of a patent application
2006-04-04	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2006-12-11	PPPP	Transfer of rights	Owner name: N.V. ORGANON, NL
2011-05-26	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20110526 Year of fee payment: 10
2012-01-13	ODBC	Application rejected